A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Phyllis Chan, Xiaofei Zhou, Nina Wang et al. · 2020 · CPT Pharmacometrics & Systems Pharmacology
Machine learning (ML) was used to leverage tumor growth inhibition (TGI) metrics to characterize the relationship with overall survival (OS) as a novel approach and to compare with traditional TGI-OS modeling methods. Historical dataset…
Alexandra Calmy, Mark Bloch, Handan Wand et al. · 2010 · HIV Medicine
BACKGROUND: Lipoatrophy can complicate thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI)-based antiretroviral therapy (ART). Lipoatrophy may be less likely with ART including ritonavir-boosted lopinavir (LPV/r). Small,…
Boris Blechacz, Gregory J. Gores · 2010 · Hepatology
A 66-year-old male patient who is hepatitis C RNA–positive without cirrhosis has been found to have a mass on ultrasound examination of the liver. The physical examination is unremarkable. The hemoglobin, white cell count, and platelet…
Kate M. Quigley, Magena R. Marzonie, Blake D. Ramsby et al. · 2021 · Frontiers in Marine Science
Novel restoration methods are currently under consideration worldwide to help coral reefs recover or become more resilient to higher temperature stress. Critical field-based information concerning the paradigm of “local is best” is lacking for many methods; information which is essential to determine the risk and feasibility associated with restoration. One method involves breeding corals from different reef regions with expected variation in heat tolerance and moving those offspring to new locations to enhance offspring survival; thereby augmenting local stock to enhance survival for anticipa
Takudzwa C. Madzivanzira, Josie South, Olaf L. F. Weyl · 2021 · Freshwater Biology
Abstract Data on ecological impacts of freshwater crayfish invasions in Africa are scarce but invasion history suggests the likelihood of negative implications for biodiversity. To evaluate the potential for ecological impacts we describe…
Jacob Guinot, Sandra Miralles, Alma Rodríguez-Sánchez et al. · 2020 · Employee Relations: The International Journal
Purpose Based on a new management paradigm rooted on care and compassion, this study explores the consequences of compassion at work on organizational learning and firm performance. Design/methodology/approach Structural equation modeling…
Talia Gonda, Frank P Deane, Ganapathi Murugesan · 2012 · Australian & New Zealand Journal of Psychiatry
Objective: The first aim of this study was to assess the proportion of patients who achieved reliable and clinically significant change over the course of treatment in an inpatient psychosocial rehabilitation program. The second aim was to…
Basil Wahn, Artur Czeszumski, Peter König · 2018 · PLoS ONE
When humans perform tasks together, they may reach a higher performance in comparison to the best member of a group (i.e., a collective benefit). Earlier research showed that interindividual performance similarities predict collective benefits for several joint tasks. Yet, researchers did not test whether this is the case for joint visuospatial tasks. Also, researchers did not investigate whether dyads and triads reach a collective benefit when they are forbidden to exchange any information while performing a visuospatial task. In this study, participants performed a joint visual search task e
Annelies Spek, Evert Scholte, Ina A. van Berckelaer‐Onnes · 2010 · Journal of Autism and Developmental Disorders
Local information processing in 42 adults with high functioning autism, 41 adults with Asperger syndrome and 41 neurotypical adults was examined. Contrary to our expectations, the disorder groups did not outperform the neurotypical group…
Erich Hoppmann · 2026 · ORDO
Der Wirtschaftspolitische Ausschus des Deutschen Bundestages erklarte bei Erlas des Kartellgesetzes, er konne und wolle den Wettbewerbsbegriff nicht definieren, das sei eine Angelegen heit der zustandigen Fachdisziplin1. Diese Aufforderung…
Amy Armstrong, Fleur Coburn, Yanyamba Nsereko et al. · 2025 · Journal of Peptide Science
Peptide-drug conjugates (PDCs) are advancing as targeted cancer therapies, leveraging lessons from antibody-drug conjugates (ADCs) to improve tumour specificity. These molecules combine a homing peptide with a cytotoxic payload via a linker, enabling precise drug delivery while sparing healthy tissue. Despite their potential, PDCs face challenges including metabolic instability, premature payload release and rapid clearance, limiting clinical success. Only Lutathera remains FDA-approved after Pepaxto's withdrawal, though Pepaxto retains EMA and MHRA approval-highlighting regulatory and technic
Tamara Beres Lederer Goldberg, Carla Cristiane da Silva, Luciana Peres et al. · 2026 · Archivos Latinoamericanos de Nutrición
Adolescents' eating habits are determined by social, psychological, economic, political, and educational influences. They tend to prefer foods with inadequate nutritional value and high fat and carbohydrate content which leads to excessive…
Marelisa Albelo-Martínez, Syed Rizvi · 2025 · Neurotherapeutics
Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no relapses nor new activity on MRIs. Clinically, neurologic worsening in MS can occur in the relapsing-remitting (RRMS) phase of disease due to incomplete recovery from neuroinflammatory relapses. However, a progressive disease course is the dominant factor related to accumulating disability. There is persistent central nervous system (CNS) compa
Pengyu Gong, Fei Wang, Yixin Hua et al. · 2025 · Journal of Nanobiotechnology
The highly fibrotic extracellular matrix (ECM) constitutes a major barrier that restricts the penetration and delivery efficiency of anticancer drugs, particularly in fibrotic tumors such as pancreatic cancer, in which cancer-associated…
José Marı́a Tolosana, Emilce Trucco, Malek Khatib et al. · 2013 · European Journal of Heart Failure
AIMS: A maximum percentage of ventricular pacing is mandatory to obtain a good response to CRT. Atrioventricular junction (AVJ) ablation has been recommended to attain this objective in patients with AF. THE AIMS OF OUR STUDY WERE: (i) to…
Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto et al. · 2019 · Lara D. Veeken
OBJECTIVES: To elucidate the association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis (AAV). METHODS: Peripheral blood from 36 patients with active AAV and 18 healthy controls was…
Mona Ghannad, Bada Yang, Mariska Leeflang et al. · 2020 · Journal of Clinical Epidemiology
OBJECTIVE: To estimate the effect of an intervention compared to the usual peer-review process on reducing spin in the abstract's conclusion of biomedical study reports. STUDY DESIGN AND SETTING: We conducted a two-arm, parallel-group RCT in a sample of primary research manuscripts submitted to BMJ Open. The authors received short instructions alongside the peer reviewers' comments in the intervention group. We assessed the presence of spin (primary outcome), types of spin, and wording change in the revised abstract's conclusion. Outcome assessors were blinded to the intervention assignment. R
Matthew S. Freiberg, Debbie M. Cheng, Natalia Gnatienko et al. · 2020 · JAMA Network Open
Importance: Zinc supplementation can reduce alcohol-related microbial translocation and inflammation. Objective: To assess whether zinc supplementation reduces markers of mortality and risk of cardiovascular disease, reduces levels of inflammation and microbial translocation, and slows HIV disease progression in people with heavy alcohol use who are living with HIV/AIDS. Design, Setting, and Participants: This study is a double-blinded placebo-controlled randomized clinical trial of zinc supplementation among participants recruited from 2013 to 2015. Participants were recruited from HIV and ad
Gardênia Marinho Cordeiro, M.F. Figueirêdo, Wagner Brandão Ramos et al. · 2017 · Industrial & Engineering Chemistry Research
Currently, process intensification using dividing-wall columns (DWCs) is one of the most promising alternatives for reducing the costs of the distillation process. However, for extractive distillation, there are still questions regarding…
W-J Xiao, J-W He, H Zhang et al. · 2010 · International Journal of Obesity
OBJECTIVE: Arachidonate 12-lipoxygenase (ALOX12) is a member of the lipoxygenase superfamily, which catalyzes the incorporation of molecular oxygen into polyunsaturated fatty acids. The products of ALOX12 reactions serve as endogenous…
Bingwen Zou, Tao Li, Qiang Zhou et al. · 2016 · Medicine
To evaluate the treatment pattern and survival of patients receiving radical resection for primary small cell carcinoma of the esophagus (PSCCE).This retrospective study included 150 patients who received radical resection of PSCCE. Data were retrieved from 4 centers in Western China. Thirty-nine of 150 patients received postoperative chemo-radiotherapy, 62 received postoperative chemotherapy, and 49 received radical resection only. The median radiation dosage was 50 Gy. The chemotherapeutic regimen was platinum-based and lasted for 2 to 6 cycles (median, 3).Median disease-free survival (mDFS)
Robert Young, Daniel Vincent Riordan, Cameron Stark · 2011 · BMC Public Health
BACKGROUND: Past studies using large population based datasets link certain perinatal circumstances (birth weight, parity, etc) with mental health outcomes such as suicide, self-harm and psychiatric problems. Problematically, population datasets omit a number of social confounds. The aim of this study is to replicate past research linking perinatal circumstances and mental health (suicidality and use of psychiatric services) and to determine if such associations remain after adjusting for social circumstances. METHODS: A longitudinal school-based survey of 2157 young people (surveyed at age 11
Madeleine P. J. White, Chris Johnston, John R. Grainger et al. · 2020 · Frontiers in Immunology
Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimise excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune diseases. Multiple sclerosis (MS) is a severe autoimmune disease characterised by inflammatory lesions within the central nervous system; there are very limited therapeutic options for the progressive forms of the disease and none are curative. Here, we used the experimental autoimmune encephalomyelitis (EAE) model to examine if the intestinal helminth He
Mark P. Purdue, Yuanqing Ye, Zhaoming Wang et al. · 2013 · Cancer Epidemiology Biomarkers & Prevention
Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) in populations of European ancestry have identified four susceptibility loci. No GWAS has been conducted among African Americans (AA), who experience a higher incidence…
Joshua A. Beckman, Allison B. Goldfine, Alison Goldin et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Antagonism of protein kinase Cbeta (PKCbeta) restores endothelial function in experimental models of diabetes and prevents vascular dysfunction in response to hyperglycemia in healthy humans. OBJECTIVE: We tested the hypothesis…
Anne‐Sophie Jannot, Xavier Vuillemin, Isabelle Étienne et al. · 2016 · Therapeutic Drug Monitoring
BACKGROUND: POR*28 is a recently newly described allelic variant of the cytochrome P450 oxidoreductase (POR), which might be associated with an increased metabolic activity of P450 cytochromes (CYP) 3A5 and 3A4. Consequently, carriers of…
I. Krzyzewska, Judith Ensink, Laura Nawijn et al. · 2018 · European Journal of Human Genetics
Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder that may develop after a traumatic event. Here we aimed to identify epigenetic and genetic loci associated with PTSD. We included 73 traumatized police officers…
Eleni Frangou, Panagiotis Garantziotis, Maria Grigoriou et al. · 2022 · Annals of the Rheumatic Diseases
OBJECTIVES: Patients with lupus nephritis (LN) are in urgent need for early diagnosis and therapeutic interventions targeting aberrant molecular pathways enriched in affected kidneys. METHODS: We used mRNA-sequencing in effector (spleen) and target (kidneys, brain) tissues from lupus and control mice at sequential time points, and in the blood from 367 individuals (261 systemic lupus erythematosus (SLE) patients and 106 healthy individuals). Comparative cross-tissue and cross-species analyses were performed. The human dataset was split into training and validation sets and machine learning was
Matthias Diebold, Hannes Vietzen, Andreas Heinzel et al. · 2023 · American Journal of Transplantation
Antibody-mediated rejection (ABMR) is a leading cause of graft failure. Emerging evidence suggests a significant contribution of natural killer (NK) cells to microvascular inflammation (MVI). We investigated the influence of genetically determined NK cell functionality on ABMR development and activity. The study included 86 kidney transplant recipients subjected to systematic biopsies triggered by donor-specific antibody detection. We performed killer immunoglobulin-like receptor typing to predict missing self and genotyped polymorphisms determining NK cell functionality (FCGR3AV/F158 [rs39699
Rebecca C. Richmond, Carlos Sillero‐Rejon, Jasmine Khouja et al. · 2021 · Clinical Epigenetics
Abstract Background Little evidence exists on the health effects of e-cigarette use. DNA methylation may serve as a biomarker for exposure and could be predictive of future health risk. We aimed to investigate the DNA methylation profile of e-cigarette use. Results Among 117 smokers, 117 non-smokers and 116 non-smoking vapers, we evaluated associations between e-cigarette use and epigenome-wide methylation from saliva. DNA methylation at 7 cytosine-phosphate-guanine sites (CpGs) was associated with e-cigarette use at p < 1 × 10 –5 and none at p < 5.91 × 10 –8 . 13 CpGs were associated wi