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Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Echocardiographic Findings in Small-Breed Dogs With Myxomatous Mitral Valve Disease and the Severity of Mitral Regurgitation, Heart Size and Clinical Signs Myxomatous Mitral Valve Disease in Dogs.

Elyasi B · 2026 · Veterinary medicine and science

Background The main goal of this study was to identify various brightness, motion and Doppler echocardiographic variables in small-breed dogs with myxomatous mitral valve disease. Animals Sixty client-owned small-breed dogs with mitral…

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Negative / Null Result ReportMedicine

EXPRESS: Longitudinal comparison of serum pancreatic lipase activity and pancreatic lipase immunoreactivity with clinical signs in cats with suspicion of pancreatitis.

Kook PH · 2026 · Journal of feline medicine and surgery

ObjectivesIt remains unclear whether pancreatic lipase immunoreactivity (PLI) and lipase activity similarly reflect clinical status and disease severity in cats with suspected pancreatitis. This retrospective cohort study aimed to directly…

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Negative / Null Result ReportMedicine

All-Suture Anchors Exhibit Less Perianchor Fluid Formation Independent of Healing Quality Compared With PEEK Anchors in Arthroscopic Rotator Cuff Repair: A Propensity Score-Matched Comparative Study.

Gül O, Ayazoglu MA, Yazıcı A et al. · 2026 · Journal of shoulder and elbow surgery

Background Perianchor fluid collection may differ according to anchor material following arthroscopic rotator cuff repair (ARCR), but its relationship with tendon healing remains unclear. This study aimed to compare perianchor fluid…

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Negative / Null Result ReportMedicine

PNEUMOCOCCAL SEROLOGICAL EVALUATION IN VACCINATED CHILDREN DIAGNOSED WITH TRANSIENT HYPOGAMMAGLOBULINEMIA OF INFANCY AND UNCLASSIFIED HYPOGAMMAGLOBULINEMIA.

Öztürk G, Orhon F, Bayrakoğlu D et al. · 2026 · International archives of allergy and immunology

The severity and incidence of invasive pneumococcal infections increase in inborn errors of immunities. However, there are limited number of studies in the literature evaluating pneumococcal antibody levels in patients with a prediagnosis…

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Negative / Null Result ReportOpen accessMedicine

Exploring the significance of fatty acid-binding protein 4 levels as a biomarker for autism spectrum disorder: a cross-sectional study.

Abdelaziz AW, Alkherkhisy MM, El-Sheikh HR et al. · 2026 · BMC psychiatry

Background Lipid metabolism and its regulatory molecules, especially adipokines, have gained significant attention in recent pathogenesis research of autism spectrum disorder (ASD). Aims To evaluate serum fatty acid-binding protein 4…

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Negative / Null Result ReportMedicine

Smell and taste dysfunction after total laryngectomy: A cross-sectional study comparing patient and physician perspectives.

Bilen YE, Sinanoğlu N, Külekci Ç · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose Total laryngectomy disrupts nasal airflow, often resulting in significant olfactory and gustatory dysfunction. While these sensory losses may adversely affect patients' quality of life and psychological well-being, they typically…

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Negative / Null Result ReportMedicine

Comparative Evaluation of Serum Hepcidin and Fecal Calprotectin for Disease Activity Assessment in Inflammatory Bowel Disease.

Akıncıoğlu P, Dağlı Ü, Koca E · 2026 · The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Background/aims Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder commonly associated with iron deficiency anemia and anemia of chronic disease. Hepcidin is a key…

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Negative / Null Result ReportMedicine

The Effect of EMG biofeedback in female patients with stress urinary incontinence: a randomized sham controlled blinded clinical study.

Cigdem-Karacay B, Bayramoglu-Demirdogen E, Konar NM et al. · 2026 · Irish journal of medical science

AIM: The effectiveness of EMG-BF in SUI has not yet been proven. This study aimed to the effectiveness of EMG-BF on pelvic floor muscle activity, pad test, severity of complaints, and quality of life in female patients with Stress Urinary…

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Negative / Null Result ReportMedicine

Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients.

Ikuma H, Hirose T, Kawasaki K et al. · 2026 · Acta medica Okayama

We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of 980nm diode laser as adjunct to flap surgery.

Patil S, Raju KN, S Kotnoor S et al. · 2026 · Bioinformation

The additional clinical benefit of diode laser irradiation as an adjunct to open flap debridement (OFD) in the treatment of chronic periodontitis remains uncertain. Therefore, it is of interest to evaluate the impact of diode laser…

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Negative / Null Result ReportMedicine

Maintenance of occupational therapy for individuals with dementia: Findings from a pragmatic randomized controlled trial.

Pimouguet C, Kret M, Francis-Oliviero F et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundThere is increasing interest in non-pharmacological approaches to address the needs of patients with Alzheimer's disease and other dementia. However, previous research highlighted the need to adapt interventions to the healthcare…

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Negative / Null Result ReportMedicine

Motivational interviewing and air cleaners for smokers with COPD (MOVE): a randomized, double-blind, placebo-controlled trial.

Hansel NN, Putcha N, Woo H et al. · 2026 · American journal of respiratory and critical care medicine

Rationale Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive -pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of a Telemedicine Exercise Program to Improve Lung Function in Young Adults After COVID-19: A Pilot Study.

Wong ECH, Lo RWM, Kwan RLC et al. · 2026 · Healthcare (Basel, Switzerland)

Background : COVID-19 can have adverse effects on individuals' lung functions for up to 6 months or more after the episode. As a result, people may be reluctant to exercise, and this can have further adverse effects on their lung capacity…

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Negative / Null Result ReportMedicine

Adolescents Who Underwent Revision Hip Arthroscopy Showed Comparable Magnitude of Improvement but Had Lower Clinical Benefit Rates and Higher Risk of Subsequent Surgeries Compared to a Propensity-Matched Primary Group at 2-Year Follow-Up.

Maldonado DR, Schab AR, Sikligar D et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purposes To compare minimum 2-year patient-reported outcomes measures (PROMs) between adolescents undergoing primary and revision hip arthroscopy. Methods Data were prospectively collected and retrospectively reviewed for adolescents who…

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Negative / Null Result ReportMedicine

Outcomes of Maximal Conventional Therapy Before Biological Treatment in Recurrent Chronic Rhinosinusitis With Nasal Polyps.

Topan YE, Bayar Muluk N, Yavuz R et al. · 2026 · The Journal of craniofacial surgery

Objective To determine whether biological therapy is a viable option for individuals with recurrent chronic rhinosinusitis with nasal polyps (CRSwNP), we will assess the clinical outcomes of maximal conventional therapy (MCT). Methods For…

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Negative / Null Result ReportMedicine

Comparative Outcomes of the Modified Woodward Procedure Versus Conservative Management in Sprengel Deformity: A Retrospective Cohort Study.

Jia Y, Dong Y, Jiang R et al. · 2026 · Journal of pediatric orthopedics

Background Sprengel deformity is a rare congenital malformation of the scapula. To date, there have been limited reports analyzing the clinical outcomes of the modified Woodward procedure and conservative management in the treatment of…

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