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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

84 results in Abandoned Hypothesis · page 1 of 3

Abandoned HypothesisOpen accessMedicine

Clinical and microbiological features of infection in alcoholic hepatitis: an international cohort study

Richard Parker, Gene Y. Im, Fiona Jones et al. · 2017 · Journal of Gastroenterology

BACKGROUND: Previous studies have described the clinical impact of infection in alcoholic hepatitis (AH) but none have comprehensively explored the aetiopathogenesis of infection in this setting. We examined the causes, consequences and treatment of infection in a cohort of patients with AH. METHODS: We undertook a retrospective cohort study of patients with AH admitted between 2009 and 2014 to seven centres in Europe and the USA. Clinical and microbiological data were extracted from medical records. Survival was analysed with Kaplan-Meier analysis and Cox proportional hazards analysis to cont

View details →DOI: 10.1007/s00535-017-1336-zCited by 28
Abandoned Hypothesis

Statistically responsible artificial intelligences

Nicholas Smith, Darby Vickers · 2021 · Ethics and Information Technology

Abstract As artificial intelligence (AI) becomes ubiquitous, it will be increasingly involved in novel, morally significant situations. Thus, understanding what it means for a machine to be morally responsible is important for machine…

View details →DOI: 10.1007/s10676-021-09591-1Cited by 14
Abandoned Hypothesis

Failed Intubation and Failed Oxygenation in a Child

A. S. Santoro, M. G. Cooper, A. Cheng · 2012 · Anaesthesia and Intensive Care

A ‘can't intubate, can't oxygenate’ scenario in a child is fortunately extremely rare. We report a case of this life-threatening event in a four-year-old boy suffering from a rare genetic disorder, fibrodysplasia ossificans progressiva. He…

View details →DOI: 10.1177/0310057x1204000620Cited by 14
Abandoned HypothesisBiochemistry, Genetics and Molecular Biology

Are we ready to genetically modify a human embryo? Or is it too late to ask?

Kirstin R.W. Matthews, Ana S. Iltis · 2019 · Accountability in Research

After the announcement that a scientist genetically altered human embryos and implanted them for gestation last November, the increased discussion has revolved around the ethical lapses that occurred in the process. The scientist, He…

View details →DOI: 10.1080/08989621.2019.1617139Cited by 10
Abandoned Hypothesis

THE FREE WILL DEFENSE REVISITED: THE INSTRUMENTAL VALUE OF SIGNIFICANT FREE WILL

Frederick CHOO, Esther GOH · 2019 · International Journal of Theology, Philosophy and Science

Alvin Plantinga has famously responded to the logical problem of evil by appealing to the intrinsic value of significant free will. A problem, however, arises because traditional theists believe that both God and the redeemed who go to…

View details →DOI: 10.26520/ijtps.2019.3.4.32-45Cited by 5
Abandoned Hypothesis

How Did Life Emerge in Chemically Complex Messy Environments?

Kenji Ikehara · 2022 · Life

One of the problems that make it difficult to solve the mystery of the origin of life is determining how life emerged in chemically complex messy environments on primitive Earth. In this article, the “chemically complex messy environments”…

View details →DOI: 10.3390/life12091319Cited by 3
Abandoned Hypothesis

Another Failed Modal Collapse Argument

William Vincent · 2026 · Analysis

Abstract The doctrine of divine simplicity says that God is not composed of parts (physical or metaphysical). Modal collapse arguments aim to show that the necessary co-existence of God and creation follows from the doctrine. As noted by…

View details →DOI: 10.1093/analys/anag013
Abandoned Hypothesis

The Failed Reader: Keats’s “Brain-Sick” Endymion

Jo-Anne Cappeluti · 2012 · Philosophy and Literature

John Keats’s subject in Endymion is the imagination operating on the failed reader: the neutral or adolescent intellect that ultimately denies the transcendence it experiences; failing to mature, willfully remaining adolescent. Keats’s…

View details →DOI: 10.1353/phl.2012.0015
Abandoned Hypothesis

How can I find my own voice through my instrument

Julia Casañas Cast · 2020 · Royal Conservatoire Research Portal

Many classical musicians can suffer from tension and nervousness during solo performance. This research looks at how practicing improvisation and creative body movement, as well as creating one’s own performance together with a dancer, can…

View details →DOI: 10.22501/koncon.792184
Abandoned Hypothesis

498 The Bristol Sign - A Technical Tip to Confirm Skin Flap Vascularity

Timothy Schrire, Ahmed Emam, Giulia Colavitti et al. · 2021 · British Journal of Surgery

Abstract Introduction In modern medicine, free flap reconstruction has become the gold standard when faced with soft tissue defects. The impressive cosmesis, and adaptability of free flaps means that we can securely state that we are in…

View details →DOI: 10.1093/bjs/znab134.010
Abandoned HypothesisMedicine

Formaldehyde metabolism in the biocatalytic upgrading of lignin.

Lalande AT, Eltis LD · 2026 · Current opinion in biotechnology

Formaldehyde is a toxic metabolite generated in the bacterial catabolism of lignin-derived aromatic compounds (LDACs) through the oxidative O-demethylation of methoxylated aromatics. Microbial cell factories designed to convert LDACs to…

View details →DOI: 10.1016/j.copbio.2026.103526
Abandoned Hypothesis

The Linear Non-Threshold Hypothesis-A Failed Concept

Joseph Bevelacqua · 2024 · Qeios

The linear non-threshold (LNT) hypothesis is based on the premise that the smallest amount of ionizing radiation produces a biological detriment. It implies that exposure to low-dose radiation be minimized. The LNT approach causes fear and…

View details →DOI: 10.32388/rdo6o0
Abandoned HypothesisOpen accessComputer Science

Active Learning with Selective Time-Step Acquisition for PDEs

Yegon Kim, Hyunsu Kim, Gyeonghoon Ko et al. · 2025 · arXiv

Accurately solving partial differential equations (PDEs) is critical to understanding complex scientific and engineering phenomena, yet traditional numerical solvers are computationally expensive. Surrogate models offer a more efficient alternative, but their development is hindered by the cost of generating sufficient training data from numerical solvers. In this paper, we present a novel framework for active learning in PDE surrogate modeling that reduces this cost. Unlike the existing AL methods for PDEs that always acquire entire PDE trajectories, our approach, STAP (**S**elective **T**ime

Abandoned HypothesisOpen accessComputer Science

Adaptive estimation of a time-varying phase with coherent states: smoothing can give an unbounded improvement over filtering

Kiarn T. Laverick, Howard M. Wiseman, Hossien T. Dinani et al. · 2017 · arXiv

The problem of measuring a time-varying phase, even when the statistics of the variation is known, is considerably harder than that of measuring a constant phase. In particular, the usual bounds on accuracy - such as the $1/(4\bar{n})$ standard quantum limit with coherent states - do not apply. Here, restricting to coherent states, we are able to analytically obtain the achievable accuracy - the equivalent of the standard quantum limit - for a wide class of phase variation. In particular, we consider the case where the phase has Gaussian statistics and a power-law spectrum equal to $κ^{p-1}/|ω

Abandoned Hypothesis

The school-to-prison pipeline: a failed holding environment

Constance Catrone · 2021 · Journal of Psychosocial Studies

The deleterious impact of the school-to-prison pipeline (STPP) on minority youth in the United States, as well as the underlying sociocultural and political factors contributing to the pipeline, are well established. While the literature…

View details →DOI: 10.1332/147867321x16215933132447
Abandoned Hypothesis

Are nonmeasurable sets significant for epistemology?

Yuanshan Li · 2025 · Synthese

Abstract Probabilism holds that rational credence functions are probability functions defined over some probability space $$(\Omega, \mathcal{F}, P)$$ . According to some recent philosophical arguments, in some situations, rational…

View details →DOI: 10.1007/s11229-025-05256-4
Abandoned HypothesisOpen accessComputer Science

Exchanging identical particles and topological quantum computing

S. J. van Enk · 2018 · arXiv

The phase factor $(-1)^{2s}$ that features in the exchange symmetry for identical spin-$s$ fermions or bosons is not simply and automatically equal to the phase factor one can observe in an interference experiment that involves physically exchanging two such particles. The observable phase contains, in general, single-particle geometric and dynamical phases as well, induced by both spin and spatial exchange transformations. By extending the analysis to (non-abelian) anyons it is argued that, similarly, there are single-anyon geometric and dynamical contributions in addition to purely topologic

Abandoned HypothesisOpen accessMathematics

Stone duality above dimension zero: Axiomatising the algebraic theory of C(X)

Vincenzo Marra, Luca Reggio · 2015 · arXiv

It has been known since the work of Duskin and Pelletier four decades ago that KH^op, the category opposite to compact Hausdorff spaces and continuous maps, is monadic over the category of sets. It follows that KH^op is equivalent to a possibly infinitary variety of algebras V in the sense of Slominski and Linton. Isbell showed in 1982 that the Lawvere-Linton algebraic theory of V can be generated using a finite number of finitary operations, together with a single operation of countably infinite arity. In 1983, Banaschewski and Rosicky independently proved a conjecture of Bankston, establishi

Abandoned Hypothesis

Failed in aging? Queering in living with dementia

Valerie Keller · 2023 · Frontiers in Sociology

This article explored the ways in which living with dementia brings potentials to queer the concept of “successful aging” and associated notions of being human. Regarding the progressive development of dementia, it can be assumed that…

View details →DOI: 10.3389/fsoc.2023.1139271
Abandoned Hypothesis

Confirm that the imaginary number i is a closed field

Ling Xie · 2023 · Annals of Mathematics and Physics

In the History of mathematics of mankind, some strange symbols appeared when dealing with some mathematical problems, which were defined as imaginary numbers by mankind. The imaginary number has been idle for a long time since it was…

View details →DOI: 10.17352/amp.000082
Abandoned HypothesisOpen accessPhysics

Modelling the Astronomical Silicate Features: I. On the Spectrum Subtraction Method

Aigen Li, J. Mayo Greenberg, Gang Zhao · 2002 · arXiv

The {\it assumption of additive absorptivity} by different components in compound particles is a widely used method applied in the literature to the analysis of the chemical and structural properties of astronomical (circumstellar, interstellar, protostellar, and cometary) silicates as well as other materials. The errors intrinsic in this additivity assumption, which, in application to astronomical spectra, amounts in some case to {\it spectrum subtraction} have not always been adequately considered in previous works on silicate mineralogy. The failings in the ``{\it spectrum subtraction metho

Abandoned Hypothesis

Did Copyright Fail Music Artists?

Rachel Landy · 2025 · SSRN Electronic Journal

Music soundtracks our lives, supports over two million domestic jobs annually, and is being listened to more than ever before. The record industry is thriving, having made over $17 billion in 2024. Yet, many professional artists…

View details →DOI: 10.2139/ssrn.5241841
Abandoned HypothesisMedicine

Early-Onset Amiodarone Pulmonary Toxicity at a Standard Maintenance Dose Masquerading as Decompensated Heart Failure: A Case Report and Literature Review.

Chabalout, Chaudhry, Inanc et al. · 2026 · Cureus

Amiodarone is a widely used antiarrhythmic agent. Pulmonary toxicity is its most feared non-cardiac complication and is classically associated with high doses and prolonged duration of therapy. We report a case of early-onset amiodarone…

View details →DOI: 10.7759/cureus.109617
Abandoned Hypothesis

Editorial Commentary: Anterolateral Ligament: How Do We Find It?

Nikhil N. Verma · 2016 · Arthroscopy

Abstract There is considerable current interest in the role of the anterolateral ligament in persistent instability after anterior cruciate ligament reconstruction. The normal ligament may be identified using magnetic resonance imaging or…

View details →DOI: 10.1016/j.arthro.2015.11.012