A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Haifei Zhang, Yànhuá Lǐ, Jie‐Zhong Yu et al. · 2013 · NeuroImmunoModulation
Macrophages/microglia exhibit phenotypic and functional heterogeneity under physiological and pathological conditions. Owing to this heterogeneity, the polarization of macrophages/microglia is capable of effecting both detrimental and…
Kevin K. Beentjes, Arjen G. C. L. Speksnijder, Menno Schilthuizen et al. · 2019 · PeerJ
Background The heterogeneous nature of environmental DNA (eDNA) and its effects on species detection and community composition estimates has been highlighted in several studies in the past decades. Mostly in the context of spatial…
Ali A. Farooqui, Bradley Hiser, Stephen L. Barnes et al. · 2013 · Journal of neurosurgery
OBJECT: Patients with traumatic brain injury (TBI) are at risk for development of thromboembolic disease. The use of chemoprophylaxis in this patient group has not fully been characterized. The authors hypothesize that early…
Björn Philips, Peter Wennberg, Per Konradsson et al. · 2018 · European Addiction Research
AIMS: There is a scarcity of clinical trials on psychological treatments for concurrent borderline personality disorder (BPD) and substance use disorder (SUD). Mentalization-based treatment (MBT) have shown efficacy in several trials on…
Jonathan W. Byrnes, Wes McKamie, Christopher J. Swearingen et al. · 2011 · ASAIO Journal
Extracorporeal membrane oxygenation (ECMO) is a lifesaving therapy, which has been used for the support of children with a broad range of diseases. Two pumps of differing mechanisms have been used to generate the extracorporeal flow:…
Francesco Sclafani, Tae‐Yop Kim, David Cunningham et al. · 2015 · JNCI Journal of the National Cancer Institute
BACKGROUND: Insulin-like growth factor type 1 receptor (IGF-1R) mediates resistance to epidermal growth factor receptor (EGFR) inhibition and may represent a therapeutic target. We conducted a multicenter, randomized, double blind, phase…
Susan M. Smith, Tom Fahey, John Smucny et al. · 2017 · Cochrane Database of Systematic Reviews
Background The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care. Objectives To assess the effects of antibiotics in improving outcomes and to…
Sung‐Wan Kim, Joon‐An Yoo, S. Y. Lee et al. · 2010 · Human Psychopharmacology Clinical and Experimental
OBJECTIVE: This study compared the effectiveness of risperidone and olanzapine in the treatment of delirium. METHODS: This was a 7-day, randomized, comparative clinical trial of risperidone and olanzapine in patients with delirium. The…
Edward S. Brewer, B. I. Reznikov, Rebecca F. Liberman et al. · 2010 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: The yield of head computed tomography (CT) for patients who suffered head trauma with a presenting Glasgow Coma Scale (GCS) score of 15 has been reported to be low, even in patients who are anticoagulated or on antiplatelet…
Santiago Acosta Ormaechea, Jiae Yoo, SAcosta Ormaechea@imf.org et al. · 2012 · IMF Working Paper
We investigate the relation between changes in tax composition and long-run economic growth using a new dataset covering a broad cross-section of countries with different income levels. We specifically consider 69 countries with at least…
Ananyananda Dasari, Sakthi Kumar Arul Prakash, László A. Jeni et al. · 2021 · npj Digital Medicine
This work investigates the estimation biases of remote photoplethysmography (rPPG) methods for pulse rate measurement across diverse demographics. Advances in photoplethysmography (PPG) and rPPG methods have enabled the development of contact and noncontact approaches for continuous monitoring and collection of patient health data. The contagious nature of viruses such as COVID-19 warrants noncontact methods for physiological signal estimation. However, these approaches are subject to estimation biases due to variations in environmental conditions and subject demographics. The performance of c
R. Abbott, H. Abe, F. Acernese et al. · 2025 · Physical review. D/Physical review. D.
The ever-increasing number of detections of gravitational waves from compact binaries by the Advanced LIGO and Advanced Virgo detectors allows us to perform ever-more sensitive tests of general relativity (GR) in the dynamical and…
Nativ Omri, Malshy Kamil, Kastin Alexander et al. · 2020 · The Prostate
Abstract Background The early diagnosis of prostate cancer (PCa) is mainly based on prostate‐specific antigen (PSA) blood levels and digital rectal examination. However, this approach may result in a high rate of negative biopsies and…
Uzma S. Rehman, Erick Janssen, Sarah K. Newhouse et al. · 2011 · Journal of Sex & Marital Therapy
The way couples communicate during conflict discussions has been found to be a reliable predictor of marital satisfaction. However, in previous research, there has been little experimental control over the selection of topics. The present…
Patricia Baxter, Jack M. Su, Arzu Onar‐Thomas et al. · 2020 · Neuro-Oncology
BACKGROUND: A Pediatric Brain Tumor Consortium (PBTC) phase I/II trial of veliparib and radiation followed by veliparib and temozolomide (TMZ) was conducted in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). The…
Allon N. Friedman, Mary Chambers, Lisa M. Kamendulis et al. · 2013 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Obesity precedes and is strongly linked to the development of type 2 diabetic nephropathy in most patients, yet little is known about the effects of weight reduction on this disease. This study aimed to establish…
Syed Khalid, Ravi S. Nunna, Samantha Maasarani et al. · 2020 · Neurosurgical FOCUS
OBJECTIVE: Patients with osteopenia or osteoporosis who require surgery for symptomatic degenerative spondylolisthesis may have higher rates of postoperative pseudarthrosis and need for revision surgery than patients with normal bone…
Mark A. Hyde, Michael L. Hadley, Payam Tristani‐Firouzi et al. · 2012 · Archives of Dermatology
OBJECTIVE: To determine if the complete response rates of lentigo maligna (LM) to imiquimod, 5%, cream can be improved by the addition of a topical retinoid. DESIGN: Prospective randomized study of patients treated with imiquimod alone vs…
William W. Ho, Igor L. Gomes‐Santos, Shuichi Aoki et al. · 2021 · Proceedings of the National Academy of Sciences
Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair-proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are unresponsive to immune checkpoint blockade (ICB) therapy. Here…
Eric J. Pedersen, William H.B. McAuliffe, Michael E. McCullough · 2018 · Journal of Experimental Psychology General
Many social scientists believe humans possess an evolved motivation to punish violations of norms-including norm violations that do not harm them directly. However, most empirical evidence for so-called altruistic punishment comes from…
Xuling Lin, M. Lee, Olivia Buck et al. · 2016 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed to examine the use of DWI and T1-weighted dynamic contrast-enhanced–MR imaging as potential discriminative tools. MATERIALS AND METHODS: We retrospectively reviewed 18 patients with primary CNS lymphoma and 36 matched patients with glioblastoma with pretreatment DWI and dynamic contrast-enhanced–MR imaging. VOIs were drawn around the tumor on contrast-enhan
Tim B. Bigdeli, Stephan Ripke, Roseann E. Peterson et al. · 2017 · Translational Psychiatry
Abstract Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects. We determined the fraction of SNPs displaying c
Sunhee Park, David J. Hendry · 2015 · American Journal of Political Science
An underlying assumption of proportional hazards models is that the effect of a change in a covariate on the hazard rate of event occurrence is constant over time. For scholars using the Cox model, a Schoenfeld residual‐based test has…
Haftu Etsay, Teklay Negash, Metkel Aregay · 2019 · Ecological Processes
Sustainable land management is considered as one of the useful approaches to combat the threat of various forms of land degradation in Ethiopia. Despite this, there is scant information regarding households’ decision towards the implementation of sustainable land management practices. This paper, therefore, looks into the determinants for the continued use and choice of the sustainable land management practices by smallholder farmers and its productivity effect in three randomly chosen districts in Tigrai region, Ethiopia. The study uses data from household survey and key informant interviews.
Hakan Gündüz · 2021 · Financial Innovation
Abstract In this study, the hourly directions of eight banking stocks in Borsa Istanbul were predicted using linear-based, deep-learning (LSTM) and ensemble learning (LightGBM) models. These models were trained with four different feature sets and their performances were evaluated in terms of accuracy and F-measure metrics. While the first experiments directly used the own stock features as the model inputs, the second experiments utilized reduced stock features through Variational AutoEncoders (VAE). In the last experiments, in order to grasp the effects of the other banking stocks on individ
Lara M. Wierenga, Marieke Bos, Fabienne van Rossenberg et al. · 2019 · Journal of Cognitive Neuroscience
Although male brains have consistently reported to be 8-10% larger than female brains, it remains not well understood whether there are differences between sexes (average or variance) in developmental trajectories. Furthermore, if sex…
Federico C. F. Calboli, Federica Tozzi, N. W. Galwey et al. · 2010 · PLoS ONE
Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of popu
Amy C. Graham, Kimberly M. Hilmer, Julianne Zickovich et al. · 2013 · The Journal of Immunology
Influenza A virus (IAV) is a major respiratory pathogen of both humans and animals. The lung is protected from pathogens by alveolar epithelial cells, tissue-resident alveolar macrophages, dendritic cells, and mast cells. The role of…
Harold Bae, Paola Sebastiani, Jenny X. Sun et al. · 2013 · Frontiers in Genetics
Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p < 10(-8)) and replicated in a
Elisa Maria Stroppa, Ilaria Toscani, Chiara Citterio et al. · 2020 · Future Oncology
Background: We describe cancer patients with coronavirus disease-2019 (COVID-19) infection treated at the Piacenza’s general hospital (north Italy). Materials & methods: 25 cancer patients infected by COVID-19 admitted at the Piacenza’s…