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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21360 results · page 593 of 712

Negative / Null Result ReportMedicine

Association of IBS-associated E. coli strains with epithelial inflammatory responses and tight junction dysregulation in Caco-2 cells.

Merzaei Z, Kazemian H, Bamzadeh Z et al. · 2026 · BMC research notes

Objective Irritable bowel syndrome (IBS) presents with symptoms of pain, abdominal discomfort, and altered bowel habits. Changes in the intestinal microbiota, including an increase in Enterobacteriaceae like E. coli, have been associated…

View details →DOI: 10.1186/s13104-026-07924-1
Negative / Null Result ReportOpen accessMedicine

Demographic, birth, parental characteristics, and the risk of early-onset colorectal cancer: A population-based nested case-control study in California.

Siddique S, Wang R, Berardi D et al. · 2026 · Cancer

Background The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50 years, has been increasing. The relationship between demographic, birth, and parental characteristics and risk…

View details →DOI: 10.1002/cncr.70458
Negative / Null Result ReportOpen accessMedicine

Immuno-Proteomic Features Associated to Relapse Risk in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Gallaccio G, Müller A, Wang M et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation

Background and objectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder that overlaps clinically with multiple sclerosis (MS) but immunopathologically distinct. Although…

View details →DOI: 10.1212/nxi.0000000000200615
Negative / Null Result ReportMedicine

Preoperative Factors Associated With Postoperative Delirium in Older Patients With Cancer Undergoing Surgery: Retrospective Cohort Study.

Kumura Y, Maruta M, Yokota H et al. · 2026 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background Post-operative delirium (POD) is a common complication in older patients with cancer undergoing surgery, leading to prolonged hospitalisation and cognitive decline. This study examined the relationship between pre-operative…

View details →DOI: 10.1111/psyg.70179
Negative / Null Result ReportOpen accessMedicine

Barium-associated intestinal ischemia complicated with massive hepatic portal venous gas: A successful survival case report.

Xu P, Zhong S, Peng X · 2026 · The Journal of international medical research

Barium-associated intestinal ischemia is a rare but life-threatening complication following upper gastrointestinal barium contrast examinations, with an incidence of less than 0.01%. Hepatic portal venous gas is a condition secondary to…

View details →DOI: 10.1177/03000605261457776
Negative / Null Result ReportMedicine

Preoperative hypoalbuminemia as a prognostic factor in patients with gastric cancer undergoing radical gastrectomy: Construction of a nomogram.

Qu ZW, Zhang Y, Guo MY · 2026 · The Journal of international medical research

ObjectiveTo investigate the association of preoperative hypoalbuminemia (serum albumin <35 g/L) with clinicopathological characteristics and survival outcomes in patients with gastric cancer undergoing radical gastrectomy and to construct…

View details →DOI: 10.1177/03000605261457301
Negative / Null Result ReportMedicine

Serum IDO1 and β-catenin levels in patients with multiple sclerosis with and without atherosclerosis: A case-control study.

Abdulridha GAO, Fadhel AS, Al-Kinany SQ et al. · 2026 · Journal of neuroimmunology

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by leukocyte infiltration, immune activation, demyelination, and axonal injury. This case-control observational study aimed to investigate…

View details →DOI: 10.1016/j.jneuroim.2026.579013
Negative / Null Result ReportMedicine

Acetazolamide-induced metabolic acidosis in pediatric idiopathic intracranial hypertension: associations with bone mineral density, growth, and kidney function.

Baltu D, Taş N, Alıcı N et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Although acetazolamide is the main medical treatment for idiopathic intracranial hypertension (IIH), data on acetazolamide-induced metabolic acidosis and its long-term outcomes are limited. This study aimed to investigate the…

View details →DOI: 10.1007/s00467-026-07431-2
Negative / Null Result ReportMedicine

Identification of Gait Patterns Associated with Paretic Propulsion and Velocity in Community-Dwelling Individuals with Stroke: A Multicenter Retrospective Study.

Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering

Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…

View details →DOI: 10.1007/s10439-026-04203-9
Negative / Null Result ReportOpen accessMedicine

Nature Connectedness and Work Engagement in the Relationship Between Emotional Exhaustion and Life Satisfaction Among Employees.

Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education

This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…

View details →DOI: 10.3390/ejihpe16060079
Replication Failure

Residual cancer cells in re-excision after breast-conserving surgery: association to invasive lobular carcinoma and locoregional recurrence (ISRCTN12077301)

Allfelt A, Bendahl PO, Alkner S et al. · 2026 · Preprint

Abstract Background Invasive lobular carcinoma (ILC) is a risk factor for positive margins after breast-conserving surgery (BCS). This retrospective observational study examined whether the presence of residual cancer cells in re-excision…

View details →DOI: 10.21203/rs.3.rs-10086880/v1
Negative / Null Result ReportMedicine

Aqueous PFOS exposure decouples gaseous carbon loss from mineral-associated carbon retention in controlled wetland-interface mesocosms.

Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…

View details →DOI: 10.1016/j.envpol.2026.128638
Negative / Null Result ReportMedicine

Factors associated with achieving knee flexion around one hundred and twenty five degrees and numerical rating scale around one at one year after posterior cruciate-retaining total knee arthroplasty.

Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics

Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…

View details →DOI: 10.1007/s00264-026-06884-2
Negative / Null Result ReportMedicine

Climate Change Worry and Flourishing Among Chinese University Students: The Roles of Anxiety-Depressive Symptoms and Physical Activity.

Liu S, Tan Y, Zang L · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether…

View details →DOI: 10.3390/healthcare14121624
Replication FailureMedicine

CMV viraemia is associated with mortality among children with HIV starting antiretroviral therapy in sub-Saharan Africa.

Fisayo T, Evans C, Mutasa K et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Cytomegalovirus (CMV) co-infection is associated with mortality in adults with HIV, but whether CMV is associated with mortality in children with HIV remains uncertain. Methods In 498 children (median age 6.3 years,…

View details →DOI: 10.1093/cid/ciag354
Negative / Null Result ReportMedicine

Quantitative Systems Toxicology Model Predicts Obeticholic Acid-Associated Liver Injury in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Mayo AK, Beaudoin JJ, Woodhead JL et al. · 2026 · Clinical pharmacology and therapeutics

Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving…

View details →DOI: 10.1002/cpt.70355
Negative / Null Result ReportOpen accessMedicine

Pulmonary Fibrosis and Pulmonary Function in Patients with Metastatic Testicular Cancer During and after Combination Chemotherapy: The BLEOTOX Study.

Frey L, Grunwald S, Ruckes C et al. · 2026 · European urology open science

Background and objective Metastatic testicular germ cell tumors (mTGCTs) are treated with combination chemotherapy (Cx) containing bleomycin (BEP [bleomycin, etoposide, and cisplatin]). Bleomycin-induced pulmonary toxicity (BPT) is a…

View details →DOI: 10.1016/j.euros.2026.04.004
Negative / Null Result ReportMedicine

Association between extubation timing and functional outcomes in patients with acute ischemic stroke after endovascular treatment.

Liang D, Tong Y, Li F et al. · 2026 · Cerebrovascular diseases (Basel, Switzerland)

Introduction General anesthesia (GA) with endotracheal intubation is standard during endovascular treatment (EVT) for acute ischemic stroke (AIS), but the optimal timing for post-procedural extubation remains unclear. Methods In this…

View details →DOI: 10.1159/000552953
Negative / Null Result ReportMedicine

Preoperative posterior pelvic tilt is associated with residual low back pain and inferior patient-reported outcomes after total hip arthroplasty.

Ito K, Fujii M, Oba Y et al. · 2026 · International orthopaedics

Purpose To determine changes in low back pain (LBP) after total hip arthroplasty (THA), identify preoperative factors associated with residual LBP and LBP improvement, and clarify the association between residual LBP and patient-reported…

View details →DOI: 10.1007/s00264-026-06885-1
Negative / Null Result Report

Association of body composition, daily physical activity and handgrip strength with mortality, cardiovascular events and cancers in Japanese patients with diabetes

Hamasaki H, Taxiarchi V · 2026 · Preprint

Aims Sarcopenia and sarcopenic obesity are associated with increased risks of cardiovascular (CV) disease and mortality. This study examined the associations of body composition and daily physical activity with mortality, CV events and…

View details →DOI: 10.64898/2026.06.09.26355239
Negative / Null Result ReportMedicine

Water intake, switching between bites and sips, and drinking behavior are associated with food intake across meals varying in spiciness: A secondary analysis of two randomized crossover studies.

Cunningham PM, Hayes JE · 2026 · Appetite

Widespread nutrition advice instructs consumers to drink water with meals to increase fullness and reduce energy intake. However, recent data indicates greater water intake is associated with more food intake at a meal, not less. Switching…

View details →DOI: 10.1016/j.appet.2026.108698
Negative / Null Result ReportMedicine

Urate-lowering therapy adherence among gout patients in Southwest China: A cross-sectional study of determinants and regional disparities.

Tang Z, Huang C, Qiu G et al. · 2026 · Clinical rheumatology

Objective Gout is directly associated with hyperuricemia. This study aims to investigate the adherence rate to urate-lowering therapy (ULT) and its influencing factors among patients with gout in Southwest China. Methods A cross-sectional…

View details →DOI: 10.1007/s10067-026-08232-6
Negative / Null Result ReportMedicine

Incidence and risk factors of acute blood pressure drops during circular-array pulsed-field ablation for pulmonary vein isolation.

Hashimoto S, Ishiguchi H, Yoshiga Y et al. · 2026 · Heart rhythm

Background Data regarding acute blood pressure (BP) drops during pulsed-field ablation (PFA) for pulmonary vein isolation (PVI) are limited. Objective This study aimed to determine the incidence and risk factors of acute BP drops during…

View details →DOI: 10.1016/j.hrthm.2026.02.050
Negative / Null Result ReportMedicine

EXPRESS: Exaggerated Self-Referencing in Body Dysmorphic Disorder.

Richards-Brown M, Castiello de Obeso S, Dennison R et al. · 2026 · Quarterly journal of experimental psychology (2006)

The self-prioritisation effect demonstrates that people have a bias to learn and process self-relevant compared to other-relevant information. This tendency may provide a tool to understand how body image and perception become disrupted in…

View details →DOI: 10.1177/17470218261465670