Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment
Kagistia Hana Utami; Nur Amirah Binte Mohammad Yusof; Jing Eugene Kwa; Ulla‐Kaisa Peteri; Maija L. Castrén; Mahmoud A. Pouladi · 2020 · Molecular Autism
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
FXS is the most common genetic cause of intellectual (ID) and autism spectrum disorders (ASD). FXS is caused by loss of FMRP, an RNA-binding protein involved in the translational regulation of a large number of neuronal mRNAs. Absence of FMRP has been shown to lead to elevated protein synthesis and is thought to be a major cause of the synaptic plasticity and behavioural deficits in FXS. The increase in protein synthesis results in part from abnormal activation of key protein translation pathways downstream of ERK1/2 and mTOR signalling. Pharmacological and genetic interventions that attenuate
Abstract by Kagistia Hana Utami; Nur Amirah Binte Mohammad Yusof; Jing Eugene Kwa; Ulla‐Kaisa Peteri; Maija L. Castrén; Mahmoud A. Pouladi, Molecular Autism (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13229-020-00350-5