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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 321 of 710

Negative / Null Result ReportMedicine

An investigation of mental rotation in infancy using change detection.

Beckner AG, Voss AT, Phillips L et al. · 2023 · Infant behavior & development

Two experiments were conducted to examine mental rotation in 6- to 12-month-old infants (N = 166) using a change detection task. These experiments were replications of Lauer and Lourenco (Lauer et al., 2015; Lauer & Lourenco, 2016), using…

View details →DOI: 10.1016/j.infbeh.2023.101834
Negative / Null Result ReportOpen accessMedicine

The Role of Spontaneous Eye Blinks in Temporal Perception: An Eye Tracking Study.

Abad-Malo D, Alvarado-Cando O, Karsilar H · 2025 · Journal of eye movement research

Our interaction with the world depends on our ability to process temporal information, which is a key component of human cognition that directly impacts decision-making, planning, and prediction of events. Visual information plays a…

View details →DOI: 10.3390/jemr18060076
Negative / Null Result ReportOpen accessMedicine

No evidence for association between pupil size and fluid intelligence among either children or adults.

Lorente P, Ruuskanen V, Mathôt S et al. · 2025 · Psychonomic bulletin & review

Recent studies have investigated resting-state, or baseline, pupil size as a general measure of cognitive abilities, based on the earlier finding that larger pupils might be predictive of higher general intelligence or working memory…

View details →DOI: 10.3758/s13423-025-02644-2
Negative / Null Result ReportOpen accessMedicine

Finding the forest in the trees: Using machine learning and online cognitive and perceptual measures to predict adult autism diagnosis.

Van der Burg E, Jertberg RM, Geurts HM et al. · 2026 · Translational psychiatry

Traditional subjective measures are limited in the insight they provide into underlying behavioral differences associated with autism and, accordingly, their ability to predict diagnosis. Performance-based measures offer an attractive…

View details →DOI: 10.1038/s41398-026-03823-y
Negative / Null Result ReportOpen accessMedicine

The Reproducibility Movement in Psychology: Does Researcher Gender Affect How People Perceive Scientists With a Failed Replication?

Ashburn-Nardo L, Moss-Racusin CA, Smith JL et al. · 2022 · Frontiers in psychology

The reproducibility movement in psychology has resulted in numerous highly publicized instances of replication failures. The goal of the present work was to investigate people's reactions to a psychology replication failure vs. success,…

View details →DOI: 10.3389/fpsyg.2022.823147
Negative / Null Result ReportOpen accessMedicine

Emotional Blunting and Time Estimation in Depression.

Mura F, Catrambone V, Valenza G et al. · 2026 · Biological psychiatry global open science

Background Various cognitive and emotional factors shape our perception of time. Notably, individuals experiencing depressive symptoms often report changes in their time perception, characterized by a phenomenon termed depressive time…

View details →DOI: 10.1016/j.bpsgos.2025.100626
Negative / Null Result ReportOpen accessMedicine

Enhanced Structural Understanding of Dissolved Organic Matter through Comparative LC/MS2 Analysis with Synthetic Carboxylate Rich Alicyclic Molecules.

Hawkes JA, Flygare AD, Moodie LWK et al. · 2025 · Analytical chemistry

Dissolved organic matter (DOM) is one of the most complex chemical mixtures known, with its chemical composition having long puzzled biogeochemists. Identifying the chemical structures within DOM is essential for unraveling its origins and…

View details →DOI: 10.1021/acs.analchem.5c02665
Negative / Null Result ReportMedicine

Losing sight of Luck: Automatic approach tendencies toward gambling cues in Canadian moderate- to high-risk gamblers - A replication study.

Galvin HR, Boffo M, Snippe L et al. · 2023 · Addictive behaviors

Evidence for approach bias tendencies to underly automatic behavioural impulses towards seeking out gambling activities in the presence of appetitive salient cues was first shown by Boffo et al. (2018) in a Dutch sample. Relative to…

View details →DOI: 10.1016/j.addbeh.2023.107778
Negative / Null Result ReportOpen accessMedicine

Alterations in epigenetic marks and expression of genes related to stress regulation: an exploratory study among newborns after fetal repair of spina bifida aperta.

Landolt MA, Strebel NL, Moehrlen U et al. · 2026 · Epigenetics

Fetal repair of spina bifida aperta (fSBA) is an established intervention that improves neurological and neurodevelopmental outcomes. The present exploratory study examines whether molecular signatures related to stress regulation are…

View details →DOI: 10.1080/15592294.2026.2632976
Negative / Null Result ReportMedicine

Preoperative Use of Glucagon-Like Peptide-1 Receptor Agonists Is Not Protective Against Pseudoarthrosis Following Small Joint Hand Arthrodesis: A Propensity-Matched Analysis.

Stump K, Morar H, Talsania A et al. · 2026 · Hand (New York, N.Y.)

Background Glucagon-like peptide-1 receptor agonist (GLP-1 RA) use has demonstrated positive effects on bone metabolism and pseudoarthrosis following fusion surgery. There is, however, little evidence regarding the preoperative use of…

View details →DOI: 10.1177/15589447261415646
Negative / Null Result Report

Second Replication of Finn & Hudson Kam (2008) Experiment 3

Ricketts W, Hartshorne JK · 2022 · Preprint

We replicated Experiment 3 of Finn & Hudson Kam (2008) The curse of knowledge: First language knowledge impairs adult learners' use of novel statistics for word segmentation, Cognition, 108(2), 477-499. This is part of a larger project…

View details →DOI: 10.31234/osf.io/yt9n8
Negative / Null Result Report

Second Replication of Finn & Hudson Kam (2008) Experiment 1

Ricketts W, Hartshorne JK · 2022 · Preprint

We replicated Experiment 1 of Finn & Hudson Kam (2008) The curse of knowledge: First language knowledge impairs adult learners’ use of novel statistics for word segmentation, Cognition, 108(2), 477-499. This is part of a larger project…

View details →DOI: 10.31234/osf.io/eu9cj
Negative / Null Result Report

Is musical engagement enough to keep the brain young?

Matziorinis AM, Gaser C, Koelsch S · 2022 · Preprint

Music-making and engagement in music-related activities have shown procognitive benefits for healthy and pathological populations, suggesting reductions in brain aging. A previous brain aging study, using Brain Age Gap Estimation…

View details →DOI: 10.21203/rs.3.rs-1991605/v1
Negative / Null Result ReportOpen accessMedicine

Genome-wide Association Study of Susceptibility to Respiratory Syncytial Virus Hospitalization in Young Children <5 Years of age.

Egeskov-Cavling AM, van Wijhe M, Yakimov V et al. · 2024 · The Journal of infectious diseases

Background Worldwide, respiratory syncytial virus (RSV) infections are among the most common causes of infant hospitalization. Host genetic factors influencing the risk and severity of RSV infection are not well known. Methods We conducted…

View details →DOI: 10.1093/infdis/jiad370
Negative / Null Result ReportOpen accessMedicine

Nicotinamide for Skin Cancer Chemoprevention: The Jury Was Out and Still is.

Tan E, Williams HC · 2026 · American journal of clinical dermatology

Nicotinamide has been widely promoted as a low-cost safe chemopreventive agent against non-melanoma skin cancer. A recent large retrospective study of more than 33,000 US veterans reported a 14% reduction in overall skin cancer risk and a…

View details →DOI: 10.1007/s40257-025-01005-y
Failed Experiment Report

Engineering Alignment has Mixed Effects on hiPSC-CM Maturation

Kalkunte NG, Delabmbre TE, Sohn S et al. · 2022 · Preprint

The potential of human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CMs) is greatly limited by their functional immaturity. Strong relationships exist between CM structure and function, leading many in the field to…

View details →DOI: 10.1101/2022.09.26.509194
Negative / Null Result ReportOpen accessMedicine

Newborns' Language Discrimination May Not Reflect Sensitivity to Speech Rhythm: Evidence From Computational Modeling.

Famularo RL, Aboelata A, Schatz T et al. · 2026 · Developmental science

Human newborns are able to discriminate between certain languages but not others. This ability has long been attributed to sensitivity to rhythm-the temporal regularities in speech of different languages. Here, we demonstrate through a…

View details →DOI: 10.1111/desc.70220
Negative / Null Result ReportOpen accessMedicine

Is there a lower visual field advantage for object affordances? A registered report.

Warman A, Clark A, Malcolm GL et al. · 2024 · Quarterly journal of experimental psychology (2006)

It's been repeatedly shown that pictures of graspable objects can facilitate visual processing, even in the absence of reach-to-grasp actions, an effect often attributed to the concept of affordances. A classic demonstration of this is the…

View details →DOI: 10.1177/17470218241230812
Negative / Null Result ReportMedicine

Does interpersonal liking lead to interpersonal synchrony in musical contexts?

Melton ZJ, Chaffin R, Kangas-Dick K et al. · 2023 · Quarterly journal of experimental psychology (2006)

The causal relationship of interpersonal liking affecting interpersonal synchrony is inconsistently documented. This study tests whether (a) interpersonal liking increases both behavioural and perceived synchrony and (b) people will…

View details →DOI: 10.1177/17470218221094306
Negative / Null Result ReportMedicine

Genome scan reveals several loci associated with torus palatinus.

Lee MK, El Sergani AM, Herrick N et al. · 2025 · Orthodontics & craniofacial research

Objective Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic…

View details →DOI: 10.1111/ocr.12857
Negative / Null Result ReportMedicine

Evaluating factors associated with paediatric cochlear implant outcome in four cochlear implant satellite centres in Malaysia.

Tengku Kamalden TMI, Azali MZ, Chong LC et al. · 2022 · The Medical journal of Malaysia

Introduction Many factors are associated with cochlear implant (CI) outcomes and various methods of assessment for auditory and speech performance outcomes in CI are available globally. The objective of this study is to identify factors…

Negative / Null Result Report

Genome-wide determination of barriers to horizontal gene transfer

Burch CL, Romanchuk A, Kelly M et al. · 2022 · Preprint

Horizontal gene transfer (HGT) is a major contributor to bacterial genome evolution, generating phenotypic diversity, driving the expansion of protein families, and facilitating the evolution of new phenotypes, new metabolic pathways, and…

View details →DOI: 10.1101/2022.06.29.498157