Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach
Joanna Hajduk; Cyrill Brunner; Sebastian Malik; Jana Bangerter; Gisbert Schneider; Marco Thomann; Dietmar Reusch; Renato Zenobi · 2020 · mAbs
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Minor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important variations concerns the N-glycosylation pattern, which directly affects an anti-tumor mechanism called antibody-dependent cell-meditated cytotoxicity (ADCC). Thus, careful engineering of mAbs is expected to enhance both protein-receptor binding and ADCC. The specific aim of this study is to evaluate the influence of terminal carbohydrates within the Fc region on the interaction with the FcγRIIIa/CD16a receptor in native and label-free condi
Abstract by Joanna Hajduk; Cyrill Brunner; Sebastian Malik; Jana Bangerter; Gisbert Schneider; Marco Thomann; Dietmar Reusch; Renato Zenobi, mAbs (2020) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1080/19420862.2020.1736975