Negative / Null Result ReportMedicine
Maheshwari D, Nagdev NG, Pillai MR et al. · 2026 · Journal of glaucoma
Precis This study concludes that combined gonioscopy assisted transluminal trabeculotomy-phacoemulsification have similar efficacy in terms of intraocular pressure and antiglaucoma medication reduction in primary open angle and primary…
View details →Negative / Null Result ReportOpen accessMedicine
Amaechi BT, Vohra R, Abdollahi S et al. · 2026 · BDJ open
Aim This in vitro study used a pH cycling model to compare the caries remineralizing efficacy of toothpaste formulations containing calcium hypophosphite (CaP), hydroxyapatite (HAP), or sodium fluoride (NaF). Methods Bovine enamel blocks…
View details →Negative / Null Result ReportOpen accessMedicine
Şen Uzeli Ü, Doğan M, Eser B et al. · 2026 · Medicine
This study aimed to examine the relationship between anxiety and kinesiophobia in individuals receiving continuous hemodialysis and peritoneal dialysis (PD) therapy. This cross-sectional study included 109 patients receiving renal…
View details →Negative / Null Result ReportMedicine
Kurtz JL, Ehlers M, Montgomery SR Jr et al. · 2026 · The American journal of sports medicine
Background Smoking has been linked to alterations in cellular inflammatory pathways and adverse outcomes in orthopaedic procedures. It is unclear how patient smoking affects the intra-articular microenvironment in the setting of…
View details →Negative / Null Result ReportMedicine
Elyeli K, Esmaeilzadeh S, Esmaeilzadeh S · 2026 · Computers, informatics, nursing : CIN
Diabetes is characterized as the "pandemic of the age" due to its increasing prevalence. Since it is a disease that affects all areas of life, it causes negative effects on the quality of life and self-care activities. This study aimed to…
View details →Negative / Null Result ReportOpen accessMedicine
Ibrahim EA, Hanno KIH, Alrafah E et al. · 2026 · The journal of advanced prosthodontics
Purpose The aim is to evaluate the trueness and displacement of tooth position as well as subjective retention of the monolithic complete denture (CD). Materials and methods Twenty-two completely edentulous patients received (n = 22)…
View details →Negative / Null Result ReportOpen accessMedicine
Youssef B, Ibrahim EA, Moselhy SS et al. · 2026 · Discover nano
Background The Late-onset Alzheimer's disease (LOAD) is progressive cognitive deficits associated with different abnormalities as cholinergic dysfunction, amyloid accumulation, inflammation, and oxidative stress. Magnolol is a polyphenolic…
View details →Negative / Null Result ReportOpen accessMedicine
Wu H, Zhang ZH, Ye T et al. · 2026 · Frontiers in medicine
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) play a regulatory roles in metabolism across several tissues and have…
View details →Negative / Null Result ReportOpen accessMedicine
Fangxin W, Bin L, Haocheng Z et al. · 2026 · Frontiers in surgery
Objective To compare the safety and efficacy of ileotransverse colon Overlap and π-shaped anastomosis in laparoscopic radical right hemicolectomy (LRRH). Methods A prospective RCT enrolled 120 right colon cancer patients (Dec 2022-Dec…
View details →Negative / Null Result ReportMedicine
Popescu-Giovanitsas I, Woudstra-de Jong JE, Vingerling JR et al. · 2026 · Acta ophthalmologica
Purpose To assess the vision-related quality of life (VRQoL) in glaucoma patients over 5 years after primary Baerveldt glaucoma implant (BGI) or trabeculectomy (TE) using a secondary analysis of a randomized clinical trial. Methods…
View details →Negative / Null Result ReportOpen accessMedicine
Yao H, Chen W, Lin Z et al. · 2026 · Journal of orthopaedic surgery and research
Objective To systematically compare the clinical efficacy and safety of four posterior surgical approaches-olecranon osteotomy (OO), triceps-reflecting approach (TRA), triceps-splitting approach (TS), and triceps tongue approach (TT)-for…
View details →Negative / Null Result ReportOpen accessMedicine
Patel DM, Wilson RF, Gharibani T et al. · 2026 · Journal of patient-reported outcomes
BACKGROUND: Patient-reported outcomes (PROs) are key outcomes of importance for people with chronic kidney disease (CKD), and may be of even higher relevance for patients with concomitant anemia which can often be symptomatic. Thus, PROs…
View details →Negative / Null Result ReportOpen accessMedicine
Advani H, Dixit A, Kumar S et al. · 2026 · Cureus
Background Gingival recession (GR) results in significant functional and cosmetic concerns and manifests as a disintegration of soft and hard tissues. Recently, clinical research has increasingly focused on the development of minimally…
View details →Negative / Null Result ReportOpen accessMedicine
Zhang Y, Guo M, Bian Q et al. · 2026 · BMC nephrology
Background Primary membranous nephropathy (pMN) is characterized by a prolonged course, frequent relapses, and variable treatment responses. While obinutuzumab (OBI) demonstrates promising efficacy in B-cell depletion, its direct…
View details →Negative / Null Result ReportOpen accessMedicine
Sfulcini M, Trevisi E, Piccioli-Cappelli F et al. · 2026 · PloS one
Weaning represents a critical transition in dairy calves, involving simultaneous dietary, social, and environmental changes. This study investigated how the weaning affects immune-related gene expression in circulating leukocytes of…
View details →Negative / Null Result ReportOpen accessMedicine
Mohamed HA, Azer A, AboElHassan RG · 2026 · International journal of dentistry
Background Advanced lithium disilicate glass ceramics offer excellent esthetics, but conservative crown preparations are not always the preferred choice. Various margin designs are available; however, more conservative vertical…
View details →Negative / Null Result ReportOpen accessMedicine
William Coley, Sree Rayavarapu, Jack H van der Meulen et al. · 2013 · PLoS ONE
BACKGROUND: Current treatments for idiopathic inflammatory myopathies (collectively called myositis) focus on the suppression of an autoimmune inflammatory response within the skeletal muscle. However, it has been observed that there is a poor correlation between the successful suppression of muscle inflammation and an improvement in muscle function. Some evidence in the literature suggests that metabolic abnormalities in the skeletal muscle underlie the weakness that continues despite successful immunosuppression. We have previously shown that decreased expression of a purine nucleotide cycle
View details →Negative / Null Result ReportOpen accessMedicine
James E Campbell, Michael Adam Meledeo, Andrew P Cap · 2014 · PLoS ONE
BACKGROUND: Acute traumatic coagulopathy (ATC) has been linked to an increase in activated protein C (aPC) from 40 pM in healthy individuals to 175 pM. aPC exerts its activity primarily through cleavage of active coagulation factor Va (fVa). Platelets reportedly possess fVa which is more resistant to aPC cleavage than plasma fVa; this work examines the hypothesis that normal platelets are sufficient to maintain coagulation in the presence of elevated aPC. METHODS: Coagulation responses of normal plasma, fV deficient plasma (fVdp), and isolated normal platelets in fVdp were conducted: prothromb
View details →Negative / Null Result ReportOpen accessMedicine
Masoud Seifi, Shirin Farivar, Malihe Sadat Mirhosseini et al. · 2020 · Regeneration, Reconstruction & Restoration
Introduction: Stem cells have gained great attention in tissue engineering and curcumin is a natural phenolic product that had showed some positive effects on these cells. The aim of this study was to evaluate the effect of curcumin on the differentiation of human dental pulp stem cells (hDPSCs). Materials and Methods: In this experimental study, hDPSCs were isolated from human third molars and treated without and with different concentrations (5, 10 and 15 µM) of curcumin and dimethyl sulfoxide (DMSO) as solvent for curcumin. Proliferation of the cells was measured by methyl-thiazol-tetrazoli
View details →Negative / Null Result ReportOpen accessMedicine
Galiya Iskakova, Bauyrzhan Iztayev, Auyelbek Iztayev et al. · 2025 · Scientific Reports
Abstract The quality of food products and a balanced diet play a key role in maintaining health and improving the quality of life. Due to the high popularity of pasta, a promising direction is the development of recipes that include whole grain flour, carrot powder and ion-ozonated water, which increase the nutritional value of the product and improve its chemical composition. The aim of this study was to optimise the technological modes of production of durum wheat pasta using carrot powder and ion-ozonated water to minimise the loss of dry matter (DM) during cooking and increase the protein
View details →Negative / Null Result ReportOpen accessMedicine
Mengting Chen, Eng Wah Teo, Sau Cheong Loh · 2026 · Scientific Reports
Abstract Cyberbullying and cybervictimization have become widespread phenomena on social media platforms, particularly in emotionally charged environments such as sports fandom. While prior research has emphasized the role of individual personality traits, the influence of social identification—specifically, fan identity—on these behaviors remains underexplored, especially within Chinese digital communities, such as Sina Weibo. Grounding the study in the Social Identity Model of Deindividuation Effects, we theorize that platform affordances, such as anonymity and group salience, amplify identi
View details →Failed Experiment ReportMedicine
White AB, Reid R, Graham GD et al. · 2026 · Journal of pediatric orthopedics
Background This prospective observational cohort study evaluates the clinical, radiographic, and functional differences between pins and screw fixation for displaced pediatric lateral condyle fractures of the elbow. Methods Skeletally…
View details →Negative / Null Result ReportOpen accessMedicine
Dong Chengtung · 1987 · 针刺研究
Somatosensory evoked potentials(SEPs)were recorded simultaneously from the cervical spine and scalp in 10 normal subjects and 22 patients with cerebrovascular attack(9)and syringomelia(13)using median nerve stimulation.Patients were considered as having abnormal studies,if either N_(18) were absent or if their peak latencies were prolonged more than 21.1 msec,or if the difference of (N_(13)-N_(18))conduction time was more than 7.53 msec.In addition,side-to-side value for(N_(13)-N_(18))were compared, these normally differ by less than 1.38 msec. The results may be summarized as followings: Acup
View details →Negative / Null Result ReportOpen accessMedicine
Manisha Kalpesh Gohel, Jashbhai B. Prajapati, Sreeja V. Mudgal et al. · 2016 · Journal of Clinical and Diagnostic Research
Introduction: Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Sufficient calcium intake has been reported to support bone growth and prevent bone loss during the ageing process. Aim: To determine the effect of Lactobacillus helveticus MTCC 5463 probiotic dietary intervention on serum calcium & haematological parameters in geriatric population. Materials and Methods: Healthy volunteers with age ranging from 64-74 years were recruited from the nearby residential areas in and around Anand, Gujarat. Study duration was from 2012 to
View details →Negative / Null Result ReportOpen accessMedicine
Viktoriia V. Yevsieieva, Volodimyr I. Cherniy, Kateryna V. Kharchenko et al. · 2023 · Клінічна та профілактична медицина
Introduction. One of the main factors affecting postoperative outcomes in patients with advanced ovarian cancer is the cardiopulmonary status. Several studies have reported that preoperative multifactorial rehabilitation and physical fitness can lead to reduced postoperative morbidity, mortality, shorter length of stay, and improved quality of life in cancer patients. The issue of adaptability to physical activity of overweight and obese patients who undergoing debulking surgery is insufficiently studied. The study of compensatory changes that occur in physically inactive obese patients remain
View details →Negative / Null Result ReportOpen accessMedicine
Björkman AS, Malusek A, Persson A et al. · 2026 · European radiology experimental
Objective The aim was to compare the image quality of photon-counting detector CT (PCD-CT) and energy-integrating detector CT (EID-CT) in patients with tibial plateau fractures treated with metallic osteosynthesis material, and to identify…
View details →Negative / Null Result ReportOpen accessMedicine
Kristiina Aalto, Hannu Kautiainen, Anders Fasth et al. · 2025 · RMD Open
Introduction The age at the onset of juvenile idiopathic arthritis (JIA) can influence the trajectory of the disease. We aimed to clarify how age at the visit 6 months after the onset as a continuous variable affects long-term remission of JIA.Methods This study investigated 358 patients from the Nordic JIA cohort study. Age at diagnosis was analysed continuously. Three age groups were studied: under 3 years, 3–5 years and over 6 years of age. JIA was categorised as oligoarthritis, seronegative polyarthritis and others (enthesitis-related, psoriatic and undifferentiated arthritis). Clinical da
View details →Negative / Null Result ReportOpen accessMedicine
Ting-Ting Xu, Rui Cao, Yan-Ling Dong et al. · 2022 · PLoS ONE
This study aimed to analyze the factors of rapid attenuation of graft endothelium in the early stage after penetrating keratoplasty (PKP), with a view to guiding patients with PKP to better long-term outcomes. This study included 226 patients who underwent PKP with follow-up time >1 year at the Qingdao Eye Hospital of Shandong First Medical University from January 2018 to June 2020. Medical records were retrospectively studied, and donor factors, patient factors, and surgical factors were comparatively analyzed to clarify those affecting the rapid decay of graft endothelium after PKP. The medi
View details →Negative / Null Result ReportOpen accessMedicine
Zerrin Tuncer, Turhan Soylu · 2012 · Türk Oftalmoloji Dergisi
Pur po se: To evaluate the long-term results of rigid gas permeable (RGP) contact lenses in severe keratoconic eyes. Ma te ri al and Met hod: Severe keratoconic eyes with RGP contact lenses were evaluated retrospectively. Re sults: Long-term follow-up results of RGP contact lenses applied to 59 eyes of 42 patients (25 women, 17 men) with a diagnosis of severe keratoconus were analyzed. Follow-up period was 3 to 12 years (mean: 6.57±3.60). The mean age at first exam was 25.88±9.10 years, the mean corneal curve K1 was 6.49±0.40 mm and K2 was 5.91±0.40 mm. Mean visual acuities with spectacles and
View details →Negative / Null Result ReportOpen accessMedicine
Tomoharu Takeuchi, Risa Nakamura, Megumi Hamasaki et al. · 2023 · BMC Research Notes
Abstract Objective Galectins are sugar-binding proteins that participate in many biological processes, such as immunity, by regulating host immune cells and their direct interaction with pathogens. They are involved in mediating infection by Schistosoma mansoni, a parasitic trematode that causes schistosomiasis. However, their direct effects on schistosomes have not been investigated. Results We found that galectin-2 recognizes S. mansoni glycoconjugates and investigated whether galectin-1, 2, and 3 can directly affect S. mansoni in vitro. Adult S. mansoni were treated with recombinant galecti
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