Negative / Null Result Report2014
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
New England Journal of Medicine
Failure-mode index
Negative results in Medicine
12,175 indexed negative results, null findings, and replication failures in Medicine. Each entry is a real published study whose primary finding was negative — learn what already failed before you repeat it.
Most-cited failures in Medicine
Negative / Null Result Report2013
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
New England Journal of Medicine
Negative / Null Result Report2010
Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis
New England Journal of Medicine
Negative / Null Result Report2010
Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
New England Journal of Medicine
Replication Failure2014
A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
New England Journal of Medicine
Negative / Null Result Report2014
Spironolactone for Heart Failure with Preserved Ejection Fraction
New England Journal of Medicine
Negative / Null Result Report2016
10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer
New England Journal of Medicine
Negative / Null Result Report2015
Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma
JAMA
Replication Failure2012
Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome
New England Journal of Medicine
Negative / Null Result Report2013
Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke
New England Journal of Medicine
Negative / Null Result Report2011
Diuretic Strategies in Patients with Acute Decompensated Heart Failure
New England Journal of Medicine
Negative / Null Result Report2012
Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care
New England Journal of Medicine
Negative / Null Result Report2014
Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients
New England Journal of Medicine
Negative / Null Result Report2012
Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study
Arthritis & Rheumatism
Replication Failure2019
Trial of Anifrolumab in Active Systemic Lupus Erythematosus
New England Journal of Medicine
Negative / Null Result Report2022
Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease
The Journal of Prevention of Alzheimer s Disease
Negative / Null Result Report2020
Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19
JAMA
Failed Experiment Report2021
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Nature
Negative / Null Result Report2015
Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial
Journal of Clinical Oncology
Negative / Null Result Report2014
High versus Low Blood-Pressure Target in Patients with Septic Shock
New England Journal of Medicine
Negative / Null Result Report2018
Validation of Digital Visual Analog Scale Pain Scoring With a Traditional Paper-based Visual Analog Scale in Adults
JAAOS Global Research and Reviews
Negative / Null Result Report2012
Prostate Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: Mortality Results after 13 Years of Follow-up
JNCI Journal of the National Cancer Institute
Negative / Null Result Report2015
Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure
New England Journal of Medicine
Replication Failure2013
Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial
Journal of Clinical Oncology
Negative / Null Result Report2011
RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative, Locally Recurrent or Metastatic Breast Cancer
Journal of Clinical Oncology
Replication Failure2018
Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease
New England Journal of Medicine
Negative / Null Result Report2015
Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
New England Journal of Medicine
Negative / Null Result Report2017
5-Year Outcomes After Left Atrial Appendage Closure
Journal of the American College of Cardiology
Replication Failure2020
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
New England Journal of Medicine
Negative / Null Result Report2021
Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19
JAMA
Negative / Null Result Report2014
Aspirin in Patients Undergoing Noncardiac Surgery
New England Journal of Medicine
Negative / Null Result Report2018
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity
JAMA
Negative / Null Result Report2010
Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)
Journal of Clinical Oncology
Negative / Null Result Report2013
Phase III Randomized Clinical Trial Comparing Tremelimumab With Standard-of-Care Chemotherapy in Patients With Advanced Melanoma
Journal of Clinical Oncology
Negative / Null Result Report2015
Prednisolone or Pentoxifylline for Alcoholic Hepatitis
New England Journal of Medicine
Negative / Null Result Report2015
Multiple Human Papilloma Virus Infections and Their Impact on the Development of High-Risk Cervical Lesions
Acta Cytologica
Negative / Null Result Report2011
Impact of Remote Telemedical Management on Mortality and Hospitalizations in Ambulatory Patients With Chronic Heart Failure
Circulation
Negative / Null Result Report2016
Long-Term Results of Stenting versus Endarterectomy for Carotid-Artery Stenosis
New England Journal of Medicine
Negative / Null Result Report2012
Short- Versus Long-Term Duration of Dual-Antiplatelet Therapy After Coronary Stenting
Circulation
Negative / Null Result Report2014
Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China
BioMed Research International
Negative / Null Result Report2017
Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes
Journal of Clinical Oncology
Negative / Null Result Report2013
High-Frequency Oscillation for Acute Respiratory Distress Syndrome
New England Journal of Medicine
Replication Failure2015
Randomized Trial of Primary PCI with or without Routine Manual Thrombectomy
New England Journal of Medicine
Negative / Null Result Report2011
Once-Only Sigmoidoscopy in Colorectal Cancer Screening: Follow-up Findings of the Italian Randomized Controlled Trial--SCORE
JNCI Journal of the National Cancer Institute
Replication Failure2010
Aspirin for Prevention of Cardiovascular Events in a General Population Screened for a Low Ankle Brachial Index<subtitle>A Randomized Controlled Trial</subtitle>
JAMA
Negative / Null Result Report2011
Reversible Cerebral Vasoconstriction Syndromes
Archives of Neurology
Negative / Null Result Report2013
Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest
JAMA
Negative / Null Result Report2012
Long-Term Update of US GI Intergroup RTOG 98-11 Phase III Trial for Anal Carcinoma: Survival, Relapse, and Colostomy Failure With Concurrent Chemoradiation Involving Fluorouracil/Mitomycin Versus Fluorouracil/Cisplatin
Journal of Clinical Oncology
Negative / Null Result Report2014
SEARCH: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Sorafenib Plus Erlotinib in Patients With Advanced Hepatocellular Carcinoma
Journal of Clinical Oncology
Replication Failure2021
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
The Lancet