A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19906 results in Negative / Null Result Report · page 623 of 664
Gutierrez, Türkan · 2024 · Preprint
Abstract Background Breathing efforts during mechanical ventilation are associated with patient self-induced lung injury (P-SILI). We examined whether a noninvasive measure of P mus , the portion of airway pressure attributed to breathing…
Malindisa EK, Dika H, Rehman AM et al. · 2025 · European journal of clinical nutrition
Background The diabetes burden in sub-Saharan Africa is rising, but there is little African data on associations between diet, insulin resistance, and beta-cell dysfunction. Objective We investigated the association between dietary…
Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine
Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…
Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…
Blackwell SE, Pasquier L, Dupont S et al. · 2024 · Preprint
Summary In many animals, male weapons are large and extravagant morphological structures that typically enhance fighting ability and reproductive success. It is generally assumed that growing and carrying large weapons is costly, thus only…
Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine
Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…
Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal
Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…
Meyer DB, Gifford A, Bradley T et al. · 2026 · Journal of gastrointestinal oncology
Background Prior studies have reported solid organ transplant (SOT) recipients have increased rates of colorectal cancer (CRC). While this increased incidence is established, the recurrence risk following curative-intent treatment for…
Huber A, Pasquier T, Demarchi M et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is…
Sanghvi K, Todorova B, Sepil I · 2025 · Ecology and evolution
Sexual selection operates across pre- and post-mating episodes, driven by intra-sexual competition and inter-sexual choice for mates or gametes. While these episodes can act in the same direction, this is not always the case; for example,…
Al Shboul S, Abu Al Karsaneh O, Alrjoub M et al. · 2025 · International journal of immunopathology and pharmacology
Objective The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introduction Cellular senescence and its secretory phenotype (the SASP) are implicated in…
Arato CVB, Guerra LM, Probst LF et al. · 2025 · Revista de saude publica
Objective To investigate the impact of prenatal care on the reduction of maternal-child mortality in Brazilian municipalities following the new primary health care financing model, the Previne Brasil program. Methods This study comprised a…
Gatterer C, Allmer D, Beitzke D et al. · 2026 · Journal of clinical medicine
Background/Objectives: Fabry disease (FD) is a lysosomal storage disorder characterized by progressive renal and cardiac involvement and an increased burden of cardiovascular and cerebrovascular events. While cardiac magnetic resonance…
Kamian S, Azadeh P, Anbiaee R et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Anthracyclines are widely used in the treatment of breast cancer but are associated with myocardial injury that may progress to cardiac dysfunction. Surveillance has traditionally relied on left ventricular ejection fraction…
Kim H, Kipp K · 2025 · Computer methods in biomechanics and biomedical engineering
The purpose of this study was to calculate and compare (1) knee loads, (2) muscle-specific contributions to knee loads, and (3) effects of knee flexion angle on knee loads and muscle-specific load contributions during a forward…
Brolin KA, Bäckström D, Wallenius J et al. · 2024 · Preprint
Variants in GBA1 are important genetic risk factors in Parkinson’s disease (PD). GBA1 T369M has been linked to an ∼80% increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A…
Nakamura T, Hatanaka KC, Kawamoto Y et al. · 2025 · Journal of cancer research and clinical oncology
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Despite the use of aggressive combination chemotherapy regimens, outcomes remain unsatisfactory. Schlafen family member 11 (SLFN11) has been reported to regulate the DNA…
Tsui ST, Zhou N, Tan KS et al. · 2025 · JTCVS open
Objectives The study objectives were to determine whether diagnostic laparoscopy improves staging accuracy in selected patients with distal esophageal adenocarcinoma and to identify clinicopathologic features associated with positive…
Tabara Y, Shoji-Asahina A, Ogawa A et al. · 2024 · International journal of obesity (2005)
Background Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy…
Tseng YT, Chen II, Wang CH · 2025 · Healthcare (Basel, Switzerland)
Background : The long-term effects of hormone replacement therapy (HRT) on inflammatory bowel disease (IBD) remain unclear, necessitating further investigations of the association between HRT and the development of ulcerative colitis and…
Schiff DM, Wheeler A, Lewis D et al. · 2026 · Journal of substance use and addiction treatment
Objective Identify sociodemographic and substance use characteristics associated with pregnancy intention and explore the relationship between pregnancy intent and postpartum contraception interest among pregnant individuals with opioid…
Reda B, Zanon G, Contardo L et al. · 2025 · Orthodontics & craniofacial research
Objective Orthodontic treatment is a common approach for correcting malocclusion but is often associated with discomfort. The aim of this study was to assess the longitudinal changes in oral behaviours, temporomandibular disorder…
Kholili U, Hidayat AA, Bintoro UY et al. · 2026 · Cancers
Introduction Mounting evidence indicates that the p53 Pro72Arg single-nucleotide polymorphisms (SNPs) may play a role in modulating hepatocarcinogenesis in the setting of chronic HBV infection. However, there is currently a lack of studies…
Petzke TM, Köteles F, Pohl A et al. · 2024 · Journal of psychosomatic research
Objective (Cardiac) interoception was long considered a key mechanism behind symptom perception in persistent somatic symptoms (PSS). In this study, we aimed to extend earlier findings to clarify this potential interoceptive mechanisms of…
Kohno C, Higuchi A, Miyagawa E et al. · 2026 · Modern rheumatology
Objectives Low-dose aspirin (LDA) is widely recommended to prevent hypertensive disorders of pregnancy (HDP). However, the evidence of its effectiveness in pregnancies with systemic lupus erythematosus (SLE) remains limited. This study…
· 2006
Lurasidone is more than 99% bound to plasma proteins, so it is unlikely that the drug would be excreted into milk in sufficient amounts to affect a breastfed infant. Data from one mother-infant pair appears to support the poor excretion…
Kishinevsky M, Ferrer-Suay M, Ives AR · 2026 · Biol Invasions.
The enemy release hypothesis—that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range—can be an important explanation for successful invasions. Testing this…
Sebbag A, SAKDAVONG J · 2025 · Preprint
In the scientific literature, avatars are representations that can take various forms and fulfill multiple functions and roles for learners. The recent emergence of ultra-realistic avatars generated by artificial intelligence presents new…
Neal RA, Corbett J, Costello JT et al. · 2026 · European journal of sport science
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterised by chronic hyperglycaemia, whereas obesity is a major risk factor which increases morbidity and mortality. Treatments that alter white adipose tissue to express a…
Abbasi H, Ashtiani MN · 2026 · Journal of motor behavior
This study investigated the impact of real-time laser-guided visual cues on spatiotemporal gait parameters during initiation and termination in people with Parkinson's (PwP). Fifteen PwP walked a 5-m path under uncued and laser-cued…