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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21379 results · page 681 of 713

Negative / Null Result ReportMedicine

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Nomura, Kimata, Ito et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: To directly compare the capabilities of hybrid-type iterative reconstruction (IR) with the newly developed deep learning reconstruction (DLR) for the inner ear on high-definition CT (HDCT) obtained using the…

View details →DOI: 10.3390/diagnostics16121756
Negative / Null Result ReportMedicine

Rural medical disparities in multimodal glioblastoma treatment.

Momii, Hata, Fudaba et al. · 2026 · Scientific reports

Glioblastoma continues to have a poor prognosis, although recent advancements in multimodal treatments have gradually improved outcomes. However, treatment options have become increasingly complex and highly specialized. In rural areas,…

View details →DOI: 10.1038/s41598-026-48867-8
Negative / Null Result ReportMedicine

Diagnosis of Small Focal Liver Lesions (≤2 cm): A Deep Learning Approach Based on B-Mode Ultrasound and Contrast-Enhanced Ultrasound.

Xu, Wei, Zhang et al. · 2026 · Ultrasound in medicine & biology

To develop and validate a deep learning (DL) model based on feature fusion with B-mode ultrasound (BMUS) and contrast enhanced ultrasound (CEUS) images for non-invasive diagnosis of benign and malignant focal liver lesions (FLLs),…

View details →DOI: 10.1016/j.ultrasmedbio.2026.01.002
Negative / Null Result ReportMedicine

Impact of hydrophobic ion pair type and self-nanoemulsifying drug delivery systems composition on the oral delivery of salmon calcitonin.

Al-Maghrabi, Müllertz, Rades · 2026 · Journal of controlled release : official journal of the Controlled Release Society

Salmon calcitonin (sCT) is a peptide with poor enzymatic stability and permeability, limiting its oral delivery. This study investigated how hydrophobic ion pair (HIP) type and self-nanoemulsifying drug delivery systems (SNEDDS)…

View details →DOI: 10.1016/j.jconrel.2026.115131
Negative / Null Result ReportMedicine

A multicenter randomized controlled trial comparing metallic stents with 10- versus 14-mm diameter for distal biliary obstruction caused by unresectable pancreatic carcinoma.

Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy

Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…

View details →DOI: 10.1016/j.gie.2026.06.037
Abandoned HypothesisMedicine

Formaldehyde metabolism in the biocatalytic upgrading of lignin.

Lalande AT, Eltis LD · 2026 · Current opinion in biotechnology

Formaldehyde is a toxic metabolite generated in the bacterial catabolism of lignin-derived aromatic compounds (LDACs) through the oxidative O-demethylation of methoxylated aromatics. Microbial cell factories designed to convert LDACs to…

View details →DOI: 10.1016/j.copbio.2026.103526
Negative / Null Result ReportMedicine

The Impact of Glucagon-Like Peptide 1 Receptor Agonists Versus Diabetes Mellitus on Endoscopic Procedures: A Case-Control Study From a Large Tertiary Care Health System.

Bahdi, Bachu, Aldzhyan et al. · 2026 · Journal of clinical gastroenterology

While glucagon-like peptide 1 receptor agonists (GLP1-RAs) increase the risk of gastric food retention (GFR) and inadequate bowel preparation (IBP), the confounding role of diabetes mellitus is still questioned. Here, we compare the…

View details →DOI: 10.1097/mcg.0000000000002414
Negative / Null Result ReportMedicine

Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms.

Baskar, Patel, Rose et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

The incidence of neuroendocrine neoplasms (NENs) is rising, particularly among younger patients, but data comparing early-onset (EO-NENs) and average-onset (AO-NENs) remain limited. Using the National Inpatient Sample (2016-2020), we…

View details →DOI: 10.1007/s00520-026-10919-0
Negative / Null Result ReportMedicine

Association between Epstein-Barr Virus viremia and cardiac function in children and young adults with perinatally acquired HIV.

Curtis, McCrary, Daud et al. · 2026 · Cardiovascular journal of Africa

Epstein-Barr virus (EBV) affects greater than 95% of the global population, and when acquired at an early age, results in poor control of viral replication and increased risk to subsequent chronic illnesses. To analye the association…

View details →DOI: 10.5830/cvja-2025-109
Negative / Null Result ReportMedicine

Minimally invasive stabilisation of anterior pelvic ring injuries through anterior infix versus percutaneous anterior retrograde pubic screw: a prospective comparative cohort study.

Goda El-Hamalawy, Abdelmoneim, Al-Sayed et al. · 2026 · Archives of orthopaedic and trauma surgery

Management of unstable anterior pelvic ring fractures has shifted toward minimally invasive fixation techniques. This prospective randomized cohort study compares anterior subcutaneous internal fixator with percutaneous retrograde pubic…

View details →DOI: 10.1007/s00402-026-06380-7
Negative / Null Result ReportMedicine

A Randomised Controlled Trial Comparing Spray Versus Paint Application of Iodine Skin Antisepsis in Head and Neck Surgery.

Fussey, Manzie, Nanayakkara et al. · 2026 · ANZ journal of surgery

It is unknown whether the method of application of povidone iodine solution for skin antisepsis affects its efficacy. The primary aim of this study was to compare the efficacy of spray-on aqueous povidone iodine solution in preventing…

View details →DOI: 10.1111/ans.70772
Negative / Null Result ReportMedicine

Comparison of head-related injuries between standing electric scooter riders and pedestrians involved in motor vehicle collisions in Japan.

Sakamoto · 2026 · Traffic injury prevention

While previous research suggests that e-scooter riders and pedestrians may exhibit similar injury patterns due to a shared standing posture, direct comparisons using unified datasets are lacking. This study aims to identify the distinctive…

View details →DOI: 10.1080/15389588.2026.2682440
Negative / Null Result ReportMedicine

Scavenging of Reactive Carbonyl Species by Dihydromyricetin and Its Thermal Degradation Products Through Consumption of Hot-Brewed and Cold-Brewed Vine Tea.

Wang, Wang, Zhang et al. · 2026 · Journal of agricultural and food chemistry

Reactive carbonyl species (RCS) are highly reactive molecules linked to chronic diseases. Dihydromyricetin (DMY), a high-activity RCS scavenger, exhibited MGO- and ACR-scavenging rates of 70.1% (0.5 h) and 70.3% (2 h) at 37 °C,…

View details →DOI: 10.1021/acs.jafc.6c06554
Negative / Null Result ReportMedicine

Two methods of intentional cranial modification from Early Holocene Songhuajiang in Northeast China.

Yin, Bae, Ni · 2026 · Journal of anthropological sciences = Rivista di antropologia : JASS

Since its appearance at the terminal Pleistocene, intentional cranial modification ("ICM") and its implications have generated considerable scientific debate regarding how or why such a tradition arose. Here, we report on newly discovered…

View details →DOI: 10.4436/jass.10404
Negative / Null Result ReportMedicine

Impact of central adiposity on the heart rate and calorie estimation accuracy of diverse smartwatches and the resulting subjective exercise experience.

Lertyongphati, Udomkhwamsuk, Amornrungrojanakul et al. · 2026 · Frontiers in sports and active living

In light of the growing global trend toward health awareness, wearable technologies like smartwatches have become essential for monitoring physiological indicators such as heart rate (HR). However, their utility faces two critical…

View details →DOI: 10.3389/fspor.2026.1829700
Negative / Null Result ReportMedicine

Transcervical carotid artery stenting compared to transfemoral carotid artery stenting and carotid endarterectomy: perioperative and short-term results from a single center.

Jin, Ni, Huang et al. · 2026 · Frontiers in cardiovascular medicine

Carotid artery stenosis is a major cause of ischemic stroke. Various revascularization strategies exist, including Carotid Endarterectomy (CEA), Transfemoral Carotid Artery Stenting (TF-CAS), and Transcervical Carotid Artery Stenting…

View details →DOI: 10.3389/fcvm.2026.1743275
Negative / Null Result ReportMedicine

Accuracy of Visual Inspection of Thickened Liquids: Implications for Multidisciplinary Dysphagia Management and Clinical Nutrition.

Fong, Kwan · 2026 · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

To evaluate the accuracy of visually estimating thickened liquid volume via video-observed conditions and to determine whether clinical experience or thickener composition influences judgement reliability. A cross-sectional online survey…

View details →DOI: 10.1111/jhn.70294
Negative / Null Result ReportMedicine

The relationship between appetite hormones and body mass index in children with intoxication type metabolic diseases.

Koç, Konyalıgil, Özen Yeşil et al. · 2026 · Orphanet journal of rare diseases

The aim of this study is to comparatively examine the effects of appetite loss and insufficient energy intake, which trigger poor metabolic control parameters, on appetite hormones and body mass index in children with intoxication-type…

View details →DOI: 10.1186/s13023-026-04375-6
Negative / Null Result ReportMedicine

The relationship between depression, falls, dizziness, and physical activity in geriatric individuals with BPPV.

Cengi̇z, Sarioğlu, Mazooğlu et al. · 2026 · BMC geriatrics

Benign Paroxysmal Positional Vertigo (BPPV) represents the most common cause of vertigo in the geriatric population. The condition constitutes a multidimensional clinical presentation characterized by dizziness, imbalance, fear of falling,…

View details →DOI: 10.1186/s12877-026-07838-4
Negative / Null Result ReportMedicine

The Effect of the Temporal Position of a Gap on Its Automatic Detection.

Omidvar, Campbell, Alain et al. · 2026 · The European journal of neuroscience

The presentation of a rarely occurring auditory stimulus that contains a silent interval (or gap) among a sequence of frequently occurring stimuli that do not contain a gap can elicit a negative-going event-related potential known as the…

View details →DOI: 10.1111/ejn.70585
Negative / Null Result ReportMedicine

Prognosis of ER-positive, HER2-negative postmenopausal early breast cancer patients based on response to neoadjuvant endocrine therapy and multigene assay results: findings from the NEOS trial.

Iwata, Masuda, Yamamoto et al. · 2026 · Breast cancer (Tokyo, Japan)

We previously reported the 21-gene Oncotype DX® assay results from TransNEOS in patients enrolled in the phase 3 NEOS trial. However, the association between assay results and long-term prognosis has remained unclear. Of the 296…

View details →DOI: 10.1007/s12282-026-01862-3
Negative / Null Result ReportMedicine

Heterogeneous Systemic IgG Responses to Porphyromonas gingivalis Gingipains in Advanced Periodontitis.

Büttner, Derman, Simonis et al. · 2026 · Clinical and experimental dental research

To evaluate serum IgG responses against Porphyromonas gingivalis gingipains RgpB and Kgp in patients with stage III and IV periodontitis and examine associations with clinical periodontal parameters. This exploratory cross-sectional study…

View details →DOI: 10.1002/cre2.70391
Negative / Null Result ReportMedicine

Learning Curve for Transbronchial Lung Cryobiopsy in Interstitial Lung Disease Diagnosis: A Multicenter Experience.

Tong, Guo, Xia et al. · 2026 · Respiration; international review of thoracic diseases

Transbronchial lung cryobiopsy (TBLC) is increasingly used to diagnose interstitial lung disease (ILD). However, the learning curve associated with this technique remains unclear. This retrospective analysis included the first 100 patients…

View details →DOI: 10.1159/000553097
Negative / Null Result ReportMedicine

Comparison of Milan versus up-to-seven criteria for liver resection in hepatocellular carcinoma: a multi-center study on risk factors and long-term outcomes.

Chen, Xu, Yan et al. · 2026 · Surgical endoscopy

This multi-center study aimed to evaluate the clinical validity of the "up-to-seven" criteria (sum of tumor number and largest diameter ≤ 7) as an expanded threshold for curative liver resection in hepatocellular…

View details →DOI: 10.1007/s00464-026-12710-y
Negative / Null Result ReportMedicine

Robotic vs. open liver resection after neoadjuvant therapy for hepatocellular carcinoma: a propensity score-matched analysis of short- and long-term outcomes.

Zhang, Li, Chen et al. · 2026 · Surgical endoscopy

Neoadjuvant therapy is recommended for hepatocellular carcinoma at advanced stages. It is unknown whether robotic liver resection (RLR) is superior to open liver resection (OLR) after neoadjuvant therapy. We analyzed consecutive RLR and…

View details →DOI: 10.1007/s00464-026-12682-z