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WASTE Journal

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Concomitant Bladder Neck Incision in Patients with Posterior Urethral Valve and Blad-der Neck Hypertrophy: Short-term Outcomes of a Randomized Controlled Trial.

ELghareeb A, Dawaba M, Eldeeb M et al. · 2026 · International braz j urol : official journal of the Brazilian Society of Urology

Introduction Concomitant bladder neck incision (BNI) with posterior urethral valve ablation (VA) was proposed to mitigate the long-term sequela of posterior urethral valve (PUV) and reduce the reoperation rates. This study aimed to…

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Negative / Null Result ReportMedicine

Dose-Escalated Stereotactic Versus Conventional Radiotherapy for Painful Bone Metastases (ROBOMET): A Multicenter, Patient-Blinded Randomized Clinical Trial.

Mercier C, Billiet C, Ost P et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose To test whether dose-escalated single fraction (SF) stereotactic body radiotherapy (SBRT) of 20 Gy to painful bone metastases is superior to conventional SF three-dimensional (3D) conformal radiotherapy (RT) to a standard dose of 8…

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Replication FailureMedicine

Chemotherapy-free combination of ibrutinib and obinutuzumab for untreated advanced follicular lymphoma: results of a phase II study from the German Lymphoma Alliance.

Schmidt C, Scheubeck G, Jurinovic V et al. · 2025 · Haematologica

Immunochemotherapy induces long-term responses in patients with follicular lymphoma. However, the toxicity of chemotherapy remains a relevant challenge. The Bruton tyrosine kinase inhibitor ibrutinib has shown significant activity in…

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Negative / Null Result ReportMedicine

Infants with bronchiolitis with high-flow nasal cannula in the paediatric ward. Is there a role for the ROXi (respiratory rate-oxygenation index) in predicting failure of high-flow nasal cannula?

Le Pallec C, Cerasuolo D, Cauvin JC et al. · 2025 · European journal of pediatrics

The respiratory rate-oxygenation index (ROXi) has been shown to be a reliable tool for predicting the risk of high-flow nasal cannula (HFNC) failure in adult patients with lower respiratory tract infections. However, the usefulness of the…

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Negative / Null Result ReportMedicine

Hyperbaric Treatment of Air or Gas Embolism: Current Recommendations.

Moon RE, Mitchell SJ · 2025 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc

Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g. breath-hold ascent by divers), veins (venous gas embolism, VGE) as a result of tissue bubble formation due to…

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Negative / Null Result ReportOpen accessMedicine

No survival benefit is associated with pelvic and para-aortic lymphadenectomy in lymph node-negative early-stage endometrioid endometrial cancer.

Yalcin Y, Yalcin SE, Demir BC et al. · 2026 · BMC surgery

OBJECTIVE: The therapeutic role of lymphadenectomy in endometrial cancer remains controversial. Although systematic pelvic and para-aortic lymphadenectomy (PPLND) has been suggested to improve survival in certain patients, randomized…

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Negative / Null Result ReportOpen accessMedicine

Adjuvant therapy for renal cell carcinoma: lessons from past failures and new opportunities in the era of immune checkpoint inhibition.

Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology

Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…

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Negative / Null Result ReportMedicine

Hypofractionated Versus Single-Session Radiosurgery to Preserve Hearing in Patients Affected by Sporadic Vestibular Schwannoma: The ACOUNEU Randomized Clinical Trial.

Marchetti M, Pinzi V, Gemma M et al. · 2025 · International journal of radiation oncology, biology, physics

Purpose During the last decades, in addition to tumor control, hearing preservation has become an important priority in the treatment of vestibular schwannoma (VS). Given that the potential advantages of hypofractionated radiosurgery (hRS)…

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Negative / Null Result ReportMedicine

Can visual acceleration evoke a sensation of tilt?

Harris LR, Jörges B, Bury N et al. · 2025 · Experimental brain research

Under the microgravity of the International Space Station, many of the normal processes that determine the perceptual upright on Earth are disrupted. For example, somatosensory cues are absent and an applied physical linear acceleration…

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Negative / Null Result ReportOpen accessMedicine

External cold and vibration with BUZZY versus topical anesthetic gel for pain and anxiety associated with infiltrative anesthesia in pediatric dentistry: a double-blinded, split-mouth, randomized, controlled trial.

Faghihian R, Tofighi MM, Ziaei S et al. · 2025 · European oral research

Purpose A way to reduce the pain of injection is applying of external cold or vibrations with BUZZY, along with spinal cord gate control systems. We aimed to evaluate the effectiveness of this method in reducing children's pain and anxiety…

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Failed Experiment ReportOpen accessMedicine

Demise of the Milwaukee Protocol for Rabies.

Jackson AC · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Human rabies has a very high fatality rate and there have only been about 34 well-documented survivors, defined as survival at 6 months after onset of clinical rabies. Many have had serious neurological sequelae. After a young patient…

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Negative / Null Result ReportOpen accessMedicine

Bioavailability as Proof to Authorize the Clinical Testing of Neurodegenerative Drugs-Protocols and Advice for the FDA to Meet the ALS Act Vision.

Niazi SK · 2024 · International journal of molecular sciences

Although decades of intensive drug discovery efforts to treat neurodegenerative disorders (NDs) have failed, around half a million patients in more than 2000 studies continue being tested, costing over USD 100 billion, despite the…

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Negative / Null Result ReportOpen accessMedicine

Beyond the evidence: The cervical collar as cultural artefact.

Nutbeam T · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine

Background Cervical collar application remains prevalent in trauma care despite the absence of evidence of neurological benefit from spinal immobilisation. Clinical behaviour in this area has proven resistant to change, and the persistence…

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Negative / Null Result ReportMedicine

A Randomized Controlled Trial on the Timing of Soft Tissue Augmentation in Immediate Implant Placement: Soft Tissue Changes and Esthetic Outcome.

Struys T, Christiaens V, De Bruyckere T et al. · 2025 · Clinical implant dentistry and related research

Aim To assess the impact of the timing of soft tissue augmentation on soft tissue changes and esthetic outcome following single immediate implant placement (IIP) in the anterior maxilla. Materials and methods Patients with a failing tooth…

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Negative / Null Result ReportOpen accessMedicine

Psychiatric morbidity following liothyronine exposure in autoimmune hypothyroidism: a Swedish nationwide cohort study.

Hedberg F, Lindh JD, Mannheimer B et al. · 2026 · Journal of the Endocrine Society

Context Levothyroxine (LT4) is the primary treatment of hypothyroidism. Despite adequate LT4 substitution some patients experience symptoms and the use of adjunct liothyronine (LT3) has increased. Several trials show no clear advantage of…

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Negative / Null Result ReportOpen accessMedicine

Multi-Criteria Decision Analysis of Biologics in Chronic Obstructive Pulmonary Disease.

Matera MG, Calzetta L, Rogliani P et al. · 2025 · International journal of chronic obstructive pulmonary disease

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with limited response to standard anti-inflammatory therapies. Biologics targeting specific inflammatory pathways have emerged as potential treatments,…

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Negative / Null Result ReportOpen accessMedicine

Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.

De Pascale G, Cutuli SL, Vargas M et al. · 2026 · Intensive care medicine

Purpose The MICROINHALO trial investigated whether personalized management of endotracheal tube cuff pressure (Pcuff) based on exhaled CO 2 measurement combined with automatic subglottic space drainage (SSD) may prevent tracheal…

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