Negative / Null Result ReportOpen accessMedicine
Kyung‐No Son, Yong-kwan Kim, Jae‐Ku Oem et al. · 2017 · Transboundary and Emerging Diseases
Outbreaks of highly pathogenic avian influenza (HPAI) have been reported worldwide. Wild waterfowl play a major role in the maintenance and transmission of HPAI. Highly pathogenic avian influenza subtype H5N6 and H5N8 viruses simultaneously emerged in South Korea. In this study, the comparative pathogenicity and infectivity of Clade 2.3.4.4 Group B H5N8 and Group C H5N6 viruses were evaluated in Mandarin duck (Aix galericulata). None of the ducks infected with H5N6 or H5N8 viruses showed clinical signs or mortality. Serological assays revealed that the HA antigenicity of H5N8 and H5N6 viruses
View details →DOI: 10.1111/tbed.12790Cited by 26 Negative / Null Result ReportNeuroscience
Mark Alfano · 2018 · PhilPapers (PhilPapers Foundation)
Virtues are dispositions that make their bearers admirable. Dispositions can be studied scientifically by systematically varying whether their alleged bearers are in (or take themselves to be in) the dispositions' eliciting conditions. In…
View details →DOI: 10.4454/teoria.v38i2.49Cited by 26 Negative / Null Result ReportOpen accessMedicine
John K. Forrest, Steven J. Yakubov, G. Michael Deeb et al. · 2026 · Journal of the American College of Cardiology
BACKGROUND: The Evolut Low Risk trial enrolled patients with severe aortic stenosis at low surgical risk. Annual follow-up is planned for 10 years, evaluating the composite of all-cause mortality or disabling stroke and key secondary…
View details →DOI: 10.1016/j.jacc.2026.02.5063Cited by 26 Negative / Null Result ReportOpen accessMedicine
Pengyu Gong, Fei Wang, Yixin Hua et al. · 2025 · Journal of Nanobiotechnology
The highly fibrotic extracellular matrix (ECM) constitutes a major barrier that restricts the penetration and delivery efficiency of anticancer drugs, particularly in fibrotic tumors such as pancreatic cancer, in which cancer-associated…
View details →DOI: 10.1186/s12951-025-03815-yCited by 26 Negative / Null Result ReportOpen accessMedicine
Mahrukh Riaz, Muhammad Zohaib Iqbal, Agnes S. Klar et al. · 2025 · MedComm
Chronic wounds-such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)-pose a serious clinical challenge due to their prolonged inflammatory phase and impaired healing. Increasing evidence reveals that dysregulated immune responses are central to the pathogenesis of chronic wounds. A complex interplay between innate and adaptive immune cells, including macrophages, neutrophils, and T cells, contributes to chronic inflammation, extracellular matrix (ECM) degradation, and tissue repair failure. While current treatments target symptoms, they often overlook the und
View details →DOI: 10.1002/mco2.70378Cited by 26 Negative / Null Result ReportOpen accessComputer Science
David Graber, Peter Stockinger, Fabian Meyer et al. · 2025 · Nature Machine Intelligence
The field of computational drug design requires accurate scoring functions to predict binding affinities for protein-ligand interactions. However, train-test data leakage between the PDBbind database and the Comparative Assessment of Scoring Function benchmark datasets has severely inflated the performance metrics of currently available deep-learning-based binding affinity prediction models, leading to overestimation of their generalization capabilities. Here we address this issue by proposing PDBbind CleanSplit, a training dataset curated by a new structure-based filtering algorithm that elim
View details →DOI: 10.1038/s42256-025-01124-5Cited by 26 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Xiaona Yang, Hong Guo, Min Zou · 2026 · Molecular Biomedicine
Inflammatory bowel disease (IBD) is a heterogeneous group of disorders characterized primarily by chronic relapsing intestinal inflammation, encompassing Crohn's disease (CD) and ulcerative colitis (UC), affecting individuals across age groups with variable clinical manifestations. With the advancement of global industrialization, its incidence continues to rise, particularly in newly industrialized regions, which not only severely impairs patients' quality of life but also emerges as a major public health concern threatening digestive system health, accompanied by a substantial healthcare bur
View details →DOI: 10.1186/s43556-025-00395-zCited by 26 Negative / Null Result ReportOpen accessMedicine
Marelisa Albelo-Martínez, Syed Rizvi · 2025 · Neurotherapeutics
Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no relapses nor new activity on MRIs. Clinically, neurologic worsening in MS can occur in the relapsing-remitting (RRMS) phase of disease due to incomplete recovery from neuroinflammatory relapses. However, a progressive disease course is the dominant factor related to accumulating disability. There is persistent central nervous system (CNS) compa
View details →DOI: 10.1016/j.neurot.2025.e00601Cited by 26 Negative / Null Result ReportOpen accessPhysics and Astronomy
Zhi-zhong Xing, Zhen-hua Zhao, Ye-Ling Zhou · 2015 · The European Physical Journal C
The Majorana nature of massive neutrinos will be crucially probed in the next-generation experiments of the neutrinoless double-beta ( $$0\nu 2\beta $$ ) decay. The effective mass term of this process, $$\langle m\rangle _{ee}$$ , may be contaminated by new physics. So how to interpret a discovery or null result of the $$0\nu 2\beta $$ decay in the foreseeable future is highly nontrivial. In this paper we introduce a novel three-dimensional description of $$|\langle m\rangle _{ee}|$$ , which allows us to see its sensitivity to the lightest neutrino mass and two Majorana phases in a transparent
View details →DOI: 10.1140/epjc/s10052-015-3656-6Cited by 26 Negative / Null Result ReportOpen accessMedicine
James D. Doecke, Giovanni Bellomo, Lisa Vermunt et al. · 2025 · Alzheimer s & Dementia
INTRODUCTION: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value in Alzheimer's disease (AD). Here we assess which markers can best identify AD from controls and other non-AD dementias in a large international multi-center study. METHODS: Plasma samples (n = 1298) were collected from six international centers. Aβ40, Aβ42, GFAP, NfL, and p-tau181 were measured using single molecule array. In each group, AD diagnosis/co-pathology was defined according to cerebrosp
View details →DOI: 10.1002/alz.14573Cited by 25 Negative / Null Result ReportOpen accessMedicine
Saeede Saadati, Rasoul Godini, Anjana Reddy et al. · 2025 · Frontiers in Immunology
Insulin resistance is a central pathological feature of several chronic metabolic disorders, including obesity, type 2 diabetes, polycystic ovary syndrome, and cardiovascular disease. While its pathogenesis is multifactorial, lipid dysregulation and chronic low-grade inflammation are recognised as two major, interconnected processes that impair insulin action across multiple tissues. This review summarises core mechanistic themes linking these processes, with a focus on three key signalling pathways that are particularly relevant to metabolic regulation and to the interplay between lipid metab
View details →DOI: 10.3389/fimmu.2025.1692742Cited by 25 Negative / Null Result ReportOpen accessMedicine
Hezixian Guo, L.-T. Pan, Qiuyi Wu et al. · 2025 · Nutrients
Type 2 diabetes (T2D) is a complex metabolic disease characterized by chronic hyperglycemia due to insulin resistance and inadequate insulin secretion. Beyond the classically implicated organs, emerging evidence highlights the gut as a central player in T2D pathophysiology through its interactions with metabolic organs. The gut hosts trillions of microbes and enteroendocrine cells that influence inflammation, energy homeostasis, and hormone regulation. Disruptions in gut homeostasis (dysbiosis and increased permeability) have been linked to obesity, insulin resistance, and β-cell dysfunction,
View details →DOI: 10.3390/nu17162708Cited by 25 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Maurizio Agelli, Nicola Corona, Fabio Maggio et al. · 2024 · Machines
Continuous crop monitoring enables the early detection of field emergencies such as pests, diseases, and nutritional deficits, allowing for less invasive interventions and yielding economic, environmental, and health benefits. The work organization of modern agriculture, however, is not compatible with continuous human monitoring. ICT can facilitate this process using autonomous Unmanned Ground Vehicles (UGVs) to navigate crops, detect issues, georeference them, and report to human experts in real time. This review evaluates the current state of ICT technology to determine if it supports auton
View details →DOI: 10.3390/machines12110750Cited by 25 Negative / Null Result ReportOpen accessNeuroscience
Sophie E. Field, Annabel J. Curle, Roger A. Barker · 2024 · Expert Opinion on Investigational Drugs
INTRODUCTION: Huntington's Disease (HD) is a genetic neurodegenerative disease for which there is currently no disease-modifying treatment. One of several underlying mechanisms proposed to be involved in HD pathogenesis is inflammation;…
View details →DOI: 10.1080/13543784.2024.2348738Cited by 25 Negative / Null Result ReportOpen accessMedicine
Marta Celorrio, Kirill Shumilov, Camryn Payne et al. · 2022 · Acta Neuropathologica Communications
Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration. Minocycline, an inhibitor of microglial activation, has been shown to be neuroprotective when administered early after experimental TBI but detrimental when administered chronically to human TBI survivors. Rather than focusing on the rescue of primary injury with early administration of therapeutics which may not be clinically feasible, we hypothesiz
View details →DOI: 10.1186/s40478-022-01310-1Cited by 25 Negative / Null Result ReportOpen accessMedicine
Noha Mahmoud Youssef, Azza Mohammed Abdelmohsen, Ahmed Atteya Ashour et al. · 2026 · PubMed
BACKGROUND: Chronic ankle instability (CAI) is a common sequence of ankle sprain. Conservative treatment of CAI is currently accepted as a primary mean of managing the condition and preventing of recurrence. OBJECTIVES: The purpose of the…
View details →DOI: 10.82161/1vv8-sf51Cited by 25 Negative / Null Result ReportOpen accessPsychology
Bram Van Bockstaele, Elske Salemink, Susan M. Bögels et al. · 2015 · Cognition & Emotion
Although attentional bias modification (ABM) can change anxiety, recent studies failed to replicate such effects, possibly because the visual probe ABM failed to induce changes in attentional bias (AB). We investigated whether visual probe…
View details →DOI: 10.1080/02699931.2015.1092418Cited by 25 Negative / Null Result ReportOpen accessComputer Science
Preesha Premsagar, Colleen Aldous, Tonya M. Esterhuizen et al. · 2022 · Informatics in Medicine Unlocked
Machine learning is used to process big data volumes with complex non-linear relationships between predictive variables and predictions. Research into the usefulness of machine learning in small data volumes remains limited. To compare…
View details →DOI: 10.1016/j.imu.2022.101103Cited by 25 Negative / Null Result ReportOpen accessVeterinary
Rachael L. Brown · 2017 · Animal Sentience
Birch’s formulation is persuasive but not nuanced enough to capture at least one situation where it is reasonable to invoke the precautionary principle (PP): when we have multiple, weak, but convergent, lines of evidence that a species is…
View details →DOI: 10.51291/2377-7478.1247Cited by 25 Negative / Null Result ReportMedicine
Fabienne Marcellin, C. Lions, Éric Rosenthal et al. · 2016 · Drug and Alcohol Review
INTRODUCTION AND AIMS: Despite cannabis use being very common in patients co-infected with HIV and hepatitis C virus (HCV), its effect on these patients' immune systems remains undocumented. Documenting the potential effect of cannabis use…
View details →DOI: 10.1111/dar.12398Cited by 25 Negative / Null Result ReportOpen accessNeuroscience
Sang‐Rae Lee, Hong J. Lee, Sang-Hoon Cha et al. · 2015 · Cell Transplantation
Cellular fate of human neural stem cells (hNSCs) transplanted in the brain of nonhuman primates (NHPs) with no immunosuppression was determined at 22 and 24 months posttransplantation (PTx) regarding survival, differentiation, and tumorigenesis. Survival of hNSCs labeled with magnetic nanoparticles was successfully detected around injection sites in the brain at 22 months PTx by MRI. Histological examination of brain sections with H&E and Prussian blue staining at 24 months revealed that most of the grafted hNSCs were found located along the injection tract. Grafted hNSCs were found to differe
View details →DOI: 10.3727/096368914x678526Cited by 25 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Suzanne Birner, Elizabeth Cottrell, J. M. Warren et al. · 2021 · Earth and Planetary Science Letters
Mid-ocean ridge peridotites record significantly greater variability in major and trace elements, isotopic compositions, and thermodynamic properties such as oxygen fugacity (fO2) than do their basaltic counterparts. This variability may derive from modern ridge processes related to melting and melt-rock interaction or from long-lived source heterogeneity related to recycled material or ancient melting events. In this study, we investigate variations in spinel geochemistry as well as silicate major and trace element chemistry and oxygen fugacity of a suite of peridotites from a single segment
View details →DOI: 10.1016/j.epsl.2021.116951Cited by 25 Replication FailureOpen accessPsychology
Nicole Harlaar, Emma L. Meaburn, Marianna E. Hayiou‐Thomas et al. · 2014 · Journal of Speech Language and Hearing Research
PURPOSE: Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the…
View details →DOI: 10.1044/1092-4388(2013/12-0303)Cited by 25 Negative / Null Result ReportOpen accessPsychology
Nivedita Mani, Melanie S. Schreiner, Julia Brase et al. · 2021 · Developmental Science
Developmental research, like many fields, is plagued by low sample sizes and inconclusive findings. The problem is amplified by the difficulties associated with recruiting infant participants for research as well as the increased variability in infant responses. With sequential testing designs providing a viable alternative to paradigms facing such issues, the current study implemented a Sequential Bayes Factor (SBF) design on three findings in the developmental literature. In particular, using the framework described by Schönbrödt and colleagues (2017), we examined infants' sensitivity to mis
View details →DOI: 10.1111/desc.13097Cited by 25 Negative / Null Result ReportOpen accessEngineering
Matthew D. Wadge, Bryan W. Stuart, Kathryn G. Thomas et al. · 2018 · Materials & Design
Infection negation and biofilm prevention are necessary developments needed for implant materials. Furthermore, an increase in publications regarding gallium (Ga) as an antimicrobial ion has resulted in bacterial-inhibitory surfaces incorporating gallium as opposed to silver (Ag). The authors present the production of novel gallium titanate surfaces through hydrothermal ion-exchange reactions. Commercially-pure Ti (S0: Cp-Ti) was initially suspended in NaOH solutions to obtain sodium titanate (S1: Na2TiO3) layers ca. 0.5–1 μm in depth (2.4 at.% Na). Subsequent suspension in Ga(NO3)3 (S2: Ga2(T
View details →DOI: 10.1016/j.matdes.2018.05.060Cited by 25 Failed Experiment Report
Vitória Piai, Kristoffer Dahlslätt, Eric Maris · 2014 · Psychophysiology
Abstract When making statistical comparisons, the temporal dimension of the EEG signal introduces problems. Guthrie and Buchwald (1991) proposed a formally correct statistical approach that deals with these problems: comparing waveforms by…
View details →DOI: 10.1111/psyp.12335Cited by 25 Negative / Null Result ReportOpen accessHealth Professions
Tom Koeman, Pauline Slottje, Hans Kromhout et al. · 2013 · Occupational and Environmental Medicine
OBJECTIVES: Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies…
View details →DOI: 10.1136/oemed-2012-100889Cited by 25 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Yeoh Kai Qing, Suhal Kusairi · 2019 · WIDYAKALA JOURNAL OF PEMBANGUNAN JAYA UNIVERSITY
The stock market has become a significant role in the economy and has attracted investor's attention, as it is to generate funds and make an investment decision for companies and investors as well. Therefore, the objective of this study is…
View details →DOI: 10.36262/widyakala.v6i2.217Cited by 25 Negative / Null Result ReportChemistry
Priyanka Lahiri, Kenneth B. Wiberg, Patrick H. Vaccaro · 2013 · The Journal of Physical Chemistry A
The optical rotatory dispersion of two monocyclic ketones, (R)-3-methylcyclopentanone [R-3MCP] and (R)-3-methylcyclohexanone [R-3MCH], has been investigated under isolated and solvated conditions to explore the role of ring size/morphology…
View details →DOI: 10.1021/jp4089194Cited by 25 Negative / Null Result ReportOpen accessNeuroscience
David R. Roalf, Martijn Figee, Desmond J. Oathes · 2024 · Translational Psychiatry
Although neuroimaging has been widely applied in psychiatry, much of the exuberance in decades past has been tempered by failed replications and a lack of definitive evidence to support the utility of imaging to inform clinical decisions. There are multiple promising ways forward to demonstrate the relevance of neuroimaging for psychiatry at the individual patient level. Ultra-high field magnetic resonance imaging is developing as a sensitive measure of neurometabolic processes of particular relevance that holds promise as a new way to characterize patient abnormalities as well as variability
View details →DOI: 10.1038/s41398-024-02781-7Cited by 25 