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Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Zinc deficiency is associated with erythropoietin-stimulating agents hyporesponsive anemia in peritoneal dialysis patients: a cross-sectional study.

Kuwahara F, Harada K, Nagata M et al. · 2026 · Clinical and experimental nephrology

Background Zinc deficiency is widely recognized as a cause of anemia, but no studies have clarified the impact of zinc deficiency on achieving target hemoglobin levels in patients undergoing peritoneal dialysis (PD) and receiving high-dose…

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Negative / Null Result ReportMedicine

Risk factors for asseptic loosening after revision total knee replacement (rTKR): a component-specific analysis of femoral and tibial reconstruction.

Souto CS, Pereira F, Carvalho A et al. · 2026 · The Knee

Background Revision total knee arthroplasty (rTKA) remains a technically demanding procedure, with re-revision representing a major clinical challenge. The role of reconstruction strategies, particularly the use of augments and metaphyseal…

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Negative / Null Result ReportMedicine

Similar Outcomes in Proximal Humerus Fractures Treated With Conventus Intramedullary Cage Device and Open Reduction Internal Fixation.

Kurkowski SC, Taleghani ER, McMillan P et al. · 2026 · Journal of orthopaedic trauma

Objectives To compare clinical outcomes between open reduction and internal fixation (ORIF) with or without Conventus intramedullary cage (CC) for proximal humerus fractures. Methods Design Retrospective cohort study. Setting Level 1…

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Negative / Null Result ReportMedicine

A comparative experimental study on the impact of radiotherapy dose rate and melatonin pretreatment in tongue and esophageal tissues.

Hacımustafaoğlu F, Aras S, Çaykara Peran B et al. · 2026 · International journal of radiation biology

Aim This study aimed to investigate the differential biological responses in tongue and esophageal tissues induced by flattening filter (FF) and flattening filter-free (FFF) beams at varying dose rates, and to assess the radioprotective…

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Negative / Null Result ReportMedicine

Impact of a multidisciplinary care pathway on follow-up and emergency department utilisation in paediatric musculoskeletal infections.

Bouchard M, Galán-Olleros M, Ng K et al. · 2026 · European journal of pediatrics

To evaluate whether implementation of a multidisciplinary care pathway was associated with changes in unplanned emergency department (ED) visits in children with musculoskeletal infections, and to assess its impact on readmissions,…

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Negative / Null Result ReportMedicine

Key factors in the diagnosis of sesame allergy in children.

Hismiogullari A, Sancakli O, Ocak M et al. · 2026 · Allergy and asthma proceedings

Background: Sesame allergy (SA) is diagnostically challenging in childhood, and data on its natural course and clinical nonreactivity development are limited. Although oral food challenge (OFC) remains the diagnostic criterion standard,…

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Negative / Null Result ReportMedicine

Comparison between drug-eluting bead transarterial chemoembolization versus conventional TACE in elderly patients with colorectal cancer liver metastases: a cohort study.

Tian L, Hu B, Song M et al. · 2026 · Frontiers in oncology

Background Drug-eluting bead (DEB) transarterial chemoembolization (TACE) possesses several advantages over conventional TACE (cTACE) such as higher intratumor drug concentration and lower systemic toxicity, which has been widely applied…

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Negative / Null Result ReportMedicine

Boric acid Attenuates premature ovarian insufficiency by Modulating oxidative stress in a Cyclophosphamide-Induced rat model.

Ozcakar TG, Kender Erturk N, Onguncan O et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Aim This study aimed to investigate whether boric acid (BA) exerts potential protective effects against cyclophosphamide (CYC)-induced premature ovarian insufficiency (POI) in rats through modulation of oxidative stress and preservation of…

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Negative / Null Result ReportMedicine

Effect of a goal-directed sedation nursing intervention bundle on comfort and compliance in children undergoing bronchoalveolar lavage under topical anesthesia with procedural sedation: a randomized controlled trial.

Luo X, Zhang H · 2026 · Frontiers in medicine

Objective To assess the impacts of goal-directed sedation nursing intervention on comfort and compliance in children undergoing bronchoalveolar lavage (BAL) under topical anesthesia with procedural sedation. Methods A total of 168 children…

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Negative / Null Result ReportMedicine

Comparison of Dacryoendoscopy-Aided Silicone Tube Intubation and Endoscopic Dacryocystorhinostomy for Complete Nasolacrimal Duct Obstruction.

Yoon Y, Yoon JS, Ko J · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the surgical outcomes of dacryoendoscopy-aided silicone tube intubation (STI) and endoscopic dacryocystorhinostomy (endo-DCR) for complete nasolacrimal duct obstruction (NLDO), and to identify factors associated with…

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Negative / Null Result ReportMedicine

Visual and refractive outcomes of small incision lenticule extraction planned with a VISULYZE-generated nomogram for myopia and astigmatism: a retrospective comparative study.

Lin Y, Wei X, Su H et al. · 2026 · BMC ophthalmology

Purpose Small-incision lenticule extraction (SMILE) is a widely used procedure for correcting myopia and myopic astigmatism. However, variability in refractive outcomes, particularly astigmatic correction, remains a concern. This study…

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Negative / Null Result ReportMedicine

Fibular allograft augmentation shows potential benefits in treating medial column comminuted proximal humeral fractures with osteoporosis: a secondary analysis of a randomized controlled trial.

Chai Y, Shi T, Jiang H et al. · 2026 · Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology

Background Fibular allograft (FA) augmentation is proposed to address the lack of medial column support in plate-fixed proximal humeral fractures; however, the role of FA augmentation in these fractures remains inadequately elucidated. Our…

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Negative / Null Result ReportOpen accessMedicine

Does Maternal Smoking Increase the Risk of Congenital Heart Disease? Insights from a Single-Center Fetal Echocardiography Study.

Kavgacı A, Kaya Ö, Örün UA et al. · 2026 · Journal of clinical medicine

Background : Congenital heart disease (CHD) represents a major cause of perinatal morbidity and mortality, and fetal echocardiography is essential for its early diagnosis and management. Maternal smoking has been suggested as a potential…

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Negative / Null Result ReportMedicine

Does previous neck dissection or irradiation mitigate the response to immunotherapy in advanced/metastatic head and neck squamous cell carcinoma?

Kampel L, Oestreicher-Kedem Y, Horowitz G et al. · 2026 · International journal of oral and maxillofacial surgery

Immunotherapy has brought new hope to patients with locally advanced, recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). This study aimed to evaluate the outcomes at our institution, focusing on the response to…

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Negative / Null Result ReportOpen accessMedicine

Underestimation of Prostate Cancer Grade in Transperineal Fusion Biopsy and Its Predictive Factors: Correlation of Biopsy Findings with Post-Da Vinci Radical Prostatectomy Specimens.

Krzepkowski HA, Ząbkowski T, Walędziak M et al. · 2026 · Journal of clinical medicine

Background/Objectives : An accurate preoperative assessment of prostate cancer malignancy is crucial for risk stratification and selection of the optimal treatment strategy. This study assessed the concordance of Gleason scores between…

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Negative / Null Result ReportMedicine

Thyroid disease and breast cancer risk in the Sister Study.

Woo JMP, Chen D, Yarosh R et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Thyroid disease (TD), and its treatments, are suspected risk factors for breast cancer (BC), attributed primarily to alterations in thyroid hormone-related metabolism. Prior literature is inconsistent, in part, due to small…

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Negative / Null Result ReportMedicine

Robot-assisted versus conventional unicompartmental knee arthroplasty: a retrospective comparative study of postoperative complications.

Gonzalez W, Riquelme JP, Arellano J et al. · 2026 · BMC musculoskeletal disorders

Background Unicompartmental knee arthroplasty (UKA) is an established procedure for selected patients with unicompartmental osteoarthritis. Robotic-assisted UKA (RA-UKA) has been introduced to improve accuracy of implant positioning.…

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