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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21300 results · page 371 of 710

Negative / Null Result ReportMedicine

Trajectories and predictors of psycho-social adjustment in patients post hepatocellular carcinoma surgery: A longitudinal study.

Li M, He H, Dong L et al. · 2026 · Journal of psychosomatic research

Background Patients post hepatocellular carcinoma (HCC) surgery encounter physiological challenges as well as psychological and social adaptation problems,yet the trajectory and predictors of their psychosocial adjustment (PSA) remain…

View details →DOI: 10.1016/j.jpsychores.2026.112691
Negative / Null Result ReportMedicine

Death Conceptualizations: How do Youth Presenting to a Pediatric Psychiatric Emergency Department View the End of their Lives?

Tezanos KM, Simeone A, Gerson R et al. · 2026 · Child psychiatry and human development

Youth are presenting to Emergency Departments (EDs) following a suicide-related crisis at higher rates and younger ages. Clinicians lack tools to effectively discern suicide risk in younger patients. The present investigation examines how…

View details →DOI: 10.1007/s10578-026-02006-6
Negative / Null Result ReportMedicine

Prenatal echocardiographic diagnosis and outcomes of fetal sustained supraventricular tachycardia: a ten-year single-center experience.

Ciriello GD, Colonna D, Morelli C et al. · 2026 · Indian pacing and electrophysiology journal

Fetal echocardiography plays a pivotal role in the diagnosis and management of fetal arrhythmias, allowing evaluation of the electrophysiological mechanism and guiding appropriate medical therapy. Herein, we describe our ten-year…

View details →DOI: 10.1016/j.ipej.2026.03.015
Negative / Null Result ReportMedicine

The interdependence of health and grandparenting intensity: A dyadic perspective from grandparent couples in the Health and Retirement Study.

Chan ACY, Stephan AT, Sneed RS · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives While the intensity of grandparent caregiving has been linked to older adults' health, limited research has examined the bidirectional associations between grandparenting intensity and health, particularly within grandparent…

View details →DOI: 10.1093/geronb/gbag022
Negative / Null Result Report

Aging is associated with uniform structural decline across cerebellar regions while preserving topological organization and showing no relation with sensorimotor function

de Witte A, Matthijs A, Nettekoven C et al. · 2026 · Preprint

Aging affects cerebellar structure, yet the regional specificity of this decline and its relationship to sensorimotor function remain unclear. In this study, we quantified age-related gray matter differences in 50 young and 80 older adults…

View details →DOI: 10.64898/2026.02.13.705695
Negative / Null Result ReportMedicine

Guiding connections: The role of therapist interventions in facilitating couples' vulnerability and responsiveness in enactments.

Kula O, Machluf Ruttner R, Shahar B et al. · 2026 · Psychotherapy (Chicago, Ill.)

The primary proposed change process in emotion-focused therapy models for couples involves partners accessing and revealing vulnerable emotions and responding to such disclosures with empathy and compassion. Therapists often use enactments…

View details →DOI: 10.1037/pst0000615
Negative / Null Result Report

Similar exercise adherence and physical fitness outcomes are observed across distinct motivation profiles in older adults participating in a home-based structured exercise programme

Munns A, Feron J, Duda J et al. · 2026 · Preprint

Purpose:Motivation and self-efficacy are established predictors of engagement and persistence within structured exercise programmes; however, it remains unclear whether these psychological factors predict objective adherence metrics and…

View details →DOI: 10.31234/osf.io/gk74p_v2
Negative / Null Result Report

Retrospective Multicenter Analysis of Withdrawal Syndromes After Stimulator Cessation in Parkinson’s Disease Patients with Deep Brain Stimulation

Özden HÖ, Çelik FND, Üstüner FŞ et al. · 2026 · Preprint

Background: Abrupt cessation of deep brain stimulation (DBS) in Parkinson’s disease (PD), most commonly due to implantable pulse generator (IPG) depletion, may lead to DBS withdrawal syndrome (DBS-WDS). However, withdrawal does not occur…

View details →DOI: 10.20944/preprints202601.1856.v1
Negative / Null Result ReportMedicine

Retrospective Multicenter Analysis of Withdrawal Syndrome in Parkinson's Disease Patients After Cessation of Deep Brain Stimulation.

Özden HÖ, Çelik FND, Üstüner FŞ et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: Abrupt cessation of deep brain stimulation (DBS) in Parkinson's disease (PD), most commonly due to implantable pulse generator (IPG) battery depletion, may lead to DBS withdrawal syndrome (DBS-WDS). However, withdrawal syndrome…

View details →DOI: 10.3390/diagnostics16040644
Negative / Null Result Report

Examining The Reciprocal Interplay between Parental Restrictive Mediation, Styles of Mediation, and Adolescent Problematic Gaming and Gambling: A Three-Wave Longitudinal Study

Bradt L, De Cock R, Zaman B et al. · 2025 · Preprint

Restrictive mediation, referring to parental strategies to limit adolescents’ gaming, aims to reduce gaming-related risks. Research grounded in Self-Determination Theory suggests that the style in which restrictions are communicated…

View details →DOI: 10.31234/osf.io/4aezy_v1
Negative / Null Result ReportMedicine

Navigating the unknown: how exploratory traits shape juvenile post-fledging behaviour and survival in gulls.

Morel M, Mitchell L, Stienen E et al. · 2026 · Proceedings. Biological sciences

The post-fledging period is a critical phase for inexperienced birds, who must navigate and explore unfamiliar environments to locate essential resources for survival. Successful foraging during this stage relies on acquiring spatial…

View details →DOI: 10.1098/rspb.2025.2904
Negative / Null Result ReportMedicine

Prediction of Anthracycline Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Early-Stage Breast Cancer by the MammaPrint 70-Gene Signature for Patients Enrolled in the FLEX Study.

O'Shaughnessy J, Brufsky AM, Layeequr Rahman R et al. · 2026 · JCO precision oncology

Purpose Randomized trials have not demonstrated clear benefit from anthracyclines for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (EBC). The MammaPrint 70-gene…

View details →DOI: 10.1200/po-25-01285
Negative / Null Result ReportMedicine

Longitudinal associations of cardiorespiratory fitness and physical activity with changes in cognitive function in breast cancer patients undergoing chemotherapy: a prospective matched-control study.

Xiao H, Warner E, Ryan J et al. · 2026 · Cancer causes & control : CCC

Purpose Cancer-related cognitive impairment (CRCI) is a common concern among breast cancer (BC) patients receiving chemotherapy, yet predictors of short-term cognitive change remain unclear. This study examined whether baseline…

View details →DOI: 10.1007/s10552-026-02165-w
Negative / Null Result ReportMedicine

Impact of Left Atrial Dilatation on Catheter Ablation Outcomes for Persistent Atrial Fibrillation: Does Size Matter?

William JB, Chieng D, Crowley R et al. · 2026 · JACC. Clinical electrophysiology

Background Left atrial (LA) enlargement is commonly used in patient selection for catheter ablation. However, its role in predicting postablation outcomes in persistent atrial fibrillation (AF) remains uncertain. Objectives The study goal…

View details →DOI: 10.1016/j.jacep.2026.04.019
Negative / Null Result ReportMedicine

Trauma-focused or non-trauma-focused? Treatment preferences and expectancies among veterans with co-occurring posttraumatic stress disorder and substance use disorder.

Alpert E, Kaplan A, Nelson D et al. · 2026 · Psychological trauma : theory, research, practice and policy

Objective Among patients with co-occurring posttraumatic stress disorder (PTSD) and substance use disorders (SUDs), little is known about early PTSD treatment processes, including treatment preference and outcome expectancy. This study…

View details →DOI: 10.1037/tra0002161
Negative / Null Result ReportMedicine

Kidney Transplantation for Lithium Nephrotoxicity is Associated With Noninferior Graft and Patient Survival: A National Donor-Stratified Registry Analysis.

Cohen H, Toro D, Zuluaga D et al. · 2026 · Clinical transplantation

Introduction To evaluate donor-stratified graft and patient survival following kidney transplantation (KT) for lithium-associated end-stage kidney disease (ESKD). Methods This retrospective analysis utilized the Organ Procurement and…

View details →DOI: 10.1111/ctr.70563
Negative / Null Result ReportMedicine

Somatic Mutations and Mutation Burden Predict Treatment Response and Survival in Adult Acquired Pure Red Cell Aplasia.

Yang L, Zhang H, Wei Y et al. · 2026 · American journal of hematology

Immunosuppressive therapy (IST) is the standard treatment for acquired pure red cell aplasia (aPRCA), but predictors of treatment response and long-term prognosis remain unclear. The clinical significance of somatic mutations in aPRCA is…

View details →DOI: 10.1002/ajh.70311
Negative / Null Result ReportOpen accessMedicine

Predictive Factors of Augmented Reality-Based Clinical Task Performance Among Novice Users: Cross-Sectional Quantitative Study.

Vellore AJ, Bhatia S, Kann MR et al. · 2026 · JMIR XR and spatial computing

Background Augmented reality (AR) can provide risk-free training for medical trainees, yet little is known about which learner characteristics facilitate adoption or inform training design. Objective We aimed to identify which learner…

View details →DOI: 10.2196/81236
Negative / Null Result ReportMedicine

Physical Frailty, Self-Care Behaviors, and 6-Month Clinical Outcomes Among Adults With Heart Failure.

Denfeld QE, Hiatt SO, Dieckmann NF et al. · 2026 · The Journal of cardiovascular nursing

Many adults with heart failure (HF) are physically frail, and HF self-care behaviors, especially symptom monitoring and management (SMM), may affect physical frailty; however, the association between SMM behaviors and physical frailty has…

View details →DOI: 10.1097/jcn.0000000000001342
Negative / Null Result ReportMedicine

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug-resistant focal epilepsy.

Gefferie SR, Jiménez-Jiménez D, Visser GH et al. · 2026 · Epilepsia open

Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB…

View details →DOI: 10.1002/epi4.70255
Negative / Null Result ReportMedicine

Hematological and Inflammatory Marker Changes Following Electroconvulsive Therapy in Bipolar Mania: A Quasi-Experimental Study.

Heidari N, Maroufi A, Shams-Alizadeh N · 2026 · Clinical neuropharmacology

Objective Neuroinflammation, reflected in hematological and inflammatory biomarkers, plays a role in bipolar disorder. Electroconvulsive therapy (ECT) is effective for treatment-resistant bipolar disorder, but its impact on these…

View details →DOI: 10.1097/wnf.0000000000000670
Negative / Null Result ReportMedicine

Cross-lagged longitudinal analysis of pain and fear of cancer recurrence in young female survivors of breast and gynaecological cancers.

Sweeney L, Schapira L, Webster S et al. · 2026 · Pain

Abstract Chronic cancer-related pain affects up to 40% of cancer survivors, yet why pain persists after cancer treatment has ended is not well-understood. The Cancer Threat Interpretation (CTI) model proposes that fear of cancer recurrence…

View details →DOI: 10.1097/j.pain.0000000000003951
Negative / Null Result ReportMedicine

Does Misinformation Have Spillover Effects on Unrelated Health Behaviors? Promising Null Results from a Longitudinal Study of U.S. Adults.

Kikut-Stein A, Jesch E, Dhawan D et al. · 2026 · Journal of health communication

In the wake of the COVID-19 pandemic, a critical question for health communication is whether misinformation exposure and misperceptions about one health topic have far-reaching, or "spillover," effects on health behavior in general. The…

View details →DOI: 10.1080/10810730.2026.2623409