A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Rezzy Eko Caraka, Youngjo Lee, Robert Kurniawan et al. · 2020 · Research Explorer (The University of Manchester)
COVID-19 has a severe and widespread impact, especially in Indonesia. COVID-19 was first reported in Indonesia on March 03, 2020 then rapidly spread to all 34 provinces by April 09, 2020. Since then, COVID-19 is declared a state of…
Siaw Cheok Liew, Esha Dasgupta, Shew Fung Wong et al. · 2012 · Nutrition Journal
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels. METHODS: This case-control study (n = 367) was conducted to investigate the correlation of the MTHFR gene polymorphism [NM_005957] and psoriasis vulgaris amongst the Malaysian population. Overnight fa
Hyunwoo Yang, Eun Jo, Hyung Jun Kim et al. · 2020 · Journal of Clinical Medicine
Patients with odontogenic cysts and tumors may have to undergo serious surgery unless the lesion is properly detected at the early stage. The purpose of this study is to evaluate the diagnostic performance of the real-time object detecting deep convolutional neural network You Only Look Once (YOLO) v2-a deep learning algorithm that can both detect and classify an object at the same time-on panoramic radiographs. In this study, 1602 lesions on panoramic radiographs taken from 2010 to 2019 at Yonsei University Dental Hospital were selected as a database. Images were classified and labeled into f
Joseph L. Dieleman, Tara Templin · 2014 · PLoS ONE
BACKGROUND: When unaccounted-for group-level characteristics affect an outcome variable, traditional linear regression is inefficient and can be biased. The random- and fixed-effects estimators (RE and FE, respectively) are two competing methods that address these problems. While each estimator controls for otherwise unaccounted-for effects, the two estimators require different assumptions. Health researchers tend to favor RE estimation, while researchers from some other disciplines tend to favor FE estimation. In addition to RE and FE, an alternative method called within-between (WB) was sugg
Bustani Bustani, Muammar Khaddafi, Rico Nur Ilham · 2022 · International Journal of Educational Review Law And Social Sciences (IJERLAS)
This study aims to examine the effect of general allocation funds, special allocation funds and profit-sharing funds on local revenue in districts/cities in Aceh Province . This study uses secondary data, namely data obtained from the…
Bruce A. Schneider, Meital Avivi-Reich, Mindaugas Mozuraitis · 2015 · Frontiers in Psychology
A number of statistical textbooks recommend using an analysis of covariance (ANCOVA) to control for the effects of extraneous factors that might influence the dependent measure of interest. However, it is not generally recognized that serious problems of interpretation can arise when the design contains comparisons of participants sampled from different populations (classification designs). Designs that include a comparison of younger and older adults, or a comparison of musicians and non-musicians are examples of classification designs. In such cases, estimates of differences among groups can
Deniz Çakır, Cem Sevik, F. M. Peeters · 2015 · Physical Review B
The effect of the number of stacking layers and the type of stacking on the electronic and optical properties of bilayer and trilayer black phosphorus are investigated by using first-principles calculations within the framework of density…
Colin M. Sayers · 2013 · Geophysics
ABSTRACT The elastic properties of reservoir rocks are important for geomechanics applications; the most important of which are: analysis of stress changes due to production, analysis of rock deformation and failure, wellbore trajectory…
Diyi Li, Cory Koedel · 2017 · Educational Researcher
We use data from 2015–2016 to document faculty representation and wage gaps by race-ethnicity and gender in six fields at selective public universities. Consistent with widely available information, Black, Hispanic, and female professors…
Elizabeth E. Hong, Cindy Yen Okitsu, Andrew D. Smith et al. · 2013 · Molecular and Cellular Biology
Although CpG methylation clearly distributes genome-wide in vertebrate nuclear DNA, the state of methylation in the vertebrate mitochondrial genome has been unclear. Several recent reports using immunoprecipitation, mass spectrometry, and…
Núria Roura‐Pascual, Cang Hui, Takayoshi Ikeda et al. · 2010 · Proceedings of the National Academy of Sciences
Because invasive species threaten the integrity of natural ecosystems, a major goal in ecology is to develop predictive models to determine which species may become widespread and where they may invade. Indeed, considerable progress has…
US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Skin cancer is the most common type of cancer in the United States. Although invasive melanoma accounts for only 2% of all skin cancer cases, it is responsible for 80% of skin cancer deaths. Basal and squamous cell carcinoma,…
Marta Serra-García, Uri Gneezy · 2021 · Science Advances
We use publicly available data to show that published papers in top psychology, economics, and general interest journals that fail to replicate are cited more than those that replicate. This difference in citation does not change after the…
Osaretin Kayode Omoregie, John Agyekum Addae, Stanley Coffie et al. · 2019 · International Journal of Bank Marketing
Purpose The increasing number of banks in the Ghanaian banking industry has brought about intense competition in the industry. The purpose of this paper is, therefore, to examine the factors that influence retail banking customers’ loyalty…
Konrad Meister, Simona Strazdaitė, Arthur L. DeVries et al. · 2014 · Proceedings of the National Academy of Sciences
We study the properties of water at the surface of an antifreeze protein with femtosecond surface sum frequency generation spectroscopy. We find clear evidence for the presence of ice-like water layers at the ice-binding site of the…
Mengyue Niu, Yang Li, Gerald Li et al. · 2020 · European Journal of Neurology
BACKGROUND AND PURPOSE: The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α-synuclein (α-syn) in plasma neuronal exosomes as a…
Belinda van Heerwaarden, Carla M. Sgrò · 2021 · Nature Communications
Forecasting which species/ecosystems are most vulnerable to climate warming is essential to guide conservation strategies to minimize extinction. Tropical/mid-latitude species are predicted to be most at risk as they live close to their upper critical thermal limits (CTLs). However, these assessments assume that upper CTL estimates, such as CTmax, are accurate predictors of vulnerability and ignore the potential for evolution to ameliorate temperature increases. Here, we use experimental evolution to assess extinction risk and adaptation in tropical and widespread Drosophila species. We find t
Manon A. van Scheppingen, Joshua J. Jackson, Jule Specht et al. · 2016 · Social Psychological and Personality Science
Social investment theory (SIT) proposes that the transition to parenthood triggers positive personality trait change in early adulthood. Using data from a representative sample of first-time parents compared to nonparents, the results of…
Nicholas J. Sitko, Thomas S. Jayne · 2014 · Food Policy
Over the last decade, Zambia has witnessed a rapid increase in the number of medium-scale “emergent farms” cultivating 5–20 ha of land. This study analyzes the factors underpinning this growth. We find that the growth of emergent farmers…
Charles Pilgrim, Richard McIntyre, Michael Bailey · 2010 · Diseases of the Colon & Rectum
PURPOSE: There is little evidence regarding the prevalence or incidence of parastomal hernia, but it is thought to be common. Repair of parastomal hernia can be troublesome, and methods of repair need to be validated based on reduced…
Kyle Peyton, Gregory A. Huber, Alexander Coppock · 2021 · Journal of Experimental Political Science
Abstract The COVID-19 pandemic imposed new constraints on empirical research, and online data collection by social scientists increased. Generalizing from experiments conducted during this period of persistent crisis may be challenging due…
Ryan K. Shahidehpour, Rebecca E. Higdon, Nicole G. Crawford et al. · 2021 · Neurobiology of Aging
Loss of physiological microglial function may increase the propagation of neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we hypothesized age could be a cause of dystrophic microglia. Stereological counts were…
David Zendle, Paul Cairns · 2019 · PLoS ONE
Loot boxes are items in video games that contain randomised contents and can be purchased with real-world money. Similarities between loot boxes and forms of gambling have led to questions about their legal status, and whether they should be regulated as gambling. Previous research has suggested a link between the amount that gamers spend on loot boxes and their problem gambling: The more individuals spent on loot boxes, the more severe their problem gambling. However, the generalisability of prior work may be limited by both the self-selected nature of the sample under test, and the fact that
Farzana Saleh, Shirin Jahan Mumu, Ferdous Ara et al. · 2014 · BMC Public Health
BACKGROUND: Non-adherence to lifestyle modification among diabetic patients develops the short-term risks and the long-term complications as well as declines the quality of life. This study aimed to find out the association between non-adherence to self-care practices, medication and health related quality of life (HR-QoL) among type 2 diabetic patients. METHODS: At least 1 year diagnosed patients with type 2 diabetes (N = 500), age>25 years were conveniently selected from the Out-Patient Department of Bangladesh Institute of Health Sciences Hospital. Patients' self-care practices were assesse
Maximilian Christopeit, Oliver Kuß, Jürgen Finke et al. · 2013 · Journal of Clinical Oncology
PURPOSE: To evaluate the role of a second allogeneic hematopoietic stem-cell transplantation (HSCT2) given for relapsed acute leukemia (AL) after related or unrelated first hematopoietic stem-cell transplantation (HSCT1) and to analyze the…
Weiwei Zhang, Steven J. Luck · 2011 · Psychological Science
Flexible-resource theories characterize working memory as a flexible resource that can store either a large number of low-quality representations or a small number of high-quality representations. In contrast, limited-item theories propose…
Laetitia Radder, Xiliang Han · 2015 · Journal of Applied Business Research (JABR)
This study determined whether Pine and Gilmores four experience economy realms (education, entertainment, escapism and esthetics) were represented by visitors experiences of three South African heritage museums, evaluated whether their experience expectations associated with the experience realms had been met, and examined the relationship between the latter, satisfaction and behavioral intentions. In addition, the relationship between personal and trip-related factors and the experience realms was investigated. Exploratory and confirmatory factor analyses identified three experience realms -
Sarah J. Marzi, Karen Sugden, Louise Arseneault et al. · 2018 · American Journal of Psychiatry
OBJECTIVE: DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become "embedded" in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether…
Jan C. van Ours, Lenny Stoeldraijer · 2011 · De Economist
Previous empirical studies on the effect of age on productivity and wages find contradicting results. Some studies find that if workers grow older there is an increasing gap between productivity and wages, i.e. wages increase with age…
Alfredo Schiavone Panni, Simone Cerciello, Nicola Maffulli et al. · 2010 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Predisposing factors to objective patellar instability include trochlear dysplasia, patella alta, patellar tilt and elevated tibial tuberosity-femoral groove distance. The shape of the patella is classically not considered a predisposing factor. Anomalies of dynamic and static factors, including excessive patellar height, tibial tubercle lateralisation or trochlear dysplasia, may influence the development of the patella. METHODS: One hundred and five patients (140 knees) with objective patellar instability were retrospectively reviewed to identify a possible association between the ab