Unilateral vs. bilateral DLPFC rTMS: comparative effects on depression, visual-spatial memory, inhibitory control and cognitive flexibility in major depressive disorder
Fatemeh Asgharian Asl; Sajjad Abbaszade; Sajjad Abbaszade; Horeyeh Derakhshani; Ladan Vaghef; Amirreza Asgharian Asl · 2024 · Frontiers in Psychiatry
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BackgroundExciting left DLPFC activity with high frequency and inhibiting right DLPFC with low frequency repetitive transcranial magnetic stimulation (rTMS) has shown antidepressant effects in major depressive disorder (MDD) and executive functions. However, few studies have directly compared unilateral and bilateral protocols.MethodsForty-seven individuals with treatment-resistant MDD underwent 10 sessions of rTMS over left DLPFC (20 Hz), bilateral DLPFC (left 20 Hz, right 1 Hz), or sham stimulation. Outcomes were depression (Beck Depression Inventory-II), visual-spatial memory (Corsi Block T
Abstract by Fatemeh Asgharian Asl; Sajjad Abbaszade; Sajjad Abbaszade; Horeyeh Derakhshani; Ladan Vaghef; Amirreza Asgharian Asl, Frontiers in Psychiatry (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fpsyt.2024.1400414