Null DatasetOpen accessComputer Science
Yu Liu, Qichun Wei, Guocan Yu et al. · 2014 · Database
Experience in clinical practice and research in systems pharmacology suggested the limitations of the current one-drug-one-target paradigm in new drug discovery. Single-target drugs may not always produce desired physiological effects on the entire biological system, even if they have successfully regulated the activities of their designated targets. On the other hand, multicomponent therapy, in which two or more agents simultaneously interact with multiple targets, has attracted growing attention. Many drug combinations consisting of multiple agents have already entered clinical practice, esp
View details →DOI: 10.1093/database/bau124Cited by 120 Null Dataset
Hatice Büşra Lüleci, Alper Yılmaz · 2022 · BioData Mining
Abstract Objectives In this study, we aimed to identify tissue-specific genes for various human tissues/organs more robustly and rigorously by extending the tau score algorithm. Introduction Tissue-specific genes are a class of genes whose…
View details →DOI: 10.1186/s13040-022-00315-9Cited by 37 Null DatasetOpen accessNeuroscience
Cyril Pernet, Christopher R. Madan · 2019 · European Journal of Neuroscience
Tomographic imaging (i.e. magnetic resonance imaging [MRI], positron emission tomography [PET], X-ray computed tomography [CT]) offers a unique window in understanding structure-function relationships in the living brain. Nowadays, it is standard practice to acquire entire brain volumes and perform statistical analyses at each voxel, an approach known as statistical parametric mapping (Friston, Frith, Liddle, & Frackowiak, 1991). Because it is impossible to report the statistical results in every voxel, summary tables and figures are of importance. The choice made by authors to create such fig
View details →DOI: 10.1111/ejn.14430Cited by 13 Null DatasetOpen accessMedicine
Peter Beckwith, Mpho Tlali, Salome Charalambous et al. · 2021 · American Journal of Tropical Medicine and Hygiene
Tuberculosis (TB) remains the leading cause of hospitalization and in-hospital mortality in HIV-positive adults. Using data from hospital and clinic files, research databases, and autopsy, we describe causes and outcomes of admissions, and…
View details →DOI: 10.4269/ajtmh.21-0133Cited by 9 Null DatasetMedicine
Zhartybayeva A, Christensen BT, Eriksen J et al. · 2026 · Agriculture, Ecosystems and Environment.
Models simulating management-induced changes in soil organic carbon (SOC) stocks in agricultural soils typically rely on crop-specific above- and belowground C inputs based on harvest yields and allometric functions. However, experimental…
Null DatasetMedicine
Kaya N, Şahin M, Çantay E et al. · 2026 · Journal of environmental radioactivity
This study quantifies and compares soil-to-plant transfer factors (F v ) for 90 Sr with stable Sr isotopes in two semi-arid agricultural regions of Türkiye. Paired soil and crop samples (wheat, barley, clover, purslane, apple, apricot and…
View details →DOI: 10.1016/j.jenvrad.2026.107935 Null DatasetMedicine
Sabagh FA, Hajimohammadi F, Fani B et al. · 2026 · Scientific reports
Distance relays may maloperate under various conditions such as improper settings, measurement distortion, or abnormal network operating states. This article investigates an overlooked mechanism leading to distance relay maloperation in…
View details →DOI: 10.1038/s41598-026-54365-8 Null DatasetMedicine
Li A, Liu C, Xing R et al. · 2026 · Carbohydrate research
Phenol-sulfuric acid method, a classical approach for total sugar quantification, suffers from substantial variation in the colorimetric efficiency among different monosaccharides, which may result in significant measurement bias. In this…
View details →DOI: 10.1016/j.carres.2026.109835 Null DatasetMedicine
Motta‐Romero HA, Guha S, Seravalli J et al. · 2024 · Cereal chemistry
BACKGROUND AND OBJECTIVES: Wheat porridge contributes to the intake of micronutrients but can also be a route of the toxic heavy metal, cadmium. This study aimed to determine the effect of processing on micronutrients, cadmium…
View details →DOI: 10.1002/cche.10778 Null DatasetOpen accessMedicine
Zheng S, Zhang X, Li W et al. · 2026 · Vaccines
Background: An accurate, sensitive, and robust potency assay is essential for the quality control of mRNA drug substances, which are characterized by complex manufacturing processes, intricate molecular structures, and high susceptibility…
View details →DOI: 10.3390/vaccines14050401 Null Dataset
Leyva A, Niazi MKK · 2026 · Preprint
There have been no systematic evaluations of purely spectral models for digital pathology tasks. We implemented and benchmarked four pipelines: binary classification on the BreaKHis dataset, multi-class region classification in…
View details →DOI: 10.64898/2026.01.30.702908 Null DatasetMedicine
Murphy L, Mingoia R, Bianchi E et al. · 2026 · Regulatory toxicology and pharmacology : RTP
Regulatory testing for agrochemicals has traditionally included a 90-day toxicity study in a non-rodent species, usually the dog. With growing emphasis on the 3Rs-replacement, reduction, and refinement of animal use-and increased adoption…
View details →DOI: 10.1016/j.yrtph.2026.106081 Null DatasetOpen accessMedicine
Rudokas V, Koliada M, Stankevic V et al. · 2026 · Sensors (Basel, Switzerland)
Magnetic sensors based on the colossal magnetoresistance (CMR) effect in manganite thin films are promising for high-field measurements due to their wide operating range, low magnetoresistance anisotropy, and ability to function without…
View details →DOI: 10.3390/s26092711 Null DatasetMedicine
Kim H, Köhn HF, Chiu CY · 2025 · The British journal of mathematical and statistical psychology
The Q-matrix of a cognitively diagnostic assessment (CDA), documenting the item-attribute associations, is a key component of any CDA. However, the true Q-matrix underlying a CDA is never known and must be estimated-typically by content…
View details →DOI: 10.1111/bmsp.70020 Null DatasetMedicine
Zeiger E, Mitchell CA, Pfuhler S et al. · 2024 · Environmental and molecular mutagenesis
The Ames test is required by regulatory agencies worldwide for assessing the mutagenic and carcinogenic potential of chemical compounds. This test uses several strains of bacteria to evaluate mutation induction: positive results in the…
View details →DOI: 10.1002/em.22597 Null DatasetOpen accessMedicine
Lisha W, Jiao Q, Mengyuan C et al. · 2025 · Microbiology spectrum
Regarding metagenomics next-generation sequencing (mNGS) negative literature, there have been much discussions about methodology; thus, we collected clinical and laboratory information for retrospective evidence-based research. We…
View details →DOI: 10.1128/spectrum.02013-24 Null DatasetOpen accessMedicine
Marland V, Nisbet L, Nic Daéid N · 2025 · Harm reduction journal
Background The detection of nitazene compounds in the United Kingdom has raised concerns among healthcare professionals, public health authorities, and law enforcement due to the increased risk of fatal overdose, particularly among opioid…
View details →DOI: 10.1186/s12954-025-01287-9 Null DatasetMedicine
Feldmeier JJ, Gesell LB · 2026 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
The application of hyperbaric oxygen (HBO₂) to the treatment and prevention of late radiation injury (LRTI) is the focus for this chapter. Additional miscellaneous topics related to radiation exposure and HBO₂ will also be explored,…
Null DatasetOpen accessMedicine
Valdezate S, Valiente M, Díaz-Ramón S et al. · 2026 · Frontiers in cellular and infection microbiology
Botulism is a rare but severe neurological disease caused by botulinum neurotoxins (BoNTs). Standard diagnostic methods including the mouse bioassay (SMB) and bont gene type-specific PCR, are often limited by the high genetic diversity…
View details →DOI: 10.3389/fcimb.2026.1758429 Null DatasetOpen accessMedicine
Kurtipek FB, Yozgat AK, Gökçek E et al. · 2026 · BMC infectious diseases
Background Febrile neutropenia (FN) is a frequent and potentially life-threatening complication in patients with hematologic malignancies. Prompt and accurate identification of bloodstream pathogens is essential to optimize antimicrobial…
View details →DOI: 10.1186/s12879-026-13352-0 Null Dataset
Ahogni I, Avanon H, Hueha C et al. · 2025 · Preprint
Abstract Background: Accurate interpretation and recording of malaria rapid diagnostic tests (RDTs) are critical for case management and surveillance in malaria-endemic settings. In Benin, where over 90% of malaria diagnoses rely on RDTs,…
View details →DOI: 10.21203/rs.3.rs-7002558/v1 Null DatasetOpen accessMedicine
Eid AM, Mabrouk WM, Amer M et al. · 2026 · Scientific reports
Accurate reservoir characterization in structurally complex fields is essential for optimizing hydrocarbon exploration and production. This study presents a detailed analysis of the AEB-3E reservoir within the Berenice Oil Field. It…
View details →DOI: 10.1038/s41598-026-53328-3 Null DatasetMedicine
Iqbal U, Manga YB, Nkhoma DE et al. · 2026 · NPJ digital medicine
Digital health interventions (DHIs) are increasingly used to strengthen patient engagement. However, despite its rapid growth, DHIs remain unevenly evaluated and poorly standardized. Six databases were searched to generate an evidence gap…
View details →DOI: 10.1038/s41746-026-02899-6 Null DatasetMedicine
He Z, Yang L, Liang Z et al. · 2026 · NPJ digital medicine
Large language models (LLMs) are being deployed in clinical settings despite an underdeveloped evidence base regarding their real-world effectiveness. This study employed systematic evidence mapping to characterize outcome measures used in…
View details →DOI: 10.1038/s41746-026-02837-6 Null DatasetMedicine
Wilcox A, Hall M, Menzies J et al. · 2025 · The Science of the total environment
The biodegradability of water-soluble carboxymethyl cellulose (CMC) polymer, degree of substitution of 0.65, was evaluated in screening and simulation assays using activated sludge as the inoculum. In an OECD 301B, CMC 0.65 was slowly…
View details →DOI: 10.1016/j.scitotenv.2025.179942 Null DatasetMedicine
King DA, Altic N · 2026 · Health physics
Calculating scan minimum detectable concentration (MDC) values using the method in NUREG-1507 can be difficult, often requiring expert knowledge and expensive software. Because of this, many projects rely on example MDC values from…
View details →DOI: 10.1097/hp.0000000000002085 Null DatasetMedicine
Khalid A, Yasir Ali M, Tul Janat R et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Sorafenib (SB) is a receptor tyrosine kinase inhibitor, currently marketed as an oral dosage form. However, due to severe irritation of the gastrointestinal tract, the drug is facing decreased acceptability as a therapeutic…
View details →DOI: 10.36721/pjps.2026.39.7.183.1 Null DatasetMedicine
Pasotti F, Da Molin S, Bosoni T et al. · 2026 · Clinica chimica acta; international journal of clinical chemistry
Serum free light chains (FLC) κ and λ, and the κ/λ ratio, are key biomarkers for the diagnosis, risk stratification and monitoring of monoclonal gammopathies. However, substantial between-method variability still limits harmonised…
View details →DOI: 10.1016/j.cca.2026.121056 Null DatasetMedicine
Lin, Cheng, Chen et al. · 2026 · Avian pathology : journal of the W.V.P.A
Abstract To enable differential detection of virulent and attenuated strains of duck short beak and dwarfism syndrome virus (SBDSV), we developed a fluorescent quantitative PCR (qPCR) assay based on locked nucleic acid (LNA)-TaqMan probes.…
View details →DOI: 10.1080/03079457.2026.2692641 Null DatasetOpen accessMedicine
Mullen LE, Romsos EL, Vallone PM · 2026 · Journal of forensic sciences
Obtaining an accepted minimum amount of extracted and purified DNA is critical for generating complete forensic short tandem repeat (STR) profiles. Certain sample types encountered in forensic laboratories may pose challenges in obtaining…
View details →DOI: 10.1111/1556-4029.70302 