Negative / Null Result ReportMedicine
Xiong GL, Iosif AM, Gonzalez AD et al. · 2025 · Journal of the American Medical Directors Association
Objective Comparison of asynchronous telepsychiatry (ATP) with traditional synchronous telepsychiatry (STP) in skilled nursing facilities (SNFs) in California, United States. Design Patient-level randomized, controlled noninferiority…
View details →DOI: 10.1016/j.jamda.2025.105753 Negative / Null Result ReportOpen accessMedicine
Büyükdemirtaş B, Benn M, Kwon HB et al. · 2026 · Psychopharmacology
Rationale Binge drinking during adolescence is associated with a higher risk of developing Alcohol Use Disorders and impaired stress reactivity in adulthood. The hypothalamic-pituitary-adrenal axis matures during adolescence and is under…
View details →DOI: 10.1007/s00213-025-06969-7 Negative / Null Result ReportMedicine
Isaacson BN, Serbin SP, Grabosky JC · 2025 · Forest Ecology and Management.
There is a vigorous debate around whether and how to manage forests for climate mitigation or for other goals such as biodiversity. To achieve any of these goals it is necessary to define the parameters within which they can exist;…
Negative / Null Result ReportOpen accessMedicine
Kanyorszky ET, Sterczer Á, Vizi Z et al. · 2026 · BMC veterinary research
BACKGROUND: Acute pancreatitis triggers the production of acute-phase proteins (APPs) in the body, among which C-reactive protein (CRP) is the most extensively studied and widely used for both diagnosis and prognosis. The diagnostic value…
View details →DOI: 10.1186/s12917-026-05409-8 Negative / Null Result Report
Ghamgosar Shahkhali M, Liu L, Ghamgosar Shahkhali MH et al. · 2025 · Preprint
Objective To explore potential genetic and/or causal associations between Post-Traumatic Stress Disorder and neurodegeneration-related isolated/idiopathic rapid-eye-movement sleep behavior disorder. Methods We conducted polygenic risk…
View details →DOI: 10.1101/2025.09.05.25335205 Negative / Null Result ReportMedicine
Yang T, Yuan X, Gao W et al. · 2024 · Internal and emergency medicine
Observational studies revealed paradoxically inverse associations between diabetes and aortic diseases (aortic aneurysm or aortic dissection), yet the causality remains to be determined. To investigate the causal associations between…
View details →DOI: 10.1007/s11739-024-03727-z Negative / Null Result ReportOpen accessMedicine
Zhang H, Zhao T, Zheng H et al. · 2026 · BMC neurology
Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disorder caused by abnormal GGC repeat expansions in the NOTCH2NLC gene, leading to multisystem involvement. Electrophysiological abnormalities in NIID…
View details →DOI: 10.1186/s12883-026-04898-2 Negative / Null Result ReportMedicine
Berger M, Bruggisser F, Schwarz A et al. · 2025 · Physiology & behavior
Objectives To investigate whether a single session of aerobic exercise improves inhibitory control in preadolescent children and whether this effect is mediated by changes in parasympathetic activity. Design In this experimental study, an…
View details →DOI: 10.1016/j.physbeh.2025.114820 Failed Experiment ReportMedicine
Martinez G, Tolentino K, Sukheja P et al. · 2025 · Bioorganic & medicinal chemistry letters
Screening of the ChemDiv molecular library in cholesterol media against Mycobacterium tuberculosis (Mtb) H37Rv strain identified a novel isoxazole thiophene hit as a putative Rv1625c/Cya activator with a promising in vitro activity and…
View details →DOI: 10.1016/j.bmcl.2025.130108 Negative / Null Result Report
Su Z, Wyble B, Fu Y · 2024 · Preprint
This study explores the relationship between working memory and attention during visual search tasks, focusing on how time constraints affect the encoding of visual information into working memory. The research is based on the premise that…
View details →DOI: 10.31234/osf.io/d4hc5 Negative / Null Result ReportMedicine
de Bruin LJE, Hoegh M, Greve C et al. · 2024 · The Journal of orthopaedic and sports physical therapy
OBJECTIVE: To assess the causal role of the relationship between loading and the onset of nonspecific low back pain (NSLBP) and persistence of NSLBP (chronic low back pain [CLBP]). DESIGN : Scoping review. LITERATURE SEARCH : We searched…
View details →DOI: 10.2519/jospt.2024.11314 Negative / Null Result ReportMedicine
Xiang C, Zheng M, Li Y et al. · 2025 · Annals of vascular surgery
Background Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial…
View details →DOI: 10.1016/j.avsg.2025.01.013 Negative / Null Result ReportOpen accessMedicine
Matsuzaki S · 2026 · Reproductive medicine and biology
Background Endometriosis is often diagnosed late due to a lack of noninvasive diagnostic tools and the varied presentation of its symptoms. Identifying risk factors for endometriosis is crucial for reducing diagnosis delays, mitigating the…
View details →DOI: 10.1002/rmb2.70041 Negative / Null Result Report
Florindo HS, Azevedo-Silva M, Pereira-Romeiro MP et al. · 2025 · Preprint
The factors that influence the organisms’ ability to reproduce are diverse. In ants, social structure may contribute to queens’ Reproductive Output (RO), alongside environmental conditions and genetic attributes. Polygynous species like…
View details →DOI: 10.1101/2025.05.05.652256 Negative / Null Result ReportOpen accessMedicine
Rolver MG, Emanuelsson F, Nordestgaard BG et al. · 2025 · Cardiovascular diabetology
Background and objectives Elevated C-reactive protein (CRP) is a well-established marker of low-grade systemic inflammation often accompanying cardiometabolic diseases like type 2 diabetes. We sought to determine if plasma CRP…
View details →DOI: 10.1186/s12933-025-03028-5 Negative / Null Result ReportOpen accessMedicine
Chen D, Zhu T, Liu C et al. · 2025 · Medicine
Several observational studies have reported the change in gut microbiota (GM) composition in individuals with osteoporosis (OP); however, the genetic correlation and causal association between GM and OP remain undetermined. Large-scale…
View details →DOI: 10.1097/md.0000000000045031 Negative / Null Result ReportMedicine
Wagner H, Lam D, Nguyen AL · 2025 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose Appropriate framing of health information influences the adoption of health behaviors. This study explored whether (1) gain- or loss-framed health promotion messages, emphasizing positive or negative consequences, respectively,…
View details →DOI: 10.1016/j.clae.2025.102387 Negative / Null Result ReportMedicine
Sirirungreung A, Lee PC, Hu YH et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Background The safety of using acetaminophen (paracetamol) during pregnancy has been questioned because of concerns about its potential negative impact on fetal development and the risk of adverse pediatric outcomes. We aimed to…
View details →DOI: 10.1158/1055-9965.epi-25-1034 Negative / Null Result Report
Bin R, Yi L, Xing-ping L · 2024 · Preprint
The sustainability of social security is increasingly important to countries worldwide, yet the impact of regulation on social security remains controversial. Most scholars and policymakers focus primarily on the influence of social…
View details →DOI: 10.20944/preprints202410.0918.v1 Negative / Null Result ReportMedicine
Prince Czarnecki JM, Shockley JM, Wasson L et al. · 2024 · Precision Agriculture
Cloudy skies reduce image quality obtained from unmanned aerial vehicles (UAV) due to variable lighting conditions imposed on the surface. This study provides a novel approach for identifying temporal windows of opportunity that show…
View details →DOI: 10.1007/s11119-023-10055-3 Negative / Null Result ReportMedicine
Peltonen K, Tammilehto J, Flykt M et al. · 2025 · Cognition & emotion
Research suggests that adverse childhood experiences (ACEs) can have life-long consequences on emotional functioning. However, it is unclear how ACEs shape the dynamic features of everyday emotions. In the current preregistered study with…
View details →DOI: 10.1080/02699931.2024.2434153 Negative / Null Result Report
Poisson CL, Green IK, Stemmler GM et al. · 2024 · Preprint
To navigate dynamic environments, animals must rapidly integrate sensory information and respond appropriately to gather rewards and avoid threats. It is well established that dopamine (DA) neurons in the ventral tegmental area (VTA) and…
View details →DOI: 10.1101/2024.10.04.616744 Negative / Null Result Report
Matsushima T, Toji N, Wada K et al. · 2024 · Preprint
Embryonic exposure to valproic acid (VPA) and imidacloprid (IMI, a neonicotinoid insecticide) impairs filial imprinting in hatchlings, and the deteriorating effects of VPA are mitigated by post-hatch injection of bumetanide, a blocker of…
View details →DOI: 10.1101/2024.09.15.613159 Negative / Null Result ReportOpen accessMedicine
Zheng H, Chen W · 2026 · Frontiers in pediatrics
Background and aims Exclusive enteral nutrition is an established induction therapy for pediatric Crohn's disease, but biochemical response varies across patients. We assessed whether baseline gut microbiome features were associated with…
View details →DOI: 10.3389/fped.2026.1833193 Negative / Null Result ReportMedicine
Che Y, Yuan J, Guo J · 2025 · Archives of dermatological research
Observational studies have shown that the risk of developing herpes zoster (HZ) increases with the use of statins. However, there are many confounding factors in observational studies. Therefore, our Mendelian randomization (MR) study…
View details →DOI: 10.1007/s00403-024-03600-1 Negative / Null Result ReportOpen accessMedicine
Tu Y, Xie D, Qian H · 2025 · Medicine
Observational studies have suggested associations between circulating creatine kinase (CK) levels and gastric cancer (GC), yet causality remains uncertain. To evaluate whether genetically predicted CK levels are causally related to GC…
View details →DOI: 10.1097/md.0000000000044756 Negative / Null Result ReportMedicine
van Lennep JPA, van Middendorp H, Leong OV et al. · 2025 · Scandinavian journal of pain
Objectives To understand how different individuals respond to placebo effects, it is relevant to disentangle the influence of someone's personality and genetic variations. The aim of this exploratory study was to investigate the role of…
View details →DOI: 10.1515/sjpain-2025-0029 Negative / Null Result ReportMedicine
Salehi-Reyhani SM, Saadat M · 2024 · Molecular biology reports
Background It is well known that telomerase activity is suppressed in normal human tissues and reactivated in tumors, suggesting that the human telomerase reverse transcriptase (hTERT, MIM: 187270) gene may be involved in carcinogenesis. A…
View details →DOI: 10.1007/s11033-024-09999-0 Negative / Null Result ReportMedicine
Naito R, Hiwa R, Inaba R et al. · 2025 · Modern rheumatology case reports
Vesiculobullous dermatomyositis (VD) is a rare manifestation of dermatomyositis (DM) and has been suggested to be associated with malignancy. Although the myositis-specific autoantibodies are associated with distinct clinical presentations…
View details →DOI: 10.1093/mrcr/rxae037 Negative / Null Result ReportOpen accessMedicine
O'Connor LE, Thoerig RC, Leta CN et al. · 2026 · Advances in nutrition (Bethesda, Md.)
Infants may be exposed to contaminants from environmental and food sources, including human milk (HM) or infant formula (IF). The objective of this series of systematic reviews (PROSPERO: CRD42024530332, CRD42024530336, CRD42024530339, and…
View details →DOI: 10.1016/j.advnut.2026.100628 