12,244 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Metsch LR, Feaster DJ, Gooden LK et al. · 2025 · Open forum infectious diseases
Background People with HIV (PWH) who use cocaine are less likely to achieve virologic suppression ( Methods Project RETAIN recruited 360 cocaine-using PWH who were not virologically suppressed in Miami, FL, and Atlanta, GA. Patients were…
View details →Ackermans N, Taylor C, Tam R et al. · 2019 · Multiple sclerosis journal - experimental, translational and clinical
Objective The objective of this paper is to evaluate potential dose-dependent adverse effects of gadolinium-based contrast agents (GBCAs) on MS progression. Methods Outcomes from a cohort of 612 secondary progressive MS (SPMS) patients,…
View details →Domsic RT, Gao S, Laffoon M et al. · 2021 · Rheumatology (Oxford, England)
Objectives Clinical trials in early diffuse cutaneous systemic sclerosis (SSc) using the modified Rodnan skin score (mRSS) as the primary outcome measure have most often been negative. We wanted to assess how the definition of disease…
View details →Kremer L, Bus JD, Webb LE et al. · 2021 · Scientific reports
Affective states can be inferred from responses to ambiguous and threatening stimuli, using Judgement Bias Tasks (JBTs) and Attention Bias Tasks (ABTs). We investigated the separate and interactive effects of personality and housing…
View details →Mason MG, Richardson EJ, Giarrusso C et al. · 2025 · Journal of the experimental analysis of behavior
This experiment explored a rodent model of functional class formation by assessing the transfer of a novel discriminative function across class members. Following simple successive discrimination reversal training and consistently strong…
View details →Chamberlain DB, Chamberlain JM · 2017 · Annals of emergency medicine
Study objective We demonstrate the application of a Bayesian approach to a recent negative clinical trial result. A Bayesian analysis of such a trial can provide a more useful interpretation of results and can incorporate previous…
View details →Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…
View details →Puvvada SD, Guillén-Rodríguez JM, Rivera XI et al. · 2017 · Oncology
Objective Aggressive lymphomas (aNHL) including diffuse large B-cell lymphoma (DLBCL) have poor outcomes in relapsed refractory patients. Prior studies have demonstrated that loss of major histocompatibility complex class II (MHCII)…
View details →Regel A, Sepriano A, Baraliakos X et al. · 2017 · RMD open
To assess the efficacy and safety of non-biological therapies in patients with axial spondyloarthritis (axSpA) to inform the update of the Assessment of SpondyloArthritis international Society (ASAS)/European League Against Rheumatism…
View details →Abdelrahman KM, Hackshaw KV · 2021 · Biomedicines
Neuropathic pain affects 7-10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake…
View details →Witzel S, Statland JM, Steinacker P et al. · 2024 · European journal of neurology
Background and purpose Rasagiline might be disease modifying in patients with amyotrophic lateral sclerosis (ALS). The aim was to evaluate the effect of rasagiline 2 mg/day on neurofilament light chain (NfL), a prognostic biomarker in ALS.…
View details →Kitchin SS, Lakshmanan S, Kinninger A et al. · 2023 · The British journal of cardiology
Atrial fibrillation (AF) is a common arrhythmia associated with poor outcomes. N-3 fatty acids have been shown to provide significant cardiovascular risk reduction, but they may exacerbate the risk of AF. The pathway by which N-3 fatty…
View details →Konishi K · 2024 · Entropy (Basel, Switzerland)
We comment on the so-called negative result experiments (also known as null measurements, interaction-free measurements, and so on) in quantum mechanics (QM), in the light of the new general understanding of the quantum-measurement…
View details →Yarnall S, Saben JL, Sun N et al. · 2025 · Journal of genetic counseling
This observational study aimed to capture patients' experiences after reviewing carrier screening (CS) and/or noninvasive prenatal cell-free DNA testing (NIPT) results with Natera's Educational Virtual Assistant (NEVA). Patients, partners…
View details →Van Der Pol B, Ippolito J, Gao R et al. · 2026 · Sexually transmitted diseases
Background Extragenital (oropharyngeal and anorectal) Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (or gonococci [GC]) infections are underdiagnosed. Here we report sensitivity and specificity estimates that were obtained from the…
View details →Ding JJ, Chiu CF, Su YT et al. · 2025 · Pediatric research
Background Maternal hypercalcemia is a rare but potentially serious cause of late-onset neonatal hypocalcemia. Data on the clinical characteristics and outcomes of mother-baby couplets with maternal hypercalcemia and subsequent neonatal…
View details →Džafić F, Ahmetović A, Čoloman N et al. · 2026 · International archives of allergy and immunology
Introduction Allergic rhinitis (AR) is a prevalent health concern. In Europe, 20-40% of the population is affected. Diagnostic methods include skin tests, measurement of serum immunoglobulin E (IgE), nasal smear for eosinophils, and…
View details →Kohan R, Gil-Campesino H, García Rodríguez IO et al. · 2026 · Emerging infectious diseases
We report 2 cases of donor-derived Strongyloides stercoralis infection in renal transplant recipients. Despite initial negative serologic testing in donor samples, retrospective testing confirmed transmission. This report underscores the…
View details →Bae-Jump VL, Sill MW, Gehrig PA et al. · 2025 · Gynecologic oncology
Introduction We evaluated the efficacy of the addition of the anti-diabetic drug metformin to standard-of-care paclitaxel and carboplatin (PC) in patients with advanced and recurrent endometrial cancer (EC). Methods In this phase II/III…
View details →Rosell R, Karachaliou N, Codony J et al. · 2014 · Translational lung cancer research
Designing molecular targeted therapy with high specificity based on novel tumor biomarkers is a high priority in lung cancer research. Several molecular aberrations have been already identified in non-small cell lung cancer (NSCLC), with…
View details →Le Duc W, Butler CR, Argyropoulos GPD et al. · 2025 · PLoS biology
Rodent and human data implicate the hippocampus in the arbitration of approach-avoidance conflict (AAC), which arises when an organism is confronted with a stimulus associated simultaneously with reward and punishment. Yet, the precise…
View details →Whitty JA, Wagner AP, Kang E et al. · 2023 · The Australian & New Zealand journal of obstetrics & gynaecology
Background There is growing evidence regarding the potential of closed incision negative pressure wound therapy (ci-NPWT) to prevent surgical site infections (SSIs) in healing wounds by primary closure following a caesarean section (CS).…
View details →Ip EH, Saldana S, Miller KD et al. · 2021 · Cancer
Background E5103 was a study designed to evaluate the efficacy and safety of bevacizumab. It was a negative trial for the end points of invasive disease-free survival and overall survival. The current work examines the tolerability of…
View details →Kim CK, Lee YR, Ong L et al. · 2022 · Journal of Alzheimer's disease : JAD
Given the acknowledged lack of success in Alzheimer's disease (AD) drug development over the past two decades, the objective of this review was to derive key insights from the myriad failures to inform future drug development. A systematic…
View details →Li W, Bunch CM, Zackariya S et al. · 2025 · Scientific reports
Disordered hemostasis associated with life-threatening hemorrhage commonly afflicts patients in the emergency department, critical care unit, and perioperative settings. Rapid and sensitive hemostasis phenotyping is needed to guide…
View details →Shepard S, Anderson JM, Heigle B et al. · 2023 · Journal of orthopaedic surgery and research
Purpose To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures. Methods We searched ClinicalTrials.gov on September 9th,…
View details →Meyers DE, Jenei K, Chisamore TM et al. · 2021 · JAMA internal medicine
Importance Cancer drugs approved by the US Food and Drug Administration have come under scrutiny for marginal clinical benefits; however, the clinical benefits of cancer drugs recommended for reimbursement in Canada have not been…
View details →O'Sullivan Coyne G, Burotto M · 2014 · Expert opinion on biological therapy
Introduction Monoclonal antibodies and small molecules targeting the VEGF pathway are part of the arsenal to treat malignant tumors. Antiangiogenesis therapies has been studied in breast cancer with partial success, reflected by the…
View details →Bajwa MS, Jackson R, Dhanda J et al. · 2023 · Cancers
Objectives High-quality randomised controlled trials (RCT) to support the use of Fibrin Sealants (FS) in neck dissection (ND) are lacking. The DEFeND trial assessed critical pilot/feasibility questions and signals from clinical outcomes to…
View details →Levy MM · 2013 · Critical care (London, England)
During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small…
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