12,375 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kiraly P, Lippera M, Ally N et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose To assess whether external drainage of subretinal fluid (SRF) improves anatomical or visual outcomes in scleral buckle surgery for rhegmatogenous retinal detachment (RRD). Methods Retrospective review of 609 primary scleral buckles…
View details →Azulay N, Singstad BJ, Schirmer H et al. · 2026 · Scientific reports
In Norway, NORRISK2 is the government-recommended risk model for predicting an individual's 10-year probability of getting cardiovascular disease (CVD). This study aims to investigate the potential for improvement of CVD prediction by…
View details →Bröer S, Filor V, Bäumer W · 2026 · Journal of veterinary pharmacology and therapeutics
According to the European Association of Establishments for Veterinary Education (EAEVE), a graduate of veterinary medicine should be able to prescribe and dispense "medicines correctly and responsibly in accordance with legislation and…
View details →Jegarl AM, Martin M, Cormier NR et al. · 2026 · Anesthesiology
Background Whether adding a bilateral superficial cervical plexus block to a thyroidectomy enhanced recovery pathway improves postoperative quality of recovery remains uncertain. Methods In a single-center prospective, randomized,…
View details →Jecan A, Melinte RM, Tomoaia G et al. · 2026 · Journal of clinical medicine
Background : Vitamin K2 (menaquinone) has been studied as a molecule with important effects on bone metabolism and has been proposed as a potential adjuvant in fracture healing, particularly under osteoporotic conditions. However, its…
View details →Kılıç HS · 2026 · European journal of dentistry
Objective This article aims to compare the polymerization effectiveness of two curing modes of a polywave LED unit in four conventional resin composites at a 2-mm increment thickness, using bottom/top microhardness ratios as the evaluation…
View details →Chang JJ, Foreman B, Kepplinger D et al. · 2026 · Neurosurgical review
Pressure reactivity index (PRx) is a surrogate for cerebral autoregulation and has been used for prognostication in aneurysmal subarachnoid hemorrhage (SAH). We examined patient-specific temporal courses of PRx and identified time…
View details →Chun SH, Seo S, Cho JH et al. · 2026 · Head & neck
Background The benefit of consolidation programmed cell death protein 1 (PD-1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II-IVB NPC were…
View details →Gupta N, Seo J, Phan F et al. · 2026 · Heart rhythm
Background Lead dwell time (DT) is associated with increased complexity of cardiac implantable electronic device (CIED) extraction. Optimal strategies for risk mitigation are not well studied. Objective This study aimed to evaluate the…
View details →Chen YF, Kou HW, Chen TH et al. · 2026 · Journal of gastrointestinal cancer
Purpose Radical surgery is the primary treatment for localized gastric cancer (GC), but the benefit of adjuvant chemotherapy in stage IB GC remains unclear. This study evaluates its impact on recurrence and survival post-gastrectomy.…
View details →Andrade A, Mureb M, Karaman N et al. · 2026 · Journal of neuro-oncology
PURPOSE: KRAS G12C mutations occur in approximately 11% of non-small-cell lung cancer (NSCLC) patients and are associated with aggressive disease and poor prognosis. Although KRAS G12C-inhibitors are now approved, their impact on Gamma…
View details →Mikami R, Imai S, Hayakawa M et al. · 2025 · Die Pharmazie
This study aimed to evaluate the temporal effect of a serum creatinine (SCr) correction intervention in critically ill patients with daily muscle wasting. A total of 5,355 critical care days in 574 patients with creatinine clearance (Clcr)…
View details →Montenegro J, Oliveira CL, Nguyen NK et al. · 2026 · The Journal of nutrition
Background Excess body weight is associated with chronic low-grade inflammation and metabolic abnormalities, such as insulin resistance, and dyslipidemia. Objectives This study aimed to assess the impact of a soy protein-yogurt-honey…
View details →Bliesner RK, Stevens AA, Holling L et al. · 2026 · Cureus
Background Being in the large majority, right-handed people are not required to use their nondominant hands throughout their daily lives, resulting in a loss of motor dexterity. As technology continues to advance, improving motor dexterity…
View details →Nascimento GO, Otávio KS, Ferreira J et al. · 2026 · Tropical animal health and production
Bioactive peptides (BP) have been investigated as potential functional feed additives due to their reported immunomodulatory and metabolic properties. This study evaluated the effects of dietary BP supplementation on growth performance,…
View details →Leal RMS, Campos MCBP, Copelli FA et al. · 2026 · International endodontic journal
Aim To evaluate the endodontic retreatment of S-shaped mesial root canals of mandibular molars using the Reciproc Blue R25 and R40 instruments, with or without the use of an orange oil solvent, and to assess the effect of additional apical…
View details →Ko E, Kim YH, Lee S et al. · 2025 · The Journal of surgical research
Introduction Sepsis is a severe pathological crisis marked by infection and systemic inflammation with high mortality rates. Sepsis induces microcirculatory dysfunction and oxidative stress, which share pathophysiological features with…
View details →Dong Z, Wu L, Du H et al. · 2026 · Gastroenterology
Background & aims Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lacking. We aimed to explore whether AI can enhance gastric neoplasm detection. Methods…
View details →Greistofer E, Taher F, Assadian A et al. · 2026 · Annals of vascular surgery
Background The objective of this study was to evaluate the prognostic value of routine postoperative laboratory parameters including renal function, inflammatory markers, and hematologic indices in patients undergoing fenestrated…
View details →Lee TY, Hunter DA, Perez R et al. · 2026 · The Journal of hand surgery
Purpose Polyethylene glycol (PEG) fusion has been reported to restore axonal continuity after nerve repair if initiated before Wallerian degeneration (WD). Sterile α and Toll/Interleukin-1 Receptor motif-containing 1 (SARM1) inhibition can…
View details →Umbricht D, Abt M, Derks M et al. · 2026 · The Journal of clinical psychiatry
Objective: Cognitive impairment associated with schizophrenia (CIAS) is a key driver of functional deficits in patients with this disorder. CIAS may involve deficient NMDA receptor-dependent neurotransmission. Negative allosteric…
View details →Kitowski A, Heise C, Sperling S et al. · 2026 · British journal of pharmacology
Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to…
View details →Alansare AB, Muldoon MF, Perera S et al. · 2026 · Experimental physiology
Lower sedentary behaviour (SB) has been associated with reduced cardiovascular disease and mortality. Yet, few trials have evaluated cardiovascular mechanisms of benefit. We examined the effects of a SB reduction intervention on heart rate…
View details →David-Neto E, David AER, Alves B et al. · 2026 · Transplantation
Background Chronic allograft dysfunction (CAD) remains a leading cause of graft loss after kidney transplantation. Dapagliflozin (DAPA) has shown renal and cardiometabolic benefits in nontransplanted patients with chronic kidney disease.…
View details →Yoo C, Jeong H, Park I et al. · 2026 · Annals of surgical oncology
Background Prospective data on stereotactic body radiation therapy (SBRT) combined with modified 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX) in patients with locally advanced unresectable pancreatic adenocarcinoma…
View details →Akbas F, Baykan O, Avcikurt AS et al. · 2026 · BMC psychiatry
Background Major depressive disorder (MDD) has been increasingly associated with low-grade inflammation, with neutrophils playing a central role. Calprotectin is a mainly neutrophil-derived inflammatory mediator. We investigated whether…
View details →Li M, Jiang C, Wang R et al. · 2026 · Clinical rehabilitation
DesignPragmatic, two-arm, parallel-group, superiority randomised controlled trial with assessor-blinding and statistician-blinding.SettingSingle orthopaedic centre in Shanghai, China.ParticipantsOne hundred and eighty adults (aged 18-50…
View details →Anteby M, Wertheimer KO, Dominsky O et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective To compare maternal and neonatal outcomes between women with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome with and without associated hypertension. Methods This was a retrospective cohort study at a…
View details →Otowa Y, Matsuda T, Ando M et al. · 2026 · Surgery today
Background The benefit of neoadjuvant chemoradiotherapy (NACRT) for elderly patients with locally advanced rectal cancer (LARC) remains unclear because these patients are often excluded from trials. We evaluated the safety and oncologic…
View details →Hu X, Murakami G, Hasegawa H · 2026 · International journal of sports physiology and performance
Purpose This study evaluated the practical feasibility of the CORE sensor for noninvasive tracking of changes in estimated core body temperature (Est-Tcore) during simulated beach volleyball match-play in the heat and examined the effects…
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