Negative / Null Result ReportMedicine
Rossmann J, Hense K, Knott M et al. · 2026 · Journal of neurosurgery
Objective Predicting language lateralization using functional MRI (fMRI) in patients with cerebral vascular malformations close to language areas is essential for treatment decision-making and patient outcomes. Functional MRI-based…
View details →DOI: 10.3171/2026.1.jns252444 Negative / Null Result ReportOpen access
SPATERNA, Andrea, MECHELLI A., SANTORO D. et al. · 2008
A case of canine cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) with generalized asymmetrical alopecia and plaques is described. Results from histopathologic examination were suggestive of SPGS and failed to demonstrate any…
Negative / Null Result ReportOpen access
Yuko Yoshimura (283970), Hirotoshi Hiraishi (283977), Mitsuru Kikuchi (140272) et al. · 2015
Two-way ANOVA (treatment × drug) failed to demonstrate any drug or treatment effects, and no significant interaction between these two factors was detected. Therefore, we failed to demonstrate any OT-related effect on…
View details →DOI: 10.1371/journal.pone.0116918.g004 Negative / Null Result ReportOpen access
Davis, Joyce Lucille, NC DOCKS at The University of North Carolina at Greensboro · 1979
The purpose of this experiment was to determine the effectiveness of reflectivity training for kindergarten and second grade subjects using one-to-one correspondence tasks. It was hypothesized that there were no significant differences…
Negative / Null Result ReportOpen accessMedicine
Jiu Chen, Guolin Wu · 2018 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
OBJECTIVE To assess the necessity of prophylactic antibiotic therapy in HCC patients undergoing transcatheter arterial chemoembolization (TACE). STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY The First Affliated Hospital,…
View details →DOI: 10.29271/jcpsp.2018.12.914 Negative / Null Result ReportOpen access
Hull, Glenn · 2017
This paper determines the effects of police interventions on darknet markets. Darknet markets have been rapidly growing and the amount of drugs being sold on them keeps rising. This paper finds no significant changes in prices of drug…
Negative / Null Result ReportOpen access
Sandra Demaria (15026216), Shannon Martello (11246282), Molykutty J. Aryankalayil (5544962) et al. · 2020
Metabolic data from PC3 cells 6h, 24h, and 48h after SD or MF radiation. Samples were sent to Metabolon for processing. Results indicate decrease in glycolysis intermediates in SD sample at 6h. No significant changes to TCA cycle…
View details →DOI: 10.1158/1078-0432.22477403.v1 Negative / Null Result ReportOpen accessMedicine
Kosaka T, Kubo K · 2026 · PloS one
This study aimed to examine the effects of muscle-tendon mechanical properties and electromyographic activity patterns on individual differences in the force-power relationship during jumping with and without countermovement. Twenty men…
View details →DOI: 10.1371/journal.pone.0350202 Negative / Null Result ReportOpen access
Andrew W. Taylor (451751) · 2013
The macrophages lysates were assayed for protein concentration and Caspase 3 activity. There was no significant change of Caspase 3 activity in cells treated with α-MSH compared to SFM cells. The graft is the mean ± SD of Caspase 3…
View details →DOI: 10.1371/journal.pone.0074488.g004 Negative / Null Result ReportMedicine
Wang, Li, He et al. · 2026 · Reviews in cardiovascular medicine
The influence of repair of congenital heart defect (CHD) via a right subaxillary thoracotomy (RSAT) on postoperative pulmonary function and prognosis in small infants is a key consideration. Data were collected from infants who underwent…
View details →DOI: 10.31083/rcm46570 Negative / Null Result ReportMedicine
Wang, Peng, Liu et al. · 2026 · Frontiers in genetics
Toll-like receptor 3 (TLR3) plays an important role in the pathogenesis of schizophrenia and the TLR3 single nucleotide polymorphism (SNP) rs3775291 is associated with central nervous system diseases. In this study, we analysed the…
View details →DOI: 10.3389/fgene.2026.1839603 Negative / Null Result ReportOpen access
Jiankang Jin (703171), Stephen J. Archibald (703175), Janani Panneerselvam (703170) et al. · 2015
A , RT-PCR analysis showed IL-24 reduced CXCR4 mRNA levels at 6 h and 24 h ( P B , CXCR4 promoter activity was determined using a luciferase reporter vector. Induction of IL-24 showed no significant reduction in luciferase activity…
View details →DOI: 10.1371/journal.pone.0122439.g004 Negative / Null Result ReportOpen access
Akerley, Wallace, Herndon, James E. 2nd, Vokes, Everett E. et al. · 2017
BACKGROUND: In Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction…
View details →DOI: 10.1097/jto.0b013e3181b27b33. Negative / Null Result ReportOpen access
Khalid Mustafa Ali (4461853), Christine Roffe (220471), Anushka Warusevitane (220475) et al. · 2011
Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12…
Negative / Null Result ReportOpen access
· 2011
Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12…
View details →DOI: 10.1371/journal.pone.0019113 Negative / Null Result ReportOpen access
ÖZGEN ALPAYDIN, AYLİN, Begum GORGULU, Aylin Özgen ALPAYDIN et al. · 2022
Background: Specific breathing exercises are reported to improve quality of life and reduce symptoms; although no significant benefit on lung function or reduction of exacerbation risk is indicated. Additionally, inspiratory muscle…
View details →DOI: 10.30621/jbachs.998416 Negative / Null Result ReportOpen access
J. R. Mondt, D. C. Siegla · 1974
Heat transfer and flow friction behavior have been measured for plain and perforated plate-fin and 10-deg herringbone surfaces. For the range of geometries and Reynolds numbers studied, the perforations produced no significant improvement…
View details →DOI: 10.1115/1.3445766 Negative / Null Result ReportOpen access
田原, 靖昭, 西澤, 昭, 管原, 正志 et al. · 1991
Aerobic exercise class was opened and blood and physical composition were examined. Results indicated that no significant improvement on measured items was observed. Frequency of participation is suggested to be increased or class goal…
Negative / Null Result ReportOpen access
Wynands, Seth · 2015
This paper examines the socio-political instability link between inequality and investment. For the period between 1960 and 2011 for 192 countries, this paper finds no significant correlation between inequality and instability and no…
View details →DOI: 10.17615/6jvd-e825 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Cristiana Mateus, Cláudio J. Maia, Fernanda Domingues et al. · 2023 · Antibiotics
Aliarcobacter butzleri is a Gram-negative bacterium associated with infections of the gastrointestinal tract and widely distributed in various environments. For successful infection, A. butzleri should be able to tolerate various stresses during gastrointestinal passage, such as bile. Bile represents an antimicrobial host barrier that acts against external noxious agents and consists of a variety of bile salts. The intestinal bile salts act as detergents involved in the antimicrobial host defense; although, on the bacterial side, they could also serve as a signal to activate virulence mechanis
View details →DOI: 10.3390/antibiotics12091387 Negative / Null Result ReportOpen accessSocial Sciences
Richie Bayuran · 2019 · JPAIR
Brown seaweed is one of the algal species that has been used as food, a source of nutritional supplements, and formulated for therapeutic and cosmetic purposes. This study evaluated the antioxidant and antistaphylococcal activities of topical fucoidan gel (TFG) from the Sargassum oligocystum. A completely randomized design was used, and the experimental protocol includes extraction, lyophilization, and characterization, quality testing, and biological assay. Physicochemical tests suggested that the lyophilized fucoidan is comparable with the properties of pharmaceutical-grade fucoidan. FTIR ch
View details →DOI: 10.7719/jpair.v38i1.731 Negative / Null Result ReportOpen accessMedicine
Wishyar Jamal Al-Bazzaz, Nihad Rifaat Jawad2 Ali W. AlKhayat · 2020 · Zanco Journal of Medical Sciences
Background and objective: Prostate Thulium laser vaporization is a novel treatment option for a bladder outlet obstruction caused by benign prostate enlargement. However, this surgical technique has not yet been standardized. We present our finding of using Tm vaporesection of the prostate. This study aimed to assess the efficacy and safety of thulium laser versus bipolar transurethral resection of the prostate for treating patients with benign prostatic obstruction. Methods: Sixty three consecutive patients with benign prostatic hyperplasia attending public and private clinics in Erbil city w
View details →DOI: 10.15218/zjms.2020.027 Negative / Null Result ReportOpen accessDentistry
Anum Tanwir, Shahbaz Ahmed, Hira Akhtar et al. · 2022 · European Endodontic Journal
Objective: The objective of this study was to compare the effectiveness of premedication drugs including single dose Piroxicam and Prednisolone in regard to post endodontic pain at different time intervals (24, 48, 72 and 96 hours) after single visit root canal treatment. Methods: This randomized clinical trial (registration no. NCT04124822) was performed in operative dentistry department of a private clinical institute. One hundred twenty patients identified with symptomatic irreversible pulpitis were included in the study. The pain intensity levels were marked through the use of visual analo
View details →DOI: 10.14744/eej.2022.24119 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yuan-yuan LU, Xu-tong ZHAO, Qing-qing WANG et al. · 2018 · Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To investigate the mitochondrial DNA (mtDNA) mutation load in hair follicles from different scalp regions of patients with mitochondrial, encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), compare the mutation load in different scalp regions, and analyze the difference in mutation load between scalp regions with lesion site in the brain and scalp regions without lesion site in the brain. Methods Seven MELAS patients with m.3243A > G mutations were studied. Hair follicles were obtained from 8 scalp regions (bilateral frontal, temporal, parietal and occipital lobe
View details →DOI: 10.3969/j.issn.1672-6731.2018.08.004 Negative / Null Result ReportOpen accessMedical technology
Carlo Calabrese, Carlo Calabrese, Dania Gelli et al. · 2022 · Frontiers in Medical Technology
BackgroundCrohn's disease (CD) is a potentially debilitating condition that burdens Italian healthcare substantially. The symptomatic management relies on prompt therapy adjustment to reduce flares and follow-up diagnostic inputs to maximise remission. Capsule endoscopy (CE) has introduced advantages in CD diagnostics, allowing the direct inspection of the entire gastrointestinal mucosa. The diagnostic procedure is comparable in effort to standard ileocolonoscopy (IC) but requires no anaesthesia. Whether CE follow-up improves clinical outcomes remains to be defined.ObjectivesTo provide a preli
View details →DOI: 10.3389/fmedt.2022.1038087 Negative / Null Result ReportOpen accessMedicine
Thaiz Ferraz Borin, Debora A P C Zuccari, Bruna V Jardim-Perassi et al. · 2014 · PLoS ONE
A selective inhibitor of 20-HETE synthesis, HET0016, has been reported to inhibit angiogenesis. 20-HETE has been known as a second mitogenic messenger of angiogenesis inducing growth factors. HET0016 effects were analyzed on MDA-MB-231 derived breast cancer in mouse and in vitro cell line. MDA-MB-231 tumor cells were implanted in animals' right flank and randomly assigned to early (1 and 2), starting treatments on day 0, or delayed groups (3 and 4) on day 8 after implantation of tumor. Animals received HET0016 (10 mg/kg) treatment via intraperitoneal injection for 5 days/week for either 3 or 4
View details →DOI: 10.1371/journal.pone.0116247 Negative / Null Result ReportOpen accessOrthopedic surgery
Taeko Fukuda, Shinobu Imai, Shunji Simoda et al. · 2020 · Journal of Orthopaedic Surgery
Purpose: It is unclear whether perioperative analgesic techniques affect the functional outcome of total knee replacement (TKR). We investigated the effects of peripheral nerve block (PNB) and local infiltration (LI) on walking ability after TKR. Methods: The medical records of 7143 patients who underwent TKR using general anesthesia with PNB or LI techniques were reviewed. Factors affecting independence and/or improvement of walking after surgery were investigated using multivariate regression analysis. To adjust for baseline differences and minimize selection bias for the chosen analgesic te
View details →DOI: 10.1177/2309499020931656 Negative / Null Result ReportOpen accessMedicine
Matthias Huber, Till Treutler, Peter Martus et al. · 2013 · PLoS ONE
Unlabelled Treatment of hypertension in hemodialysis (HD) patients is characterised by lack of evidence for both the blood pressure (BP) target goal and the recommended drug class to use. Telmisartan, an Angiotensin receptor blocker (ARB) that is metabolised in the liver and not excreted via HD extracorporeal circuit might be particularly suitable for HD patients. We designed and conducted a randomised, placebo-controlled, double-blind and cross-over trial for treatment of dialysis-associated hypertension with telmisartan 80 mg once daily or placebo on top of standard antihypertensive treatmen
View details →DOI: 10.1371/journal.pone.0079322 Negative / Null Result ReportOpen accessSports medicine
Mario Hevesi MD, PhD, Alexander M. Boos, Allen Wang et al. · 2024 · Orthopaedic Journal of Sports Medicine
Objectives: Medial meniscus posterior root tears (MMPRTs) render the meniscus essentially non-functional, resulting in increased peak contact pressures, reduced forced dissipation, and increased risk of early osteoarthritis. Transtibial root repair has shown promise at restoring meniscus function and improving clinical outcomes; however, a paucity of literature exists evaluating the prognostic clinical and radiographic factors for poor outcomes following isolated meniscus root repair. The purpose of this study was to 1) describe the patient reported clinical outcomes after isolated MMPRT repai
View details →DOI: 10.1177/2325967124s00200 Negative / Null Result ReportOpen accessPublic aspects of medicine
Ahmed M. Aman Allah, Waad M. Malibarey, Sarah S. Bin Baz et al. · 2025 · The Saudi Journal of Health Systems Research
Introduction: Telehealth is a potential method for improving the quality of care for people diagnosed with type 2 diabetes (T2D). In Saudi Arabia, there is limited research on the effectiveness of telehealth for glycemic control compared to usual care. Thus, the aim of the current study was to determine the impact of telehealth on glycemic control in individuals diagnosed with T2D, with a specific focus on the examination of hemoglobin A1c (HbA1c) values. Methods: A retrospective case-control cohort study was conducted between January and August 2024 on people diagnosed with T2D who were manag
View details →DOI: 10.1159/000544061 