Failed Experiment ReportOpen accessMedicine
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol et al. · 2021 · Nature
Abstract Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1–5 . Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients for optimal response to therapy is an unmet need 6,7 . Here we report the progressive accumulation of exhausted, unconventionally activated CD8 + PD1 + T cells in NASH-affected livers. In preclinical models of NASH-induced HCC, therapeutic immunotherapy targeted at programmed death-1 (PD1) expanded activated CD8 + PD1 + T cells within tumours but did n
View details →DOI: 10.1038/s41586-021-03362-0Cited by 1,249 Failed Experiment ReportSocial Sciences
Victor Shih, Christopher Adolph, Mingxing Liu · 2012 · American Political Science Review
Spectacular economic growth in China suggests the ruling Chinese Communist Party (CCP) has somehow gotten it right. A key hypothesis in both economics and political science is that the CCP's cadre evaluation system, combined with China's…
View details →DOI: 10.1017/s0003055411000566Cited by 848 Failed Experiment ReportNeuroscience
C. Warren Olanow, Raymond T. Bartus, Tiffany Baumann et al. · 2015 · Annals of Neurology
OBJECTIVE: A 12-month double-blind sham-surgery-controlled trial assessing adeno-associated virus type 2 (AAV2)-neurturin injected into the putamen bilaterally failed to meet its primary endpoint, but showed positive results for the…
View details →DOI: 10.1002/ana.24436Cited by 282 Failed Experiment ReportOpen accessNeuroscience
Raymond T. Bartus, Tiffany Baumann, João Siffert et al. · 2013 · Neurology
OBJECTIVE: In an effort to account for deficiencies in axonal transport that limit the effectiveness of neurotrophic factors, this study tested the safety and feasibility, in moderately advanced Parkinson disease (PD), of bilaterally…
View details →DOI: 10.1212/wnl.0b013e3182904faaCited by 213 Failed Experiment ReportOpen accessImmunology and Microbiology
Eric Ubil, Laura S. Caskey, Alisha Holtzhausen et al. · 2018 · Journal of Clinical Investigation
Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In…
View details →DOI: 10.1172/jci97354Cited by 213 Failed Experiment ReportOpen accessPsychology
René F. Kizilcec, Justin Reich, Michael Yeomans et al. · 2020 · Proceedings of the National Academy of Sciences
Online education is rapidly expanding in response to rising demand for higher and continuing education, but many online students struggle to achieve their educational goals. Several behavioral science interventions have shown promise in…
View details →DOI: 10.1073/pnas.1921417117Cited by 202 Failed Experiment ReportOpen accessNeuroscience
Eric Lowet, Mark Roberts, Pietro Bonizzi et al. · 2016 · PLoS ONE
Synchronization or phase-locking between oscillating neuronal groups is considered to be important for coordination of information among cortical networks. Spectral coherence is a commonly used approach to quantify phase locking between neural signals. We systematically explored the validity of spectral coherence measures for quantifying synchronization among neural oscillators. To that aim, we simulated coupled oscillatory signals that exhibited synchronization dynamics using an abstract phase-oscillator model as well as interacting gamma-generating spiking neural networks. We found that, wit
View details →DOI: 10.1371/journal.pone.0146443Cited by 158 Failed Experiment Report
Tracy Hall, Min Zhang, David Bowes et al. · 2014 · ACM Transactions on Software Engineering and Methodology
We investigate the relationship between faults and five of Fowler et al.'s least-studied smells in code: Data Clumps, Switch Statements, Speculative Generality, Message Chains, and Middle Man. We developed a tool to detect these five…
View details →DOI: 10.1145/2629648Cited by 146 Failed Experiment ReportOpen accessPhysics and Astronomy
Eric M Kenney, Brenden R Ortiz, Chennan Wang et al. · 2021 · Journal of Physics Condensed Matter
Abstract We have carried out muon spin relaxation and rotation measurements on the newly discovered kagome metal KV 3 Sb 5 , and find a local field dominated by weak magnetic disorder which we associate with the nuclear moments present,…
View details →DOI: 10.1088/1361-648x/abe8f9Cited by 140 Failed Experiment ReportOpen accessEngineering
Md Nadim Ferdous Hoque, Mengjin Yang, Zhen Li et al. · 2016 · ACS Energy Letters
Researchers have debated whether methylammonium lead iodide (MAPbI 3 ), with a perovskite crystal structure, is ferroelectric and therefore contributes to the current–voltage hysteresis commonly observed in hybrid perovskite solar cells…
View details →DOI: 10.1021/acsenergylett.6b00093Cited by 120 Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yaping Lin-Moshier, Michael V. Keebler, Robert Hooper et al. · 2014 · Proceedings of the National Academy of Sciences
The two-pore channels (TPC1 and TPC2) belong to an ancient family of intracellular ion channels expressed in the endolysosomal system. Little is known about how regulatory inputs converge to modulate TPC activity, and proposed activation…
View details →DOI: 10.1073/pnas.1407004111Cited by 120 Failed Experiment ReportOpen accessMedicine
Laura Evgin, Amanda L. Huff, Phonphimon Wongthida et al. · 2020 · Nature Communications
The application of adoptive T cell therapies, including those using chimeric antigen receptor (CAR)-modified T cells, to solid tumors requires combinatorial strategies to overcome immune suppression associated with the tumor microenvironment. Here we test whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells. Contrary to our hypothesis, VSVmIFNβ infection is associated with attrition of murine EGFRvIII CAR T cells in a B16EGFRvIII model, despite inducing a robust proinflam
View details →DOI: 10.1038/s41467-020-17011-zCited by 118 Failed Experiment ReportEngineering
Gaëtan Ndo, Fabrice Labeau, Marthe Kassouf · 2013 · IEEE Transactions on Power Delivery
Transmission over channels impaired by impulsive noise, such as in power substations, calls for peculiar mitigation techniques at the receiver side in order to cope with signal deterioration. For these techniques to be effective, a…
View details →DOI: 10.1109/tpwrd.2013.2273942Cited by 111 Failed Experiment ReportOpen accessEnvironmental Science
Douglas C. Woodhams, CC Geiger, LK Reinert et al. · 2011 · Diseases of Aquatic Organisms
Amphibian conservation goals depend on effective disease-treatment protocols. Desirable protocols are species, life stage, and context specific, but currently few treatment options exist for amphibians infected with the chytrid fungus…
View details →DOI: 10.3354/dao02429Cited by 108 Failed Experiment ReportOpen accessNeuroscience
Therésa M. Jones, Joanna Durrant, Ellie B. Michaelides et al. · 2015 · Philosophical Transactions of the Royal Society B Biological Sciences
The mechanisms underpinning the ecological impacts of the presence of artificial night lighting remain elusive. One suspected underlying cause is that the presence of light at night (LAN) supresses nocturnal production of melatonin, a key…
View details →DOI: 10.1098/rstb.2014.0122Cited by 107 Failed Experiment ReportOpen accessMedicine
Kaori Kuramitsu, Deanna Sverdlov, Susan B. Liu et al. · 2013 · American Journal Of Pathology
Failure of fibrotic liver to regenerate after resection limits therapeutic options and increases demand for liver transplantation, representing a significant clinical problem. The mechanism underlying regenerative failure in fibrosis is…
View details →DOI: 10.1016/j.ajpath.2013.03.018Cited by 107 Failed Experiment ReportOpen accessMedicine
Thomas R. Lerner, Cristiane de Souza Carvalho‐Wodarz, Urška Repnik et al. · 2016 · Journal of Clinical Investigation
In extrapulmonary tuberculosis, the most common site of infection is within the lymphatic system, and there is growing recognition that lymphatic endothelial cells (LECs) are involved in immune function. Here, we identified LECs, which…
View details →DOI: 10.1172/jci83379Cited by 105 Failed Experiment ReportOpen accessImmunology and Microbiology
Subhajit Ghosh, Jiayi Huang, Matthew Inkman et al. · 2023 · Science Translational Medicine
Severe and prolonged lymphopenia frequently occurs in patients with glioblastoma after standard chemoradiotherapy and has been associated with worse survival, but its underlying biological mechanism is not well understood. To address this,…
View details →DOI: 10.1126/scitranslmed.abn6758Cited by 97 Failed Experiment ReportOpen accessEnvironmental Science
Robert Steinmetz, David L. Garshelis, Wanlop Chutipong et al. · 2013 · Journal of Mammalogy
Asiatic black bears (Ursus thibetanus) and sun bears (Helarctos malayanus) are ecologically similar and coexist extensively across Southeast Asia. We used foraging signs identified to bear species to examine their food selection and…
View details →DOI: 10.1644/11-mamm-a-351.1Cited by 92 Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tim B. Bigdeli, Stephan Ripke, Roseann E. Peterson et al. · 2017 · Translational Psychiatry
Abstract Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects. We determined the fraction of SNPs displaying c
View details →DOI: 10.1038/tp.2016.292Cited by 88 Failed Experiment ReportComputer Science
Lori G. Beaman, Dean Karlan, Bram Thuysbaert et al. · 2013 · American Economic Review
We conducted an experiment providing fertilizer grants to female rice farmers in Mali. We found that women who received fertilizer used both more fertilizer and more complementary inputs such as herbicides and hired labor. This shows that…
View details →DOI: 10.1257/aer.103.3.381Cited by 86 Failed Experiment ReportOpen accessMedicine
Lauren A. Wise, Edward Ruiz-Narváez, Julie R. Palmer et al. · 2012 · American Journal of Epidemiology
Rates of uterine leiomyomata (UL) are 2-3 times higher in African Americans than in European Americans. It is unclear whether inherited factors explain the ethnic disparity. To investigate the presence of risk alleles for UL that are…
View details →DOI: 10.1093/aje/kws276Cited by 84 Failed Experiment ReportOpen accessEnvironmental Science
Tetsu K. Tokunaga, Jiamin Wan, Jongwon Jung et al. · 2013 · Water Resources Research
In geologic carbon sequestration, reliable predictions of CO 2 storage require understanding the capillary behavior of supercritical (sc) CO 2 . Given the limited availability of measurements of the capillary pressure ( P c ) dependence on…
View details →DOI: 10.1002/wrcr.20316Cited by 81 Failed Experiment ReportOpen accessComputer Science
Xuhan Liu, Kai Ye, Herman van Vlijmen et al. · 2023 · Journal of Cheminformatics
Abstract Rational drug design often starts from specific scaffolds to which side chains/substituents are added or modified due to the large drug-like chemical space available to search for novel drug-like molecules. With the rapid growth of deep learning in drug discovery, a variety of effective approaches have been developed for de novo drug design. In previous work we proposed a method named DrugEx , which can be applied in polypharmacology based on multi-objective deep reinforcement learning. However, the previous version is trained under fixed objectives and does not allow users to input a
View details →DOI: 10.1186/s13321-023-00694-zCited by 80 Failed Experiment ReportOpen accessMedicine
Michael A. Castello, John D. Jeppson, Salvador Soriano · 2014 · BMC Neurology
BACKGROUND: High-profile Phase 3 clinical trials of bapineuzumab and solanezumab, antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. Neither drug improves clinical outcomes in patients with late onset AD, joining a long list of unsuccessful attempts to treat AD with anti-amyloid therapies. DISCUSSION: These therapies are based on the assumption that Aβ accumulation is the primary pathogenic trigger of AD. Current evidence suggests that Aβ may actually accumulate as part of an adaptive response to long-term chronic brain stress stimuli that would make
View details →DOI: 10.1186/s12883-014-0169-0Cited by 80 Failed Experiment ReportOpen accessEnvironmental Science
Mélanie Abécassis, Inna Senina, Patrick Lehodey et al. · 2013 · PLoS ONE
Habitat preferences for juvenile loggerhead turtles in the North Pacific were investigated with data from two several-year long tagging programs, using 224 satellite transmitters deployed on wild and captive-reared turtles. Animals ranged between 23 and 81 cm in straight carapace length. Tracks were used to investigate changes in temperature preferences and speed of the animals with size. Average sea surface temperatures along the tracks ranged from 18 to 23 °C. Bigger turtles generally experienced larger temperature ranges and were encountered in warmer surface waters. Seasonal differences be
View details →DOI: 10.1371/journal.pone.0073274Cited by 79 Failed Experiment ReportDecision Sciences
Tibor Besedeš, Cary Deck, Sudipta Sarangi et al. · 2015 · The Review of Economics and Statistics
Previous studies have demonstrated that a multitude of options can lead to choice overload, reducing decision quality. Through controlled experiments, we examine sequential choice architectures that enable the choice set to remain large…
View details →DOI: 10.1162/rest_a_00506Cited by 67 Failed Experiment ReportOpen accessEnvironmental Science
Alban de Lavenne, Vazken Andréassian, Guillaume Thirel et al. · 2019 · Water Resources Research
Abstract In semidistributed hydrological modeling, sequential calibration usually refers to the calibration of a model by considering not only the flows observed at the outlet of a catchment but also the different gauging points inside the…
View details →DOI: 10.1029/2018wr024266Cited by 63 Failed Experiment ReportOpen accessMedicine
Darryl Falzarano, David Safronetz, Joseph Prescott et al. · 2015 · Emerging infectious diseases
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
View details →DOI: 10.3201/eid2106.150176Cited by 63 Failed Experiment ReportOpen accessNeuroscience
Michael Devitt, Nicolas Porot · 2018 · Cognitive Science
Experiments on theories of reference have mostly tested referential intuitions. We think that experiments should rather be testing linguistic usage. Substantive Aim (I): to test classical description theories of proper names against usage…
View details →DOI: 10.1111/cogs.12609Cited by 62 