Negative / Null Result ReportOpen accessMedicine
Dong Dong, Nicky Thomas, Benjamin Thierry et al. · 2015 · PLoS ONE
BACKGROUND: Staphylococcus aureus and Pseudomonas aeruginosa are major pathogens in chronic rhinosinusitis (CRS) and their biofilms have been associated with poorer postsurgical outcomes. This study investigated the distribution and anti-biofilm effect of cationic (+) and anionic (-) phospholipid liposomes with different sizes (unilamellar and multilamellar vesicle, ULV and MLV respectively) on S. aureus and P. aeruginosa biofilms. METHOD: Specific biofilm models for S. aureus ATCC 25923 and P. aeruginosa ATCC 15692 were established. Liposomal distribution was determined by observing SYTO9 sta
View details →DOI: 10.1371/journal.pone.0131806Cited by 93 Negative / Null Result ReportMedicine
Ian Y. Wong, Raymond Wong, Paul Zhao et al. · 2012 · Retina
PURPOSE: To investigate the relationship of hypercholesterolemia and choroidal thickness in normal healthy volunteers. METHOD: This was a cross-sectional observational study. Volunteers with no ocular abnormalities were examined using…
View details →DOI: 10.1097/iae.0b013e3182753b5aCited by 93 Replication FailureMedicine
Sebastian Wolfrum, Kevin Roedl, Alexia Hanebutte et al. · 2022 · Circulation
Background: This study was conducted to determine the effect of hypothermic temperature control after in-hospital cardiac arrest (IHCA) on mortality and functional outcome as compared with normothermia. Methods: An investigator initiated,…
View details →DOI: 10.1161/circulationaha.122.060106Cited by 93 Negative / Null Result ReportOpen accessImmunology and Microbiology
E. J. Kerschen, Irene Hernández, Mark Zogg et al. · 2010 · Journal of Clinical Investigation
Activated protein C (aPC) therapy reduces mortality in adult patients with severe sepsis. In mouse endotoxemia and sepsis models, mortality reduction requires the cell signaling function of aPC, mediated through protease-activated…
View details →DOI: 10.1172/jci42629Cited by 93 Negative / Null Result ReportOpen accessMedicine
Robert D. Boutin, Sara Bamrungchart, Cyrus Bateni et al. · 2017 · American Journal of Roentgenology
OBJECTIVE: Our objective was to determine the association between muscle cross-sectional area and attenuation, as measured on routine CT scans, and mortality in older patients with hip fracture. MATERIALS AND METHODS: A retrospective…
View details →DOI: 10.2214/ajr.16.17226Cited by 93 Negative / Null Result ReportOpen accessMedicine
Nancy L. Bartlett, Sarit Assouline, Pratyush Giri et al. · 2023 · Blood Advances
As part of a phase 1 or 2 study, this single-arm expansion cohort established the efficacy and safety of mosunetuzumab monotherapy in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) (received ≥2 previous lines…
View details →DOI: 10.1182/bloodadvances.2022009260Cited by 93 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Philip T. Leftwich, Naomi V. E. Clarke, Matthew I. Hutchings et al. · 2017 · Proceedings of the National Academy of Sciences
Significance The evolutionary significance of assortative mating by diet, mediated by gut bacteria is a puzzle, but it has had a huge impact and has provided a keystone to support increasing interest in the “holobiome.” However, in species…
View details →DOI: 10.1073/pnas.1708345114Cited by 93 Negative / Null Result Report
Hande Sezgin, Omer B Berkalp · 2016 · Journal of Industrial Textiles
In this study, four plied jute, carbon, E-glass fabric-reinforced and their hybridized composites are manufactured. Nine composite laminates with different stacking sequences are manufactured by vacuum infusion technique. In order to…
View details →DOI: 10.1177/1528083716644290Cited by 93 Negative / Null Result ReportOpen accessMedicine
Claudia Torino, Fabio Manfredini, Davide Bolignano et al. · 2014 · Kidney & Blood Pressure Research
BACKGROUND/AIMS: Scarce physical activity predicts shorter survival in dialysis patients. However, the relationship between physical (motor) fitness and clinical outcomes has never been tested in these patients. METHODS: We tested the…
View details →DOI: 10.1159/000355798Cited by 92 Negative / Null Result ReportMedicine
Wentao Zhao, Fengliang Hu, Yuying Li et al. · 2012 · World Journal of Surgery
BACKGROUND: The aim of the present study was to investigate the usefulness of the transanal drainage tube for prevention of anastomotic leakage and bleeding after anterior resection for rectal cancer. METHODS: Between January 2007 and May…
View details →DOI: 10.1007/s00268-012-1812-9Cited by 92 Negative / Null Result ReportMedicine
Daniel Brock Hewitt, Nicholas Nissen, Hassan Hatoum et al. · 2020 · Annals of Surgery
OBJECTIVES: To compare the efficacy and safety of algenpantucel-L [HyperAcute-Pancreas algenpantucel-L (HAPa); IND# 12311] immunotherapy combined with standard of care (SOC) chemotherapy and chemoradiation to SOC chemotherapy and…
View details →DOI: 10.1097/sla.0000000000004669Cited by 92 Negative / Null Result ReportMedicine
Leigh L. van den Heuvel, Nathaniel Chishinga, Eugene Kinyanda et al. · 2013 · AIDS Care
We determined the frequency and correlates of current common mental disorders (CMDs) in a consecutive series of 649 adult patients with human immunodeficiency virus (HIV), tuberculosis (TB) or both receiving treatment at 16 primary health…
View details →DOI: 10.1080/09540121.2013.793263Cited by 92 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Davide Fiore Bavaro, Alessandra Belati, Lucia Diella et al. · 2021 · Antibiotics
Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as “rescue” treatments in immunocompromised or critically ill patients or in patients with post-surgical infections who had failed previous regimens. A total of 13 patients were treated from 1 September 2020 to 31 March 2021. In total, 5/13 (38%) patients were classified as critically ill, due to severe COVID-19 lung failure; 4/13 (31%) patients had post-surgical infections and 4/13 (31%) had severe infections in immunoc
View details →DOI: 10.3390/antibiotics10060652Cited by 92 Negative / Null Result ReportOpen accessMedicine
Maximilian Salcher‐Konrad, Huseyin Naci, Courtney Davis · 2020 · Milbank Quarterly
Policy Points Regulatory agencies may have limited evidence on the clinical benefits and harms of new drugs when deciding whether new therapeutic agents are allowed to enter the market and under which conditions, including whether approval is granted under special regulatory pathways and obligations to address knowledge gaps through postmarketing studies are imposed. In a matched comparison of marketing applications for cancer drugs of uncertain therapeutic value reviewed by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), we found frequent discordance be
View details →DOI: 10.1111/1468-0009.12476Cited by 92 Negative / Null Result ReportOpen accessMedicine
Marco Metra, Cathal O’Connor, Beth A. Davison et al. · 2011 · European Heart Journal
AIMS: Dyspnoea and pulmonary and/or peripheral congestion are the most frequent manifestations of acute heart failure (AHF) and are important targets for therapy. We have assessed changes in dyspnoea, their relationship with mortality, and…
View details →DOI: 10.1093/eurheartj/ehr042Cited by 92 Negative / Null Result ReportMedicine
Susanna Wiegand, Dagmar l’Allemand, Hanna Hübel et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: To study whether metformin reduces obesity, homeostasis model assessment for insulin resistance index (HOMA-IR), and the metabolic syndrome (MtS) in obese European adolescents in addition to previous unsuccessful lifestyle…
View details →DOI: 10.1530/eje-10-0570Cited by 92 Negative / Null Result ReportOpen accessNursing
Muhammed A. Usman, Daniel Callo-Concha · 2021 · Agricultural and Food Economics
Abstract Market access influences the dietary diversity and food security for smallholder households in many ways. In Ethiopia, most smallholders are subsistence farmers who have poor access to markets. This study used primary data from a household survey to examine the relationship between market access and the dietary diversity and food security for 324 smallholder households in the Yayu area of southwestern Ethiopia in early 2018. Multivariate regression analysis showed that households located far from market centers consumed not only less diverse foods but also spend less on food consumpti
View details →DOI: 10.1186/s40100-021-00190-8Cited by 92 Negative / Null Result ReportOpen accessDecision Sciences
Ariella Kristal, Ashley V. Whillans, Max H. Bazerman et al. · 2020 · Proceedings of the National Academy of Sciences
Honest reporting is essential for society to function well. However, people frequently lie when asked to provide information, such as misrepresenting their income to save money on taxes. A landmark finding published in PNAS [L. L. Shu, N. Mazar, F. Gino, D. Ariely, M. H. Bazerman, Proc. Natl. Acad. Sci. U.S.A. 109, 15197–15200 (2012)] provided evidence for a simple way of encouraging honest reporting: asking people to sign a veracity statement at the beginning instead of at the end of a self-report form. Since this finding was published, various government agencies have adopted this practice.
View details →DOI: 10.1073/pnas.1911695117Cited by 92 Failed Experiment ReportOpen accessEnvironmental Science
Robert Steinmetz, David L. Garshelis, Wanlop Chutipong et al. · 2013 · Journal of Mammalogy
Asiatic black bears (Ursus thibetanus) and sun bears (Helarctos malayanus) are ecologically similar and coexist extensively across Southeast Asia. We used foraging signs identified to bear species to examine their food selection and…
View details →DOI: 10.1644/11-mamm-a-351.1Cited by 92 Negative / Null Result ReportOpen accessMedicine
Ashley Woodcock, Eugene R. Bleecker, Jan Lötvall et al. · 2013 · CHEST Journal
BACKGROUND: The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting β2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to…
View details →DOI: 10.1378/chest.13-0178Cited by 92 Replication FailureOpen accessPsychology
Tobias Schuwerk, Beate Priewasser, Beate Sodian et al. · 2018 · Royal Society Open Science
Influential studies showed that 25-month-olds and neurotypical adults take an agent's false belief into account in their anticipatory looking patterns (Southgate et al. 2007 Psychol. Sci. 18 , 587–592 ( doi:10.1111/j.1467-9280.2007.01944.x ); Senju et al. 2009 Science 325 , 883–885 ( doi:10.1126/science.1176170 )). These findings constitute central pillars of current accounts distinguishing between implicit and explicit Theory of Mind. In our first experiment, which initially included a replication as well as two manipulations, we failed to replicate the original finding in 2- to 3-year-olds (
View details →DOI: 10.1098/rsos.172273Cited by 92 Negative / Null Result ReportOpen accessMedicine
Kelly A. Liebman, Steven T. Stoddard, Amy C. Morrison et al. · 2012 · PLoS neglected tropical diseases
BACKGROUND: Knowledge of spatial patterns of dengue virus (DENV) infection is important for understanding transmission dynamics and guiding effective disease prevention strategies. Because movement of infected humans and mosquito vectors plays a role in the spread and persistence of virus, spatial dimensions of transmission can range from small household foci to large community clusters. Current understanding is limited because past analyses emphasized clinically apparent illness and did not account for the potentially large proportion of inapparent infections. In this study we analyzed both c
View details →DOI: 10.1371/journal.pntd.0001472Cited by 91 Negative / Null Result ReportOpen accessEnvironmental Science
Rahul Gondalia, Antoine Baldassari, Katelyn M. Holliday et al. · 2019 · Environment International
DNA methylation (DNAm) may contribute to processes that underlie associations between air pollution and poor health. Therefore, our objective was to evaluate associations between DNAm and ambient concentrations of particulate matter (PM)…
View details →DOI: 10.1016/j.envint.2019.03.071Cited by 91 Negative / Null Result ReportOpen accessNeuroscience
Alex I. Wiesman, Jennifer O’Neill, Mackenzie S. Mills et al. · 2018 · Brain
Combination antiretroviral therapies have revolutionized the treatment of HIV infection, and many patients now enjoy a lifespan equal to that of the general population. However, HIV-associated neurocognitive disorders (HAND) remain a major…
View details →DOI: 10.1093/brain/awy097Cited by 91 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
R. Anand, Kartik Shah, Hengyao Niu et al. · 2011 · Nucleic Acids Research
DNA sequences that form secondary structures or bind protein complexes are known barriers to replication and potential inducers of genome instability. In order to determine which helicases facilitate DNA replication across these barriers,…
View details →DOI: 10.1093/nar/gkr836Cited by 91 Negative / Null Result ReportOpen accessMedicine
H Grubek-Jaworska, Magdalena Paplińska‐Goryca, Joanna Hermanowicz-Salamon et al. · 2012 · Respiration
BACKGROUND: IL-6 is strongly implicated in the development of chronic obstructive pulmonary disease (COPD). IL-13 is the well-documented central mediator in allergic asthma. IL-6 is attributed to the proinflammatory activities in COPD as…
View details →DOI: 10.1159/000334900Cited by 91 Replication FailureOpen accessMedicine
Mikkael A. Sekeres, J. E. Lancet, Brent L. Wood et al. · 2012 · Haematologica
Improving outcomes in older adults with acute myeloid leukemia remains a formidable challenge. Lintuzumab (SGN-33; HuM195) is a humanized monoclonal antibody directed against CD33, which is expressed on the majority of myeloblasts in acute…
View details →DOI: 10.3324/haematol.2012.066613Cited by 91 Negative / Null Result ReportChemistry
Xiao‐Qiang Hu, Yuxing Zhang, Yixin Zhang et al. · 2020 · ChemCatChem
Abstract Ligand steric bulk is one of the most important parameters on determining activity, polymer molecular weight, and branching density in α‐diimine Ni(II) and Pd(II) catalyzed ethylene polymerization. In this contribution, we…
View details →DOI: 10.1002/cctc.202000141Cited by 91 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Elizabeth Nance, Siva P. Kambhampati, Elizabeth S. Smith et al. · 2017 · Journal of Neuroinflammation
Rett syndrome (RTT) is a pervasive developmental disorder that is progressive and has no effective cure. Immune dysregulation, oxidative stress, and excess glutamate in the brain mediated by glial dysfunction have been implicated in the pathogenesis and worsening of symptoms of RTT. In this study, we investigated a new nanotherapeutic approach to target glia for attenuation of brain inflammation/injury both in vitro and in vivo using a Mecp2-null mouse model of Rett syndrome. To determine whether inflammation and immune dysregulation were potential targets for dendrimer-based therapeutics in R
View details →DOI: 10.1186/s12974-017-1004-5Cited by 91 Negative / Null Result ReportOpen accessMedicine
Rachna T. Shroff, Mark Yarchoan, Ashley O’Connor et al. · 2017 · British Journal of Cancer
BACKGROUND: Cholangiocarcinoma is an aggressive malignancy with limited therapeutic options. MEK inhibition and antiangiogenic therapies have individually shown modest activity in advanced cholangiocarcinoma, whereas dual inhibition of…
View details →DOI: 10.1038/bjc.2017.119Cited by 91 