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WASTE Journal

Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Male partner treatment and the potential sexual transmission of bacterial vaginosis: considerations for patient counseling and clinical application in the United States.

Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology

Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…

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Negative / Null Result ReportMedicine

PACAP and migraine.

Diener HC · 2025 · Brain : a journal of neurology

A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…

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Negative / Null Result ReportOpen accessMedicine

Nonpigmented Adenoid Subtype of Basal Cell Carcinoma: A Case Report.

Ichimura Y, Niiyama S, Hirata A · 2026 · Case reports in dermatology

Introduction Basal cell carcinoma (BCC) is the most common skin cancer, with a rising incidence globally. We encountered a patient with the nonpigmented adenoid subtype of BCC. The nonpigmented subtype of BCC accounts for only a small…

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Replication FailureMedicine

Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label, parallel-group, randomised controlled trial.

Feng J, Yang C, Xie L et al. · 2026 · The Lancet. Neurology

Background Decompressive craniectomy has been widely evaluated across heterogeneous types of brain injury but its effect in patients with large acute epidural haematoma complicated by tentorial herniation remains unclear. We aimed to…

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Replication FailureMedicine

Impact of Persistent Hypogonadism on Overall Survival After Androgen Deprivation Therapy in Localized Prostate Cancer Patients: Long-Term Prospective Data.

Nabid A, Carrier N, Vigneault É et al. · 2026 · International journal of radiation oncology, biology, physics

Purpose The impact of persistent hypogonadism post-androgen deprivation therapy (ADT) on overall survival (OS) of patients with prostate cancer (PCa) is poorly documented. We compared OS between patients who recovered testosterone and…

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Negative / Null Result ReportOpen accessMedicine

Effects of current smoking on treatment outcomes in metastatic and locally advanced pancreatic carcinoma: a retrospective cohort study using the international PURPLE pancreas cancer registry.

Hayat F, Chiu S, Stuart A et al. · 2025 · Journal of gastrointestinal oncology

Background Tobacco smoking accounts for 22% of the pancreatic cancer burden in Australia. Smoking may increase therapy-related adverse effects and was associated with shorter survival in the previous analysis of all stages of pancreatic…

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Negative / Null Result ReportOpen accessMedicine

Revisiting Janus Kinase Inhibitors in Hospitalized COVID-19: Evidence for Baricitinib's Superiority and the Absence of a Class Effect.

Gu L, Lin J, Yue J et al. · 2025 · Journal of inflammation research

Janus kinase (JAK) inhibitors, developed for autoimmune diseases, have been repurposed as potential therapies for severe COVID-19. Growing evidence indicates that their clinical utility is heterogeneous and cannot be generalized as a class…

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Negative / Null Result ReportMedicine

Use of a Personalised Early Warning Decision Support System for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Results of the "Predict & Prevent" Phase III Trial.

Gkini E, Mehta RL, Tearne S et al. · 2025 · COPD

Rationale The Predict&Prevent trial was designed to provide a definitive randomised clinical trial of a personalised early warning decision support system, COPDPredict™. Methods Adults with ≥1 AECOPD were randomly assigned in a 1:1 ratio…

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Negative / Null Result ReportMedicine

Machine Learning and Urinary Incontinence in Prostate Cancer: A Generalized Additive Model of Physical Activity and Recovery Patterns.

Manolitsis I, Feretzakis G, Tzelves L et al. · 2025 · Studies in health technology and informatics

The ASCAPE project aims to improve the health-related quality of life of prostate cancer patients using artificial intelligence-driven solutions. This study tries to unravel the complex relationships between patient data variables and…

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Negative / Null Result ReportMedicine

Long-term Results from the LEA Randomized Trial: Extended Versus Standard Lymph Node Dissection in Patients with Bladder Cancer Undergoing Radical Cystectomy.

Heck MM, Lehmann J, Amiel T et al. · 2025 · European urology

The extent of lymph node dissection (LND) at the time of radical cystectomy (RC) for bladder cancer (BC) may affect oncologic outcomes. We present updated long-term data from a prospective, multicenter, phase 3 trial involving patients…

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Negative / Null Result ReportMedicine

[Hortitherapy and well-being in day care centres].

Zivkovic Habibi L, Zaibat M, Frenkiel J et al. · 2025 · Soins. Gerontologie

Day care centers are medical and social facilities that provide day care for people over 60 with Alzheimer's or related diseases. The main aim of the study presented here was to assess the impact of horticultural therapy sessions on the…

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Negative / Null Result ReportMedicine

Combination of short pulse and smooth modality of Er: YAG laser versus short pulse alone in treatment of striae distensae: a split-lesion study.

Sadeghinia A, Emadi SN, Jamshidi S et al. · 2025 · Lasers in medical science

Background Despite extensive research, there is still no consensus on the optimal treatment for Striae distensae (SD). Aim To evaluate the efficacy of ablative (short pulse (SP) mode) versus combined ablative and non-ablative (short pulse…

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Negative / Null Result ReportOpen accessMedicine

Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study.

Ryou S, Jung Y, Kim DS et al. · 2026 · The Korean journal of internal medicine

Background/aims Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR…

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Negative / Null Result ReportMedicine

Neoadjuvant chemoradiation and surgical excision versus definitive radiotherapy for locally advanced cervix uteri carcinoma: in terms of early and late complications and locoregional recurrence.

Khalifa H, Ayaty M, Oreaba R et al. · 2025 · Journal of the Egyptian National Cancer Institute

Objectives Following external beam radiation therapy (EBRT) with concurrent chemotherapy, we analyzed the benefits of surgical resection for locally advanced cervical carcinoma in terms of the frequency and severity of complications and…

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Negative / Null Result ReportMedicine

[Comparison of the modified Kadish, AJCC T and Dulguerov T staging systems for olfactory neuroblastoma: analysis of the SEER database].

Lyu HH, Wen X, Lin JT et al. · 2025 · Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

Objective: To compare the Kadish T staging, AJCC T staging, and Dulguerov T staging system in terms of their impact on surgical treatment selection and survival prognosis in patients with olfactory neuroblastoma (ONB). Methods: The cases…

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Negative / Null Result ReportMedicine

Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss After COVID-19 Vaccine in Asian Population: A Preliminary Study.

Chen PY, Young TC, Lin CY et al. · 2025 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To determine the hearing outcomes in patients with sudden sensorineural hearing loss (SSNHL) after exposure to different brands of vaccines against COVID-19. Study design Cohort study. Setting Tertiary referral center. Patients…

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Negative / Null Result ReportMedicine

Effects of different positive end-expiratory pressure strategies on treating overweight patients with acute respiratory distress syndrome: A retrospective study based on large intensive care unit databases.

Zheng X, Zhang T, Zhan T et al. · 2025 · Respiratory medicine

Purpose Positive end-expiratory pressure (PEEP) refers to a vital respiratory therapeutic tool for treating ARDS. Since overweight individuals face a greater risk of pulmonary complications than others, this study aims to assess whether…

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