Negative / Null Result ReportOpen accessPediatrics
Karl Ove Hufthammer, Trond Markestad, Claus Klingenberg et al. · 2022 · BMJ Paediatrics Open
Objective To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks.Setting All neonatal intensive care units (NICUs) in Norway during 2012–2018.Methods Defined population-based data were prospectively entered into a national registry. We compared LISA infants with all non-LISA infants and with non-LISA infants who received surfactant following intubation. We used propensity score (PS) matching to identify non-LISA infants who were similar regarding potential confounders.Main outco
View details →DOI: 10.1136/bmjpo-2022-001527 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Takehiro Sugiyama, Takashi Furuno, Yuichi Ichinose et al. · 2024 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction A recent US Food and Drug Administration report highlighted concerns over nitrosamine (7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine [NTTP]) impurities in sitagliptin, prompting investigations into its safety profile. The present study aimed to determine if the use of NTTP‐contaminated sitagliptin, in comparison with other dipeptidyl peptidase‐4 (DPP‐4) inhibitors, is associated with an increased cancer risk. Materials and Methods This retrospective cohort study secondarily used the National Database of Health Insurance Claims and S
View details →DOI: 10.1111/jdi.14281 Negative / Null Result ReportOpen accessMedicine
Luis M. Pérez-Belmonte, José David Torres-Peña, María D. López-Carmona et al. · 2020 · BMC Medicine
Abstract Background Limited evidence exists on the role of glucose-lowering drugs in patients with COVID-19. Our main objective was to examine the association between in-hospital death and each routine at-home glucose-lowering drug both individually and in combination with metformin in patients with type 2 diabetes mellitus admitted for COVID-19. We also evaluated their association with the composite outcome of the need for ICU admission, invasive and non-invasive mechanical ventilation, or in-hospital death as well as on the development of in-hospital complications and a long-time hospital st
View details →DOI: 10.1186/s12916-020-01832-2 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Pankaj Puar, Nikhil Mistry, Kim A. Connelly et al. · 2023 · ESC Heart Failure
Abstract Aims Given recent suggestions that serum levels of insulin‐like growth factor‐binding protein 7 (IGFBP7) may identify patients who derive greater cardiorenal benefits from treatment with sodium‐glucose transport 2 inhibitors (SGLT2i), this exploratory sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized controlled trial evaluated the association between serum levels of IGFBP7 and empagliflozin‐mediated left ventricular mass regression. Methods and results The EMPA‐HEART CardioLink‐6 trial used gold‐standard cardiac magnetic resonance imaging to detect change in left ventricular mass
View details →DOI: 10.1002/ehf2.14335 Negative / Null Result ReportOpen accessMedicine
Mina Niusha, Seyed Ali Rahmani, Leila Kohan et al. · 2023 · Asian Pacific Journal of Reproduction
Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this study, 359 embryos from 62 couples were screened for chromosomes 13, 21, 18, X, and Y by fluorescence insitu hybridization. For biopsy of blastomere, a laser was used to remove a significantly smaller portion of the zona pellucida. One blastomere was gently biopsied by an aspiration pipette through the hole. After biopsy, the embryo was immediately returned to
View details →DOI: 10.4103/2305-0500.365228 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Baravan Al-Kassou, Hasanin Al-Shaikh, Adem Aksoy et al. · 2023 · International Journal of Cardiology: Heart & Vasculature
Background: Vascular injury and bleeding complications remain frequent after transcatheter aortic valve replacement (TAVR). Whether the access-site of preprocedural coronary angiography (CAG) affects TAVR-related complications is not known. The aim of this study was to evaluate the impact of transradial (TRA) versus transfemoral access (TFA) for preprocedural CAG on outcomes in patients undergoing subsequent TAVR. Methods: The study cohort included 1002 patients undergoing transfemoral TAVR, of whom 39.4% (395/1002) had undergone radial and 60.6% (607/1002) femoral access for pre-TAVR CAG. The
View details →DOI: 10.1016/j.ijcha.2023.101205 Negative / Null Result ReportOpen accessBusiness
Choudhury Mousumi, Singh Ranjit · 2016 · Acta Universitatis Sapientiae: Economics and Business
Bancassurance has evolved as a strong distribution channel in India. Bancassurance means that the insurance company and the bank come together to offer insurance products from the counter of the banks to the bank’s customer. The present study attempts to analyse customers’ perception regarding assurance of bancassurance channel in providing insurance-related services. The study also tries to find out the impact of various demographic variables on customers’ perception regarding assurance of bancassurance channel. The study finds that customers consider bancassurance channel having high assuran
View details →DOI: 10.1515/auseb-2016-0005 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Shih-Wei Lai, Shih-Wei Lai, Cheng-Li Lin et al. · 2017 · Frontiers in Pharmacology
Background/Objectives: Previous studies showed that zolpidem use could be associated with increased cancer risk, but the role of zolpidem on hepatocellular carcinoma (HCC) risk remains undetermined. The study purpose was to examine the association between HCC risk and zolpidem use in Taiwan.Methods: Using the database from the Taiwan National Health Insurance Program, we designed a case-control study which consisted of 77986 subjects aged 20 years or older with newly diagnosed HCC as the case group, and 77986 subjects without HCC as the control group, from 2000 to 2011. Ever use of zolpidem wa
View details →DOI: 10.3389/fphar.2017.00767 Negative / Null Result ReportOpen accessPublic aspects of medicine
Sonia Oveisi, Roghaye Keshavarz Sadegh, Sina Hosainzade et al. · 2025 · Discover Social Science and Health
Abstract Background Parenting self-efficacy (PSE) describes the beliefs and attitudes of parents on their capabilities to perform well on parenting tasks. Considering its direct relation to the physical and mental development of the children, we evaluated PSE in Iranian parents and investigated its potential effects on children's growth as a reflection of their self-regulation. Methods This investigation was conducted in 2019 in Takestan, Iran, and aimed to assess PSE in 300 parents of children under 2 years old. Families filled out a demographic questionnaire and a PSE questionnaire containin
View details →DOI: 10.1007/s44155-025-00196-3 Negative / Null Result ReportOpen accessMedicine
Zainab Almussa · 2021 · The Medical Journal of Basrah University
Abstract: Introduction: Low birth weight is the best indicator of the impact in the health system and the best predictor of mortality and morbidity in the neonatal, post neonatal and childhood periods. Objectives: This study was planned to study the association between birth weight and selected risk factors in Basrah governorate with special reference to: Socio demographic factors, Present obstetric history, Past obstetric history, History of Ante Natal Care, and Medical history. Methods: This is hospital- based cross sectional study was conducted on 362 infants delivered and /or admitted to A
View details →DOI: 10.33762/mjbu.2021.129962.1070 Negative / Null Result ReportOpen accessMedicine
Nihal Al Riyami, Intisar Al-Ruheili, Fatma Al-Shezawi et al. · 2013 · Oman Medical Journal
Objectives: Preterm premature rupture of membranes (PPROM) is defined as a rupture of the amniotic membranes occurring before 37 weeks of gestation and before the onset of labor. Extreme PPROM occurs prior to 26 weeks gestation and contributes to an increased risk of prematurity, leading to maternal and fetal complications. This study aims to estimate the risk factors associated with various maternal complications and to determine the worst outcomes in Omani females with extreme PPROM.Methods: A retrospective cohort study was conducted on 44 women with extreme PPROM, who delivered at Sultan Qa
Negative / Null Result ReportOpen accessOrthopedic surgery
Jaehyung Lee, Janghyun Kim, Sungkuk Chae et al. · 2024 · Foot & Ankle Orthopaedics
Category: Diabetes; Other Introduction/Purpose: Foot ulcers and subsequent amputations are disabling complications in diabetic patients, and major amputations, including below-knee amputations, leave patients with catastrophic disabilities. Diabetes is the most common cause of causing end-stage renal disease which results in hemodialysis, and patients with diabetes on hemodialysis have a higher prevalence of several co-morbidities compared to those without diabetes. The purpose of this study is to compare survival rates after below knee amputation in patients with diabetes who are on hemodialy
View details →DOI: 10.1177/2473011424s00513 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Ko Yoon, Won Hye, Jeon Eun et al. · 2011 · BMC Cancer
Abstract Background CD44s is a cell adhesion molecule known to mediate cellular adhesion to the extracellular matrix, a prerequisite for tumor cell migration. CD44s plays an important role in invasion and metastasis of various cancers. In the present study, we sought to determine whether CD44s is involved in clinical outcomes of patients with resected non-small cell lung cancer (NSCLC). Methods Using immunohistochemical staining, we investigated CD44s protein expression using tissue array specimens from 159 patients with resected NSCLC (adenocarcinoma (AC; n = 82) and squamous cell carcinoma (
View details →DOI: 10.1186/1471-2407-11-340 Negative / Null Result ReportOpen accessPublic aspects of medicine
Siqi Luo, Bingquan Xiong, Yuling Chen et al. · 2026 · Critical Public Health
Engagement in physical activity (PA) is a key health-promoting behavior in the prevention and management of chronic kidney disease (CKD). However, evidence regarding the associations between domain-specific PA and CKD remains limited. This study examined the relationships between different PA domains and CKD. Data were obtained from a large population-based survey. PA was self-reported and categorized into transportation-related (TPA), occupational (OPA), and leisure-time PA (LTPA). Multivariable logistic regression, restricted cubic spline models, and subgroup analyses were used to assess ass
View details →DOI: 10.1080/09581596.2026.2674262 Negative / Null Result ReportOpen accessMedicine
Dana S Forcey, Jane S Hocking, Sepehr N Tabrizi et al. · 2014 · PLoS ONE
BACKGROUND: We investigated the detection of chlamydia at different stages of the menstrual cycle. METHODS: Electronic medical records for women attending Melbourne Sexual Health Centre between March 2011 and 31(st) December 2012, who were tested for chlamydia by nucleic acid amplification of high vaginal, cervical, or urinary samples, and who recorded a date of last normal menstrual period (LNMP) between 0-28 days were included in the analysis. Logistic regression was used to calculate adjusted odds ratio (aOR) and 95% confidence intervals (CI) for the association of chlamydia with menstrual
View details →DOI: 10.1371/journal.pone.0085263 Negative / Null Result ReportOpen accessOther systems of medicine
Nuha Shawarb, Manal Badrasawi, Hassan Abu Qaoud et al. · 2023 · BMC Complementary Medicine and Therapies
Abstract Background The medicinal application of natural plant remedies is well established. These medicinal plants are still in use within the Palestinian community to treat several illnesses. This research is intended to study the use of natural plants to treat different types of respiratory tract disorders. Method This ethno botanical study focused on the medicinal plants that are used to treat respiratory diseases in the northern part of Palestine; Nablus, Tulkarm, Qalqilia, and Jenin. A questionnaire was distributed to 120 respondents. The data obtained included names of the plants used,
View details →DOI: 10.1186/s12906-023-04176-5 Negative / Null Result ReportOpen accessMedicine
Liugang Xu, Yajun Wang, Hongyun Ji et al. · 2024 · PLoS ONE
Background Numerous observational studies have reported an association between frailty and atherosclerosis. However, the causal relationship between frailty and the occurrence of atherosclerosis in different anatomical sites remains unclear. we conducted a bidirectional Mendelian randomization (MR) study to evaluate the causal relationship between the frailty index (FI), and both systemic atherosclerosis and lipids. Methods We obtained summary statistics from large-scale genome-wide association studies (GWAS) of various phenotypes, including frailty (n = 175,226), coronary atherosclerosis (n =
View details →DOI: 10.1371/journal.pone.0304300 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Suming Dai, Ping Wang, Sijia Wang et al. · 2025 · Frontiers in Nutrition
BackgroundExisting epidemiological studies investigated the association between a single vitamin and hypertension. However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat-soluble vitamin levels and blood pressure.MethodsA total of 2052 participants with essential hypertension were sampled nationwide. The plasma concentrations of fat-soluble vitamins (A, E, D, and K) were assessed using liquid chromatography coupled with the mass spectrometry method. Participants wer
View details →DOI: 10.3389/fnut.2024.1502139 Negative / Null Result ReportOpen accessPublic aspects of medicine
Farshad Teymoori, Hossein Farhadnejad, Ebrahim Mokhtari et al. · 2021 · BMC Public Health
Abstract Background Inflammation is a precursor of chronic disease, which is affected by lifestyle and dietary habits. Recently empirical dietary inflammatory patterns (EDIP), dietary inflammation scores (DIS), and lifestyle inflammation scores (LIS) were developed to indicate lifestyle and dietary contributions in systemic inflammation. The current study aimed to investigate the associations between these indices and the incidence of diabetes among Tehranian adults. Methods A total of 4624 individuals, aged 20–75 years, who were free of diabetes at baseline (2008–2011), were followed for 5.71
View details →DOI: 10.1186/s12889-021-11327-1 Negative / Null Result ReportOpen accessMedicine
Gieira S Jones, Heather Spencer Feigelson, Roni T Falk et al. · 2019 · PLoS ONE
Background Breast density, as estimated by mammography, is a strong risk factor for breast cancer in pre- and postmenopausal women, but the determinants of breast density have not yet been established. The aim of this study was to assess if urinary estrogens or gut microbiota alterations are associated with mammographic density in postmenopausal women. Methods Among 54 cancer-free, postmenopausal controls in the Breast and Colon Health study, we classified low- versus high-density women with Breast Imaging Reporting and Data System (BI-RADS, 5th edition) mammographic screening data, then asses
View details →DOI: 10.1371/journal.pone.0216114 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Babak B. Navi, Mitchell S. V. Elkind, Cenai Zhang et al. · 2025 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Approximately 50% of strokes in patients with cancer are classified as cryptogenic after standard evaluation. Atrial cardiopathy could explain some cancer‐related cryptogenic strokes. However, the relationship between cancer and atrial cardiopathy is uncertain. Methods AND RESULTS We conducted a post hoc cross‐sectional analysis of baseline data collected from participants enrolled in ARCADIA (Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke), a clinical trial conducted from 2018 to 2023 at 185 sites. The analytical cohort presented herein included
View details →DOI: 10.1161/jaha.124.040543 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Shih-Hao Chen, Hung-Chieh Chang, Po-Wei Chiu et al. · 2023 · BMC Cardiovascular Disorders
Abstract Background Fever can occur after acute myocardial infarction (MI). The influence of body temperature (BT) after hospital arrival on patients with acute MI has rarely been investigated. Methods Patients who were diagnosed with acute MI in the emergency department (ED) of a tertiary teaching hospital between 1 January 2020 and 31 December 2020 were enrolled. Based on the tympanic temperature obtained at the ED triage, patients were categorized into normothermic (35.5°C-37.5°C), hypothermic ( 37.5°C) groups. The primary outcome was in-hospital cardiac arrest (IHCA), while the secondary o
View details →DOI: 10.1186/s12872-023-03372-y Negative / Null Result Report
Ade Harwoko, Lestari Kurniawati · 2022 · Jurnal Akademi Akuntansi
This study aims to determine changes in corporate tax aggressiveness after the application of Statement of Financial Accounting Standards (PSAK) 73. The sample of this research is the financial statements of pharmaceutical industry…
View details →DOI: 10.22219/jaa.v5i1.18732 Negative / Null Result ReportOpen accessBiochemistry
Rostami Shilan, Fathollahpour Asadollah, Abdi Mohammad et al. · 2018 · Journal of Medical Biochemistry
Background: There is a paucity of studies regarding oxidative balance and selenium (Se) status in congenital hypothyroidism. Recently, more attention has been given to the use of Se supplementation as a new treatment for thyroid disorders. Oxidative stress increases in different thyroid disorders and causes many pathological outcomes. The present study aimed to determine the serum prooxidant-antioxidant balance (PAB), Se, thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentration in congenital hypothyroidism (CH) patients and the association of their probable change with hematolo
Negative / Null Result ReportOpen accessPediatrics
Fatma Sargin, Mehmet Alçı, Büşra Kaygusuz Aydemir et al. · 2026 · BMC Pediatrics
Abstract Background Childhood epilepsy is one of the most common neurological disorders worldwide, significantly affecting cognitive, emotional, and social development. As caregivers often seek medical guidance online, the readability, understandability, and quality of internet-based patient education materials (IPEMs) are crucial for health literacy and decision-making. This study evaluates the readability, understandability, quality, and popularity of online pediatric epilepsy materials in relation to established health communication standards. Methods A Google search using the term ‘epileps
View details →DOI: 10.1186/s12887-026-06602-2 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Huanhuan Zuo, Xiaochen Xie, Jiahuan Peng et al. · 2019 · Analytical Cellular Pathology
Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the
View details →DOI: 10.1155/2019/5189165 Negative / Null Result ReportOpen accessNursing
Simone Maria Muniz da Silva Bezerra, Eduardo Tavares Gomes, Paulo César da Costa Galvão et al. · Revista Brasileira de Enfermagem
ABSTRACT Objective: To characterize relations between spiritual well-being and hope of patients in the preoperative period of cardiac surgery. Method: Exploratory cross-sectional study with quantitative approach, performed in the infirmaries of a reference hospital in cardiology. We evaluated 69 patients hospitalized in preoperative period of myocardial revascularization, valve repair or replacement. Results: We verified that patients hold relevant scores of hope and welfare in all areas, being the existential well-being significantly lower than the religious one. The average of the spiritual
View details →DOI: 10.1590/0034-7167-2016-0642 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Ovi Sofia, Muna Amalia, Herryanto Thomassawa et al. · 2024 · Interdisciplinary Perspectives on Infectious Diseases
Introduction. The imbalance of the immune response is an important factor contributing to the incidence of ocular toxoplasmosis (OT). Regulatory T cells (Treg) play a key role in maintaining the balance between Th1 and Th17 immune responses, while interleukin-27 (IL-27) levels are related to the differentiation of Th17 cells. This study analyzes the differences in the number of Treg cells and the level of IL-27 between OT patients and seropositive individuals without ocular lesions and its correlation with retinal lesion size. Methods. This analytic observational study, conducted for 8 months,
View details →DOI: 10.1155/2024/3495376 Negative / Null Result ReportOpen accessOrthopedic surgery
Neal Singleton, Vaughan Poutawera · 2017 · Journal of Orthopaedic Surgery
Aim: It has been reported in the literature that patients with poor preoperative mental health are more likely to have worse functional outcomes following primary total hip and knee arthroplasty. We could find no studies investigating whether preoperative mental health also affects length of hospital stay following surgery. The aim of this study was to determine whether preoperative mental health affects length of hospital stay and long-term functional outcomes following primary total hip and knee arthroplasty. We also aimed to determine whether mental health scores improve after arthroplasty
View details →DOI: 10.1177/2309499017718902 Negative / Null Result ReportOpen accessGynecology and obstetrics
Divya Anantharaman, Aiswaryah Radhakrishnan, Vidhyalakshmi Anantharaman · 2023 · Journal of Pregnancy
Aim. Multisystemic physiological changes in pregnancy can result in tear film and refractive changes in the eye. We report dry eye prevalence in pregnant women using Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire. Methods. The SPEED questionnaire was self-administered cross-sectionally to 428 pregnant women (mean age: 26.8±4.4 years) with clinically confirmed pregnancy from two obstetric clinics in Chennai, India. Subjects with predisposing risk factors for dry eye were excluded from the study. Subjects were categorized as normal, moderate, and severe dry eye based on the SPE
View details →DOI: 10.1155/2023/3421269 