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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 320 of 710

Negative / Null Result ReportMedicine

Acceptability of Adolescent Portal Access Policies to Parents and Adolescents: A Delphi Study.

Sisk BA, Antes AL, Bereitschaft C et al. · 2025 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Purpose United States healthcare systems have enacted varied adolescent online patient portal policies. No prior work has established whether these policies are acceptable to adolescents and parents. Methods Mixed-method Delphi approach…

View details →DOI: 10.1016/j.jadohealth.2024.10.021
Negative / Null Result ReportOpen accessMedicine

Safety Audit of a Large Language Model for Lay Self-Triage Using Japanese Symptom Vignettes: Persistent Red-Flag Under-Triage Despite Improved Reproducibility Under Near-Deterministic Decoding.

Harada Y · 2026 · Cureus

Introduction Large language models are increasingly discussed as tools for patient-facing symptom assessment, but safe self-triage depends on the concrete next action recommended to the user rather than on generic urgency language alone.…

View details →DOI: 10.7759/cureus.105878
Negative / Null Result ReportMedicine

Comparing the Effect of 2 Artificial Tear Formulations on Daytime Ocular Surface Parameters After Orthokeratology Contact Lenses Wearing.

Lin CY, Liao WL, Lin HJ et al. · 2025 · Eye & contact lens

Purpose To compare the ocular comfort and tear film stability of low viscous and medium viscous lubricant eye drops in orthokeratology lens users. Method This is a prospective, two-arm, randomized, crossover trial. After a 7±2 day run-in…

View details →DOI: 10.1097/icl.0000000000001207
Negative / Null Result ReportMedicine

The State of Surgery in Botswana, 2018 to 2022.

Romeo DJ, Wagner CS, Ahluwalia V et al. · 2025 · The Journal of craniofacial surgery

Many people living in low-income and middle-income countries (LMICs) lack access to safe surgical and anesthetic care. The Lancet Commission on Global Surgery (LCGS) recommended that all countries track surgical volume and target 5,000…

View details →DOI: 10.1097/scs.0000000000011940
Negative / Null Result ReportMedicine

Factors associated with failure to achieve Scoliosis Research Society-22r minimal clinically important difference despite achieving optimal global alignment in adult spinal deformity surgery.

Park SJ, Park JS, Kang DH et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To identify factors associated with failure to achieve the minimal clinically important difference (MCID) in the Scoliosis Research Society-22r (SRS-22r) despite achieving optimal global alignment in adult spinal deformity (ASD)…

View details →DOI: 10.1007/s00586-025-09043-0
Negative / Null Result ReportOpen accessMedicine

Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery.

Drew RH, Turner NA, Keil E et al. · 2026 · Infection control and hospital epidemiology

In a propensity-matched cohort of adult cardiac or neurosurgical procedures ( n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically…

View details →DOI: 10.1017/ice.2025.10365
Negative / Null Result ReportMedicine

Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry.

Schmitt A, Behnes M, Bertsch T et al. · 2025 · European journal of internal medicine

Background Elevated uric acid (UA) is a recognized biomarker in patients with cardiovascular disease. However, the prognostic significance of UA levels in patients with heart failure (HF), particularly those with HF with mildly reduced…

View details →DOI: 10.1016/j.ejim.2025.06.033
Negative / Null Result ReportMedicine

Vaccine hesitancy among nurses in the Marche Region.

Fortunato C, Gasperini B, Mengarelli Rinaldini D et al. · 2025 · Annali di igiene : medicina preventiva e di comunita

Background Vaccine hesitancy is considered one of the top ten threats to global health by the World Health Organization due to the potential public health consequences. Since April 1, 2021, the Italian Government has made COVID-19…

View details →DOI: 10.7416/ai.2025.2680
Negative / Null Result ReportOpen accessMedicine

A randomised, double-blind, placebo-controlled trial to assess the postprandial dose-dependent effects of wild blueberries on metabolic and cognitive outcomes following a high-carbohydrate breakfast.

Ellis LR, O'Connor D, Khan H et al. · 2026 · European journal of nutrition

Purpose Despite equivocal human study data, anthocyanin-rich blueberries are associated with positive glycaemic effects which could benefit satiety and other cardiometabolic outcomes. The objective of this study was to examine the…

View details →DOI: 10.1007/s00394-026-03974-0
Negative / Null Result ReportOpen accessMedicine

Diastology and MitraClip<sup>®</sup> Outcomes: Multicenter Real-World Evidence Study.

Joseph Varughese V, Richardson C, Pollock J et al. · 2025 · Medicina (Kaunas, Lithuania)

Background and Objectives : MitraClip ® (MC) placement has been extensively used as an intervention for mitral transcatheter edge-to-edge repair (mTEER) for functional mitral regurgitation (FMR). The aim of our study is to analyze the…

View details →DOI: 10.3390/medicina61061092
Negative / Null Result ReportMedicine

Discovery of HCV vaccine: Where do we stand?

Balakrishnan P, Saravanan S, Vignesh R et al. · 2025 · Indian journal of medical microbiology

Background Hepatitis C virus (HCV) is still a serious public health issue because it can cause cirrhosis, hepatocellular carcinoma (HCC), and chronic hepatitis. In almost 70 % of cases, HCV infection results in chronic persistence, which…

View details →DOI: 10.1016/j.ijmmb.2025.100940
Negative / Null Result ReportOpen accessMedicine

Application of Autologous Platelet-Rich Plasma-Supplemented Medium Promotes <i>In Vitro</i> Maturation of Human Germinal Vesicle Oocytes.

Rezaie MJ, Allahveisie A, Nikkhoo B et al. · 2025 · International journal of fertility & sterility

Background Oocyte in vitro maturation (IVM) is a valuable technology applied to acquire fully developed oocytes for several clinical purposes. Despite substantial research on optimizing culture media, the success rate of IVM remains low.…

View details →DOI: 10.22074/ijfs.2025.2037467.1744
Negative / Null Result ReportOpen accessMedicine

Register-based observational study of associations between inflammatory remission, formal treatment targets and the use of disease-modifying antirheumatic drugs among patients with early rheumatoid arthritis.

Lindqvist J, Askling J, Lampa J · 2023 · RMD open

Objective To assess associations between inflammatory remission, formal treatment targets and the likelihood of starting a new disease-modifying antirheumatic drug (DMARD), among patients with early rheumatoid arthritis (RA). Methods…

View details →DOI: 10.1136/rmdopen-2023-003111
Negative / Null Result Report

Effects of multimodal and unimodal physical training interventions on visual function in glaucoma and elderly controls – a pilot study

Moffack D, Al-Nosairy K, Beyer R et al. · 2025 · Preprint

Objective To investigate the effect of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma patients (GLA) and…

View details →DOI: 10.1101/2025.01.30.25321400
Negative / Null Result ReportMedicine

Operative Management of Perianal Crohn's Disease.

Wilkinson T, Booth K · 2025 · The Surgical clinics of North America

The management of perianal Crohn's disease is challenging and complex and requires a multidisciplinary approach as a favorable working relationship between gastroenterologists and colorectal surgeons is necessary to provide excellent care…

View details →DOI: 10.1016/j.suc.2024.09.007
Negative / Null Result ReportOpen accessMedicine

Evaluating oral ketamine's adverse side effects in chronic pain patients.

Hom B, McIntee D, Zhang YP et al. · 2025 · Saudi journal of anaesthesia

Background Ketamine has been shown to be an effective treatment at sub-anesthetic doses for various chronic pain conditions. This study assesses the relationship between oral ketamine and the incidence of adverse side effects in patients…

View details →DOI: 10.4103/sja.sja_87_25
Negative / Null Result ReportMedicine

Standardization of Lesion Classification and Assessment by Investigators in Clinical Trials for Hidradenitis Suppurativa: A Consensus Exercise Using a Modified Delphi Approach.

Garg A, Strunk A, Midgette B et al. · 2026 · JAMA dermatology

Importance Accurate classification and reliability in assessment for lesions of hidradenitis suppurativa (HS) by investigators is critical to the determination of responder status and to overall data quality in clinical trials. Objective…

View details →DOI: 10.1001/jamadermatol.2025.4652
Negative / Null Result ReportOpen accessMedicine

No Association Between Face Recognition and Spatial Navigation: Evidence from Developmental Prosopagnosia and Super-Recognizers.

Estudillo AJ, Dark O, Wiener JM et al. · 2025 · Brain sciences

Background/Objectives: Previous studies have reported associations between prosopagnosia and spatial navigation, but it remains unclear whether this link is merely coincidental (i.e., observable only in prosopagnosia) or genuinely…

View details →DOI: 10.3390/brainsci15111140
Negative / Null Result ReportOpen accessMedicine

The use of cellphone based automated pupillometry to quantify opioid withdrawal in patients receiving treatment for opioid use disorder.

Evonko CJ, Vigilante KC, Leli NB et al. · 2026 · Journal of substance use and addiction treatment

Introduction Overdose deaths attributed to opioid misuse resulted in over 50,000 deaths in 2024. Opioid agonist therapies such as methadone and buprenorphine are effective for the treatment of opioid use disorder (OUD). Yet, patient…

View details →DOI: 10.1016/j.josat.2026.209927
Negative / Null Result ReportMedicine

Investigation of circulating natural autoantibodies against ANXA1 and MYC as potential biomarkers in hepatocellular carcinoma.

Wang J, Liu S, Zhang X · 2025 · Advances in medical sciences

Purpose In this study, we examined novel autoantibodies targeting tumor-associated antigens (TAAs) as biomarkers for clinical assessment of hepatocellular carcinoma (HCC) in a Chinese population. Methods and methods A total of 119 patients…

View details →DOI: 10.1016/j.advms.2025.01.004
Negative / Null Result ReportOpen accessMedicine

Effectiveness of dilution ventilation in mitigating occupational exposure to volatile organic compounds (VOCs) at the breathing zone of nail technicians: a simulation study.

Salari S, Fazeli-Tabar S, Karimi A et al. · 2026 · Scientific reports

Volatile Organic Compounds (VOCs) from nail products pose potential health risks to technicians and clients. The present study investigates the exposure of nail technicians to VOC and assesses the effectiveness of dilution ventilation in…

View details →DOI: 10.1038/s41598-025-33777-y
Negative / Null Result ReportOpen accessMedicine

Medication count, including statin or metformin use, is not associated with influenza vaccine responses in older adults.

Li V, McClure H, Patel R et al. · 2025 · Vaccine

Background Vaccination helps prevent infections and associated sequelae, especially in older adults. Since the degree to which vaccine responses are influenced by medications is not well described, we examined the association of medication…

View details →DOI: 10.1016/j.vaccine.2025.127913
Negative / Null Result ReportOpen accessMedicine

Motives of Children for Digital Gaming and Physical Activity and Their Parents' Perceptions: Cross-Sectional Matched-Pair Study.

Wachholz F, Gamper N, Kruse S et al. · 2026 · JMIR pediatrics and parenting

Background Physical activity (PA) is essential for the healthy development of children. However, the pervasive presence of digital technologies has made digital gaming (DG) a prominent part of children's everyday lives. As children grow up…

View details →DOI: 10.2196/80129
Failed Experiment ReportMedicine

Effect of cross-head speed on the bond strength of dental resin to tooth structure - A review and re-analysis.

Hassan Elnadif H, Darvell BW · 2024 · Dental materials : official publication of the Academy of Dental Materials

Objective To review the published evidence for the role of cross-head speed on the apparent mechanical properties and bond strength of filled resins to tooth structure in order to identify the causes of inconsistency and contradictory…

View details →DOI: 10.1016/j.dental.2024.09.020
Negative / Null Result Report

Altered coagulation profile of patients with high-grade glioma: clinical study with control group.

Quispe-Pastor NJ, Gorritti-Rubio AP, Fernández-Rodríguez LJ · 2024 · Preprint

Background: Disregulation of coagulation is a common phenomenon in patients with high-grade glioma, a primary malignant brain tumor. Objective Identify if there is an alteration in the coagulation profile in patients with high-grade glioma…

View details →DOI: 10.12688/f1000research.154700.2
Negative / Null Result ReportOpen accessMedicine

Extent of Pelvic Lymph Node Dissection at Partial Cystectomy: Effect on Cancer-Specific Mortality.

Longoni M, Marmiroli A, Falkenbach F et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Introduction We assessed the extent of pelvic lymph node dissection (PLND) at partial cystectomy (PC) according to PC eligibility (≤cT2 stage, tumor ≤ 3 cm and segmental resection possible) and tested its effect on cancer-specific…

View details →DOI: 10.1111/iju.70483
Negative / Null Result ReportMedicine

Evaluation of pharmacological thromboprophylaxis in critically Ill elderly patients: A multicenter cohort Study.

Alqahtani R, Sulaiman KA, Aljuhani O et al. · 2025 · Heart & lung : the journal of critical care

Background Older adults are at a higher risk of developing venous thromboembolism (VTE), particularly when admitted to the Intensive Care Units (ICUs). Parenteral anticoagulation is the primary method used for thromboprophylaxis in…

View details →DOI: 10.1016/j.hrtlng.2025.07.013