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Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

In relation to anxiety severity, puberty moderates functional connectivity between the amygdala and anterior cingulate cortex for negative relative to neutral stimuli during an emotional categorization task.

Suss SJ Jr, Kimbler A, Baker AE et al. · 2026 · Developmental cognitive neuroscience

Anxiety symptoms often escalate in peri-adolescence (ages 10-13 years), a sensitive period when puberty-related changes occur in neural systems implicated in psychopathology. Greater amygdala activation and altered functional connectivity…

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Negative / Null Result ReportOpen accessMedicine

Predicting treatment outcomes by door-to-device time and baseline characteristics in STEMI patients undergoing PPCI: a cross-sectional study in southern Iran.

Vosoughi S, Adineh M, Kardooni A et al. · 2026 · ARYA atherosclerosis

Background Primary percutaneous coronary intervention (PPCI) is considered the gold standard for ST-elevation myocardial infarction (STEMI) treatment. While door-to-device (DTD) time critically influences outcomes, its combined impact with…

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Negative / Null Result ReportOpen accessMedicine

A Retrospective Study of the Presentation, Imaging Findings, and Outcomes in 195 Patients with Maxillofacial Fractures Treated with Closed Reduction or Open Reduction with Internal Fixation.

Durmuş Hİ, Polat ME · 2025 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Maxillofacial fractures represent one of the most common forms of traumatic injuries, affecting both function and aesthetics, and are associated with significant morbidity and long-term sequelae. The incidence and distribution…

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Negative / Null Result ReportOpen accessMedicine

Clinical characteristics, medication use, and mortality outcomes in pediatric chronic kidney disease: A retrospective study at national hospital in Jakarta.

Eff ARY, Yuliana S, Afifah NN et al. · 2026 · Journal of advanced pharmaceutical technology & research

Chronic kidney disease (CKD) in children necessitates the use of a variety of drugs to reduce disease progression and manage complications. Polypharmacy is common in children with CKD, which can increase the occurrence of harmful drug…

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Negative / Null Result ReportMedicine

Interpersonal Relationship, Academic Performance, & Life Skills: A Comparative Study of Children With and Without Emotional and Behavioral Problems.

Kheto P, Pallerla S, Bhattacharjee K et al. · 2026 · Clinical child psychology and psychiatry

BackgroundEmotional and behavioral problems (EBPs) in children significantly influence developmental domains, including interpersonal relationships, academic performance, and life skills.MethodsA cross-sectional study was adopted with…

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Negative / Null Result ReportMedicine

Comparing Self-Reports, Pill Counts, and Electronic Devices in Assessing ART Adherence and its Association with Viral Suppression in Adolescents Living with HIV.

Kizito S, Ssewamala FM, Nabayinda J et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)

Background We compared the performance of self-reports, pill counts, and electronic adherence measures in monitoring antiretroviral therapy (ART) adherence and association with viral suppression among adolescents living with HIV (ALHIV).…

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Negative / Null Result ReportMedicine

Vertical Maxillary Movement Is Associated With Incisal Display in Orthognathic Surgery.

Han MD, Shimchuk A, Dosoudil E et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Maxillary incisal display (MID) is a key feature in orthodontic and orthognathic surgical planning that critically impacts esthetics and forms the basis for the vertical positioning of the maxilla. In orthognathic surgical…

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Negative / Null Result ReportMedicine

Impact of emergency medical services volume on outcomes and management in prehospital traumatic cardiac arrest: a retrospective cohort study.

Morcel B, Yordanov Y, Mercier E et al. · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine

Background While volume-outcome relationships for non-traumatic out-of-hospital cardiac arrest have been reported in hospital settings, the impact of prehospital exposure, particularly for the rare and clinically complex entity of…

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Negative / Null Result ReportOpen accessMedicine

Postoperative Consequences of Fear and Anxiety in Open Heart Surgery: A Comparative Analysis of Two Patient Groups.

Dizdar E, Kiliç A, Alkan Kayhan S et al. · 2026 · The journal of nursing research : JNR

Background Patients undergoing open heart surgery may experience negative emotions such as anxiety, fear, panic, and anger in the preoperative period that may negatively affect their postoperative recovery. Purpose This study was designed…

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Negative / Null Result ReportOpen accessMedicine

COVID-19 vaccination remains essential for healthcare professionals: clinical evidence from a Polish cross-sectional study.

Hoffmann K, Michalak M, Jarząb M et al. · 2026 · Frontiers in public health

Introduction Six years after the emergence of SARS-CoV-2, vaccination remains still central to preventing severe COVID-19. The aim was to determine the impact of the vaccine type and number of doses on the course of COVID-19 infection…

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Negative / Null Result ReportMedicine

Associations of 2000 m Rowing Ergometer Performance With Load-Velocity Relationship Variables Obtained During Bilateral and Unilateral Prone Bench Pull and Leg Press.

Pérez-Castilla A, Quidel-Catrilelbún MEL, Baena-Raya A et al. · 2026 · Journal of strength and conditioning research

Abstract Pérez-Castilla, A, Quidel-Catrilelbún, MEL, Baena-Raya, A, Miras-Moreno, S, Conceição, F, Fernandes, JFT, and Ramirez-Campillo, R. Associations of 2000 m rowing ergometer performance with load-velocity relationship variables…

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Failed Experiment ReportOpen accessMedicine

The impact of infertility-related stress, physiological stress and some fertility indices on clinical pregnancy in women undergoing in vitro fertilization.

Omidifar N, Najafi E, Nasiri K et al. · 2025 · BMC pregnancy and childbirth

BACKGROUND: Despite numerous studies on the impact of stress on post-in vitro fertilization (IVF) clinical outcomes are contradictory and researchers recommend the need for further studies. Therefore, the purpose of the present study was…

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Negative / Null Result ReportMedicine

The Elevated Eosinophil Counts and Neutrophils/Lymphocytes Ratio as Predicting Biomarkers in Non-responders, Chronic Spontaneous Urticarial Patients to Cetirizine/Famotidine Treatment.

Khalili A, Estakhri Z, Shams A et al. · 2026 · Iranian journal of allergy, asthma, and immunology

The responses of patients with chronic spontaneous urticaria (CSU) to regular therapeutic options vary. While these methods are effective for some patients, many do not respond successfully. Despite several studies conducted to identify…

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Negative / Null Result ReportOpen accessMedicine

The relationship between compassion fatigue and perceptions of spirituality and spiritual care in intensive care unit nurses: a cross-sectional study.

Neşe A, Yiğit B, Bakır E · 2026 · BMC nursing

BACKGROUND: Intensive care units (ICUs) are high-stress environments that significantly predispose nurses to compassion fatigue, affecting both their well-being and the quality of patient care. Spirituality and spiritual care are often…

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Negative / Null Result ReportOpen accessMedicine

Relationship of vitamin D receptor expression with hormone receptors and other clinicopathological features in primary breast carcinomas: A retrospective cross-sectional study.

Ünlü Y, Ömeroğlu E, Ay AS et al. · 2025 · Medicine

Breast cancer is a heterogeneous disease in which estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 play crucial roles in molecular subtyping, diagnosis, treatment, and…

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Negative / Null Result ReportMedicine

Incidence of thromboembolic events in testicular cancer patients receiving cisplatin (TESTCIS study).

Dubois M, Joly M, Dionne A et al. · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

IntroductionDespite the increased incidence of testicular cancer in men aged 15 to 35, patients with this neoplasm have a high five-year survival rate thanks to chemotherapy. However, cisplatin, a drug used in the standard treatment for…

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Negative / Null Result ReportMedicine

The relationship between individual characteristics and musculoskeletal disorders in tuna fishermen in Pelita Jaya Hamlet, West Seram Regency, in 2024.

Mailuhu JT, Silalahi PY, Maruanaya S et al. · 2025 · International maritime health

Background Indonesia is a country with vast marine areas. It is also part of the world's coral reef triangle, which means that Indonesia has various types of coral reef species. This gives Indonesia a very strong maritime potential.…

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Negative / Null Result ReportMedicine

A microplastic meal: A baseline assessment of microplastic polymer presence within manta-ray (Mobula alfredi) feeding grounds at D'Arros Island and the St. Joseph Atoll.

Choppy MT, Duncan MI, Gordon N et al. · 2026 · Marine pollution bulletin

Microplastic ingestion by reef manta rays (Mobula alfredi) is a threat to their health and population stability. Seychelles' outer islands are vital habitats for M. alfredi but nothing is known about marine microplastic pollution in the…

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