Chronic Administration of Dimebon does not Ameliorate Amyloid-β Pathology in 5xFAD Transgenic Mice
Owen M. Peters; Tatyana A. Shelkovnikova; Tatiana Tarasova; Signe Springe; Michail S. Kukharsky; Gaynor A. Smith; Simon P. Brooks; Sergey A. Kozin · 2013 · Journal of Alzheimer s Disease
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Dimebon has been tested as a potential modifier of Alzheimer's disease (AD), resulting in mixed clinical trial outcomes. Originally utilized as an antihistamine, Dimebon was later found to ameliorate AD symptoms in initial human trials.…
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Metadata source: OpenAlex · DOI 10.3233/jad-130071