Effect of breastfeeding on immunogenicity of oral live-attenuated human rotavirus vaccine: a randomized trial in HIV-uninfected infants in Soweto, South Africa
Michelle J Groome; Sung-Sil Moon; Daniel Velasquez; Stephanie Jones; Anthonet Koen; Nadia van Niekerk; Baoming Jiang; Umesh D Parashar · 2014 · Bulletin of the World Health Organization
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective To investigate the effect of abstention from breastfeeding, for an hour before and after each vaccination, on the immune responses of infants to two doses of rotavirus vaccine. Methods In Soweto, South Africa, mother–infant pairs who were uninfected with human immunodeficiency virus (HIV) were enrolled as they presented for the “6-week” immunizations of the infants. Each infant was randomly assigned to Group 1 – in which breastfeeding was deferred for at least 1 h before and after each dose of rotavirus vaccine – or Group 2 – in which unrestricted breastfeeding was encouraged. Enzyme
Abstract by Michelle J Groome; Sung-Sil Moon; Daniel Velasquez; Stephanie Jones; Anthonet Koen; Nadia van Niekerk; Baoming Jiang; Umesh D Parashar, Bulletin of the World Health Organization (2014) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.2471/blt.13.128066