A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21363 results · page 631 of 713
Abdelgalil KAA, Fathi N, El Nouby FH et al. · 2025 · BMC rheumatology
BACKGROUND: Rheumatoid Arthritis (RA) is a prevalent autoimmune disease affecting approximately 84,338 individuals in Egypt. Genetic predispositions, such as the PTPN22 and PADI4 genes, are linked to RA risk. PTPN22, a protein tyrosine…
de Oliveira CAF, Amaral LMB, Micheleto JPC et al. · 2024 · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Introduction Diabetes, obesity, and CKD collectively impact musculoskeletal health and increase the risk of severe coronavirus disease 2019 (COVID-19) outcomes. Methods This cross-sectional study included 32 dialysis patients, categorized…
Meins IA, van der Stouwe ECD, Aan Het Rot M et al. · 2026 · Schizophrenia research. Cognition
Background Empathy as a key component of social cognition may be impaired in individuals at ultra-high risk (UHR) for psychosis. The Empathic Accuracy Task (EAT) was designed to address the dynamic and interactive nature of real-world…
Joseph J, Chandranaath A, Louis J et al. · 2025 · Cureus
Background Wound healing relies on a balance between extracellular matrix remodelling by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Among all the MMPs, elevated MMP-9 levels are implicated in…
Alharazy S · 2024 · Pakistan journal of medical sciences
Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…
Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America
Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…
Gu Y, Zhang W, Zhou J et al. · 2025 · International journal of nephrology
Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients…
Agbektas T, Genc HC, Zontul C et al. · 2025 · International journal of molecular sciences
(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls)…
Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…
Taft D, Quinones JM, Moreno ML et al. · 2024 · Preprint
Blood levels of uremic molecules generated through gut microbial metabolism are associated with disease risk, reduced quality of life, and mortality in patients with renal insufficiency. Modulation of the microbiome may offer therapeutic…
Nasirzadeh A, Mohammadzadeh F, Kazeminia S et al. · 2025 · Scientific reports
The presence of a known labor companion was shown to improve childbirth satisfaction. However, a companion's anxiety might affect the satisfaction of laboring women. Therefore, this study aimed to evaluate the relationship between the…
Alroba R, Alfakhri A, Badreldin HA et al. · 2024 · Preprint
Purpose: This study aims to investigate the potential causal relationship between the use of indapamide and rhabdomyolysis. Previous research and pharmacovigilance monitoring activities have suggested a potential association between…
Veenman F, Tibbertsma S, Wolvius EB et al. · 2025 · Caries research
Introduction Asthma and dental caries may be linked through frequent mouth breathing and the use of inhaled asthma medication. However, the current literature is inconclusive on whether asthma or asthma medications increase the risk of…
Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer
Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…
Seizer L, Löchner J, Renner TJ · 2026 · Brain, behavior, & immunity - health
The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This…
Howard KA, Witrick B, Clark A et al. · 2026 · The Journal of surgical research
Introduction Implicit bias can influence behavior and decision-making, such as treatment decisions in clinical settings. Given documented Black-White disparities in vascular care, the purpose of this study was to describe the prevalence…
Pires S, Freitas M, Pinho F et al. · 2025 · Sensors (Basel, Switzerland)
Objective We aimed to quantify the mechanical pressure required to reach the deep cervical and thoracolumbar fasciae, to examine its association with pressure pain threshold (PPT) and adipose tissue thickness, and to determine whether PPT…
Haahr Vad O, Önnestam L, Bengtsson Boström K et al. · 2025 · PloS one
Aims The aim of the study was to investigate the association between breastfeeding duration and body mass index (BMI), overweight and obesity in children during follow-up until 16 years of age. Methods Observational cohort study of mothers…
Montoya-Delgado IB, Ochoa-García IV, Escobedo-Salcedo ZL et al. · 2026 · International journal of molecular sciences
Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and…
Sacre H, Haddad C, Rizk R et al. · 2025 · Frontiers in public health
Objectives To investigate the association between food insecurity (FI), eating disorders (EDs), and orthorexia nervosa (ON) among Lebanese university students. Methods This cross-sectional study, conducted between 2021 and 2022, enrolled…
Wistrand H, Kaartinen NE, Jousilahti P et al. · 2024 · Integrated blood pressure control
Purpose The complex pathogenesis of hypertension, potentially involving inflammatory pathways, remains elusive. This study aimed to evaluate the relationship between 24-hour urinary sodium excretion and inflammatory cytokines alongside…
Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives
We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…
Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine
Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…
Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…
Blackwell SE, Pasquier L, Dupont S et al. · 2024 · Preprint
Summary In many animals, male weapons are large and extravagant morphological structures that typically enhance fighting ability and reproductive success. It is generally assumed that growing and carrying large weapons is costly, thus only…
Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine
Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…
Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal
Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…
Meyer DB, Gifford A, Bradley T et al. · 2026 · Journal of gastrointestinal oncology
Background Prior studies have reported solid organ transplant (SOT) recipients have increased rates of colorectal cancer (CRC). While this increased incidence is established, the recurrence risk following curative-intent treatment for…
Huber A, Pasquier T, Demarchi M et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is…
Sanghvi K, Todorova B, Sepil I · 2025 · Ecology and evolution
Sexual selection operates across pre- and post-mating episodes, driven by intra-sexual competition and inter-sexual choice for mates or gametes. While these episodes can act in the same direction, this is not always the case; for example,…