Methods Dead-EndOpen accessMedicine
Zadrożniak M, Biskupski M, Szymański M et al. · 2025 · Antioxidants (Basel, Switzerland)
(1) Aminoglycosides remain indispensable in modern medicine but share a serious dose-limiting adverse effect: irreversible cochleovestibular ototoxicity. (2) This scoping review systematically maps experimental and clinical strategies…
View details →DOI: 10.3390/antiox14121467 Failed Experiment ReportOpen accessMedicine
El Gazar SM, El Backly RN, Lotfy WA et al. · 2026 · BMC oral health
Aim To evaluate the antimicrobial effects of Nd: YAG laser irradiation, antimicrobial photodynamic therapy (aPDT), and passive ultrasonic irrigation (PUI) in comparison with conventional irrigation with Sodium hypochlorite (NaOCl) in root…
View details →DOI: 10.1186/s12903-026-08651-6 Methods Dead-EndMedicine
Hatch-McChesney A, Whitney CC, Richardson M et al. · 2024 · Appetite
Consuming enough energy to meet high energy demands can be challenging for military personnel wherein logistical constraints limit food availability. Increasing dietary energy density (ED) and/or volume density (VD) of rations may be…
View details →DOI: 10.1016/j.appet.2024.107537 Failed Experiment ReportMedicine
Moubayed NMS, Alsabbagh R, Smiline GAS et al. · 2025 · Natural product research
Plants contain many bioactive compounds with potent antibacterial and efflux pump inhibitory activity (EPI). In this study, gallic acid extracted from pomegranate molasses by analytical HPLC holds promise as an EPI drug for Staphylococcus…
View details →DOI: 10.1080/14786419.2024.2349810 Replication FailureMedicine
Bi W, Li J, Xiong M et al. · 2024 · Genetic testing and molecular biomarkers
Objective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) ( EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of…
View details →DOI: 10.1089/gtmb.2023.0562 Replication Failure
Zhao Q, Nie W, Dong J et al. · 2024 · Preprint
Aim: Disorders of mineral metabolism, including elevated levels of serum calcium, phosphate, 25-hydroxyvitamin D (25OH-VitD), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23), have been reported in patients with calcific…
View details →DOI: 10.21203/rs.3.rs-4014064/v1 Replication FailureMedicine
Kong G, Aberkane C, Desoche C et al. · 2024 · Journal of experimental psychology. Human perception and performance
Intentional binding refers to the subjective temporal compression between a voluntary action and its subsequent sensory outcome. Despite some studies challenging the link between temporal compression and intentional action, intentional…
View details →DOI: 10.1037/xhp0001204 Negative / Null Result ReportOpen accessMedicine
Baker JF · 2026 · Hip & pelvis
Purpose Surgeons are both interested in the relationship between spinopelvic parameters and acetabular orientation since concomitant diseases of the spine and hip are common. Spondylolysis of L5 is common in 4% to 8% of the population. L5…
View details →DOI: 10.5371/hp.2026.38.1.27 Negative / Null Result ReportOpen accessMedicine
Könemann H, Güler-Eren S, Ellermann C et al. · 2024 · Current heart failure reports
Purpose of review Arrhythmias are common in patients with heart failure (HF) and are associated with a significant risk of mortality and morbidity. Optimal antiarrhythmic treatment is therefore essential. Here, we review current approaches…
View details →DOI: 10.1007/s11897-023-00642-w Negative / Null Result ReportOpen accessMedicine
Zafarani F, Soleimani Mehranjani M, Ghaffari F et al. · 2024 · International journal of fertility & sterility
Background This study aimed to determine the alteration of endometrial expression levels of HOXA9/HOXA10/ HOXA11/HOXD10 genes and HOX transcript antisense intergenic RNA (HOTAIR) in mid-luteal phase endometrium in patients with…
View details →DOI: 10.22074/ijfs.2024.2026081.1655 Negative / Null Result ReportOpen accessMedicine
Gandhi A, Parhizgar A · 2025 · Frontiers in endocrinology
Initially developed for type 2 diabetes and obesity, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are now emerging as promising candidates for modifying the course of neurodegenerative diseases. This potential stems from the…
View details →DOI: 10.3389/fendo.2025.1708565 Negative / Null Result ReportMedicine
Aragón-Sánchez J, Víquez-Molina G, López-Valverde ME et al. · 2023 · Diabetic medicine : a journal of the British Diabetic Association
Aims We hypothesize that microbiology- and pathology-confirmed positive bone margins after the resection of diabetes-related foot osteomyelitis are associated with worse outcomes. Methods We conducted a prospective study consisting of a…
View details →DOI: 10.1111/dme.15162 Negative / Null Result ReportMedicine
Ahmed N, Russo L, Kuo YH · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives To compare levetiracetam and phenytoin as prophylaxis for the short-term development of status epilepticus (SE) during care of pediatric patients with acute severe traumatic brain injury (TBI). Design Nonprespecified secondary…
View details →DOI: 10.1097/pcc.0000000000003526 Negative / Null Result ReportOpen accessMedicine
Shefner JM, Cudkowicz ME, Genge A et al. · 2025 · JAMA neurology
Importance Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective To assess the effect of reldesemtiv vs…
View details →DOI: 10.1001/jamaneurol.2025.0241 Negative / Null Result ReportOpen accessMedicine
Apivatgaroon A, Sukkarnkosol S, Pukrittayakamee NC et al. · 2025 · JSES international
Background Suspension stabilization is a commonly used surgical method for acute acromioclavicular (AC) joint dislocation. However, a failure rate of around 26% caused various emerging surgical techniques and recommendations. We aimed to…
View details →DOI: 10.1016/j.jseint.2024.12.020 Negative / Null Result ReportMedicine
Rannikko EH, Pajula S, Suominen SH et al. · 2025 · Plastic and reconstructive surgery
Background Breast cancer-related lymphedema is a common complication lacking medical treatment. Lymfactin is an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial growth…
View details →DOI: 10.1097/prs.0000000000011675 Negative / Null Result ReportOpen accessMedicine
Kim S, Shin MJ, Krauss RM · 2025 · Current atherosclerosis reports
Purpose of review This paper reviews the effects of major macronutrients and specific dietary interventions on atherogenic dyslipidemia, a common trait characterized by increased concentrations of triglyceride-rich and small, dense LDL…
View details →DOI: 10.1007/s11883-025-01335-6 Negative / Null Result Report
Idani D, Mashhadi SM, Babaei H et al. · 2024 · Preprint
Purpose: To evaluate vascular changes in patients with diabetic macular ischemia (DMI) after systemic oxygen therapy using Optical coherence tomography angiography (OCTA). Methods: : This interventional before-after study included 26 eyes…
View details →DOI: 10.21203/rs.3.rs-3882237/v1 Negative / Null Result ReportOpen accessMedicine
Cavalcante FP, Cardoso A, Antonini M et al. · 2025 · Translational breast cancer research : a journal focusing on translational research in breast cancer
Background Neoadjuvant chemotherapy (NAC) is widely accepted as standard treatment in breast cancer, particularly in cases of tumors with aggressive biology. NAC has increased the rates of breast-conserving surgery (BCS) and the conversion…
View details →DOI: 10.21037/tbcr-24-54 Negative / Null Result ReportOpen accessMedicine
Díaz de Terán T, Bolado J, Palomo P et al. · 2025 · Sleep & breathing = Schlaf & Atmung
Objective To assess the effectiveness of an intervention programme combining Oropharyngeal Myofunctional Therapy (OMT) and cervical spine exercises in the general population with mild to moderate Obstructive Sleep Apnoea (OSA), analysing…
View details →DOI: 10.1007/s11325-025-03487-w Negative / Null Result ReportMedicine
Shamsi F, Aligholi H, Karimi MT et al. · 2024 · Journal of motor behavior
The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO)…
View details →DOI: 10.1080/00222895.2024.2320904 Negative / Null Result ReportOpen accessMedicine
Tadesse M, Tesfaye BA, Taye B et al. · 2026 · Medicine
Hyperthyroidism accelerates bone turnover and increases the risk of secondary osteoporosis. However, evidence from sub-Saharan Africa remains scarce. This study assessed the prevalence and predictors of osteoporosis among hyperthyroid…
View details →DOI: 10.1097/md.0000000000048715 Negative / Null Result ReportOpen accessMedicine
Makino M, Shishikura D, Kusumoto H et al. · 2026 · Cardiovascular diagnosis and therapy
Background The micro-axial intravascular flow pump (mAFP) may potentially improve the prognosis of cardiogenic shock (CS). Despite its advanced hemodynamic profile, efficacy remains undetermined. Safety and mid-term outcomes were compared…
View details →DOI: 10.21037/cdt-2025-302 Negative / Null Result ReportMedicine
Serwer T, Wahid M, Imtiaz F et al. · 2024 · JPMA. The Journal of the Pakistan Medical Association
Objective To identify the mutation in codon 201 of the deleted in colorectal cancer gene in colorectal cancer, and to correlate that mutation to the histopathological grading of colorectal cancer. Methods The cross-sectional study was…
View details →DOI: 10.47391/jpma.9158 Negative / Null Result ReportOpen accessMedicine
Dureha R, Navit S, Khan SA et al. · 2024 · International journal of clinical pediatric dentistry
Aim The aim of this study was to evaluate the antimicrobial efficacy and minimum inhibitory concentration (MIC) of commercially available pediatric dentifrices containing different compositions against Streptococcus mutans and…
View details →DOI: 10.5005/jp-journals-10005-2939 Negative / Null Result ReportMedicine
Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V et al. · 2024 · Free radical biology & medicine
Calcium (Ca 2+ )/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca 2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammatory, metabolic and…
View details →DOI: 10.1016/j.freeradbiomed.2024.08.030 Negative / Null Result ReportOpen accessMedicine
O'Leary RM, Zavlun N, Kinney A et al. · 2025 · Frontiers in psychology
Pupil dilation has become a well-established physiological index of cognitive effort. Here we examined the often-cited finding of an inverted U-shaped function of pupil size across the continuum from highly degraded to clear speech. Unlike…
View details →DOI: 10.3389/fpsyg.2025.1685938 Negative / Null Result ReportMedicine
Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin
Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…
View details →DOI: 10.1248/bpb.b24-00439 Negative / Null Result Report
Bukhari SS, Saeed F, Tahir I et al. · 2023 · Preprint
Abstract Background: The standard of care for gliomas includes maximum safe resection of the tumor. This may lead to inadvertent damage to tissue directly or vasculature supplying normal brain tissue. This may result in perilesional brain…
View details →DOI: 10.21203/rs.3.rs-2616875/v1 Negative / Null Result ReportOpen accessMedicine
Karra DA, Suchodolski JS, Newman SJ et al. · 2025 · Journal of veterinary internal medicine
Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/objectives To evaluate the efficacy of a single enema fecal microbiota transplantation…
View details →DOI: 10.1111/jvim.70054 