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Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Looking for Biomarkers Which May Explain Idiopathic Environmental Intolerance Attributed to Electromagnetic Fields (IEI-EMF): Does RF-EMF Exposure Influence Salivary Cortisol Response?

Verrender A, Manley J, Wallace NK et al. · 2025 · Bioelectromagnetics

In order to understand Idiopathic Environmental Intolerance attributed to Electromagnetic Fields (IEI-EMF), it has been argued that it is crucial to test for effects of radiofrequency electromagnetic fields (RF-EMF) on biomarkers, given…

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Negative / Null Result ReportOpen accessMedicine

Cognitive Therapy vs. Short-Term Dynamic Psychotherapy in a Community Mental Health Setting: A Preliminary Analysis of Effects in Several Severity Domains.

Gibbons MBC, Kodkany N, Liow Y et al. · 2026 · Clinical psychology & psychotherapy

Objective To investigate the effectiveness of cognitive therapy (CT) and short-term dynamic psychotherapy (STDP) among patients with greater severity, defined in several ways, in a community mental health setting. Method Using data from a…

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Negative / Null Result ReportMedicine

White matter integrity and verbal memory following a first episode of psychosis: A longitudinal study.

Ghanem J, Totzek JF, Henri-Bellemare C et al. · 2025 · Progress in neuro-psychopharmacology & biological psychiatry

Psychotic disorders are heterogeneous disorders for which there is evidence of structural and functional brain abnormalities. The role of white matter integrity, often measured via Fractional Anisotropy (FA), has played a controversial…

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Negative / Null Result ReportOpen accessMedicine

Plasma Neurofilament Light Chain Is Associated with Cognitive Functions but Not Patient-Reported Outcomes in Multiple Sclerosis.

Nicolella V, Novarella F, Falco F et al. · 2025 · Neurology international

Objective We aimed to explore associations between plasma neurofilament light chain (pNfL) and cognition through patient-reported outcomes (PROs) in multiple sclerosis (MS). Methods In this cross-sectional study, we included 211 people…

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Negative / Null Result ReportOpen accessMedicine

Model-based planning is unaffected by ketamine, antidepressant and internet delivered cognitive behavioural therapy treatments in depression.

Donegan KR, Hossein S, Panny BM et al. · 2025 · Translational psychiatry

Cognitive impairments have been observed in patients with depression. These include deficits in inhibition, shifting, and updating; cognitive processes that are critical for goal-directed control over behavior ('model-based planning').…

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Negative / Null Result ReportOpen accessMedicine

No Impact of COVID-19 Pandemic on Early Mortality for Thyroid Cancer in the US. Comment on Lee et al. Impact of the COVID-19 Pandemic on Thyroid Cancer Surgery. <i>Curr. Oncol.</i> 2024, <i>31</i>, 3579-3590.

Nocini R, Lippi G, Mattiuzzi C · 2024 · Current oncology (Toronto, Ont.)

Thyroid cancer is relatively rare in the general population compared to other malignancies, but its incidence appears to have increased in recent decades [...].

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Negative / Null Result ReportOpen accessMedicine

Cognitive and physiological impacts of psychotherapy incorporating human-equine interactions during substance withdrawal: A scoping review.

Friend MM, Nicodemus MC, Cavinder CA et al. · 2025 · Journal of equine rehabilitation

The use of psychotherapy incorporating equine interaction (PIE) is becoming widely utilized for the treatment of a range of conditions; however, evidence supporting the efficacy of this treatment is highly variable, inconsistently defined,…

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Negative / Null Result ReportMedicine

Synthetic Versus Biologic Mesh for Complex Open Ventral Hernia Repair: 3-Year Follow-Up of a Pilot Randomized Controlled Trial.

Dhanani NH, Lyons NB, Lee KH et al. · 2025 · HCA healthcare journal of medicine

Background Biologic mesh is often used in complex hernia repair, but there has been limited clinical evidence to date to support this practice. The aim of this study was to compare clinical and patient-reported outcomes of biologic versus…

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Negative / Null Result ReportMedicine

Derailment in adolescence: Factor analytic structure and correlates.

Ratner K, Zhu G, Li Q et al. · 2024 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Derailment is the sense of being "off-course" in life. But what could this mean for adolescents, who are often establishing identity and self-direction for the first time? We examined the structure and correlates of the Derailment Scale…

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Negative / Null Result ReportMedicine

Early Sodium Bicarbonate Use in Pediatric In-Hospital Cardiac Arrest: A Single-Center, Retrospective Cohort Study, 2013-2023.

Duster NA, Grossestreuer AV, Sorcher JL et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To explore the association of intra-arrest sodium bicarbonate (SB) use with outcomes in pediatric in-hospital cardiac arrest (p-IHCA) when accounting for the timing of initial SB administration. We hypothesized that…

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Negative / Null Result ReportMedicine

Sudden Sensorineural Hearing Loss Before COVID-19, During COVID-19, and After Inactivated Vaccination: Experience From a Tertiary Referral Center in China.

Cao X, Yi H · 2024 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective The purpose of this study was to investigate the incidence rate and audiological characteristics of sudden sensorineural hearing loss (SSHL) before the COVID-19 pandemic, during the COVID-19 pandemic, and after inactivated…

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Negative / Null Result ReportOpen accessMedicine

Parent emotion regulation difficulties statistically mediate the association between parental adverse childhood experiences and child emotion regulation.

Freeman SE, Staples AD, Loverich TM et al. · 2025 · Frontiers in global women's health

Introduction Emotion regulation (ER) abilities predict positive outcomes among children. While parenting behaviors that promote young children's ER development have been widely studied, less is known about how a parent's history of early…

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Negative / Null Result ReportOpen accessMedicine

Less Than Zero?

Hackländer RPM, Schlüter H, Rolke AK et al. · 2025 · Experimental psychology

Not all information encountered is equally important to remember. Some information may be valuable, while others may be irrelevant. Importantly, retrieving and acting upon some information may even have negative consequences. Research has…

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Negative / Null Result ReportMedicine

Internalizing symptoms, negative urgency, and coping motives: Potential pathways to alcohol consequences.

McDonald A, Corbin W · 2025 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

Objective Building upon prior research, the present study tested coping motives as a mediator of relations between both negative urgency and internalizing symptoms (depression, anxiety, and stress), and alcohol-related consequences using…

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Abandoned HypothesisOpen accessMedicine

Finding Ramón: Navigating Failure and Luck in Mexico.

Jones GA · 2025 · Critical criminology

Failure is taboo. Yet as researchers we often encounter failure in the field and engage in confessional conversations with colleagues about 'what went wrong'. Failure is regarded as an unfortunate and unproductive part of research. Better…

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Negative / Null Result ReportOpen accessMedicine

Stable White Matter Structure in the First Three Years After Psychosis Onset.

Van Dyken PC, Yang K, Faria AV et al. · 2025 · Biological psychiatry global open science

Background White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date…

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