Negative / Null Result ReportOpen accessNeuroscience
Sang‐Rae Lee, Hong J. Lee, Sang-Hoon Cha et al. · 2015 · Cell Transplantation
Cellular fate of human neural stem cells (hNSCs) transplanted in the brain of nonhuman primates (NHPs) with no immunosuppression was determined at 22 and 24 months posttransplantation (PTx) regarding survival, differentiation, and tumorigenesis. Survival of hNSCs labeled with magnetic nanoparticles was successfully detected around injection sites in the brain at 22 months PTx by MRI. Histological examination of brain sections with H&E and Prussian blue staining at 24 months revealed that most of the grafted hNSCs were found located along the injection tract. Grafted hNSCs were found to differe
View details →DOI: 10.3727/096368914x678526Cited by 25 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Suzanne Birner, Elizabeth Cottrell, J. M. Warren et al. · 2021 · Earth and Planetary Science Letters
Mid-ocean ridge peridotites record significantly greater variability in major and trace elements, isotopic compositions, and thermodynamic properties such as oxygen fugacity (fO2) than do their basaltic counterparts. This variability may derive from modern ridge processes related to melting and melt-rock interaction or from long-lived source heterogeneity related to recycled material or ancient melting events. In this study, we investigate variations in spinel geochemistry as well as silicate major and trace element chemistry and oxygen fugacity of a suite of peridotites from a single segment
View details →DOI: 10.1016/j.epsl.2021.116951Cited by 25 Replication FailureOpen accessPsychology
Nicole Harlaar, Emma L. Meaburn, Marianna E. Hayiou‐Thomas et al. · 2014 · Journal of Speech Language and Hearing Research
PURPOSE: Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the…
View details →DOI: 10.1044/1092-4388(2013/12-0303)Cited by 25 Negative / Null Result ReportOpen accessPsychology
Nivedita Mani, Melanie S. Schreiner, Julia Brase et al. · 2021 · Developmental Science
Developmental research, like many fields, is plagued by low sample sizes and inconclusive findings. The problem is amplified by the difficulties associated with recruiting infant participants for research as well as the increased variability in infant responses. With sequential testing designs providing a viable alternative to paradigms facing such issues, the current study implemented a Sequential Bayes Factor (SBF) design on three findings in the developmental literature. In particular, using the framework described by Schönbrödt and colleagues (2017), we examined infants' sensitivity to mis
View details →DOI: 10.1111/desc.13097Cited by 25 Negative / Null Result ReportOpen accessEngineering
Matthew D. Wadge, Bryan W. Stuart, Kathryn G. Thomas et al. · 2018 · Materials & Design
Infection negation and biofilm prevention are necessary developments needed for implant materials. Furthermore, an increase in publications regarding gallium (Ga) as an antimicrobial ion has resulted in bacterial-inhibitory surfaces incorporating gallium as opposed to silver (Ag). The authors present the production of novel gallium titanate surfaces through hydrothermal ion-exchange reactions. Commercially-pure Ti (S0: Cp-Ti) was initially suspended in NaOH solutions to obtain sodium titanate (S1: Na2TiO3) layers ca. 0.5–1 μm in depth (2.4 at.% Na). Subsequent suspension in Ga(NO3)3 (S2: Ga2(T
View details →DOI: 10.1016/j.matdes.2018.05.060Cited by 25 Failed Experiment Report
Vitória Piai, Kristoffer Dahlslätt, Eric Maris · 2014 · Psychophysiology
Abstract When making statistical comparisons, the temporal dimension of the EEG signal introduces problems. Guthrie and Buchwald (1991) proposed a formally correct statistical approach that deals with these problems: comparing waveforms by…
View details →DOI: 10.1111/psyp.12335Cited by 25 Negative / Null Result ReportOpen accessHealth Professions
Tom Koeman, Pauline Slottje, Hans Kromhout et al. · 2013 · Occupational and Environmental Medicine
OBJECTIVES: Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies…
View details →DOI: 10.1136/oemed-2012-100889Cited by 25 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Yeoh Kai Qing, Suhal Kusairi · 2019 · WIDYAKALA JOURNAL OF PEMBANGUNAN JAYA UNIVERSITY
The stock market has become a significant role in the economy and has attracted investor's attention, as it is to generate funds and make an investment decision for companies and investors as well. Therefore, the objective of this study is…
View details →DOI: 10.36262/widyakala.v6i2.217Cited by 25 Negative / Null Result ReportChemistry
Priyanka Lahiri, Kenneth B. Wiberg, Patrick H. Vaccaro · 2013 · The Journal of Physical Chemistry A
The optical rotatory dispersion of two monocyclic ketones, (R)-3-methylcyclopentanone [R-3MCP] and (R)-3-methylcyclohexanone [R-3MCH], has been investigated under isolated and solvated conditions to explore the role of ring size/morphology…
View details →DOI: 10.1021/jp4089194Cited by 25 Negative / Null Result ReportOpen accessNeuroscience
David R. Roalf, Martijn Figee, Desmond J. Oathes · 2024 · Translational Psychiatry
Although neuroimaging has been widely applied in psychiatry, much of the exuberance in decades past has been tempered by failed replications and a lack of definitive evidence to support the utility of imaging to inform clinical decisions. There are multiple promising ways forward to demonstrate the relevance of neuroimaging for psychiatry at the individual patient level. Ultra-high field magnetic resonance imaging is developing as a sensitive measure of neurometabolic processes of particular relevance that holds promise as a new way to characterize patient abnormalities as well as variability
View details →DOI: 10.1038/s41398-024-02781-7Cited by 25 Negative / Null Result Report
J. Duguay, P. M. Biron, J. Lacey · 2022 · Water Resources Research
Abstract When rivers collide, complex three‐dimensional coherent flow structures are generated along the confluence's mixing interface. These structures mix streamborne pollutants and suspended sediment and have considerable bearing on the…
View details →DOI: 10.1029/2021wr031527Cited by 25 Negative / Null Result Report
Travis M. Seale-Carlisle, Laura Mickes · 2016 · Royal Society Open Science
In the USA and the UK, many thousands of police suspects are identified by eyewitnesses every year. Unfortunately, many of those suspects are innocent, which becomes evident when they are exonerated by DNA testing, often after having been…
View details →DOI: 10.1098/rsos.160300Cited by 25 Negative / Null Result ReportOpen accessMedicine
Saeede Saadati, Rasoul Godini, Anjana Reddy et al. · 2025 · Frontiers in Immunology
Insulin resistance is a central pathological feature of several chronic metabolic disorders, including obesity, type 2 diabetes, polycystic ovary syndrome, and cardiovascular disease. While its pathogenesis is multifactorial, lipid dysregulation and chronic low-grade inflammation are recognised as two major, interconnected processes that impair insulin action across multiple tissues. This review summarises core mechanistic themes linking these processes, with a focus on three key signalling pathways that are particularly relevant to metabolic regulation and to the interplay between lipid metab
View details →DOI: 10.3389/fimmu.2025.1692742Cited by 25 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Maurizio Agelli, Nicola Corona, Fabio Maggio et al. · 2024 · Machines
Continuous crop monitoring enables the early detection of field emergencies such as pests, diseases, and nutritional deficits, allowing for less invasive interventions and yielding economic, environmental, and health benefits. The work organization of modern agriculture, however, is not compatible with continuous human monitoring. ICT can facilitate this process using autonomous Unmanned Ground Vehicles (UGVs) to navigate crops, detect issues, georeference them, and report to human experts in real time. This review evaluates the current state of ICT technology to determine if it supports auton
View details →DOI: 10.3390/machines12110750Cited by 25 Negative / Null Result ReportOpen accessEnvironmental Science
Michele Duarte de Menezes, Sérgio Henrique Godinho Silva, Carlos Rogério de Mello et al. · 2016 · Scientia Agricola
This study compared the performance of ordinary kriging (OK) and regression kriging (RK) to predict soil physical-chemical properties in topsoil (0-15 cm). Mean prediction of error and root mean square of prediction error were used to assess the prediction methods. Two watersheds with contrasting soil-landscape features were studied, for which the prediction methods were performed differently. A multiple linear stepwise regression model was performed with RK using digital terrain models (DTMs) and remote sensing images in order to choose the best auxiliary covariates. Different pedogenic facto
View details →DOI: 10.1590/0103-9016-2015-0071Cited by 25 Negative / Null Result ReportOpen accessMedicine
Oliver Shutkever, David J. Gracie, Caroline Young et al. · 2018 · Inflammatory Bowel Diseases
Background: The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD…
View details →DOI: 10.1093/ibd/izy052Cited by 25 Negative / Null Result ReportOpen accessEnvironmental Science
Chris H. Carlson, Solomon Z. Dobrowski, Hugh D. Safford · 2012 · Carbon Balance and Management
BACKGROUND: Forest fuel treatments have been proposed as tools to stabilize carbon stocks in fire-prone forests in the Western U.S.A. Although fuel treatments such as thinning and burning are known to immediately reduce forest carbon stocks, there are suggestions that these losses may be paid back over the long-term if treatments sufficiently reduce future wildfire severity, or prevent deforestation. Although fire severity and post-fire tree regeneration have been indicated as important influences on long-term carbon dynamics, it remains unclear how natural variability in these processes might
View details →DOI: 10.1186/1750-0680-7-7Cited by 25 Negative / Null Result ReportOpen accessMedicine
Mikael Fink Vallentin, Asger Granfeldt, Carsten Meilandt et al. · 2022 · Resuscitation
OBJECTIVE: The Calcium for Out-of-hospital Cardiac Arrest (COCA) trial was a randomized, placebo-controlled, double-blind trial of calcium for out-of-hospital cardiac arrest. The primary and secondary outcomes have been reported previously. This article describes the long-term outcomes of the trial. METHODS: Patients aged ≥18 years were included if they had a non-traumatic out-of-hospital cardiac arrest during which they received adrenaline. The trial drug consisted of calcium chloride (5 mmol) or saline placebo given after the first dose of adrenaline and again after the second dose of adrena
View details →DOI: 10.1016/j.resuscitation.2022.07.034Cited by 25 Negative / Null Result ReportOpen accessMedicine
Paul Blanc‐Durand, Axel Van Der Gucht, Antoine Verger et al. · 2018 · PLoS ONE
INTRODUCTION: Aim was to develop a full automatic clustering approach of the time-activity curves (TAC) from dynamic 18F-FET PET and evaluate its association with IDH1 mutation status and survival in patients with gliomas. METHODS: Thirty-seven patients (mean age: 45±13 y) with newly diagnosed gliomas and dynamic 18F-FET PET before any histopathologic investigation or treatment were retrospectively included. Each dynamic 18F-FET PET was realigned to the first image and spatially normalized in the Montreal Neurological Institute template. A tumor mask was semi-automatically generated from Z-sco
View details →DOI: 10.1371/journal.pone.0199379Cited by 25 Abandoned Hypothesis
Kariem Ezzat, Andrea Sturchio, Alberto J. Espay · 2022 · Biology
Protein aggregation into amyloid fibrils affects many proteins in a variety of diseases, including neurodegenerative disorders, diabetes, and cancer. Physicochemically, amyloid formation is a phase transition process, where soluble…
View details →DOI: 10.3390/biology11040535Cited by 25 Negative / Null Result ReportOpen accessMedicine
Jinhua Chen, Yu‐Chun Yen, Shing‐Hwa Liu et al. · 2016 · Medicine
The use of induction chemotherapy (CT) is controversial. We compared the survival of head and neck cancer patients receiving docetaxel- or platinum-based induction CT before concomitant chemoradiotherapy (CCRT) with the survival of those receiving upfront CCRT alone. Data from the National Health Insurance and cancer registry databases in Taiwan were linked and analyzed. We enrolled patients who had head and neck cancer between January 1, 2002 and December 31, 2011. Follow-up was from the index date to December 31, 2013. We included head and neck patients diagnosed according to the Internation
View details →DOI: 10.1097/md.0000000000002845Cited by 25 Negative / Null Result ReportOpen accessSocial Sciences
Laura M. Wasielewski · 2016 · Journal of Catholic Education
The purpose of this study was to determine if students with disabilities perform comparably to students without disabilities academically at a small liberal arts college. Quantitative results were gathered through the comparison of end of semester and cumulative grade point averages for students with disabilities and students without disabilities (n=56). The t test for independent means and a 2-way analysis of variance were used to test hypotheses. Students without disabilities had significantly higher academic performances than students with disabilities as measured by grade point averages. F
View details →DOI: 10.15365/joce.2001062016Cited by 25 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sean M. Carroll, Katherine S. Xue, Christopher J. Marx · 2014 · BMC Microbiology
BACKGROUND: A common assumption of microorganisms is that laboratory stocks will remain genetically and phenotypically constant over time, and across laboratories. It is becoming increasingly clear, however, that mutations can ruin strain integrity and drive the divergence or "domestication" of stocks. Since its discovery in 1960, a stock of Methylobacterium extorquens AM1 ("AM1") has remained in the lab, propagated across numerous growth and storage conditions, researchers, and facilities. To explore the extent to which this lineage has diverged, we compared our own "Modern" stock of AM1 to a
View details →DOI: 10.1186/1471-2180-14-2Cited by 25 Negative / Null Result ReportOpen accessEnvironmental Science
Patrick Moore, R. Justin DeRose, James N. Long et al. · 2012 · Forests
Enhancement of forest growth through silvicultural modification of stand density is one strategy for increasing carbon (C) sequestration. Using the Fire and Fuels Extension of the Forest Vegetation Simulator, the effects of even-aged, uneven-aged and no-action management scenarios on C sequestration in a southern Appalachian red spruce-Fraser fir forest were modeled. We explicitly considered C stored in standing forest stocks and the fate of forest products derived from harvesting. Over a 100-year simulation period the even-aged scenario (250 Mg C ha−1) outperformed the no-action scenario (241
View details →DOI: 10.3390/f3020300Cited by 25 Failed Experiment Report
Lukas Ernstbrunner, Torsten Pastor, Manuel Waltenspül et al. · 2021 · The American Journal of Sports Medicine
Background: The Latarjet is a successful procedure but can be associated with significant complications, including failure. Iliac crest bone grafting (ICBG) is one of the salvage options for such failure. Purpose: To analyze factors…
View details →DOI: 10.1177/03635465211040468Cited by 25 Negative / Null Result ReportOpen accessMedicine
Min Liu, Zhiyao Wang, Huifang Shang · 2024 · Journal of Neurology
Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is pathologically characterized by oligodendroglial cytoplasmic inclusions containing abnormally aggregated α-synuclein. According to the updated Movement Disorder Society diagnostic criteria for multiple system atrophy, the diagnosis of clinically established multiple system atrophy requires the manifestation of autonomic dysfunction in combination with poorly levo-dopa responsive parkinsoni
View details →DOI: 10.1007/s00415-024-12269-5Cited by 24 Negative / Null Result Report
Marie R. Johnston, Nick J. Balster, Anita M. Thompson · 2020 · Water
Rain gardens are residential bioretention practices widely used to manage urban runoff, yet their design as plant-soil systems lacks understanding. We hypothesized that vegetative treatment (turfgrass, prairie, and shrubs, plus a…
View details →DOI: 10.3390/w12113151Cited by 24 Negative / Null Result ReportOpen accessEnergy
Casey M. Godwin, David C. Hietala, Aubrey R. Lashaway et al. · 2017 · Environmental Science & Technology
For algal biofuels to be economically sustainable and avoid exacerbating nutrient pollution, algal cultivation and processing must maximize rates of biofuel production while simultaneously minimizing the consumption of nitrogen (N) and…
View details →DOI: 10.1021/acs.est.7b02137Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Boshu Ru, Dingcheng Li, Yueqi Hu et al. · 2019 · IEEE Transactions on NanoBioscience
Serendipitous drug usage refers to the unexpected relief of comorbid diseases or symptoms when taking medication for a different known indication. Historically, serendipity has contributed significantly to identifying many new drug…
View details →DOI: 10.1109/tnb.2019.2909094Cited by 24 Negative / Null Result Report
Asia Mendelevich, Svetlana Vinogradova, Saumya Gupta et al. · 2021 · Nature Communications
Abstract A sensitive approach to quantitative analysis of transcriptional regulation in diploid organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near-universal practice in such studies is to prepare and…
View details →DOI: 10.1038/s41467-021-23544-8Cited by 24 