Negative / Null Result ReportOpen accessPsychology
on behalf of the Pediatric Imaging Neurocognition Genetics study, John D. Eicher, Angela Montgomery et al. · 2015 · Brain Imaging and Behavior
Dyslexia and language impairment (LI) are complex traits with substantial genetic components. We recently completed an association scan of the DYX2 locus, where we observed associations of markers in DCDC2, KIAA0319, ACOT13, and FAM65B with reading-, language-, and IQ-related traits. Additionally, the effects of reading-associated DYX3 markers were recently characterized using structural neuroimaging techniques. Here, we assessed the neuroimaging implications of associated DYX2 and DYX3 markers, using cortical volume, cortical thickness, and fractional anisotropy. To accomplish this, we examin
View details →DOI: 10.1007/s11682-015-9392-6Cited by 31 Negative / Null Result ReportMedicine
Mikko T. Holmberg, Aleksi Tornio, Maria Paile‐Hyvärinen et al. · 2018 · Clinical Pharmacology & Therapeutics
CYP3A enzymes participate in the elimination of ticagrelor and the bioactivation of clopidogrel and prasugrel. We studied the effects of functional CYP3A genetic variants (CYP3A4*22; rs35599367 and CYP3A5*3; rs776746) on the…
View details →DOI: 10.1002/cpt.1177Cited by 31 Failed Experiment ReportOpen accessMedicine
Huyen Tran, Tim Brighton, Andrew Grigg et al. · 2014 · British Journal of Haematology
The efficacy of a fixed-dose rituximab schedule was prospectively explored in primary/acute refractory, relapsed or chronic (platelet count >10 × 10(9) /l and ≤50 × 10(9) /l) idiopathic thrombocytopenic purpura (ITP). Patients received two…
View details →DOI: 10.1111/bjh.13029Cited by 31 Negative / Null Result ReportOpen accessPsychology
Stijn A.H. Friederichs, Anke Oenema, Catherine Bolman et al. · 2016 · Psychology and Health
OBJECTIVE: This study explores whether a web-based physical activity (PA) intervention grounded in self-determination theory (SDT) and motivational interviewing (MI) is more effective and better appreciated than a traditional web-based PA…
View details →DOI: 10.1080/08870446.2016.1151018Cited by 31 Negative / Null Result ReportMedicine
Xuelian He, Junhong Xia, Chunming Wang et al. · 2011 · Animal Genetics
Prolactin (encoded by PRL) is a multifunctional hormone involved in osmoregulation, reproduction, growth, development, immunomodulation, endocrine and metabolic regulation. We cloned the full-length cDNA of Asian seabass PRL, searched for…
View details →DOI: 10.1111/j.1365-2052.2011.02230.xCited by 31 Negative / Null Result ReportOpen accessMedicine
Jianghua Zhou, Bin Wu, Wenxin Wang et al. · 2020 · World Journal of Clinical Cases
BACKGROUND: Dipeptidyl peptidase-4 (DPP4) is commonly targeted to achieve glycemic control and has potent anti-inflammatory and immunoregulatory effects. Recent structural analyses indicated a potential tight interaction between DPP4 and…
View details →DOI: 10.12998/wjcc.v8.i22.5576Cited by 31 Negative / Null Result ReportOpen accessMedicine
Manuel Blesa, Paola Galdi, Gemma Sullivan et al. · 2020 · Frontiers in Neurology
Preterm birth is closely associated with cognitive impairment and generalized dysconnectivity of neural networks inferred from water diffusion MRI (dMRI) metrics. Peak width of skeletonized mean diffusivity (PSMD) is a metric derived from histogram analysis of mean diffusivity across the white matter skeleton, and it is a useful biomarker of generalized dysconnectivity and cognition in adulthood. We calculated PSMD and five other histogram based metrics derived from diffusion tensor imaging (DTI) and neurite orientation and dispersion imaging (NODDI) in the newborn, and evaluated their accurac
View details →DOI: 10.3389/fneur.2020.00235Cited by 31 Negative / Null Result ReportOpen accessNeuroscience
Ashley M. Brouillette, Gülin Öz, Christopher M. Gómez · 2015 · Disease Markers
Neurodegenerative diseases, including the spinocerebellar ataxias (SCA), would benefit from the identification of reliable biomarkers that could serve as disease subtype-specific and stage-specific indicators for the development and monitoring of treatments. We analyzed the cerebrospinal fluid (CSF) level of tau, α-synuclein, DJ-1, and glial fibrillary acidic protein (GFAP), proteins previously associated with neurodegenerative processes, in patients with the autosomal dominant SCA1, SCA2, and SCA6, and the sporadic disease multiple system atrophy, cerebellar type (MSA-C), compared with age-ma
View details →DOI: 10.1155/2015/413098Cited by 31 Negative / Null Result ReportOpen accessMedicine
Evan M. Graboyes, Kevin Y. Zhan, Elizabeth Garrett‐Mayer et al. · 2017 · Cancer
BACKGROUND: The current study was conducted to determine the effect of postoperative radiotherapy (PORT) on overall survival in patients with surgically managed pT3-T4aN0 laryngeal squamous cell carcinoma (SCC). METHODS: A review of the…
View details →DOI: 10.1002/cncr.30586Cited by 31 Negative / Null Result ReportOpen accessMedicine
Morten Vester‐Andersen, Tina Waldau, Jørn Wetterslev et al. · 2015 · British journal of surgery
BACKGROUND: Emergency abdominal surgery carries a considerable risk of death and postoperative complications. Early detection and timely management of complications may reduce mortality. The aim was to evaluate the effect and feasibility…
View details →DOI: 10.1002/bjs.9749Cited by 31 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kagistia Hana Utami, Nur Amirah Binte Mohammad Yusof, Jing Eugene Kwa et al. · 2020 · Molecular Autism
FXS is the most common genetic cause of intellectual (ID) and autism spectrum disorders (ASD). FXS is caused by loss of FMRP, an RNA-binding protein involved in the translational regulation of a large number of neuronal mRNAs. Absence of FMRP has been shown to lead to elevated protein synthesis and is thought to be a major cause of the synaptic plasticity and behavioural deficits in FXS. The increase in protein synthesis results in part from abnormal activation of key protein translation pathways downstream of ERK1/2 and mTOR signalling. Pharmacological and genetic interventions that attenuate
View details →DOI: 10.1186/s13229-020-00350-5Cited by 31 Negative / Null Result ReportMedicine
Kazunari Misawa, Yoshinari Mochizuki, Munetoshi Sakai et al. · 2019 · British journal of surgery
BACKGROUND: A survival benefit of extensive intraoperative peritoneal lavage (EIPL) has been reported in patients with gastric cancer with positive peritoneal cytology. The hypothesis of this study was that EIPL may reduce peritoneal…
View details →DOI: 10.1002/bjs.11303Cited by 31 Negative / Null Result ReportOpen accessMedicine
Tasneem Zaihra, Christopher J. Walsh, Sara Ahmed et al. · 2016 · BMC Pulmonary Medicine
BACKGROUND: Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability of phenotypes based on a combination of physiological, clinical and biomarker data are currently lacking. Our objective was to assess the longitudinal stability of clusters derived from repeated measures of airway and physiological data over a 1-year period in moderate and severe asthmatics. METHODS: A total of 125 subjects, 48 with moderate asthma (MA) and 77 with severe asth
View details →DOI: 10.1186/s12890-016-0232-2Cited by 31 Negative / Null Result ReportMedicine
Taro Oshikiri, Hodaka Numasaki, Junya Oguma et al. · 2021 · Annals of Surgery
OBJECTIVE: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. SUMMARY OF BACKGROUND DATA: Although TD resection can cause nutritional disadvantage…
View details →DOI: 10.1097/sla.0000000000005340Cited by 31 Negative / Null Result ReportOpen accessMedicine
Pierre‐Édouard Bollaert, Alexandra Monnier, Francis Schneider et al. · 2023 · Critical Care
BACKGROUND: In critically ill patients, positive fluid balance is associated with excessive mortality. The POINCARE-2 trial aimed to assess the effectiveness of a fluid balance control strategy on mortality in critically ill patients. METHODS: POINCARE-2 was a stepped wedge cluster open-label randomized controlled trial. We recruited critically ill patients in twelve volunteering intensive care units from nine French hospitals. Eligible patients were ≥ 18 years old, under mechanical ventilation, admitted to one of the 12 recruiting units for > 48 and ≤ 72 h, and had an expected length of stay
View details →DOI: 10.1186/s13054-023-04357-1Cited by 31 Negative / Null Result ReportOpen accessMedicine
Byung Kook Lee, In Soo Cho, Joo Suk Oh et al. · 2018 · PLoS ONE
INTRODUCTION: The aim of this trial was to investigate the effect of a continuous infusion of a neuromuscular blockade (NMB) in comatose out-of-hospital cardiac arrest (OHCA) subjects who underwent targeted temperature management (TTM). METHODS: In this open-label, multicenter trial, subjects resuscitated from OHCA were randomly assigned to receive either NMB (38 subjects) or placebo (43 subjects) for 24 hours. Sedatives and analgesics were given according to the protocol of each hospital during TTM. The primary outcome was serum lactate levels at 24 hours after drug infusion. The secondary ou
View details →DOI: 10.1371/journal.pone.0209327Cited by 31 Negative / Null Result Report
Carl J. Rothfels, Anne K. Johnson, Michael D. Windham et al. · 2014 · TAXON
Abstract Here we present the first nuclear phylogeny for Cystopteridaceae (Polypodiales), using the single‐copy locus gapCp “ short ”. This phylogeny corroborates broad results from plastid data in demonstrating strong support for the…
View details →DOI: 10.12705/635.32Cited by 31 Negative / Null Result Report
Prayut Jain, Shashi Jain · 2019 · Risks
The Hierarchical risk parity (HRP) approach of portfolio allocation, introduced by Lopez de Prado (2016), applies graph theory and machine learning to build a diversified portfolio. Like the traditional risk-based allocation methods, HRP…
View details →DOI: 10.3390/risks7030074Cited by 31 Negative / Null Result ReportOpen accessPsychology
Janna N. Vrijsen, Ben Grafton, Ernst H. W. Koster et al. · 2024 · Behaviour Research and Therapy
Cognitive bias modification (CBM) has evolved from an experimental method testing cognitive mechanisms of psychopathology to a promising tool for accessible digital mental health care. While we are still discovering the conditions under which clinically relevant effects occur, the dire need for accessible, effective, and low-cost mental health tools underscores the need for implementation where such tools are available. Providing our expert opinion as Association for Cognitive Bias Modification members, we first discuss the readiness of different CBM approaches for clinical implementation, the
View details →DOI: 10.1016/j.brat.2024.104557Cited by 31 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Urko M. Marigorta, Óscar Lao, Ferrán Casals et al. · 2011 · BMC Genomics
BACKGROUND: Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of
View details →DOI: 10.1186/1471-2164-12-55Cited by 31 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Iacopo Morchio, Christian Moser · 2026 · American Economic Review
Using linked employer-employee data from Brazil, we document a significant gender pay gap, which is largely attributed to women working at lower-paying employers. To interpret this fact, we develop an equilibrium search model with…
View details →DOI: 10.1257/aer.20231107Cited by 30 Negative / Null Result ReportOpen accessNeuroscience
Anja Achtziger, Carlos Alós‐Ferrer, Sabine Hügelschäfer et al. · 2015 · Social Cognitive and Affective Neuroscience
Standard economic thinking postulates that increased monetary incentives should increase performance. Human decision makers, however, frequently focus on past performance, a form of reinforcement learning occasionally at odds with rational…
View details →DOI: 10.1093/scan/nsv036Cited by 30 Negative / Null Result ReportMedicine
J. B. Warren · 2020 · BMJ
Widespread prescribing has not reduced mental disability or suicide, raising questions about the assessment of evidence on effectiveness and safety of antidepressants, writes John Warren
View details →DOI: 10.1136/bmj.m3200Cited by 30 Negative / Null Result ReportOpen accessPhysics and Astronomy
Matthew S. Clement, Nathan A. Kaib, John E. Chambers · 2019 · The Astronomical Journal
Abstract Of the solar system’s four terrestrial planets, the origin of Mercury is perhaps the most mysterious. Modern numerical simulations designed to model the dynamics of terrestrial planet formation systematically fail to replicate…
View details →DOI: 10.3847/1538-3881/ab164fCited by 30 Negative / Null Result ReportAgricultural and Biological Sciences
Kateřina Hotová Svádová, Alice Exnerová, Michala Kopečková et al. · 2013 · Ethology
Abstract We tested the importance of innate wariness, avoidance learning, memory and generalization for the formation of predatory behaviour in naive great tits ( P arus major ) towards mimetic complex of four aposematic species of true…
View details →DOI: 10.1111/eth.12121Cited by 30 Negative / Null Result ReportMathematics
Rebecca Kanive, Peter M. Nelson, Matthew K. Burns et al. · 2013 · The Journal of Educational Research
ABSTRACT The authors’ purpose was to determine the effects of computer-based practice and conceptual interventions on computational fluency and word-problem solving of fourth- and fifth-grade students with mathematics difficulties. A…
View details →DOI: 10.1080/00220671.2012.759405Cited by 30 Negative / Null Result ReportOpen accessMedicine
Tracie C. Rosser, Jamie O. Edgin, George T. Capone et al. · 2018 · American Journal on Intellectual and Developmental Disabilities
The cause of the high degree of variability in cognition and behavior among individuals with Down syndrome (DS) is unknown. We hypothesized that birth defects requiring surgery in the first years of life (congenital heart defects and…
View details →DOI: 10.1352/1944-7558-123.6.514Cited by 30 Negative / Null Result ReportSocial Sciences
Jason E. Strickhouser, Ethan Zell, Kara Harris · 2018 · Social Psychological and Personality Science
Why do White Americans perceive less racism than Black Americans? Two provocative studies on the Marley hypothesis suggest that White Americans are more ignorant of historical instances of racism than Black Americans and that ignorance of…
View details →DOI: 10.1177/1948550618808863Cited by 30 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
José‐Antonio Daròs, Verónica Aragonés, Teresa Cordero · 2018 · Scientific Reports
Viruses have been engineered into useful biotechnological tools for gene therapy or to induce the synthesis of products of interest, such as therapeutic proteins and vaccines, in animal and fungal cells, bacteria or plants. Viroids are a particular class of infectious agents of higher plants that exclusively consist of a small non-protein-coding circular RNA molecule. In the same way as viruses have been transformed into useful biotechnological devices, can viroids be converted into beneficial tools? We show herein that, by expressing Eggplant latent viroid (ELVd) derived RNAs in Escherichia c
View details →DOI: 10.1038/s41598-018-20314-3Cited by 30 Negative / Null Result ReportMedicine
Owen M. Peters, Tatyana A. Shelkovnikova, Tatiana Tarasova et al. · 2013 · Journal of Alzheimer s Disease
Dimebon has been tested as a potential modifier of Alzheimer's disease (AD), resulting in mixed clinical trial outcomes. Originally utilized as an antihistamine, Dimebon was later found to ameliorate AD symptoms in initial human trials.…
View details →DOI: 10.3233/jad-130071Cited by 30 