Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice
E. J. Kerschen; Irene Hernández; Mark Zogg; Shuang Jia; Martin J. Hessner; José A. Fernández; John H. Griffin; Claudia S. Huettner · 2010 · Journal of Clinical Investigation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Activated protein C (aPC) therapy reduces mortality in adult patients with severe sepsis. In mouse endotoxemia and sepsis models, mortality reduction requires the cell signaling function of aPC, mediated through protease-activated…
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Metadata source: OpenAlex · DOI 10.1172/jci42629