Abandoned HypothesisOpen accessMedicine
Ghosh AK, Bhattacharjee A, Jayashankar U et al. · 2026 · Organic & biomolecular chemistry
We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…
View details →DOI: 10.1039/d5ob01897h Abandoned Hypothesis
khoiriyah z, Pandin MGR · 2026 · Preprint
Abstract Indonesia faces a persistent labor market paradox wherein rapid expansions in formal educational attainment have not yielded a proportional decline in educated unemployment. This mini literature review synthesizes five…
View details →DOI: 10.21203/rs.3.rs-9997028/v1 Methods Dead-End
Upreti A, Shonkwiler K, Riddick SN et al. · 2026 · Preprint
Methane (CH4) is a major component of natural gas and a potent greenhouse gas. Increasing atmospheric methane concentrations are attributed to emissive anthropogenic activities by an average of 13 ppb per yr since 2020 and are linked to a…
View details →DOI: 10.20944/preprints202603.0217.v1 Negative / Null Result ReportMedicine
Ashouri R, Reynolds PS, Rajavel S et al. · 2026 · Urology
Objective To guide biopsy decision making via a predictive model for clinically significant prostate cancer (csPCa) in men with positive imaging (PI-RADS 3-5). We aim to elucidate the influence of zone on the predictive accuracy of PI-RADS…
View details →DOI: 10.1016/j.urology.2026.01.028 Negative / Null Result ReportOpen accessMedicine
Christianson G, Howard ZM, Kenney S et al. · 2026 · mAbs
The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of…
View details →DOI: 10.1080/19420862.2026.2649990 Negative / Null Result ReportMedicine
Lutfi W, Desai ND, Pan Z et al. · 2026 · The Annals of thoracic surgery
Background The choice between bioprosthetic or mechanical surgical aortic valve replacement (SAVR) for dialysis patients is debated. Rapid adoption of transcatheter aortic valve replacement (TAVR) complicates decision-making further. This…
View details →DOI: 10.1016/j.athoracsur.2026.03.007 Negative / Null Result Report
Keskinel I, Eryilmaz M, Diktas Tahtasakal S · 2026 · Preprint
Objectives: Streptococcus pneumoniae is a major respiratory pathogen. Reports during the COVID-19 era suggest decreased pneumococcal activity. This study aimed to assess the frequency of S. pneumoniae in adult sputum cultures and its…
View details →DOI: 10.20944/preprints202606.0633.v1 Negative / Null Result ReportMedicine
Akmansoy ŞC, Kahramanoğlu E · 2026 · Journal of oral science
Purpose This study compares the marginal and internal gaps for four restorative materials produced by two fabrication methods in both minimally invasive occlusal veneer and conventional onlay cavities. Methods Eighty mandibular molars…
View details →DOI: 10.2334/josnusd.25-0348 Negative / Null Result ReportMedicine
Xie J, Song Z, Fang W et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
This study aimed to elucidate the potential molecular mechanisms by which artificial sweeteners contribute to the initiation and progression of atherosclerosis, with the goal of providing a theoretical basis for the safety evaluation of…
View details →DOI: 10.1007/s00210-026-05241-9 Negative / Null Result ReportMedicine
Robinson E, Chapman C, Orchard F et al. · 2026 · Journal of child and adolescent mental health
Background: Exposure of children and young people to potentially traumatic events is common. There is a need for increased access to early interventions following a potentially traumatic event. Objective: This review aimed to identify…
View details →DOI: 10.2989/17280583.2025.2581754 Failed Experiment Report
Leinbach D, Burcham DC, Kane B · 2026 · Preprint
Trees are routinely pruned to mitigate the risk of wind damage, but there are few studies examining changes in wind loads after pruning, especially for large conifers. In this study, ten Colorado spruces ( Picea pungens ) were monitored…
View details →DOI: 10.64898/2026.06.11.731663 Negative / Null Result Report
Ross SR, Suzuki H, Urabe J et al. · 2026 · Preprint
1 Ecosystem functioning can be maintained in species-rich communities even under fairly severe perturbations. This is because communities with high richness include variation both in species’ functional roles ( functional diversity ) and…
View details →DOI: 10.64898/2026.06.19.733370 Abandoned HypothesisMedicine
AlTahan FA, AlHadlag A · 2026 · Ocular immunology and inflammation
Purpose To report the first documented case of postoperative endophthalmitis progressing to panophthalmitis in a silicone oil-filled eye (SO) following pars plana vitrectomy (PPV), and to review the relevant literature. Methods A single…
View details →DOI: 10.1080/09273948.2026.2681735 Abandoned HypothesisMedicine
Fan J, Zeng J, Li H · 2026 · Research in developmental disabilities
Background/aims Children with autism spectrum disorder (ASD) often experience conversational difficulties that hinder social interactions and peer relationships. This study examined whether a conversational AI-enhanced peer-mediated…
View details →DOI: 10.1016/j.ridd.2026.105249 Negative / Null Result ReportMedicine
Zheng, Jia, Jing et al. · 2026 · International journal of cancer
This single-center retrospective study evaluated radiation pneumonitis (RP) in 209 treatment-naive EGFR-mutant non-small cell lung cancer (NSCLC) patients receiving first-line third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)…
View details →DOI: 10.1002/ijc.70630 Negative / Null Result ReportMedicine
Ng Fat, West, E Jackson · 2026 · BMJ public health
Stopping tobacco smoking, reducing alcohol consumption from high-risk levels, increasing physical activity and improving diet can improve mental well-being. To gain a preliminary estimate of the potential benefits of healthy lifestyle…
View details →DOI: 10.1136/bmjph-2025-004301 Negative / Null Result ReportMedicine
Karlsson, Ekendahl, Lindner · 2026 · Child and adolescent psychiatry and mental health
Individuals with substance use problems have higher mortality risks than the general population. This study aimed to assess all-cause and specific-cause mortality among adolescents and young adults in specialized substance use treatment in…
View details →DOI: 10.1186/s13034-026-01125-1 Negative / Null Result ReportMedicine
Harmantepe, Canturk, Küçük et al. · 2026 · BMC surgery
Low anterior resection syndrome (LARS) is a frequent functional disorder following sphincter-preserving surgery for rectal cancer. This study aimed to assess the impact of surgical approach and anastomosis distance on LARS development. We…
View details →DOI: 10.1186/s12893-026-03975-0 Null DatasetMedicine
Lin, Cheng, Chen et al. · 2026 · Avian pathology : journal of the W.V.P.A
Abstract To enable differential detection of virulent and attenuated strains of duck short beak and dwarfism syndrome virus (SBDSV), we developed a fluorescent quantitative PCR (qPCR) assay based on locked nucleic acid (LNA)-TaqMan probes.…
View details →DOI: 10.1080/03079457.2026.2692641 Negative / Null Result ReportMedicine
Sun, Li, Li et al. · 2026 · Journal of food science
Lead (Pb) exposure is a major environmental risk factor for cognitive impairment. This effect is mainly caused by oxidative stress, mitochondrial dysfunction in the hippocampus, and neuronal apoptosis. This study examined whether black…
View details →DOI: 10.1111/1750-3841.71233 Negative / Null Result ReportMedicine
Manca, Paulus, Almeida et al. · 2026 · Neuroscience
Social connectedness strongly influences health and longevity, and adult pair bonds provide psychological benefits distinct from other social relationships. Oxytocin (OT), corticotropin-releasing hormone (CRH), and opioids play an…
View details →DOI: 10.1016/j.neuroscience.2026.06.028 Negative / Null Result ReportMedicine
Ertürkmen Aru, Büke, Saat et al. · 2026 · Familial cancer
Biallelic loss-of-function variants in NTHL1 are associated with an autosomal recessive cancer predisposition syndrome, whereas the cancer risk associated with monoallelic NTHL1 variants remains uncertain. The recurrent truncating variant…
View details →DOI: 10.1007/s10689-026-00578-9 Negative / Null Result ReportMedicine
Fiorenza, Millot, Lecomte et al. · 2026 · The Journal of antimicrobial chemotherapy
Prosthetic joint infections (PJI) of the hip and knee are most often caused by Staphylococcus spp. and require long-term treatment with rifampicin and fluoroquinolone as first-line treatment. However, resistance, contraindications or…
View details →DOI: 10.1093/jac/dkag219 Negative / Null Result ReportMedicine
Kobayashi, Yabuki, Sugiyama et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveNo studies have examined the effectiveness of platelet-rich plasma (PRP) alone and platelet-rich fibrin (PRF) without alveolar bone grafting or other bone substitutes for alveolar cleft repair during infancy. This study evaluated…
View details →DOI: 10.1177/10556656261417033 Negative / Null Result ReportMedicine
Sulciner, Wang, Fairweather et al. · 2026 · Cureus
ON-Q pumps, or surgically placed wound catheters, provide analgesia without the side effects of epidural catheters. This study aimed to evaluate perioperative outcomes, including total postoperative oral morphine milligram equivalents…
View details →DOI: 10.7759/cureus.109129 Negative / Null Result ReportMedicine
Sæther, Butt, Eubank et al. · 2026 · Frontiers in psychology
Psychological stressors have become a natural part of the process of developing skills in talent development environments of youth athletes. However, there is little research on psychological stressors among talented female athletes and…
View details →DOI: 10.3389/fpsyg.2026.1803701 Negative / Null Result ReportMedicine
Jamei-Martel, Garibaldi, Castroviejo Fernández et al. · 2026 · JSES international
The optimal management of high-grade acromioclavicular (AC) joint dislocations remains controversial. While surgical treatment improves radiographic alignment, its impact on functional outcomes remains debated. This study prospectively…
View details →DOI: 10.1016/j.jseint.2026.101722 Negative / Null Result ReportMedicine
Huang, Yin, Lin · 2026 · Transplantation proceedings
The utilization of hepatitis B surface antigen-positive (HBsAg+) living kidney donors is a strategy to expand the donor pool. However, concerns regarding their renal safety after nephrectomy persist due to the potential impact of chronic…
View details →DOI: 10.1016/j.transproceed.2026.06.001 Negative / Null Result ReportMedicine
Foster, Millist, Germaine et al. · 2026 · Epilepsia open
ES-481 is a novel potent and selective antagonist of TARP-y8-dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES-481 as an add-on anti-seizure…
View details →DOI: 10.1002/epi4.70294 Negative / Null Result ReportMedicine
Ucan Gunduz, Nizam Tekcan, Erdem et al. · 2026 · Journal of pediatric ophthalmology and strabismus
To investigate microstructural alterations in the retina, choroid, and optic nerve head in children with spina bifida using optical coherence tomography. Thirty-eight children with spina bifida and 32 children without spina bifida were…
View details →DOI: 10.3928/01913913-20260417-01 