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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21360 results · page 594 of 712

Negative / Null Result ReportMedicine

Predictive value of aortic propagation velocity for cardiovascular events in asymptomatic individuals with elevated ASCVD risk.

Bigdelu L, Ahmadi M, Shahri B et al. · 2026 · Scientific reports

Prediction of cardiovascular diseases (CVD) is a challenge that cardiologists have always faced all the times. Aortic propagation velocity (APV) is an echocardiography index that can be helpful with this regard; however, few studies have…

View details →DOI: 10.1038/s41598-026-56810-0
Negative / Null Result ReportMedicine

Assessment of the relationship between sustainable and healthy eating behaviours, acceptance of alternative protein sources (plant-based products, mushroom protein, algae, artificial meat, edible insects) and food neophobia in young adults.

Karahan Yılmaz S, Güldüren S · 2026 · Nutricion hospitalaria

Introduction Introduction: a growing world population, constraints on natural resources and changing nutritional preferences all point to the need to find an alternative to traditional animal protein sources however food neophobia can come…

View details →DOI: 10.20960/nh.06309
Negative / Null Result ReportMedicine

Haemoglobin threshold-based blood transfusion practices in patients following hip fracture surgery: a multicentre retrospective study.

Berube M, Bortman JM, Law AC et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Background The optimal threshold to blood transfusion in patients after hip fracture surgery is unclear. This study leveraged regression discontinuity to quantify blood transfusion practices across haemoglobin thresholds of 7.0, 8.0, and…

View details →DOI: 10.1177/11207000251409092
Negative / Null Result ReportMedicine

Expression of tardigrade extremotolerance-associated proteins improves recovery but not acute stress response of human microvascular endothelial cells.

Darch W, Soliman J, Higgins NC et al. · 2026 · Scientific reports

Vascular endothelial cells (VECs) play a critical role in tissue and organ homeostasis, wound healing, and immune function. VECs are commonly utilized for in vitro cell culture and in vivo tissue engineering applications which experience…

View details →DOI: 10.1038/s41598-026-57258-y
Negative / Null Result ReportMedicine

Microsurgical Denervation of the Penis for Lifelong Premature Ejaculation: A Prospective Multicenter Study Evaluating Technique Modification and Early Clinical Outcomes.

Almekaty K, Alhefnawy M, Ismael A et al. · 2026 · Urology

Objective To prospectively assess the clinical outcomes and safety of microsurgical denervation of the penis (MSDP) for treatment of lifelong premature ejaculation (LPE); and to examine the impact of transitioning from partial to more…

View details →DOI: 10.1016/j.urology.2026.06.030
Negative / Null Result ReportMedicine

Dento-facial changes and oral health-related quality of life assessment in management of anterior crossbite in mixed dentition: a randomized clinical trial.

Salem AS, Albelasy NF, El-Bialy AA · 2026 · The Angle orthodontist

Objectives To compare the effectiveness of clear aligner (CA) vs removable inclined plane (RP) in improving the dentofacial changes and oral health-related quality of life (OHRQoL) in children with anterior crossbite in the mixed…

View details →DOI: 10.2319/020325-109.1
Negative / Null Result ReportMedicine

Size Dependent Effects of Aluminum Oxide Particles on Tissue Accumulation and Antioxidant Enzyme Activities of Oreochromis niloticus.

Tuncsoy M, Tuncsoy B · 2026 · Bulletin of environmental contamination and toxicology

Aluminum (Al) is a widely occurring element in nature and is the most abundant element in the earth's crust after oxygen and silicon. In this study, metal accumulation levels in the gills, liver and muscle tissues and liver SOD, CAT and…

View details →DOI: 10.1007/s00128-025-04178-8
Negative / Null Result ReportOpen accessMedicine

Impact of cigarette smoking on genetic stability, cell division, and cytotoxicity in buccal cells of old and young women.

Nersesyan A, Kundi M, Muradyan R et al. · 2026 · Mutagenesis

We investigated the impact of cigarette smoking, daily exposure to tar and nicotine, and the duration of smoking on genetic instability (chromosomal damage-micronuclei, MN, nuclear buds-gene amplification) as well as on disturbances in…

View details →DOI: 10.1093/mutage/geaf003
Negative / Null Result ReportMedicine

Assessing the Risk of Adverse Maternal and Infant Outcomes Following Prenatal Modafinil Exposure: A French Nationwide Cohort Study.

Kaplan S, de Nascimento J, Contini A · 2026 · Drug safety

Background and objectives Concerns about modafinil and armodafinil use in pregnancy emerged from animal reproductive toxicity and limited human data, including a US registry suggesting increased risk of major congenital malformations…

View details →DOI: 10.1007/s40264-026-01686-2
Negative / Null Result ReportMedicine

Conversion Rates From Initial Consultation to Bariatric Surgery: A Single-Center Community Practice Experience.

McDonough W, Gevorkian J, Wong D et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques

Background As part of the accreditation process for bariatric surgery, patients must go through a preoperative pathway. There will inevitably be patients who are seen in the clinic but never undergo surgery. This rate of attrition is…

View details →DOI: 10.1097/sle.0000000000001443
Negative / Null Result ReportOpen accessMedicine

Pemafibrate therapy increases serum zinc levels in patients with metabolic dysfunction-associated steatohepatitis: a prospective study.

Wakui N, Ogino Y, Nagumo H et al. · 2026 · BMC gastroenterology

Background Zinc deficiency is common in chronic liver disease and is closely associated with the progression of hepatic fibrosis and metabolic dysfunction. Although pemafibrate, a selective peroxisome proliferator-activated receptor alpha…

View details →DOI: 10.1186/s12876-026-04806-5
Negative / Null Result ReportMedicine

Influence of rubbing during etching on surface roughness and interfacial characteristics of intact enamel.

Biedermann M, Sifakakis I, Zinelis S et al. · 2026 · European journal of oral sciences

Rubbing phosphoric acid during etching has been shown to improve surface roughness in prepared enamel. This study aimed to compare intact enamel's surface roughness and resin tag lengths after etching with and without rubbing. Extracted…

View details →DOI: 10.1111/eos.70108
Failed Experiment ReportMedicine

Mavacamten and left ventricular dysfunction in hypertrophic cardiomyopathy with left bundle branch block.

Van Overmeiren T, de Alaiza Ortega SG, Calle S et al. · 2026 · Progress in cardiovascular diseases

Background Mavacamten is a cardiac myosin inhibitor used for patients with obstructive hypertrophic cardiomyopathy (oHCM). The efficacy and safety of this negative inotropic agent in oHCM and concomitant left bundle branch block (LBBB)…

View details →DOI: 10.1016/j.pcad.2026.06.001
Negative / Null Result ReportMedicine

Gestational Diabetes and Hypothyroidism: Do Other Factors Play a Role? A Retrospective Case-Control Study.

Firoozjaei IT, Sabzi Z, Rajabloo M et al. · 2026 · Nursing research and practice

Background During pregnancy, extensive hormonal and metabolic changes can occur. Gestational diabetes can cause maternal and neonatal complications. Follow-ups have shown that women who first develop metabolic diseases during pregnancy…

View details →DOI: 10.1155/nrp/8165809
Negative / Null Result ReportOpen accessMedicine

The effect of a community intervention based on protection motivation theory on brucellosis preventive behaviors in rural residents.

Ebrahimi S, Tehrani H, Ghavami V et al. · 2025 · Journal of education and health promotion

Background Brucellosis is a major bacterial infectious disease common to human beings and animals. It is considered a prevalent infection in developing countries. The present research was carried out to explore the effect of an educational…

View details →DOI: 10.4103/jehp.jehp_1034_24
Negative / Null Result Report

T3 and Curcumin Regulates Collagen-IV and Collagen-VI Expression: Role in Suppression of Amyloid-β via TGFβ1-Sp1 Signaling in Hypothyroid Mice Brain

Sahu SK, Nayak M, Samal A et al. · 2026 · Preprint

Abstract Hypothyroidism has been associated with cognitive disorders and high risk of neurodegenerative disorders like Alzheimer's disease (AD), which is caused by amyloid-β (Aβ) accumulation in brain. The aim of the study is to examine…

View details →DOI: 10.21203/rs.3.rs-9659339/v1
Negative / Null Result ReportMedicine

Safety of Biologic and Immune-modulating Agents in Breast Surgery Procedures: A Retrospective Cohort Analysis.

Chaudhry AS, Tian W, Adam TH et al. · 2026 · Aesthetic surgery journal

Background Biologic and targeted immune-modulating agents are increasingly used to manage autoimmune diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease. As more patients receiving these therapies undergo elective…

View details →DOI: 10.1093/asj/sjag112
Negative / Null Result ReportOpen accessMedicine

Short-term CoQ10 supplementation reduces markers of cardiac stress in soccer players following heavy exercise: A randomized double-blind placebo-controlled trial.

Rahimi MR, Morton AB, Golpasandi H et al. · 2025 · BMC sports science, medicine & rehabilitation

Background Coenzyme Q10 (CoQ10), a vital mitochondrial antioxidant, may enhance cardiovascular recovery and delay fatigue in athletes. This double-blind, randomized, placebo-controlled trial investigated CoQ10's effects on cardiac stress…

View details →DOI: 10.1186/s13102-025-01456-0
Negative / Null Result ReportMedicine

Maternal Response to Therapeutic Plasma Exchange in Early Gestation: A Case Series of Thrombotic Microangiopathies and Neurological Disorders.

Karaaslan O, Türkyılmaz G, Hacıoğlu L et al. · 2026 · Biomedicines

Background/Objectives: Therapeutic plasma exchange (TPE) is an extracorporeal treatment used in thrombotic microangiopathies (TMAs) and various autoimmune and neurological disorders. However, data regarding its use during early pregnancy…

View details →DOI: 10.3390/biomedicines14061403
Negative / Null Result ReportMedicine

Enhancing Immunity and Gut Microbiota Balance with Black Soldier Fly Larvae (BSFL) Meal: A Sustainable Feed Ingredient That Maintains Growth Performance in Pekin Ducks.

Long L, Liu G, Gao G et al. · 2026 · Insects

The effects of substituting soybean meal with black soldier fly larvae (BSFL) meal on the growth performance, immunological response, intestinal morphology, and gut microbiota of Pekin ducks were assessed. A total of 150 one-day-old Pekin…

View details →DOI: 10.3390/insects17060548