12,244 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Humes LE, Dhar S, Singh J · 2025 · International journal of audiology
Objective To evaluate use of the Hearing Handicap Inventory for the Elderly (HHIE), and its derivatives, as hearing-aid outcome measures. Design A targeted narrative literature review identified 12 studies in the primary research…
View details →Dalbeni A, Vicardi M, Natola LA et al. · 2026 · Oncology research
Objectives The combination of atezolizumab plus bevacizumab (A+B) represents one of the standards first-line treatments for unresectable hepatocellular carcinoma (HCC). Metformin has garnered attention for its potential antitumour and…
View details →Lapner P · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Rotator cuff retears remain the most frequently observed complication after arthroscopic cuff repair, with tendon nonhealing rates reported between 20% and 68%. Biological solutions to improve healing rates are needed, and bone marrow…
View details →Schonhaut EB, Scherpereel KL, Young AJ · 2026 · IEEE transactions on bio-medical engineering
Objective Accurate, non-invasive methods for estimating joint and muscle physiological states have the potential to greatly enhance control of wearable devices during real-world ambulation. Traditional modeling approaches and current…
View details →Lusilla Lopez A, Fält UA, Buchwald P et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Aim Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the…
View details →Marsh A, Quelch D, Mackonochie M et al. · 2026 · The international journal of neuropsychopharmacology
The incidence of cognitive disorders is rising, and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence…
View details →Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery
Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…
View details →Aggarwal A, Adie S, Harris IA et al. · 2025 · The Cochrane database of systematic reviews
Background Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life within three to six months. It is,…
View details →Bi Z, Ren T, Wang Y · 2025 · Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9% between the experimental and control groups. That is to say, in the intermediate-risk hormone receptor positive/human…
View details →Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation
Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…
View details →Wee YC, Hewage U, Horwood C et al. · 2026 · Journal of clinical medicine
Background : Statins have anti-inflammatory properties beyond their lipid-lowering effects, but their impact on skin and soft tissue infections (SSTIs) remains unclear. This study evaluated whether statins improve clinical outcomes in…
View details →Robertson NP · 2025 · Journal of neurology
The first of several phase 3 trials examining efficacy in relapsing MS has not been able to demonstrate a significant benefit and has also raised important safety concerns. More results are on their way and it will be important to…
View details →Tabibian K, Vadlakonda A, Coaston T et al. · 2025 · The American journal of cardiology
Despite advancements in cardiogenic shock (CS) management, mortality remains high. While hospital volume has been linked to reduced mortality across myriad complex procedures, the cross-volume effects of mechanical circulatory support…
View details →Ghotboddin Mohammadi S, Shafie D, Feizi A et al. · 2026 · Scientific reports
Chronic inflammation and dyslipidemia are common pathophysiological features of heart failure (HF). Astaxanthin, a potent marine-derived antioxidant, has shown anti-inflammatory and lipid-lowering properties. This study conducted to…
View details →Cardoso A, Naghibi M, Climent E et al. · 2026 · Allergy
Background Allergic rhinitis (AR) is an increasingly common chronic inflammatory condition of the nasal mucosa. While conventional anti-allergy treatments are widely used, they can come with side effects and are not always effective. As a…
View details →Wang AI, Duong MP, Frohlich JR et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS
Systemic analgesics, such as opioids and nonsteroidal anti-inflammatory drugs, may be contraindicated in certain studies due to their mechanisms of action and risk for systemic effects. Local anesthetics (LAs) are therefore crucial in…
View details →Mongia N, Mohammed AI, McCullough M et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease…
View details →Guo P, Yang Y, Chen X et al. · 2026 · PLoS neglected tropical diseases
Objectives This study seeks to investigate the characteristics, dynamics, and association with disease progression of monocyte inflammation in patients with AIDS/Talaromycosis Marneffei (TSM). The findings are expected to contribute to a…
View details →de Marcos Carpio I, de Vicente F, Vallefuoco R · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T
Objectives (1) To describe and compare the morphometric changes of the tibia following four virtual proximal tibial osteotomies for treatment of canine cranial cruciate ligament deficiency and (2) to determine how these changes are…
View details →Tan-Ho G, Choo PY, Ma SHXY et al. · 2026 · Psychological trauma : theory, research, practice and policy
Objective Caring for a loved one with dementia imposes significant physical strain, emotional burden, and psychological trauma on family caregivers. Singaporean caregivers face added pressures under cultural norms that emphasize familial…
View details →Ortíz Aguirre MJ, Barrientos Chinchilla AC, León-Velásquez M et al. · 2026 · Journal of gynecology obstetrics and human reproduction
Objective To assess the efficacy of topical lidocaine versus placebo in reducing pain during manual vacuum aspiration (MVA) for endometrial sampling in patients with endometrial thickening, as measured by the visual analog scale (VAS).…
View details →Espinoza Ramirez J, Durango M, Santalo O et al. · 2026 · Journal of the American Pharmacists Association : JAPhA
Background Many organizations have developed criteria for pharmacy practice models; however, most of these models are not based on studies evaluating clinical outcomes. Currently, there is no consensus on the ideal pharmacy practice model.…
View details →Chang YJ, Hsu TC, Chan CH et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveTo evaluate 3-dimensional pharyngeal airway changes following 2-jaw orthognathic surgery in skeletal Class III patients and to assess their association with surgical movements.DesignRetrospective observational study.SettingSingle…
View details →Shi K, Li J · 2026 · Psychological research
This study adopts the Think/No-Think (TNT) paradigm for the first time to examine whether activation of thematic semantic relation representations is intrusive. In Experiment 1, during the learning phase, participants memorized cue–target…
View details →Özdemir HE, Albayrak MT, Koçluk Y · 2026 · Journal of clinical medicine
Purpose : To investigate whether the season in which photorefractive keratectomy (PRK) with mitomycin C (MMC) is performed influences postoperative corneal transparency considering seasonal variations in ultraviolet (UV) exposure. Methods…
View details →Dong B, Xian Z · 2026 · Journal of visualized experiments : JoVE
Adolescent bipolar disorder is a severe psychiatric condition frequently complicated by school refusal behavior, a debilitating functional impairment that often persists even after the pharmacological stabilization of mood symptoms. While…
View details →Suematsu Y, Minei A, Sumita Y et al. · 2026 · European journal of preventive cardiology
Aims Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among…
View details →Omerovic E, Råmunddal T, Jha S et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy
Two contemporary randomized trials of β-blocker therapy after myocardial infarction (MI) reached apparently conflicting conclusions. REBOOT, conducted in Spain and Italy, found no reduction in death or major cardiovascular events among…
View details →Mittal H, Thattaruthody F, Akella M et al. · 2026 · Indian journal of ophthalmology
Abstract This experiment was designed to study the effect of mitomycin C (MMC) on conjunctival lymphatics and the lymphangiogenesis potential of synthetic retinoic acid (ec23) in rat eyes. This prospective animal experimental study…
View details →Royo M, Jiménez Á, Molina-Martin A et al. · 2026 · European journal of ophthalmology
PurposeTo analyze the amplitude of accommodation and its changes at a 6-month follow-up in healthy subjects implanted with an anterior chamber pIOL, assessing whether accommodative function is affected. Additionally, changes in visual…
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