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Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The fluid paradox: dissociation between clinical and ultrasound parameters of fluid overload - results of the INCIVEX exploratory study.

Wong A, Cheah K, Papathanakos G et al. · 2026 · Anaesthesiology intensive therapy

Introduction Fluid management in critically ill patients relies on clinical assessment, fluid balance calculations and, increasingly, point-of-care ultrasound. However, the rela-tionships between these assessment modalities remain poorly…

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Negative / Null Result ReportMedicine

Survival outcomes of the use of adjuvant chemotherapy in resected esophagus cancer after neoadjuvant chemoradiotherapy.

Ke TM, Lin T, Chow WH et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for esophageal cancer, but the role of adjuvant chemotherapy remains unclear. This study investigates the survival benefits of adjuvant…

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Negative / Null Result ReportMedicine

Does the Timing of Lysis of Adhesions After Anterior Cruciate Ligament Reconstruction Affect Final Range of Motion?

Schneble CA, Miltenberg B, Jurgensmeier K et al. · 2025 · The American journal of sports medicine

Background Arthrofibrosis is seen in 1.7% to 38% of patients after anterior cruciate ligament reconstruction (ACLR) and has been associated with worse postoperative patient-reported outcomes. There are limited data regarding the optimal…

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Negative / Null Result ReportMedicine

Collaborative Navigation Improves Spatial Learning Across Symmetric and Asymmetric Locomotion in Virtual Reality.

Chakraborty S, Gagnon H, McNamara TP et al. · 2026 · IEEE transactions on visualization and computer graphics

Multi-user virtual reality (VR) systems support multiple locomotion methods, but coordination may be challenging when partners use different methods. We studied dyads navigating a shared virtual maze using symmetric (same) or asymmetric…

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Negative / Null Result ReportMedicine

Family satisfaction with intensive care and preexisting family and patient characteristics: equivalence analysis of cross-sectional surveys.

Riguzzi M, Verweij L, Naef R · 2025 · Intensive & critical care nursing

Objectives This study aims to demonstrate that family satisfaction with intensive care and decision-making is independent of sociodemographic family member and patient characteristics and the patient outcomes of mortality and length of…

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Negative / Null Result ReportMedicine

Effect of an educational antimicrobial stewardship programme on antibiotic prescriptions' appropriateness in three medical units of a large university hospital: an interrupted time series analysis.

Giovannenze F, Del Vecchio P, Frondizi F et al. · 2025 · The Journal of hospital infection

Background Antimicrobial stewardship (AMS) programmes aim to enhance antibiotic prescription quality, reduce antibiotic use, and combat multi-drug-resistant pathogens. However, the optimal AMS intervention for different clinical settings…

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Negative / Null Result ReportOpen accessMedicine

Tremor Recurrence in MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: DBS vs. Re-lesion.

Walker-Pizarro N, Chan JL, Yu J et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)

Clinical vignette A 59-year-old man with essential tremor (ET) and bilateral symptoms initially underwent left thalamic MRI-guided focused ultrasound (MRgFUS) at an outside institution to address tremor in the right upper extremity.…

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Negative / Null Result ReportOpen accessMedicine

Effect of Ultrasound-Guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures: A Randomized Controlled Noninferiority Trial.

Steensbæk MT, Yousef S, Bahuet AR et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Closed reduction of distal radius fractures is painful, and current analgesic strategies may be inadequate. Ultrasound-guided lateral infraclavicular brachial plexus block may offer complete analgesia and muscle relaxation,…

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Replication FailureMedicine

Chemotherapy-free combination of ibrutinib and obinutuzumab for untreated advanced follicular lymphoma: results of a phase II study from the German Lymphoma Alliance.

Schmidt C, Scheubeck G, Jurinovic V et al. · 2025 · Haematologica

Immunochemotherapy induces long-term responses in patients with follicular lymphoma. However, the toxicity of chemotherapy remains a relevant challenge. The Bruton tyrosine kinase inhibitor ibrutinib has shown significant activity in…

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Negative / Null Result ReportMedicine

Infants with bronchiolitis with high-flow nasal cannula in the paediatric ward. Is there a role for the ROXi (respiratory rate-oxygenation index) in predicting failure of high-flow nasal cannula?

Le Pallec C, Cerasuolo D, Cauvin JC et al. · 2025 · European journal of pediatrics

The respiratory rate-oxygenation index (ROXi) has been shown to be a reliable tool for predicting the risk of high-flow nasal cannula (HFNC) failure in adult patients with lower respiratory tract infections. However, the usefulness of the…

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Negative / Null Result ReportMedicine

Hyperbaric Treatment of Air or Gas Embolism: Current Recommendations.

Moon RE, Mitchell SJ · 2025 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc

Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g. breath-hold ascent by divers), veins (venous gas embolism, VGE) as a result of tissue bubble formation due to…

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Negative / Null Result ReportOpen accessMedicine

No survival benefit is associated with pelvic and para-aortic lymphadenectomy in lymph node-negative early-stage endometrioid endometrial cancer.

Yalcin Y, Yalcin SE, Demir BC et al. · 2026 · BMC surgery

OBJECTIVE: The therapeutic role of lymphadenectomy in endometrial cancer remains controversial. Although systematic pelvic and para-aortic lymphadenectomy (PPLND) has been suggested to improve survival in certain patients, randomized…

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Negative / Null Result ReportOpen accessMedicine

Adjuvant therapy for renal cell carcinoma: lessons from past failures and new opportunities in the era of immune checkpoint inhibition.

Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology

Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…

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Negative / Null Result ReportOpen accessMedicine

Bioavailability as Proof to Authorize the Clinical Testing of Neurodegenerative Drugs-Protocols and Advice for the FDA to Meet the ALS Act Vision.

Niazi SK · 2024 · International journal of molecular sciences

Although decades of intensive drug discovery efforts to treat neurodegenerative disorders (NDs) have failed, around half a million patients in more than 2000 studies continue being tested, costing over USD 100 billion, despite the…

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Negative / Null Result ReportOpen accessMedicine

Beyond the evidence: The cervical collar as cultural artefact.

Nutbeam T · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine

Background Cervical collar application remains prevalent in trauma care despite the absence of evidence of neurological benefit from spinal immobilisation. Clinical behaviour in this area has proven resistant to change, and the persistence…

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Negative / Null Result ReportMedicine

A Randomized Controlled Trial on the Timing of Soft Tissue Augmentation in Immediate Implant Placement: Soft Tissue Changes and Esthetic Outcome.

Struys T, Christiaens V, De Bruyckere T et al. · 2025 · Clinical implant dentistry and related research

Aim To assess the impact of the timing of soft tissue augmentation on soft tissue changes and esthetic outcome following single immediate implant placement (IIP) in the anterior maxilla. Materials and methods Patients with a failing tooth…

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Negative / Null Result ReportOpen accessMedicine

Psychiatric morbidity following liothyronine exposure in autoimmune hypothyroidism: a Swedish nationwide cohort study.

Hedberg F, Lindh JD, Mannheimer B et al. · 2026 · Journal of the Endocrine Society

Context Levothyroxine (LT4) is the primary treatment of hypothyroidism. Despite adequate LT4 substitution some patients experience symptoms and the use of adjunct liothyronine (LT3) has increased. Several trials show no clear advantage of…

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