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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21309 results · page 373 of 711

Negative / Null Result ReportOpen accessMedicine

Can a Targeted Pre-Exercise Education Intervention Enhance the Exercise-Induced Hypoalgesia (EIH) Response in Individuals With Knee Osteoarthritis (OA)?

Toomey D, Lewis G, Tuck N et al. · 2026 · International journal of rheumatic diseases

Objective Recent evidence suggests that education on the pain-relieving effects of exercise may enhance exercise-induced hypoalgesia (EIH) in healthy individuals. However, its impact in populations with osteoarthritis (OA), where EIH…

View details →DOI: 10.1111/1756-185x.70587
Negative / Null Result ReportOpen accessMedicine

Pleistocene island connectivity did not enhance dispersal or impact population size change in Galápagos geckos.

Myers EA, Bell RC, Overcast I et al. · 2025 · Proceedings. Biological sciences

Patterns of biodiversity on remote archipelagos are largely shaped by intra-archipelago colonization followed by in situ diversification. Pleistocene sea-level fluctuations purportedly enhanced gene flow among terrestrial organisms by…

View details →DOI: 10.1098/rspb.2025.0746
Negative / Null Result ReportMedicine

Belowground Interactions in a Barley Cultivar Mixture: Root Distribution and Arbuscular Mycorrhizal Contributions to Uptake of Heterogeneous Phosphorus

Siegwart L, Müller‐Stöver D, Dresbøll DB et al. · 2025 · Physiologia Plantarum.

Cultivar mixtures have the potential to mitigate abiotic stress and stabilize crop yields, but their belowground dynamics remain poorly understood. We evaluated phosphorus (P) uptake by two contrasting spring barley (Hordeum vulgare L.)…

Failed Experiment ReportOpen accessMedicine

Effect of Short-Anchored PEGylated Lipids on Lipid Nanoparticle Characterization Profiles, Stability, and Efficacy.

Souleyrette CER, West PC, Kirkpatrick SS et al. · 2026 · Biomedicines

Background/Objectives : RNA interference (RNAi) is a promising strategy for mitigating diseases at the molecular level. However, RNAi is limited by its instability in biological fluids and impermeability to cellular membranes. In response,…

View details →DOI: 10.3390/biomedicines14051002
Negative / Null Result ReportMedicine

Data-Driven Techniques for Estimating Energy Expenditure in Wheelchair Users.

Doshmanziari R, Strand Aandahl H, Pettersen Reierstad H et al. · 2025 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Providing feedback on energy expenditure (EE) may be an important tool to support obesity prevention among manual wheelchair users (MWU). This paper presents a data-driven approach for estimating EE based on data collected from 40…

View details →DOI: 10.1109/tnsre.2025.3537333
Negative / Null Result ReportMedicine

Responses to Hypoxia and Hyperoxia in Embryonic Tiger Keelbacks (Rhabdophis tigrinus lateralis; Colubridae).

Li XM, Su S, Zhang LW et al. · 2025 · Journal of experimental zoology. Part A, Ecological and integrative physiology

Studies examining the oxygen dependency of embryonic survival, growth, and differentiation have been conducted for decades in a diverse array of animal taxa but including only one oviparous snake, the viperine water snake Natrix maura.…

View details →DOI: 10.1002/jez.2910
Negative / Null Result ReportMedicine

Effect of preharvest boron spraying on the firmness and microstructure of winter-harvested frozen broccoli among maturity types.

Viriyarattanasak C, Takemura Y, Hashimoto T et al. · 2025 · Journal of the science of food and agriculture

Background Softening of winter-harvested frozen broccoli is a challenge. Application of boron (B) can improve fruit texture, but its effects on processed vegetables remain unexplored. This study is the first to investigate the impact of…

View details →DOI: 10.1002/jsfa.14249
Negative / Null Result ReportOpen accessMedicine

In-house 3D printed porous implants: does strontium-coating enhance osseointegration? An <i>in-vivo</i> study in large animals.

Borgognoni AB, Freund SS, Baas J et al. · 2026 · Frontiers in surgery

Introduction Early osseointegration is essential for the long-term success of uncemented custom-made prostheses, particularly in oncologic bone reconstruction where bone stock is compromised. Strontium (Sr) has demonstrated osteogenic…

View details →DOI: 10.3389/fsurg.2026.1818358
Negative / Null Result ReportMedicine

The temporal copulatory patterns of female rat sexual behavior.

Oyem JC, Heijkoop R, Snoeren EMS · 2025 · Behavioural processes

Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…

View details →DOI: 10.1016/j.beproc.2025.105148
Negative / Null Result ReportOpen accessMedicine

Limited Utility of the CALLY Index in Enhancing Mortality Prediction for Trauma Patients in Intensive Care Units: A Retrospective Analysis.

Kuo PJ, Huang CY, Liao KH et al. · 2026 · Risk management and healthcare policy

Background Accurate prognostication for trauma patients in intensive care units (ICUs) remains challenging. This study investigated whether incorporating the C-reactive protein-albumin-lymphocyte (CALLY) index into traditional ICU scoring…

View details →DOI: 10.2147/rmhp.s557174
Negative / Null Result ReportMedicine

Effect of one-week New Zealand blackcurrant extract on rowing performance and cognitive function in National team male rowers.

Naderi A, Gharaat MA, Berjisian E et al. · 2025 · Research in sports medicine (Print)

This research investigated the impact of New Zealand blackcurrant (NZBC) on 2000-meter rowing ergometer performance and cognitive abilities. Nine trained male rowers from Iran's national team participated in a double-blind,…

View details →DOI: 10.1080/15438627.2025.2455971
Negative / Null Result ReportMedicine

Increasing cervical penetrability in sheep by long-acting treatments with oxytocin (Carbetocin) and/or prostaglandin E2 (Dinoprostone).

Rodríguez-Piñón M, Casuriaga D, García-Barcelo G et al. · 2025 · Domestic animal endocrinology

The aim was to study the effect of long-acting treatments with oxytocin (Carbetocin, Cb) and/or prostaglandin E2 (Dinoprostone, Dp) on cervical penetrability and collagenolysis in synchronized ewes (12 days MAP-eCG). At 42 h post eCG, ewes…

View details →DOI: 10.1016/j.domaniend.2025.106920
Negative / Null Result ReportMedicine

PLASMA UTILIZATION EXACERBATES RENAL CORTEX INFLAMMATION IN A RODENT MODEL OF HEMORRHAGIC SHOCK AND RESUSCITATION.

Risinger WB, Matheson PJ, Franklin ME et al. · 2025 · Shock (Augusta, Ga.)

Abstract Background and Hypothesis: Resuscitation strategies incorporating fresh frozen plasma have become the standard of care in the management of traumatic hemorrhagic shock. While plasma resuscitation has been shown to augment the…

View details →DOI: 10.1097/shk.0000000000002563
Negative / Null Result ReportMedicine

Differential Impact of Concomitant Methotrexate and Glucocorticoids Dosages on Biologics and JAK Inhibitors: The ANSWER Cohort Study.

Ebina K, Etani Y, Okita Y et al. · 2025 · International journal of rheumatic diseases

Aim This multicenter retrospective study evaluated the differential impact of concomitant methotrexate (MTX) and glucocorticoids (GCs) administration by dosage on the effectiveness and safety of biological disease-modifying antirheumatic…

View details →DOI: 10.1111/1756-185x.70351
Negative / Null Result ReportMedicine

Oral Peanut Immunotherapy With Butyrate Adjuvant (OPIA) in Children: A Randomised, Controlled Trial.

Hsu PS, Barnes EH, Barnes M et al. · 2025 · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Background Sustained unresponsiveness (SU) remains a major challenge for peanut OIT. The short chain fatty acid (SCFA) butyrate has the potential to upregulate regulatory T cells (Tregs) to improve long term tolerance. We conducted a…

View details →DOI: 10.1111/cea.70127
Negative / Null Result ReportMedicine

Sigma-1 receptor antagonism as a promising strategy for postoperative pain treatment: A study in laparotomized mice.

Santos-Caballero M, Ruiz-Cantero MC, Mayr HK et al. · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Postoperative pain remains a major clinical challenge, as it often persists despite analgesic treatment even with opioids. We studied the effects of sigma-1 receptor antagonists (BD-1063 and S1RA), administered alone or in combination with…

View details →DOI: 10.1016/j.biopha.2025.118298
Negative / Null Result ReportMedicine

Patients Presenting to the Emergency Department with Bleeding in Early Pregnancy: Comparing Different Models to Predict Pregnancy Success.

Essel NOM, Couperthwaite S, Yang EH et al. · 2025 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Objectives Bleeding in early pregnancy is a common obstetric presentation in the emergency department (ED), and the outcome is difficult to predict. We developed and compared random forest machine learning (Live Birth Risk Score [LiBRisk])…

View details →DOI: 10.1016/j.jogc.2025.102789
Negative / Null Result ReportMedicine

Evidence for the dependence of visual and kinesthetic motor imagery on isolated visual and motor practice.

Peters CM, Scott MW, Jin R et al. · 2025 · Consciousness and cognition

Motor imagery (MI) is a cognitive process believed to rely on the representation developed through experience. The equivalence between MI and execution has been questioned and the relationship between experience types and MI is unclear. We…

View details →DOI: 10.1016/j.concog.2024.103802
Negative / Null Result ReportMedicine

Validation and Modified Application of the 2023 International Expert Consensus Criteria for Diagnosing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Among Children With Acquired Demyelination in Resource-Limited Regions.

Sondhi V, Desai N, Lingappa L et al. · 2025 · Pediatric neurology

Background This study was undertaken to validate the 2023 myelin oligodendrocyte glycoprotein (MOG) antibody (Ab)-associated disease (MOGAD) diagnostic criteria among children with acquired demyelinating syndromes. Methods In this…

View details →DOI: 10.1016/j.pediatrneurol.2025.08.010
Negative / Null Result ReportMedicine

Variability in adolescent reception of parental support: Testing the domain-matching hypothesis.

Altinoz ZS, Erath SA, Pettit GS et al. · 2024 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

The present study investigated matches and mismatches between adolescent and parent socialization domains (i.e., protection, guidance) as related to adolescent reception of parental support during a laboratory-based social evaluation…

View details →DOI: 10.1037/fam0001225
Negative / Null Result ReportMedicine

Effects of polyphenol-rich extracts and compounds on methane and ammonia emissions from pig slurry during 28-day incubation

Vazifehkhoran AH, Pedersen J, Guldberg LB et al. · 2024 · Biosystems engineering.

Animal manure in livestock production facilities is a major source of methane (CH₄) and ammonia (NH₃) emissions from agriculture. In this study, we investigated different polyphenol-rich extracts and chemicals including commercial chestnut…

View details →DOI: 10.1016/j.biosystemseng.2024.11.002
Negative / Null Result Report

Effect of Short-Term High CO 2 Treatments on Maintaining the Firmness of Highbush and Rabbiteye Blueberries During Cold Storage

Toledo-Guerrero JD, Alvarez MD, Herranz B et al. · 2024 · Preprint

Global demand for blueberries has surged in recent years, primarily due to their health benefits. However, blueberries postharvest losses, particularly firmness loss and decay, remain significant challenges. This study applied high…

View details →DOI: 10.20944/preprints202410.1910.v1
Negative / Null Result ReportMedicine

The Effects of the Nocturnal Sleep on Learning of a Complex Motor Skill in Young and Older Adults.

Leal MG, Dos Martírios Luz JE, Fidelix YL et al. · 2025 · Experimental aging research

Background/study context Research on older adults has shown impairments in nocturnal sleep, impacting motor memory consolidation and learning. However, previous studies primarily focus on simple tasks, limiting generalization to complex…

View details →DOI: 10.1080/0361073x.2024.2439741
Negative / Null Result ReportMedicine

Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa persister cells and biofilms.

Mahmoud M, Richter P, Arnold P et al. · 2025 · Photodiagnosis and photodynamic therapy

Pseudomonas aeruginosa is a hard-to-treat human pathogen for which new antimicrobial agents are urgently needed. P. aeruginosa is known for forming biofilms, a complex aggregate of bacteria embedded in a self-generated protective matrix…

View details →DOI: 10.1016/j.pdpdt.2024.104456