Phosphatidylserine enriched with polyunsaturated n‐3 fatty acid supplementation for attention‐deficit hyperactivity disorder in children and adolescents with epilepsy: A randomized placebo‐controlled trial
Sylvain Rheims; Vania Herbillon; Ségolène Gaillard; Catherine Mercier; Nathalie Villeuve; Frédéric Villéga; Claude Cances; Pierre Castelnau · 2024 · Epilepsia Open
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Attention‐deficit hyperactivity disorder (ADHD) is a frequent comorbidity in children with epilepsy, which management mostly relies on the usual treatments of ADHD, especially methylphenidate. Supplementation with polyunsaturated n‐3 Fatty Acid (PUFA) has been proposed as an alternative therapeutic approach in ADHD without epilepsy but has never been evaluated in epilepsy‐associated ADHD. Methods A multicenter double blind randomized placebo‐controlled trial evaluating supplementation with PUFA, in eicosapentaenoic‐ and docosahexaenoic‐acid form, conjugated to a phospholipi
Abstract by Sylvain Rheims; Vania Herbillon; Ségolène Gaillard; Catherine Mercier; Nathalie Villeuve; Frédéric Villéga; Claude Cances; Pierre Castelnau, Epilepsia Open (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/epi4.12892