Negative / Null Result ReportOpen accessMedicine
Julie Faverial, Denis Cornet, Jacky Paul et al. · 2016 · PLoS ONE
Previous studies indicated that the quality of tropical composts is poorer than that of composts produced in temperate regions. The aim of this study was to test the type of manure, the use of co-composting with green waste, and the stabilization method for their ability to improve compost quality in the tropics. We produced 68 composts and vermicomposts that were analysed for their C, lignin and NPK contents throughout the composting process. Bayesian networks were used to assess the mechanisms controlling compost quality. The concentration effect, for C and lignin, and the initial blend qual
View details →Negative / Null Result ReportOpen accessMedicine
Cardona PJ · 2026 · Frontiers in immunology
Tuberculosis (TB) vaccine development is hindered by the absence of validated correlates of protection, the low proportion of infected individuals who progress to disease, and the pervasive impact of reinfection in endemic settings.…
View details →Negative / Null Result ReportOpen accessMedicine
Duangdee Trangsuwan, Malai Wongchanchailert, Ladda Mo-suwan et al. · 2018 · Journal of Health Science and Medical Research (JHSMR)
Objective: To evaluate the volume of blood transfusion requirements as well as hemolytic and oxidative biochemical variables in transfusion-dependent β-thalassemia patients supplemented with vitamin E. Material and Methods: A prospective, double-blind, randomized, placebo-controlled, crossover study was undertaken between December, 2012 and September, 2014 in the Pediatric Clinic of Songklanagarind Hospital. The participants were β-thalassemia major and Hb E/β-thalassemia patients aged between 5 and 18 years. A random allocation sequence was generated to receiving either 6 months of vitamin E
View details →Negative / Null Result ReportOpen accessMedicine
SHINY JOHN, KAVITARATI DHARWADKAR, MANJUNATH V MOTAGI · 2014 · Journal of Clinical and Diagnostic Research
Background: Cholesterol is especially abundant in nervous system, where it plays important role in different aspects of cellular structure (e.g. fluidity of cell membranes) and function (e.g. membrane). Several studies showed that there may be a link between depression and low cholesterol because of altered central serotonergic functions. On the other hand, some studies also showed either no such association or yielded inconsistent results. However, many studies have related low cholesterol with different psychiatric disorders. Hence, we intend to see the possible link between the two. Aim: To
View details →Negative / Null Result ReportOpen accessMedicine
Geum-Bong Lee, Hyunhee Woo, Su-Yoon Lee et al. · 2019 · PLoS ONE
Background and objective Education of disease plays an important role in management of Parkinson's disease (PD). However, little is known about the link between the understanding of disease and the burden of care. This study was carried out to find the correlation between the burden of care and the understanding of disease in caregivers for PD patients. Methods Non-demented patients with PD and their caregivers participated in structured interviews. Understanding of patients and caregivers was evaluated through newly-devised questions. The caregiver burden inventory was used to assess the burd
View details →Negative / Null Result ReportOpen accessMedicine
Chang Mo Moon, Sung-Ae Jung, Seong-Eun Kim et al. · 2015 · PLoS ONE
Diagnostic delay frequently occurs in Crohn's disease (CD) patients because of diagnostic limitations. However, diagnostic delay and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with diagnostic delay and to evaluate the impact of diagnostic delay on clinical course in a Korean CD patient cohort. We performed a multicenter retrospective analysis of 1,047 CD patients registered in the Crohn's Disease Clinical Network and Cohort study in Korea. The mean interval of diagnostic delay was 16.0 ± 33.1 months. Multivariate analysis showed that ol
View details →Negative / Null Result ReportOpen accessMedicine
Kanglai Li, BD, Shangyan Liang, MD, Yuyan Shi, BD et al. · 2021 · Sexual Medicine
Introduction: Dehydroepiandrosterone sulfate (DHEAS) has been reported to be associated with sexual function and general psychological health respectively, however, no one has ever examined their mutual relationships in a single study. Aim: The aim of the present study was to find out whether DHEAS, general psychological health, and erectile function were all associated with each other. Methods: A cross-sectional study was conducted on 34 patients with erectile dysfunction (ED) and 32 healthy controls (HC). The levels of serum DHEAS were assessed by chemiluminescence method. Erectile function
View details →Negative / Null Result ReportOpen accessMedicine
Piyusha Milani Atapattu, Chemindra Biyanwila, Manamalabaduge Upul Jerard Fernando · 2017 · American Journal of Experimental and Clinical Research
Chest radiographs are widely available, even in most hospitals in developing countries, and can detect a variety of lung pathologies. When adults are admitted to hospital with acute asthma, chest radiographs are often obtained. Studies on the usefulness of chest radiographs in acute asthma have shown varying results. This study aimed at evaluating the usefulness of chest radiographs in the management of acute asthma in adult asthmatics in a developing country. Plain chest radiographs performed within 24 hours of admission in 115 consecutive adult asthmatic patients (asthma defined by Asthma Ed
View details →Negative / Null Result ReportOpen accessMedicine
Hawra Al-Ghafli, Bright Varghese, Mushira Enani et al. · 2019 · PLoS ONE
Despite low infectious potential of extrapulmonary tuberculosis (EPTB), it poses significant clinical challenges in terms of diagnosis and treatment monitoring. Understanding the main demographical risk factors for disease characteristics of EPTB plays a crucial role in speeding up diagnosis process and improving overall clinical experience. The aim of this study was to investigate the main demographical and clinical risk factors for EPTB among adults and adolescents for the first time in Saudi Arabia. A cross-sectional multicenter study was carried out on a collection of 902 extrapulmonary My
View details →Negative / Null Result ReportOpen accessMedicine
Martin Söderholm, Yan Borné, Bo Hedblad et al. · 2015 · PLoS ONE
Increased red cell distribution width (RDW) has been related to poor prognosis in patients with cardiovascular disease, and is a predictor of cardiovascular mortality in the general population. The purpose of the present study was to investigate if RDW is associated with increased incidence of stroke and its subtypes in individuals from the general population.Red cell distribution width was measured in 26,879 participants (16,561 women and 10,318 men aged 45-73 years) without history of coronary events or stroke, from the population-based Malmö Diet and Cancer Study. Incidences of total stroke
View details →Negative / Null Result ReportMedicine
Lauer, Leng, Chembe et al. · 2026 · The British journal of nutrition
Small-quantity lipid-based nutrient supplements (SQ-LNS) have been shown to improve growth, development, and survival among young children in low-resource settings. One hypothesized pathway is through improvements in intestinal health,…
View details →Negative / Null Result ReportOpen accessMedicine
Paschalina C Ezechukwu, Emmanuel O Ugwu, Samuel N Obi et al. · 2023 · International Journal of Medicine and Health Development
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality in Nigeria and worldwide. It is not yet concluded as to whether or not elevated levels of serum creatinine and/or uric acid could be regarded as a predictive indicator for the severity of the disease. Objectives: To compare the mean serum levels of uric acid and creatinine in preeclamptic and normotensive pregnant women and assess for any associations between these renal biomarkers and the severity of preeclampsia in Nigeria. Materials and Methods: It was a cross-sectional analytical study o
View details →Negative / Null Result ReportOpen accessMedicine
Kibum Kim, Linda Kaitlyn Craft · 2022 · BMJ Open
Objective Non-invasive prenatal testing (NIPT) is a front-line screening for fatal chromosomal aneuploidy. In pregnant women with a risk of having fetal congenital disorders, NIPT is anticipated to reduce the needs of invasive prenatal diagnostic test (IPD). The objective of this study was to understand the acceptance of NIPT and the utility of NIPT to mitigate concerns about IPD in the US high-risk pregnancy management.Design and setting This was a retrospective observational research using healthcare records obtained from an academic healthcare system in the US. The study consisted of site-l
View details →Negative / Null Result ReportOpen accessMedicine
Muhammad Hussain Iqbal, Tanveer Hussain, Fariha Khalid et al. · 2020 · Pakistan Armed Forces Medical Journal
Objective: To determine the frequency of diastasis recti abdominis and its associated risk factors in postpartum women. Study Design: Cross-sectional study. Place and Duration of Study: Omar Medical Center Lahore, Yaseen Medical Center Lahore and Social Security Hospital Lahore, from Sep 2019 to Dec 2019. Methodology: This study included 128 participants fulfilling the eligibility criteria. The assessment of diastasis recti abdominis was done manually by a female physiotherapist using single finger, double finger and three finger methods on abdomen at three levels: at the umbilicus, 4.5 cm bel
View details →Short NoteOpen accessMedicine
Camelia C. Diaconu · 2019 · Archives of the Balkan Medical Union
Oxidative stress is involved in the pathophysiology of many chronic diseases, including heart failure. Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense. The overproduction of ROS can lead to cellular damage and eventually cellular death. This applies also in patients with chronic heart failure, who present a dramatic increase of oxidative stress associated with a pronounced decrease of the antioxidant defense mechanisms. The components of the antioxidant defense mechanism of myocardial cells are superoxide dismutase (SOD), cat
View details →Negative / Null Result ReportOpen accessMedicine
Abida Shaheen, Syed Mahboob Alam, Fahad Azam et al. · 2022 · PLoS ONE
Background and objective Gabapentinoids are the first-line drugs for neuropathic pain. These drugs are the substrate of organic cation transporter (OCTN1) for renal excretion and absorption across the intestinal epithelium. Gabapentinoids exhibit wide interindividual variability in daily dosage and therapeutic efficacy which makes titration regimens prolonged for optimal efficacy. The present study aimed to investigate the possible influence of the single nucleotide polymorphism (SNP) of OCTN1 on therapeutic efficacy and safety of gabapentinoids in neuropathic pain patients of the Pakistani po
View details →Negative / Null Result ReportOpen accessMedicine
Al-mustafa Mahmoud, Massad Islam, Alsmady Moaath et al. · 2010 · Saudi Journal of Kidney Diseases and Transplantation
Vertical infraclavicular brachial plexus block is utilized in patients with chronic renal failure at the time of creation of an arterio-venous fistula (AVF). The aim of this study is to test the effect of impaired renal function, with the resulting deranged serum electrolytes and blood gases, on the success rate and the onset of action of the local anesthetics used. In this prospective clinical study, we investigated the effect of the serum levels of sodium, potassium, urea, crea-tinine, pH, and bicarbonate on the onset of action of a mixture of lidocaine and bupivacaine administered to create
View details →Negative / Null Result ReportMedicine
Selma Celen Yuceturk, Sumeyye Aydogan Turkoglu, F. Kockar et al. · 2021 · Zeitschrift für Naturforschung C - A Journal of Biosciences
Abstract In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using…
View details →Negative / Null Result ReportOpen accessMedicine
Ayman Mohammed Baabdullah, Abdulmalik Ghassan Abumohssin, Yara Aedh Alqahtani et al. · 2019 · Journal of Nature and Science of Medicine
Background: The use of smartphones has increased exponentially. Excessive usage of smartphones has been shown to have a negative impact on ocular health. This study aimed to evaluate the relationship between smartphone addiction and dry eye disease (DED) and determine the risk factors of DED in participants associated with smartphone addiction. Materials and Methods: This cross-sectional study was conducted in May 2017. Participants were selected from the Faculty of Medicine at King Abdulaziz University in Jeddah, Saudi Arabia. Stratified random sampling technique was used to recruit participa
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Novo-Rodríguez, Beatriz García-Fontana, Juan De Dios Luna-Del Castillo et al. · 2018 · PLoS ONE
Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and it has recently been linked to vascular biology. The current study aimed to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardiovascular mortality in individuals with and without type 2 diabetes. We followed up a cohort of 130 participants (mean age 56.8 years; 48.5% fem
View details →Negative / Null Result ReportOpen accessMedicine
Megumi Yokota, Akira Hirasawa, Kazuya Makita et al. · 2015 · Menopause Review
Introduction : Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related gene
View details →Negative / Null Result ReportOpen accessMedicine
Mehmet Yortanlı, Ramazan Köylü, Öznur Köylü et al. · 2025 · Eurasian Journal of Emergency Medicine
Aim: This study aimed to evaluate the diagnostic and prognostic significance of serum beta-trace protein (BTP) levels in patients diagnosed with sepsis in the emergency department. Materials and Methods: This prospective, single-center, observational clinical study was conducted in the emergency department and intensive care unit of a tertiary hospital. A total of 104 sepsis patients and 48 healthy adult volunteers who presented to the emergency department between April 2015 and October 2015 were included. Blood samples were collected on days 1 and 3, and BTP levels were measured using the ELI
View details →Negative / Null Result ReportOpen accessMedicine
Aditi Prayag, Salima Bijapuri, Shweta Bhatbolan et al. · 2025 · Journal of Clinical and Diagnostic Research
Introduction: Breastmilk is recognised as the best infant nutrition, but Exclusive Breastfeeding (EBF) rates remain as low as 63.7% in India and 48% worldwide. One barrier is the development of Musculoskeletal Disorders (MSDs) in postpartum mothers due to a lack of education on proper breastfeeding posture. These factors can impact the quality of the infant’s latch, resulting in early cessation of breastfeeding. Aim: This study aimed to assess the impact of ergonomic breastfeeding on the risk of developing MSD in lactating mothers and infant latch quality. Materials and Methods: The present qu
View details →Negative / Null Result ReportOpen accessMedicine
Yaser Mokhayeri, Seyed Saeed Hashemi-Nazari, Mohammad Ali Mansournia et al. · 2017 · Epidemiology and Health
OBJECTIVES Although the effect of physical activity (PA) on the incidence of atrial fibrillation (AF) has been studied, contradictory results have been reported. Such discrepancies may reflect the different effects of various types of PA upon AF, as well as gender interactions. Therefore, we aimed to evaluate the associations of PA types (total, moderate/vigorous, and intentional), as well as walking pace, with AF risk in men and women. METHODS Using the Multi-Ethnic Study of Atherosclerosis Typical Week Physical Activity Survey, 3 PA measures and walking pace were calculated among 6,487 men a
View details →Negative / Null Result ReportOpen accessMedicine
Onyinyechi Bede-Ojimadu, Nwakasi Nnamah, Jude A. Onuegbu et al. · 2025 · Scientific Reports
Abstract The ability of selenium to both prevent and induce cancer at varying biological concentrations has been reported in previous studies. We studied the associations between selenium exposure and prostate diseases such as prostate cancer (PCa) and benign prostatic hyperplasia (BPH), and estimated the optimal range of selenium concentrations that may be needed to prevent these diseases among Nigerian men. Blood and urine samples from men with histologically diagnosed PCa (n = 90), BPH (n = 97), and controls (n = 98) were analyzed for trace elements, including selenium. The associations bet
View details →Negative / Null Result ReportOpen accessMedicine
Camila Salazar-Fernández, María José Baeza-Rivera, Diego Manríquez-Robles et al. · 2023 · Vaccines
The embrace of coronavirus disease 2019 (COVID-19) vaccine conspiracies has been linked to vaccine hesitancy. This study aimed to investigate the relationship between COVID-19 vaccine conspiracy theories and perceived vaccine effectiveness. The study utilized a longitudinal follow-up study in which adults in Chile completed surveys in December 2020 (T1) and May 2021 (T2). The psychometric properties of the five-item instrument on conspiracy theories for the COVID-19 vaccine were evaluated using data from T1 ( n = 578). A confirmatory one-factor structure with suitable indicators of reliability
View details →Short NoteOpen accessMedicine
Montsu KP, Boshoff CI, Etter E et al. · 2026 · The Onderstepoort journal of veterinary research
African swine fever (ASF) outbreaks in Gauteng province (2012, 2019-2022) occurred outside South Africa's (SA's) traditional control zones and highlighted biosecurity deficiencies among smallholder producers. This study aimed to assess…
View details →Negative / Null Result ReportOpen accessMedicine
Lauren S. Keenan-Devlin, Ann E. B. Borders, Alexa Freedman et al. · 2023 · Scientific Reports
Abstract Exposure to traumatic events during pregnancy may influence pregnancy and birth outcomes. Growing evidence suggests that exposure to traumatic events well before pregnancy, such as childhood maltreatment (CM), also may influence the course of pregnancy and risk of adverse birth outcomes. We aimed to estimate associations between maternal CM exposure and small-for-gestational-age birth (SGA) and preterm birth (PTB) in a diverse US sample, and to examine whether common CM-associated health and behavioral sequelae either moderate or mediate these associations. The Measurement of Maternal
View details →Negative / Null Result ReportOpen accessMedicine
Amir Mari, Wasef Na’amnih, Loay Ghantous et al. · 2023 · Scientific Reports
Abstract Gastro-esophageal reflux disease (GERD) can cause erosive esophagitis (EE) and compromise the quality of life (QoL). We examined differences in symptom severity and QoL according to EE severity grade. A follow-up study was conducted among GERD patients at the Nazareth Hospital in Israel. Patients underwent a baseline gastroscopy in 2014–2020 during which the EE grade was determined using the Los Angeles classification. Follow-up telephone interviews were conducted during 2019–2020 with a mean time interval of 18.9 months (SD = 14.9) after the baseline gastroscopy to assess GERD sympto
View details →Abandoned HypothesisOpen accessMedicine
A. Saiiari, M. Kashef, M. Adel et al. · 2017
Background: In the majority of cardiovascular diseases, cardiovascular structure changes in line with the type of disease. One of the goals of cardiac rehabilitation is the improvement of cardiac performance and reversibility of…
View details →