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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 631 of 725

Negative / Null Result ReportOpen accessCities. Urban geography

Effect of information and communication technology on cashew nut export in Benin

Armand Fréjuis Akpa, Augustin Foster Chabossou · 2024 · Research in Globalization

The introduction of information and communication technology (ICT) has altered the way society operates things. ICT is used in various sectors, including agriculture. It can be used in the agricultural sector to distribute pricing and encourage agricultural commodity exports. The study aims to investigate the effect of ICT on cashew nut export in Benin using an autoregressive distributed lag (ARDL) approach. Data were collected over the period of 31 years (1990–2020) in Benin. The estimated results showed that mobile cellular telephone subscription is negatively and significantly correlated wi

View details →DOI: 10.1016/j.resglo.2024.100197
Negative / Null Result ReportOpen accessOphthalmology

Severe ocular and adnexal complications in dengue hemorrhagic fever: A report of 29 eyes

V S Vijitha, Tarjani Vivek Dave, Somasheila I Murthy et al. · 2021 · Indian Journal of Ophthalmology

Purpose: To describe a series of sight-threatening ocular and adnexal involvement associated with dengue hemorrhagic fever and their treatment options. Methods: Retrospective, interventional, non-comparative case series. Medical records of patients who presented with ocular symptoms attributed to dengue hemorrhagic fever were reviewed. Demography, presenting features, and treatment outcomes were recorded. Outcome measures assessed included globe salvage, vision salvage, and visual improvement. The outcome was deemed as favorable if vision salvage was possible and unfavorable if the vision was

View details →DOI: 10.4103/ijo.ijo_1588_20
Negative / Null Result ReportOpen accessAnimal culture

Effects of chromium methionine on growth performance, antioxidant, serum biochemical indicators, and hepatopancreas health of common carp fed with high carbohydrate diet

CUI Pei, LI Nan, LI Min et al. · 2025 · Siliao yanjiu

The experiment aimed to investigate the effects of adding chromium methionine (CrMet) to high carbohydrate feed on the growth performance, antioxidant capacity, serum biochemical indicators, and hepatopancreas health in common carp. A total of 180 healthy carp with an initial weight of (86.61±6.68) g were randomly divided into three groups, with three replicates per group and 20 carp per replicate. Three types of feed were prepared: Control group (CK, carbohydrate level 25%), high carbohydrate group (HCD, carbohydrate level 45%), and high carbohydrate feed supplemented with CrMet (HCD+Cr, 1 mg

Negative / Null Result ReportOpen accessMedicine

Effect of Curcumin on Odontogenic/Osteogenic Differentiation of Dental Pulp Stem Cells

Masoud Seifi, Shirin Farivar, Malihe Sadat Mirhosseini et al. · 2020 · Regeneration, Reconstruction & Restoration

Introduction: Stem cells have gained great attention in tissue engineering and curcumin is a natural phenolic product that had showed some positive effects on these cells. The aim of this study was to evaluate the effect of curcumin on the differentiation of human dental pulp stem cells (hDPSCs). Materials and Methods: In this experimental study, hDPSCs were isolated from human third molars and treated without and with different concentrations (5, 10 and 15 µM) of curcumin and dimethyl sulfoxide (DMSO) as solvent for curcumin. Proliferation of the cells was measured by methyl-thiazol-tetrazoli

View details →DOI: 10.22037/rrr.v5i.31127
Negative / Null Result ReportOpen accessForestry

PEMATAHAN DORMANSI BENIH AREN (Arenga pinnata (wurmb.) Merr.) PADA TINGKAT KEMASAKAN YANG BERBEDA MENGGUNAKAN METODE PERENDAMAN

Irwan Mahakam Lesmono Aji, Raden Sutriono, Arna Diansyah · 2020 · Jurnal Belantara

This study aims to find out the effect of submersion by using 1% acetic acid, 100% palm juice, and 100% coconut water to break the dormancy of palm seeds at different maturity levels. The research was conducted in the Green House of Forestry Study Program, University of Mataram, using the experimental method with Complet Random Design (CRD) three factors. The first factor is the maturity level consists of 3 levels, the second factor is the submersion liquid substance consist of 3 levels, and the third factor is the period of submersion consist of 4 levels.The results of this study indicate tha

Negative / Null Result ReportOpen accessDentistry

Flexural strength of polymethyl methacrylate reinforced with high-performance polymer and metal mesh

Zahra Hashemi Ardakani, Rashin Giti, Shima Dabiri et al. · 2021 · Dental Research Journal

Background: The flexural strength (FS) of a denture base material is of great concern, and many approaches have been used to strengthen the denture acrylic resins. The present study aimed to evaluate the effect of high-performance polymer (BioHPP) and metal mesh reinforcement on the FS of a heat-cured poly methyl methacrylate (PMMA) acrylic resin. Materials and Methods: This experimental study was done on 30 rectangular specimens (64 mm × 13 mm × 3 mm) of a heat-cured PMMA resin. The specimens were divided into three groups (n = 10) to be reinforced with either metal mesh or BioHPP mesh; one g

View details →DOI: 10.4103/1735-3327.316647
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Effects of Src on Proliferation and Invasion of Lung Cancer Cells

Rui ZHENG, Xiaosong QIN, Wenjie LI et al. · 2011 · Chinese Journal of Lung Cancer

Background and objective It has been proven that Src played pivotal roles in carcinogenesis, cancer progression and metastasis. The aim of this study is to explore the roles of Src phosphorylation on lung cancer cells. Methods Western blot and immunoprecipitation was used to detect the expression and phosphorylation of Src in lung cancer cells. MTT and Boyden chamber assay was used to examine the effects of inhibition of Src phosphorylation on proliferation and invasion of lung cancer cells in vitro, respectively. Results pp60src was expressed in all lung cancer cell lines in this study. All 5

Negative / Null Result ReportOpen accessFinance

DETERMINANTS OF THE USE OF BRI INTERNET BANKING ADOPTION: A STUDY ON POLITEKNIK NEGERI SEMARANG STUDENTS

Cindy Maycherles, Moh Muslikh · 2021 · Keunis

The purposes of this research are to analyze and obtain empirical evidence on the effect of usefulness perception, ease perception, and risk perception toward the use of BRI Internet banking in (Politeknik Negeri Semarang) Polines students both simultaneously and partially. The population of this research was Polines students of all departments from 2017 to 2019 as customers of BRI Internet banking users with a sample of 87 respondents. The research used primary and secondary data. The data analysis model uses the Multiple Linear Regression Analysis Model while the data analysis technique uses

View details →DOI: 10.32497/keunis.v9i1.2167
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

Changes in Essential Oil Content and Yield of Basil in Response to Different Levels of Nitrogen and Plant Density

M Dadvand Sarab, H Naghdi Badi, M Nasri et al. · 2008 · Journal of Medicinal Plants

Background: Basil (Ocimum basilicum L.) is a valuable medicinal and aromatic plant which is cultivated throughout the world. Therefore, it is necessary to determine effect of important agronomical factors on quality and quantity of its volatile oil. Objective: To determine plant density and nitrogen fertilization effects on quality and quantity yield of basil. Method: This study was done in Research farm of ACECR, Institute of Medicinal Plants & Natural Products Research in 2006 on the base of factorial experiment in randomized complete block design with four replications. All possible combina

Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

18β-Glycyrrhetinic Acid Induces Metabolic Changes and Reduces Staphylococcus aureus Bacterial Cell-to-Cell Interactions

Alan J. Weaver, Timothy R. Borgogna, Galen O’Shea-Stone et al. · 2022 · Antibiotics

The rise in bacterial resistance to common antibiotics has raised an increased need for alternative treatment strategies. The natural antibacterial product, 18β-glycyrrhetinic acid (GRA) has shown efficacy against community-associated methicillin-resistant Staphylococcus aureus (MRSA), although its interactions against planktonic and biofilm modes of growth remain poorly understood. This investigation utilized biochemical and metabolic approaches to further elucidate the effects of GRA on MRSA. Prolonged exposure of planktonic MRSA cell cultures to GRA resulted in increased production of staph

View details →DOI: 10.3390/antibiotics11060781
Negative / Null Result ReportOpen accessPublic aspects of medicine

Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT

Rob Horne, Caroline Sabin, Trudie Chalder et al. · 2025 · Programme Grants for Applied Research

Background Antiretroviral therapy has transformed human immunodeficiency virus infection intoa chronic condition associated with normal life expectancy. In the United Kingdom, the uptake of antiretroviral therapy is generally high, but a delay in starting antiretroviral therapy and non-adherence compromise the health and well-being of people living with human immunodeficiency virus, increase the risk of transmission of human immunodeficiency virus and increase National Health Service costs. Objectives The overall aim was to improve antiretroviral therapy uptake and adherence by addressing perc

View details →DOI: 10.3310/kppw8401
Negative / Null Result ReportOpen accessScience (General)

Relationships Between pH Buffer Capacity and Selected Soil Properties of an Agrarian area in Samaru, Nigeria

Ayodele Owonubi, Favour Kenneth Chiwendu · 2022 · UMYU Scientifica Journal

The objectives of this research were to investigate the nature of pH buffer capacity and evaluate its association selected soil characteristics the study area. Soil samples from ten profile pits from within the study area were collected from genetic horizons. Soil samples were tested in the laboratory for electrical conductivity and pH buffer capacity using standard procedures. Soil data were analyzed using descriptive statistics. One-way analysis of variance and correlation analysis were applied to determine effects and relationships of selected soil properties with soil pH buffer capacity. T

View details →DOI: 10.56919/usci.1222.006
Negative / Null Result ReportOpen accessTechnology

Biochar from experimental sewage sludge gasification as an adsorbent for phosphate removal

Domagoj Nakić, Katarina Licht, Hana Posavčić et al. · 2025 · Results in Engineering

Increasing amounts of sewage sludge (SS) and phosphorus-induced eutrophication are major global issues, and this study addresses both under a unified approach, by exploring the potential of biochar derived from SS gasification in an experimental plant as an efficient adsorbent for phosphate removal in synthetic wastewater. The key innovation involves the use of a novel biochar, generated as a byproduct of an innovative gasification process, without any additional pretreatment. This approach could help reduce both environmental and economic burdens in potential real-world applications. Pristine

View details →DOI: 10.1016/j.rineng.2025.106077
Negative / Null Result ReportOpen accessAgriculture (General)

EFFECT OF BIO HEALTH, TECAMIN MAX AND BENZYL ADENINE ON GROWTH CHARACTERISTICS OF SWEET ORANGE SEEDLINGS

A. S. Abdulrhman, Sh. M. M. Al-Atrushy · 2024 · The Iraqi Journal of Agricultural science

This investigation was aimed to study the effect of soil application of Bio health and foliar application with Tecamin max and Benzyl adenine on growth characteristic of sweet orange (Citrus sinensis L.) seedlings during two successive seasons (2020 and 2021). Bio health was added with three concentrations (0, 6 and 12 g.L-1) to the soil and foliar application of Tecamin max with three concentration (0, 5 and 10 ml.L-1), Benzyl adenine with three concentration (0, 100 and 200 mg. L-1) on the sweet orange seedlings which were brought from private nursery in Duhok city and have two- years old an

View details →DOI: 10.36103/w0z2q378
Negative / Null Result ReportOpen accessPsychiatry

Family psychoeducation to support patients with psychotic illness: two-year outcomes from a pre–post longitudinal pilot study

Roxoliana Tsisar, Kristen E. Zentner, Katherine Shettell et al. · 2026 · Frontiers in Psychiatry

BackgroundPsychoeducation for families of young adults with psychosis is an evidence-based intervention that alleviates carer burden. The implementation of programming is limited, leaving family carers shouldering a heavy burden without appropriate support.ObjectiveThis pre-post longitudinal pilot study evaluated the preliminary outcomes of a psychoeducational group intervention for family carers of young adults with psychosis, aimed at building skills and reducing carer burden to support recovery in their loved ones.MethodsThe intervention, co-developed and co-facilitated by healthcare profes

View details →DOI: 10.3389/fpsyt.2026.1724396
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach

Joanna Hajduk, Cyrill Brunner, Sebastian Malik et al. · 2020 · mAbs

Minor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important variations concerns the N-glycosylation pattern, which directly affects an anti-tumor mechanism called antibody-dependent cell-meditated cytotoxicity (ADCC). Thus, careful engineering of mAbs is expected to enhance both protein-receptor binding and ADCC. The specific aim of this study is to evaluate the influence of terminal carbohydrates within the Fc region on the interaction with the FcγRIIIa/CD16a receptor in native and label-free condi

View details →DOI: 10.1080/19420862.2020.1736975
Negative / Null Result ReportOpen accessMedicine (General)

The Effect of Combined Exercise Training and Feroglobin Supplementation on Serum Iron and Lipid Profile in Women with Iron Deficiency Anemia

Sepide Ghasemian, Zahra Hojjati Zidashti · 2018 · Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum

Background and Objectives: Iron can play an important role in exercise performance of women. The purpose of the present research was to determine the effects of combined exercise training and Feroglobin supplementation on serum iron and lipid profile in Women with iron deficiency anemia. Methods: In this study, 36 trained females with iron deficiency anemia (mean age, 26.8±6.3 years and body mass index, 19.55±4.4kg/m2) of Lahijan city, were selected as subjects and randomly divided into three groups of supplement+combined training, placebo+combined training, and control. Iron lev

Negative / Null Result ReportOpen accessAgriculture (General)

Insecticides in Bait Spray Solutions: Validation, Determination, and Stability: The Role of Trophic Attractants

Eleftheria Bempelou, Kyriaki Varikou, Antonios Nikolakakis et al. · 2026 · Agriculture

In Greece, the protection of olive orchards against the olive fruit fly ( Bactrocera oleae ), the most serious pest of olive fruits, is implemented through a national control program. This program is implemented by the Ministry of Rural Development and Food in co-operation with various public and private organizations. A new approach followed for this goal is the use of insecticide spray solutions combined with trophic attractant to attract and kill the olive fruit fly. In the present study, a method for the determination of the major insecticides, lambda-cyhalothrin and Spinosad, in their spr

View details →DOI: 10.3390/agriculture16090957
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

Drug Interaction Potential of Berberine Hydrochloride When Co-Administered with Tofacitinib and Filgotinib in Rats

Wang J, Lu S, Zhang C et al. · 2025 · Drug Design, Development and Therapy

Jinglong Wang, Shijia Lu, Chenxiao Zhang, Junjie Wang, Huiru Wu, Guofei Li Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Guofei Li, Department of Pharmacy, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, People’s Republic of China, Tel/Fax +86-24-23925108, Email sylgf2009@163.comPropose: The co-treatment of ulcerative colitis with berberine hydrochloride (BBR), the Janus kinase(JAK) inhibitor Tofacitinib (TOFA), and Fligotinib (FIGA) is feasible and sophisti

Negative / Null Result ReportOpen accessPhysiology

Effects of compression running pants and treadmill running stages on knee proprioception and fatigue-related physiological responses in half-marathon runners

Lin Chang, Silin Fu, Jianghua Li et al. · 2022 · Frontiers in Physiology

Background: Knee injury is common in half-marathon runners, however, the effect of compression running pants on fatigue and knee proprioception remains unclear.Objectives: The study aims to investigate whether wearing compression running pants (CRP) and treadmill running stages affect knee proprioception and fatigue-related physiological responses during half-marathon running.Methods: Eighteen half-marathon runners completed two self-paced 21 km treadmill running trials, once wearing CRP and once wearing loose running shorts (LRS). For each 21 km run, RPE, heart rate, blood lactic acid, and kn

View details →DOI: 10.3389/fphys.2022.1035424
Negative / Null Result ReportOpen accessMedicine

Optimization of technological parameters for durum wheat pasta production with carrot powder and ion-ozonated water

Galiya Iskakova, Bauyrzhan Iztayev, Auyelbek Iztayev et al. · 2025 · Scientific Reports

Abstract The quality of food products and a balanced diet play a key role in maintaining health and improving the quality of life. Due to the high popularity of pasta, a promising direction is the development of recipes that include whole grain flour, carrot powder and ion-ozonated water, which increase the nutritional value of the product and improve its chemical composition. The aim of this study was to optimise the technological modes of production of durum wheat pasta using carrot powder and ion-ozonated water to minimise the loss of dry matter (DM) during cooking and increase the protein

View details →DOI: 10.1038/s41598-025-28027-0
Negative / Null Result ReportOpen accessBibliography. Library science. Information resources

User Willingness to Use Generative Artificial Intelligence Based on AIDUA Framework

WANG Weizheng, QIAO Hong, LI Xiaojun, WANG Jingjing · 2024 · Nongye tushu qingbao xuebao

[Purpose/Significance] Generative artificial intelligence (AI) technology has been widely used in many fields, and the application of this technology has become popular among researchers. However, there are few studies on the willingness of researchers willingness to accept generative AI. This leads to an insufficient understanding of the psychological mechanism, cognitive process and behavioral pattern of users' acceptance of generative AI, which limits the ability of theoretical innovation and practical exploration in user information behavior. This study focuses on researchers acceptance of

View details →DOI: 10.13998/j.cnki.issn1002-1248.24-0076
Negative / Null Result ReportOpen accessBusiness

The Success of Online Passport Queue Registration Applications Using Delone and Mclean Models

Ivan Ramos, Lilik Noor Yuliati, Megawati Simanjuntak · 2022 · Jurnal Aplikasi Bisnis dan Manajemen

Advancement in sophisticated information technology can be used for innovation in access to public services. In this study, the public service studied was the Online Passport Queue Registration Application (APAPO) at the Class I Non-TPI Bogor Immigration Office. This study aims to analyze the effect of system quality, information quality, service quality, user characteristics, usage rate, user satisfaction on net benefits APAPO using DeLone and McLean and find out the priority factors for improvement using the Important-Performance Analysis (IPA) method. The sampling technique used was conveni

View details →DOI: 10.17358/jabm.8.1.33
Negative / Null Result ReportOpen accessNutrition. Foods and food supply

Evaluation the effects of red yeast rice in combination with statin on lipid profile and inflammatory indices; a randomized clinical trial

Ali Tavan, Saam Noroozi, Bardia Zamiri et al. · 2022 · BMC Nutrition

Abstract Background Dyslipidemia is a prominent cause of cardiovascular disease as it leads to inflammation and plaque deposition within arteries. Treatment includes lifestyle modifications and lipid-lowering medications. We aimed to assess the therapeutic effects of red yeast rice (RYR) alongside statin therapy. Methods This triple-blind randomized clinical trial involved 92 dyslipidemia patients and was performed in 2019. Standard laboratory tests were used to assess the serum LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), total cholesterol, triglyceride (TG), and high sensitivity C-react

View details →DOI: 10.1186/s40795-022-00639-z
Negative / Null Result ReportOpen accessAgriculture

The Impact of Intra-City and Inter-City Innovation Networks on City Economic Growth: A Case Study of the Yangtze River Delta in China

Xianzhong Cao, Bo Chen, Yi Guo et al. · 2023 · Land

Innovation networks promote regional innovation and economic growth. Using the patent data of cooperative inventions and the panel data of socio-economic statistics for 2010–2019, this study quantitatively analyzes the spatial structure evolution of intra-city and inter-city innovation networks for 41 cities in the Yangtze River Delta and their influence on economic growth. This study shows that these networks are increasingly connected and have a highly similar Z-shaped spatial structure. City economic growth is generally high, relatively stable, and mainly positively influenced by inter-city

View details →DOI: 10.3390/land12071463
Negative / Null Result ReportOpen accessSocial Sciences

The Influence of Empowerment towards Agricultural Business Actors’ Ability in Surakarta, Indonesia

Suminah Suminah, Sapja Anantanyu, Suwarto Suwarto et al. · 2023 · Social Sciences

The situation of micro, small, and medium enterprises (MSMEs) in agriculture in Surakarta after the pandemic are still worrying; thus, effective empowerment efforts are needed to revive and develop MSMEs in agriculture. Empowerment will be maximally successful if various resources are available for its implementation. This study aimed to directly and indirectly analyze the effect of empowerment, human capital, economic capital, actors’ perceptions of their business, and financial capital on the ability of agricultural business actors. This research study used quantitative methods with survey t

View details →DOI: 10.3390/socsci12020076
Negative / Null Result ReportOpen accessPublic aspects of medicine

Occupational heat exposure alone does not explain chronic kidney disease of uncertain aetiology (CKDu) in Sri Lanka

P. Mangala C.S. De Silva, E.M.D.V. Ekanayake, T.D.K.S.C. Gunasekara et al. · 2022 · The Journal of Climate Change and Health

Aim: Chronic kidney disease of uncertain aetiology (CKDu) is an emerging health concern in tropical farming communities. The role of occupational heat exposure as a potential driver of CKDu remains debated. Our study examines occupational heat exposure and kidney health in three occupational groups in Sri Lanka. Methodology: We recruited participants from three occupational groups from three climatic zones; fisherfolk from the dry and intermediate zones (N = 225), paddy farmers from the intermediate zone (N = 180) and tea plantation workers from the wet zone (N = 70). Serum creatinine, cystati

View details →DOI: 10.1016/j.joclim.2022.100143
Negative / Null Result ReportOpen accessEconomic growth, development, planning

The role of foreign banks in the transmission of monetary policy: Empirical evidence from Tunisia

Gassouma Mohamed Sadok, Ben-Ahmed Kais · 2021 · Ekonomski Anali

This paper presents an empirical analysis of the effect of monetary policy shocks on credit supply in Tunisia, using a vector autoregressive model and a nonlinear interactive model. The focus is on the magnitude of these shocks in the presence of foreign banks. The variables of interest are the concentration index of deposit banks, and monetary policy shocks based on the monthly data of 27 universal and business banks covering the period 1993 to 2016. The results support a positive and significant impact of concentration index on credit supply. However, monetary policy shocks appear to have no

View details →DOI: 10.2298/eka2128101g
Negative / Null Result ReportOpen accessEcology

Using accelerometers for tracking loggerhead and green sea turtle behaviour

Jessica Harvey-Carroll, Daire Carroll, Jose Luis Crespo-Picazo et al. · 2025 · Animal Biotelemetry

Abstract Background Understanding animal behaviour is critical for the design of effective conservation and management strategies. Animal-borne tri-axial accelerometers constitute a type of biologging device which have the potential to provide continuous high-resolution behavioural data. For marine animals, device attachment position may influence both the accuracy of behavioural predictions and the hydrodynamic profile of the animal. We present a case study on the use of accelerometers for the behavioural classification of two sea turtle species in captivity: the loggerhead (Caretta caretta)

View details →DOI: 10.1186/s40317-025-00415-3
Negative / Null Result ReportOpen accessBusiness

Catur purusa artha: Antecedent and moderator for improving business performance

Dewa Nyoman Benni Kusyana, Putu Sri Hartati, Ida Ayu Widani Sugianingrat et al. · 2024 · Jurnal Ekonomi dan Bisnis

This research was conducted to determine the influence of organizational culture on business performance, mediated by innovation and moderated by catur purusa artha. The subjects of this research were the cooperative heads or managers of 503 cooperative units in Denpasar City. The Yamane formula was used to determine the sample size, which was determined to be 83 cooperative heads/managers using a proportionate random sampling technique. Data analysis was carried out using structural equation modelling – partial least squares (SEM-PLS). Data analysis using PLS was carried out with two measurem

View details →DOI: 10.24914/jeb.v27i2.10287