Negative / Null Result ReportOpen accessMedicine
Marika Fallenius, Markus B. Skrifvars, Matti Reinikainen et al. · 2017 · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine
BACKGROUND: Intensive care scoring systems are widely used in intensive care units (ICU) around the world for case-mix adjustment in research and benchmarking. The aim of our study was to investigate the usefulness of common intensive care scoring systems in predicting mid-term mortality in patients with spontaneous intracerebral hemorrhage (ICH) treated in intensive care units (ICU). METHODS: We performed a retrospective observational study including adult patients with spontaneous ICH treated in Finnish ICUs during 2003-2012. We used six-month mortality as the primary outcome of interest. We
View details →DOI: 10.1186/s13049-017-0448-zCited by 30 Negative / Null Result ReportMedicine
Davide Ferrari, Massimo Locatelli · 2020 · International Journal for Vitamin and Nutrition Research
Abstract. The world is currently overwhelmed by a novel coronavirus disease (COVID-19). Clinically, COVID-19 shows a broad range of manifestations: from asymptomatic to severe and possibly lethal interstitial pneumonia. Several studies…
View details →DOI: 10.1024/0300-9831/a000687Cited by 30 Negative / Null Result ReportNeuroscience
Fabian A. Soto · 2018 · Journal of Experimental Psychology General
In a recent article, Maes et al. (2016) report the results from 15 experiments in the blocking effect, all of which failed to replicate the basic phenomenon. Whereas Maes et al. did not dispute the reality of the blocking effect, they…
View details →DOI: 10.1037/xge0000341Cited by 30 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Iacopo Morchio, Christian Moser · 2026 · American Economic Review
Using linked employer-employee data from Brazil, we document a significant gender pay gap, which is largely attributed to women working at lower-paying employers. To interpret this fact, we develop an equilibrium search model with…
View details →DOI: 10.1257/aer.20231107Cited by 30 Negative / Null Result ReportOpen accessMedicine
Hazem Aboaid, Taimur Khalid, Abbas Hussain et al. · 2025 · Frontiers in Immunology
Head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy with suboptimal survival outcomes despite advances in surgery, radiotherapy, and chemotherapy. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1), has transformed treatment paradigms, yet its full potential in HNSCC is still being explored. This review evaluates the current landscape of immunotherapy in both locally advanced (LA) and recurrent/metastatic (R/M) HNSCC, discussing key clinical trials, emerging biomarker
View details →DOI: 10.3389/fimmu.2025.1596583Cited by 30 Negative / Null Result ReportOpen accessMathematics
Murray G. Efford · 2026 · Ecology
Spatially explicit capture-recapture (SECR) methods are used widely to estimate animal population density and related parameters. Maximum likelihood has been applied to two flavors of the SECR model-a full model that includes absolute…
View details →DOI: 10.1002/ecy.70455Cited by 30 Negative / Null Result ReportOpen accessNursing
Christian Stoppe, Aileen Hill, Kenneth B. Christopher et al. · 2024 · Critical Care Medicine
Precision in critical care nutrition is paramount, as it focuses nutrition interventions on those patients most likely to benefit, or those who might potentially be harmed. Critical care nutrition must therefore be tailored to individual…
View details →DOI: 10.1097/ccm.0000000000006537Cited by 29 Negative / Null Result ReportOpen accessMedicine
Francisco Llavero, Adrián Castillo‐García, Carmen Fiuza‐Luces et al. · 2026 · PubMed
BACKGROUND: Regular exercise, particularly moderate-intensity continuous training (MICT), can improve immune function. Natural killer (NK) cells, a subset of lymphocytes that react to infections, are the most responsive innate immune cells…
View details →DOI: 10.22029/eir.2021.1745Cited by 29 Negative / Null Result ReportOpen accessNursing
Ana Carolina de Aguiar, Damila Rodrigues de Morais, Leandra P. Santos et al. · 2026 · Archivos Latinoamericanos de Nutrición
This study analyzed the effects of different concentrations of flaxseed oil (FO) on the proximate composition and the contents of alpha-linolenic acid (LNA, 18:3n-3), eicosapentaenoic (EPA, 20:5n-3), and docosahexaenoic (DHA, 22:6n-3)…
View details →DOI: 10.37527/2007.57.3.009Cited by 29 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Aditi Mathur, Matthew H. Law, Ian L. Megson et al. · 2010 · Psychiatric Genetics
OBJECTIVES: A number of studies have reported a genetic association of the AKT1 gene with schizophrenia, although some have failed to replicate the AKT1 association. This study was undertaken to further explore the AKT1 association with…
View details →DOI: 10.1097/ypg.0b013e32833a2234Cited by 29 Negative / Null Result ReportOpen accessEngineering
Marwa Radwan, Abdelhameed Ibrahim, M. A. Abdelsalam et al. · 2026 · Scientific Reports
Deep learning models often encounter two key challenges in developing intelligent and scalable forecasting frameworks for renewable energy systems: input feature space dimensionality and sensitivity to hyperparameter settings. These limitations increase computational cost and compromise generalization and robustness. This paper presents a hybrid deep learning-optimization framework that leverages cognitively inspired metaheuristics to address these challenges, employing the Binary iHow Optimization Algorithm (biHOW) for feature selection and its continuous counterpart, iHOW, for hyperparameter
View details →DOI: 10.1038/s41598-026-39632-yCited by 29 Negative / Null Result ReportOpen accessEngineering
S. M. Abd Elazim, M.H. Elkholy, Abdelrahman Elgarhy et al. · 2025 · Scientific Reports
Growing integration of renewable energy sources (RESs) into power grids has several advantages, including reduced greenhouse gas emissions and improved energy sustainability. Despite the related benefits, RES integration also poses actual…
View details →DOI: 10.1038/s41598-025-14143-4Cited by 29 Negative / Null Result ReportOpen accessMedicine
Thibaut Vaulet, M. Al‐Memar, H. Fourie et al. · 2021 · Computer Methods and Programs in Biomedicine
BACKGROUND: Clinical models to predict first trimester viability are traditionally based on multivariable logistic regression (LR) which is not directly interpretable for non-statistical experts like physicians. Furthermore, LR requires…
View details →DOI: 10.1016/j.cmpb.2021.106520Cited by 29 Negative / Null Result Report
Arjen Alink, Hunar Abdulrahman, Richard N. Henson · 2018 · Nature Communications
Abstract Inferring neural mechanisms from functional magnetic resonance imaging (fMRI) is challenging because the fMRI signal integrates over millions of neurons. One approach is to compare computational models that map neural activity to…
View details →DOI: 10.1038/s41467-018-05957-0Cited by 29 Negative / Null Result Report
Otto A. Sanchez, Elizabeth A. Copenhaver, Christopher P. Elder et al. · 2010 · Magnetic Resonance in Medicine
Abstract Blood oxygenation level dependent (BOLD) contrast in skeletal may reflect the contributions of both intravascular and extravascular relaxation effects. The purpose of this study was to determine the significance of the…
View details →DOI: 10.1002/mrm.22449Cited by 29 Negative / Null Result ReportMedicine
Hsi‐Chin Wu, Chao‐Hsiang Chang, Ru-Yin Tsai et al. · 2010 · PubMed
Prostate cancer is the most common cause of cancer death in men and is a major health problem worldwide. Methylene tetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is also an important source of DNA…
Negative / Null Result ReportOpen accessPsychology
Chun-Yu Kuo, Yang-Ming Huang, Yei‐Yu Yeh · 2018 · Frontiers in Psychology
Cognitive training and social engagement are two of the routes that potentially improve cognitive functions in older adults. The former targets specific functions so that an intervention can trigger the plasticity and efficiency of the underpinning neural systems, and the latter also provides an environment supportive of social and emotional needs. We investigated whether an integration of the two routes could enhance cognitive functions related to executive control, because no prior research has adopted a theory-driven approach to design a group-based cognitive training program for executive
View details →DOI: 10.3389/fpsyg.2018.02482Cited by 29 Negative / Null Result Report
Ullrich K. H. Ecker, Caitlin X. M. Sharkey, Briony Swire-Thompson · 2023 · PLOS ONE
Individuals often continue to rely on misinformation in their reasoning and decision making even after it has been corrected. This is known as the continued influence effect, and one of its presumed drivers is misinformation familiarity.…
View details →DOI: 10.1371/journal.pone.0281140Cited by 29 Negative / Null Result Report
Amanda E. Haponski, Diarmaid Ó Foighil · 2019 · PeerJ
The genus Corbicula consists of estuarine or freshwater clams native to temperate/tropical regions of Asia, Africa, and Australia that collectively encompass both sexual species and clonal (androgenetic) lineages. The latter have become…
View details →DOI: 10.7717/peerj.7484Cited by 29 Negative / Null Result ReportOpen accessMedicine
Michael Weller, Michael Lim, Ahmed Idbaïh et al. · 2021 · Neuro-Oncology
Abstract BACKGROUND Novel therapies are needed in newly diagnosed glioblastoma as nearly all patients experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ), including patients with tumors with methylated…
View details →DOI: 10.1093/neuonc/noab196.217Cited by 29 Replication FailureOpen accessMedicine
Clark DuMontier, Hajime Uno, Tammy Hshieh et al. · 2022 · PubMed
We conducted a randomized controlled trial in older adults with hematologic malignancies to determine the impact of geriatrician consultation embedded in our oncology clinic alongside standard care. From February 2015 to May 2018,…
View details →DOI: 10.3324/haematol.2021.278802Cited by 29 Negative / Null Result ReportMedicine
Shiow‐Ching Shun, Kun‐Huei Yeh, Jin‐Tung Liang et al. · 2013 · Oncology nursing forum
PURPOSE/OBJECTIVES: To explore the association between supportive care needs and type D personality, and to identify personality traits, including negative affectivity (NA) and social inhibition (SI), and their influence on the supportive…
View details →DOI: 10.1188/14.onf.e3-e11Cited by 29 Negative / Null Result ReportOpen accessEnergy
Xiaoyu Chen, Dongli Wei, Mårten S. G. Ahlquist · 2021 · Organometallics
A CoPc/CNT system has been only recently reported to transform CO2 to methanol via electrochemical reductions, despite the fact that catalyst has been studied extensively since the 1980s. The explanation of high methanol selectivity lies behind the fact that in the new report CoPc exists mainly as a monomer, while in earlier works aggregates dominate. Here, we have studied the reactivity of monomeric and dimeric CoPc by DFT. The mechanism involves rate-limiting CO2 association, with the C–O cleavage step having very similar activation free energy. Once the Co–CO– intermediate is formed, the re
View details →DOI: 10.1021/acs.organomet.1c00431Cited by 29 Negative / Null Result ReportOpen accessMedicine
Liangzhi Zhong, Lu Chen, Shengqing Lv et al. · 2019 · Radiation Oncology
PURPOSE: Despite recent advances in multimodal treatments, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. The aim of this study was to evaluate the efficacy of moderately hypofractionated simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) combined with temozolomide (TMZ) for the postoperative treatment of GBM. MATERIALS AND METHODS: From February 2012 to February 2018, 80 patients with newly diagnosed and histologically confirmed GBM in our institute were reviewed retrospectively. All patients underwent complete resection or partial resection
View details →DOI: 10.1186/s13014-019-1305-1Cited by 29 Negative / Null Result ReportMedicine
Alisa M. Higgins, Sandra Peake, Rinaldo Bellomo et al. · 2019 · Critical Care Medicine
OBJECTIVES: To examine long-term survival and quality of life of patients with early septic shock. DESIGN: Prospective, randomized, parallel-group trial. SETTING: Fifty-one hospitals in Australia, New Zealand, Finland, Hong Kong, and the…
View details →DOI: 10.1097/ccm.0000000000003762Cited by 29 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Francesco Giuseppe De Rosa, Silvia Corcione, Giovanni Di Perri et al. · 2015 · PubMed
Tigecycline, the first member of the glycylcyclines, has been approved for complicated skin and soft tissue infections (cSSTIs) and complicated intra-abdominal infections (cIAIs). It has a wide range of activity against Gram-positive and…
Negative / Null Result ReportMedicine
Amy Thomas, Khaled Dajani, John P. Neoptolemos et al. · 2010 · Digestive Diseases
Pancreatic cancer is one of the major causes of cancer death in Europe with a 5-year survival rate of less than 5%. Although surgery cannot guarantee a cure, the 5-year survival does improve to around 10% following resection and increases…
View details →DOI: 10.1159/000320099Cited by 29 Negative / Null Result ReportMedicine
Vivian E. Strong, Sam S. Yoon · 2013 · World Journal of Surgery
Much debate still exists regarding the appropriate extent of lymphadenectomy for gastric adenocarcinoma. In high incidence countries in Eastern Asia, more extensive (e.g. D2) lymphadenectomies are standard, and these surgeries are…
View details →DOI: 10.1007/s00268-013-2070-1Cited by 29 Negative / Null Result ReportOpen accessMedicine
C. Gianna Hoffman-Luca, Chao-Yie Yang, Jianfeng Lü et al. · 2015 · PLoS ONE
SAR405838 is a potent and specific MDM2 inhibitor currently being evaluated in Phase I clinical trials for the treatment of human cancer. Using the SJSA-1 osteosarcoma cell line which harbors an amplified MDM2 gene and wild-type p53, we have investigated the acquired resistance mechanisms both in vitro and in vivo to SAR405838. Treatment of SJSA-1 cells with SAR405838 in vitro leads to dose-dependent cell growth inhibition, cell cycle arrest and robust apoptosis. However, prolonged treatment of SJSA-1 cells in vitro with SAR405838 results in profound acquired resistance to the drug. Analysis o
View details →DOI: 10.1371/journal.pone.0128807Cited by 29 Negative / Null Result ReportOpen accessMedicine
Mingqiu Chen, Minmin Shen, Yu Lin et al. · 2018 · Radiation Oncology
BACKGROUND: The aim of the present study was to assess the efficacy of adjuvant chemotherapy (AC) in patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT). METHODS: The clinical data of patients with ESCC treated with chemoradiotherapy with or without AC were collected and retrospectively reviewed. The overall survival (OS), locoregional failure-free survival (LFFS) and distant failure-free survival (DFFS) rates were analyzed statistically. RESULTS: A total of 187 patients fulfilled the inclusion criteria, 98 of whom were treated with CRT-alone
View details →DOI: 10.1186/s13014-018-1086-yCited by 29 