The elasticity of silicone-stabilized liposomes has no impact on their in vivo behavior
Alicja Hinz; Joanna Lewandowska-Łańcucka; Ewa Werner; Agnieszka Cierniak; Krystyna Stalińska; Grzegorz Dyduch; Michał Szuwarzyński; Monika Bzowska · 2024 · Journal of Nanobiotechnology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background The elastomechanical properties of nanocarriers have recently been discussed as important for the efficient delivery of various therapeutics. Some data indicate that optimal nanocarriers’ elasticity can modulate in vivo nanocarrier stability, interaction with phagocytes, and uptake by target cells. Here, we presented a study to extensively analyze the in vivo behavior of LIP-SS liposomes that were modified by forming the silicone network within the lipid bilayers to improve their elastomechanical properties. We verified liposome pharmacokinetic profiles and biodistribution,
Abstract by Alicja Hinz; Joanna Lewandowska-Łańcucka; Ewa Werner; Agnieszka Cierniak; Krystyna Stalińska; Grzegorz Dyduch; Michał Szuwarzyński; Monika Bzowska, Journal of Nanobiotechnology (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12951-024-02698-9