Negative / Null Result ReportOpen accessEngineering
Tien‐Yu Yang, Tsan-Wen Huang, Po‐Yao Chuang et al. · 2018 · BMC Musculoskeletal Disorders
BACKGROUND: Displaced transverse fractures of the body of the patella are usually associated with disruption of extensor mechanism and should be fixed surgically. The most common method is a tension band wiring (TBW) technique. Some surgeons concurrently employ an augmented circumferential cerclage wiring (ACCW) technique to help fracture stabilization and aid in fracture healing; however, its role and effect on the treatment outcomes is unclear. METHODS: We performed a STROBE-compliant retrospective observational cohort study on all cases of acute closed patella fracture that were treated at
View details →DOI: 10.1186/s12891-018-2092-9Cited by 32 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marjorie L. McCullough, Rebecca A. Hodge, Peter T. Campbell et al. · 2021 · Metabolites
Untargeted metabolomic studies have identified potential biomarkers of colorectal cancer risk, but evidence is still limited and broadly inconsistent. Among 39,239 Cancer Prevention Study II Nutrition cohort participants who provided a blood sample between 1998–2001, 517 newly diagnosed colorectal cancers were identified through 30 June 2015. In this nested case–control study, controls were matched 1:1 to cases on age, sex, race and date of blood draw. Mass spectroscopy-based metabolomic analyses of pre-diagnostic plasma identified 886 named metabolites, after quality control exclusions. Condi
View details →DOI: 10.3390/metabo11030156Cited by 32 Negative / Null Result ReportOpen accessMedicine
Robert G. Miller, Rongzhen Zhang, Paige M. Bracci et al. · 2022 · Muscle & Nerve
INTRODUCTION/AIMS: ALS is a heterogeneous disease that may be complicated or in part driven by inflammation. NP001, a regulator of macrophage activation, was associated with slowing disease progression in those with higher levels of the…
View details →DOI: 10.1002/mus.27511Cited by 32 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jade Chapman, Elliott Rees, Denise Harold et al. · 2012 · Human Molecular Genetics
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the Genetic and…
View details →DOI: 10.1093/hmg/dds476Cited by 32 Negative / Null Result ReportOpen accessEngineering
Anna A. Stec, T. Richard Hull, David Purser et al. · 2014 · Fire Safety Science
In a fire, normally non-hazardous thermoplastic materials can produce lethal concentrations of toxic effluents in the smoke. The toxic product yields of the asphyxiants carbon monoxide (CO) and hydrogen cyanide (HCN) from developed fires…
View details →DOI: 10.3801/iafss.fss.11-404Cited by 32 Negative / Null Result ReportOpen accessMedicine
Yumiko Matsuoka, Amorsolo L. Suguitan, Marlene S. Orandle et al. · 2014 · Journal of Virology
Live attenuated cold-adapted (ca) H5N1, H7N3, H6N1, and H9N2 influenza vaccine viruses replicated in the respiratory tract of mice and ferrets, and 2 doses of vaccines were immunogenic and protected these animals from challenge infection…
View details →DOI: 10.1128/jvi.00425-14Cited by 32 Negative / Null Result ReportOpen accessMedicine
Constance Wose Kinge, Christine Espiritu, Nishi Prabdial‐Sing et al. · 2014 · Antimicrobial Agents and Chemotherapy
Hepatitis C virus (HCV) exists as six major genotypes that differ in geographical distribution, pathogenesis, and response to antiviral therapy. In vitro replication systems for all HCV genotypes except genotype 5 have been reported. In…
View details →DOI: 10.1128/aac.03534-14Cited by 32 Negative / Null Result ReportOpen accessNeuroscience
Tomer Fekete, Andrey R. Nikolaev, Floris De Knijf et al. · 2018 · Frontiers in Neuroscience
Transcranial alternating-current stimulation (tACS) for entraining alpha activity holds potential for influencing mental function, both in laboratory and clinical settings. While initial results of alpha entrainment are promising, questions remain regarding its translational potential-namely if tACS alpha entrainment is sufficiently robust to context and to what extent it can be upscaled to multi-electrode arrangements needed to direct currents into precise brain loci. We set out to explore these questions by administering alternating current through a multi-electrode montage (mtACS), while va
View details →DOI: 10.3389/fnins.2018.00428Cited by 32 Negative / Null Result ReportMedicine
Cyril Messaraa, Nicola J. Robertson, Melissa Walsh et al. · 2019 · Journal of Cosmetic Dermatology
BACKGROUND: The use of a skin care routine is commonly promoted by the cosmetic industry, yet there is a lack of clinical evidence to support this practice over the use of a single skin care product. AIMS: In the present study, we aimed at…
View details →DOI: 10.1111/jocd.13252Cited by 32 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
K.E. Giller, Euan K. James, Julie Ardley et al. · 2024 · Plant and Soil
Abstract Background Despite more than 50 years of research, no robust evidence suggests that inoculation of cereals and other non-legumes with free-living and/or endophytic bacteria leads to fixation of agronomically significant quantities of dinitrogen gas (N 2 ) from the atmosphere. A plethora of new products claims to increase the growth and yields of major cereals and other crops through stimulating N 2 -fixation by inoculating with bacteria. Scope We review the literature on N 2 -fixation by bacteria in the rhizosphere and as endophytes in non-legume plants. We find no unequivocal evidenc
View details →DOI: 10.1007/s11104-024-07001-1Cited by 32 Negative / Null Result ReportOpen accessComputer Science
Dipesh Niraula, Kyle C. Cuneo, Ivo D. Dinov et al. · 2025 · Nature Communications
AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals' cancer progression for effective personalized care. However, AI's imperfections can lead to suboptimal therapeutics if clinicians over or under rely on AI. To investigate such collaborative decision-making process, we conducted a Human-AI interaction study on response-adaptive radiotherapy for non-small cell lung cancer and hepatocellular carcinoma. We investigated two levels of collaborative behavior: model-agnostic and model-specific; and found that Human-AI
View details →DOI: 10.1038/s41467-024-55259-xCited by 32 Negative / Null Result ReportOpen accessComputer Science
The First Waters · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This paper develops government structural reference infrastructure for AI and AGI environments. It addresses the need for public institutions to preserve reference continuity across public records, citizen submissions, administrative documents, authority-condition references, state histories, seal-reference contexts, role accountability records, economic references, and propagation-sensitive records without becoming dependent on a single AI provider, platform, model, or cloud environment. The framework does not perform public decision-making, grant authority, issue permits, approve benefits, c
View details →DOI: 10.5281/zenodo.20371945Cited by 32 Negative / Null Result ReportOpen accessComputer Science
J. M. Górriz, R. Martin-Clemente, F. Segovia et al. · 2026 · Information Fusion
As a technique that can compactly represent complex patterns, machine learning has significant potential for predictive inference in multi-source and heterogeneous information fusion scenarios. K-fold cross-validation (CV) is the most common approach for ascertaining the likelihood that a machine learning outcome is generated by chance and frequently outperforms conventional hypothesis testing. This improvement arises from measures directly obtained from machine learning classifications, such as accuracy, that do not have a parametric description. To approach a frequentist analysis within fusi
View details →DOI: 10.1016/j.inffus.2026.104404Cited by 32 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Bo Zou, Dan Zhao, Shuang Zhou et al. · 2025 · Frontiers in Nutrition
Emerging evidence suggests that Omega-3 polyunsaturated fatty acids (PUFAs) are essential structural and functional nutrients that significantly influence the composition and function of the gut microbiota, a key mediator of host health. Although evidence suggests that increasing tissue Omega-3 levels through dietary intervention may optimize gut microbiota-host interaction through modulation of composition, metabolite production, and the intestinal mucus barrier, some studies have reported inconsistent findings regarding these protective effects. Studies indicate that a high Omega-6/Omega-3 r
View details →DOI: 10.3389/fnut.2025.1575323Cited by 32 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Walter Acevedo, Bijan Fallah, Sebastian Reich et al. · 2017 · Climate of the past
Abstract. Paleoclimate data assimilation (DA) is a promising technique to systematically combine the information from climate model simulations and proxy records. Here, we investigate the assimilation of tree-ring-width (TRW) chronologies into an atmospheric global climate model using ensemble Kalman filter (EnKF) techniques and a process-based tree-growth forward model as an observation operator. Our results, within a perfect-model experiment setting, indicate that the "online DA" approach did not outperform the "off-line" one, despite its considerable additional implementation complexity. On
View details →DOI: 10.5194/cp-13-545-2017Cited by 32 Negative / Null Result ReportOpen accessMedicine
Jung Sun Kim, Eun Joo Kang, Dae Sik Kim et al. · 2018 · BMC Cancer
BACKGROUND: This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were also investigated. METHODS: A total of 216 patients diagnosed with metastatic pancreatic cancer who received gemcitabine-based palliative chemotherapy at our institution were retrospectively evaluated. RESULTS: VTE occurred in 51 (23.6%) patients during treatment and did not affect survival. However, patients who were diagnosed with VTE at the beginning of chemotherapy showed p
View details →DOI: 10.1186/s12885-018-5154-3Cited by 32 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Michael H Castle, Bradley Lubben, Joe D. Luck · 2026 · Lincoln (University of Nebraska)
An ever-increasing world population and increasingly-volatile commodity prices have charged producers with the task of becoming more efficient. To combat this, precision agriculture technologies aimed at increasing production efficiency…
View details →DOI: 10.22004/ag.econ.413436Cited by 32 Negative / Null Result ReportOpen accessDecision Sciences
Felix Chopra, Ingar Haaland, Christopher Roth et al. · 2023 · The Economic Journal
Abstract We examine how the evaluation of research studies in economics depends on whether a study yielded a null result. Studies with null results are perceived to be less publishable, of lower quality, less important and less precisely…
View details →DOI: 10.1093/ej/uead060Cited by 31 Negative / Null Result ReportOpen accessPsychology
Janna N. Vrijsen, Ben Grafton, Ernst H. W. Koster et al. · 2024 · Behaviour Research and Therapy
Cognitive bias modification (CBM) has evolved from an experimental method testing cognitive mechanisms of psychopathology to a promising tool for accessible digital mental health care. While we are still discovering the conditions under which clinically relevant effects occur, the dire need for accessible, effective, and low-cost mental health tools underscores the need for implementation where such tools are available. Providing our expert opinion as Association for Cognitive Bias Modification members, we first discuss the readiness of different CBM approaches for clinical implementation, the
View details →DOI: 10.1016/j.brat.2024.104557Cited by 31 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Urko M. Marigorta, Óscar Lao, Ferrán Casals et al. · 2011 · BMC Genomics
BACKGROUND: Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of
View details →DOI: 10.1186/1471-2164-12-55Cited by 31 Negative / Null Result ReportOpen accessMathematics
Andreas Deutsch, Josué Manik Nava-Sedeño, Simon Syga et al. · 2021 · PLoS Computational Biology
Collective dynamics in multicellular systems such as biological organs and tissues plays a key role in biological development, regeneration, and pathological conditions. Collective tissue dynamics-understood as population behaviour arising from the interplay of the constituting discrete cells-can be studied with on- and off-lattice agent-based models. However, classical on-lattice agent-based models, also known as cellular automata, fail to replicate key aspects of collective migration, which is a central instance of collective behaviour in multicellular systems. To overcome drawbacks of class
View details →DOI: 10.1371/journal.pcbi.1009066Cited by 31 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michelle G. Pitts, Tanya Myers‐Morales, Sarah E. F. D’Orazio · 2016 · The Journal of Immunology
Type I IFN (IFN-α/β) is thought to enhance growth of the foodborne intracellular pathogen Listeria monocytogenes by promoting mechanisms that dampen innate immunity to infection. However, the type I IFN response has been studied primarily…
View details →DOI: 10.4049/jimmunol.1502192Cited by 31 Negative / Null Result ReportPsychology
Paul A. Jewsbury, Stephen C. Bowden · 2016 · Journal of Psychoeducational Assessment
Fluency is an important construct in clinical assessment and in cognitive taxonomies. In the Cattell–Horn–Carroll (CHC) model, Fluency is represented by several narrow factors that form a subset of the long-term memory encoding and…
View details →DOI: 10.1177/0734282916648041Cited by 31 Negative / Null Result ReportNeuroscience
William H.B. McAuliffe · 2018 · Thinking & Reasoning
The past few decades of moral psychology research have yielded empirical anomalies for rationalist theories of moral judgments. An increasing number of psychologists and philosophers argue that these anomalies are explained well by…
View details →DOI: 10.1080/13546783.2018.1499552Cited by 31 Negative / Null Result ReportEngineering
Matthias Langer, Ashley Hall, Zhen He et al. · 2018 · IEEE Transactions on Parallel and Distributed Systems
Many distributed deep learning systems have been published over the past few years, often accompanied by impressive performance claims. In practice these figures are often achieved in high performance computing (HPC) environments with fast…
View details →DOI: 10.1109/tpds.2018.2833074Cited by 31 Negative / Null Result Report
Frank Kreienkamp, Philip Lorenz, Tobias Geiger · 2020 · Atmosphere
Climate modelling output that was provided under the latest Coupled Model Intercomparison Project (CMIP6) shows significant changes in model-specific Equilibrium Climate Sensitivity (ECS) as compared to CMIP5. The newer versions of many…
View details →DOI: 10.3390/atmos11111245Cited by 31 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Giovanna Morelli, Marco Mele · 2020 · International Journal of Energy Economics and Policy
This study will demonstrate, through an econometric approach, the relationship among per capita GDP, CO2 emissions, and energy use in Vietnam. Using annual data for years 1970-2014, stationarity, structural breaks, Toda-Yamamoto test, Johansen and Juselius approach, and Variance decomposition have been conducted. The causality results in our analysis highlight that the presence of unidirectional causality was running from economic growth to energy consumption. This result will be significant since it supports the conservation hypothesis for the economy of Vietnam. Finally, the results of the v
View details →DOI: 10.32479/ijeep.8248Cited by 31 Negative / Null Result ReportOpen accessMedicine
Federica Albanese, Daniela Mercatelli, Luca Finetti et al. · 2021 · Neurobiology of Disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease. LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving the quality control of cellular proteins and organelles. Since…
View details →DOI: 10.1016/j.nbd.2021.105487Cited by 31 Failed Experiment ReportComputer Science
Jihan Yang, Shusheng Yang, Anjali Gupta et al. · 2025
Humans possess the visual-spatial intelligence to remember spaces from sequential visual observations. However, can Multimodal Large Language Models (MLLMs) trained on million-scale video datasets also "think in space" from videos? We…
View details →DOI: 10.1109/cvpr52734.2025.00994Cited by 31 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Guohao Xie, Glenn C Duff, L.W. Hall et al. · 2013 · Journal of Animal Science
The effects of bacitracin methylene disalicylate (BMD) and scours on the fecal microbiome, animal performance, and health were studied in Holstein bull calves. Holstein bull calves (n = 150) were obtained from a single source at 12 to 24 h…
View details →DOI: 10.2527/jas.2013-6304Cited by 31 