A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21173 results · page 31 of 706
Shannon Fraser, Paul A. Gardner, Maria Koutourousiou et al. · 2017 · Journal of neurosurgery
OBJECTIVE The aim in this paper was to determine risk factors for the development of a postoperative CSF leak after an endoscopic endonasal approach (EEA) for resection of skull base tumors. METHODS A retrospective review of patients who…
Nina Johnston, Johan Bodegård, Susanna Jerström et al. · 2016 · American Heart Journal
BACKGROUND: Patients with myocardial infarction (MI) seldom reach recommended targets for secondary prevention. This study evaluated a smartphone application ("app") aimed at improving treatment adherence and cardiovascular lifestyle in MI…
Marisa N. Spann, Linda C. Mayes, Jessica H. Kalmar et al. · 2011 · Child Neuropsychology
Childhood maltreatment (CM) has been associated with diminished executive functioning in children and adults; however, there is a relative paucity of study of executive function in adolescents exposed to CM. Yet, executive dysfunction in…
Angela Kuznia, Anita K Hernandez, Lydia U Lee · 2020 · PubMed
Adolescent idiopathic scoliosis affects 1% to 3% of U.S. adolescents. It is defined by a lateral curvature of the spine (Cobb angle) of at least 10 degrees in the absence of underlying congenital or neuromuscular abnormalities. Adolescent…
Sara E. Rimm‐Kaufman, Ross Larsen, Alison E. Baroody et al. · 2014 · American Educational Research Journal
This randomized controlled field trial examined the efficacy of the Responsive Classroom ( RC) approach on student achievement. Schools ( n = 24) were randomized into intervention and control conditions; 2,904 children were studied from…
Peter Sundström, Anders Wåhlin, Khalid Ambarki et al. · 2010 · Annals of Neurology
The prevailing view on multiple sclerosis etiopathogenesis has been challenged by the suggested new entity chronic cerebrospinal venous insufficiency. To test this hypothesis, we studied 21 relapsing-remitting multiple sclerosis cases and…
Roham T. Zamanian, David B. Badesch, Lorinda Chung et al. · 2021 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Systemic sclerosis (SSc)–pulmonary arterial hypertension (PAH) is one of the most prevalent and deadly forms of PAH. B cells may contribute to SSc pathogenesis. Objectives We investigated the safety and efficacy of…
Konstantinos K. Tsilidis, Despoina Capothanassi, Naomi E. Allen et al. · 2014 · Diabetes Care
OBJECTIVE: Meta-analyses of epidemiologic studies have suggested that metformin may reduce cancer incidence, but randomized controlled trials did not support this hypothesis. RESEARCH DESIGN AND METHODS: A retrospective cohort study,…
Haibo Zhou, Rommert Dekker, A.H. Kleinknecht · 2011 · Industrial and Corporate Change
Firms with high shares of workers on fixed-term contracts tend to have higher sales of imitative new products but perform significantly worse on sales of innovative new products ("first on the market"). High functional flexibility in…
Myung‐Ju Ahn, Kentaro Tanaka, Luis Paz‐Ares et al. · 2024 · Journal of Clinical Oncology
PURPOSE The randomized, open-label, global phase III TROPION-Lung01 study compared the efficacy and safety of datopotamab deruxtecan (Dato-DXd) versus docetaxel in patients with pretreated advanced/metastatic non–small cell lung cancer…
Ilaria Montagni, Elie Guichard, Claire Carpenet et al. · 2015 · Cephalalgia
Objective The objective of this article is to investigate whether excessive screen time exposure is associated with non-migraine headache and migraine in young adults. Background Increased levels of television time have been associated…
DK Patel, R Kumar, SK Prasad et al. · 2011 · Asian Pacific Journal of Tropical Biomedicine
OBJECTIVE: To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models. METHODS: The oral glucose tolerance test (OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus (AHE) were…
Guido Makransky, Gustav Bøg Petersen, Sara Klingenberg · 2020 · British Journal of Educational Technology
Abstract Science‐related competencies are demanded in many fields, but attracting more students to scientific educations remains a challenge. This paper uses two studies to investigate the value of using Immersive Virtual Reality (IVR)…
Miriam M. Boxer, Shalini Vinod, Jesmin Shafiq et al. · 2011 · Cancer
BACKGROUND: There is limited evidence regarding the effectiveness of multidisciplinary team (MDT) meetings in lung cancer. The objective of this study was to compare the patterns of care for patients with newly diagnosed lung cancer who…
Ranjani R. Starr · 2015 · American Journal of Public Health
Millions of people in the United States consume dietary supplements hoping to maintain or improve their health; however, extensive research has failed to demonstrate the efficacy of numerous supplements in disease prevention. In addition,…
Chinedu Francis Egbunike, Chinedu U. Okerekeoti · 2018 · Asian Journal of Accounting Research
Purpose The purpose of this paper is to explore the interrelationship between macroeconomic factors, firm characteristics and financial performance of quoted manufacturing firms in Nigeria. Specifically, the study investigates the effect of interest rate, inflation rate, exchange rate and the gross domestic product (GDP) growth rate, while the firm characteristics were size, leverage and liquidity. The dependent variable financial performance is measured as return on assets (ROA). Design/methodology/approach The study used the ex post facto research design. The population comprised all quoted
J. F. Keating, Elizabeth Will · 2011 · Journal of Bone and Joint Surgery - British Volume
A total of 80 patients with an acute rupture of tendo Achillis were randomised to operative repair using an open technique (39 patients) or non-operative treatment in a cast (41 patients). Patients were followed up for one year. Outcome…
Michele Casini, Filip Käll, Martin Hansson et al. · 2016 · Royal Society Open Science
) in the Baltic Sea has dramatically decreased during the past two decades, with large implications for the fishery relying on this resource. Here, we statistically investigated the potential drivers of the Baltic cod condition during the past 40 years using newly compiled fishery-independent biological data and hydrological observations. We evidenced a combination of different factors operating before and after the ecological regime shift that occurred in the Baltic Sea in the early 1990s. The changes in cod condition related to feeding opportunities, driven either by density-dependence or fo
Karl Nordström, Markus Sällman Almén, Monika M. Edstam et al. · 2011 · Molecular Biology and Evolution
Several families of G protein-coupled receptors (GPCRs) show no significant sequence similarities to each other, and it has been debated which of them share a common origin. We developed and performed integrated and independent HHsearch,…
Jennifer Stowell, Guannan Geng, Eri Saikawa et al. · 2019 · Environment International
BACKGROUND: exposure. OBJECTIVES: levels. METHODS: for overall and age-stratified outcomes using 2-day averaging windows for cardiovascular disease and 3-day windows for respiratory disease. RESULTS: were observed for asthma and combined respiratory disease in children, and for asthma, bronchitis, COPD, and combined respiratory disease in adults. No significant associations were found in older adults. DISCUSSION: exposure in a changing climate.
Tim Schneider, Lee-Hsueh Hung, Silke Schreiner et al. · 2016 · Scientific Reports
Circular RNAs (circRNAs) constitute a new class of noncoding RNAs in higher eukaryotes generated from pre-mRNAs by alternative splicing. Here we investigated in mammalian cells the association of circRNAs with proteins. Using glycerol gradient centrifugation, we characterized in cell lysates circRNA-protein complexes (circRNPs) of distinct sizes. By polysome-gradient fractionation we found no evidence for efficient translation of a set of abundant circRNAs in HeLa cells. To identify circRNPs with a specific protein component, we focused on IMP3 (IGF2BP3, insulin-like growth factor 2 binding pr
Alex Nisthal, Connie Y. Wang, Marylouise Ary et al. · 2019 · Proceedings of the National Academy of Sciences
The accurate prediction of protein stability upon sequence mutation is an important but unsolved challenge in protein engineering. Large mutational datasets are required to train computational predictors, but traditional methods for…
Erin Hartman, F. Daniel Hidalgo · 2018 · American Journal of Political Science
Abstract Recent emphasis on credible causal designs has led to the expectation that scholars justify their research designs by testing the plausibility of their causal identification assumptions, often through balance and placebo tests.…
Armin Zittermann, Jana B. Ernst, Sylvana Prokop et al. · 2017 · European Heart Journal
AIMS: Circulating 25-hydroxyvitamin D (25OHD) levels <75 nmol/L are associated with a nonlinear increase in mortality risk. Such 25OHD levels are common in heart failure (HF). We therefore examined whether oral vitamin D supplementation…
Seema A. Khan, Fengmin Zhao, Lori J. Goldstein et al. · 2022 · Journal of Clinical Oncology
PURPOSE Distant metastases are present in 6% or more of patients with newly diagnosed breast cancer. In this context, locoregional therapy for the intact primary tumor has been hypothesized to improve overall survival (OS), but clinical…
Eva van het Reve, Patrícia Silveira, Florian Daniel et al. · 2014 · Journal of Medical Internet Research
BACKGROUND: Home-based exercise programs can improve physical functioning and health status of elderly people. Successful implementation of exercise interventions for older people presents major challenges and supporting elderly people properly while doing their home-based exercises is essential for training success. We developed a tablet-based system-ActiveLifestyle-that offers older adults a home-based strength-balance training program with incorporated motivation strategies and support features. OBJECTIVE: The goal was to compare 3 different home-based training programs with respect to thei
Robert H. Squires, Anil Dhawan, Estella M. Alonso et al. · 2012 · Hepatology
UNLABELLED: N-acetylcysteine (NAC) was found to improve transplantation-free survival in only those adults with nonacetaminophen (non-APAP) acute liver failure (ALF) and grade 1-2 hepatic encephalopathy (HE). Because non-APAP ALF differs…
David C. Mohr, Jenna Duffecy, Joyce Ho et al. · 2013 · PLoS ONE
BACKGROUND: Web-based interventions for depression that are supported by coaching have generally produced larger effect-sizes, relative to standalone web-based interventions. This is likely due to the effect of coaching on adherence. We evaluated the efficacy of a manualized telephone coaching intervention (TeleCoach) aimed at improving adherence to a web-based intervention (moodManager), as well as the relationship between adherence and depressive symptom outcomes. METHODS: 101 patients with MDD, recruited from primary care, were randomized to 12 weeks moodManager+TeleCoach, 12 weeks of self-
Morris M. Kleiner, Allison Marier, Kyoung Won Park et al. · 2016 · The Journal of Law and Economics
Occupational licensing laws have been relaxed in a large number of US states to give nurse practitioners the ability to perform more tasks without the supervision of medical doctors. We investigate how these regulations affect wages, hours…
Germà Bel, Mildred E. Warner · 2015 · Journal of Economic Policy Reform
Inter-municipal cooperation is an important public service delivery reform, whose drivers move beyond simple concerns with costs and economic efficiency, to policy issues related to governance structure and spatial context. We conduct a meta-regression analysis based on the existing multivariate empirical literature to explore what factors explain divergence in results in the existing empirical studies. We find strong evidence that fiscal constraints, spatial, and organizational factors are significant drivers of cooperation. Our meta-regressions do not yield results to explain divergence in r