Methods Dead-EndOpen accessDairy processing. Dairy products
R.B. Standish, A.D. Wright, N.L. Whitehouse et al. · 2024 · Journal of Dairy Science
ABSTRACT: The purpose of this experiment was to determine if nicotinic acid (NA) effects on dairy cows and rumen microbial characteristics are forage-type dependent (corn silage, CS; grass silage, GS). Four late-lactation (DIM = 225 ± 12 d) Holstein cows were used in a 4 × 4 Latin square design with a 2 × 2 factorial arrangement of treatments. The main effects were a CS (66.10% CS) based diet or a GS (79.59%) based diet with or without 12 g/d NA. Each experimental period lasted for 28 d. Milk production and milk components, blood metabolites, apparent total-tract nutrient digestibilities, minu
View details →DOI: 10.3168/jds.2023-24483 Methods Dead-EndOpen accessSports
Marcus Vinicius Machado, Alexandre Rosas Batista, Leandro Ricardo Altimari et al. · 2010 · Revista Brasileira de Cineantropometria e Desempenho Humano
The aim of this study was to evaluate the effect of caffeine intake on critical power model parameters determined on a cycle ergometer. Eight male subjects participated in this study. A double-blind protocol consisting of the intake of pure caffeine (6 mg/kg) or placebo (maltodextrin) 60 min before testing was used. Subjects were submitted to four constant-load tests on a cycle ergometer. These tests were conducted randomly in the caffeine and placebo groups [checar] at intensities of 80, 90, 100 and 110% maximum power at a rate of 70 rpm until exhaustion to determine the critical power. As a
Methods Dead-EndOpen accessMedical emergencies. Critical care. Intensive care. First aid
Dimitri Titeca-Beauport, Delphine Daubin, Ly Van Vong et al. · 2020 · Critical Care
Abstract Background The urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyzed the utility of these biomarkers for distinguishing between transient and persistent AKI in the early phase of septic shock. Methods We performed a prospective, multicenter study in 11 French ICUs. Patients presenting septic shock, with the development of AKI within the first 6 h, were included. Urine [TIMP-2]*[IGFBP7] was determined at inclusion (0 h), 6 h, 12 h, an
View details →DOI: 10.1186/s13054-020-02984-6 Failed Experiment ReportOpen accessMedicine
A. J. Oswald, R. L. Hollis, M. Churchman et al. · 2026 · Scientific Reports
Abstract Copy number loss (CNL) of tumour suppressors genes, such as BRCA1/2, are frequent but under-researched tumour driver events. Accurate identification of BRCA1/2 CNL has potential therapeutic implications, particularly in high grade serous tubo-ovarian carcinoma (HGSOC), and cost-effective detection methods are desirable. This study assessed quantitative PCR (qPCR) as a method of BRCA1/2 CNL detection in HGSOC, in two patient cohorts (cohort 1 n = 355, cohort 2 n = 86) and a cell line panel (n = 10) using sequencing-based copy number (CN) assessment as a comparator (panel-based sequenci
View details →DOI: 10.1038/s41598-025-34516-z Failed Experiment ReportOpen accessPsychology
Christian Nawroth, Zoe M. Martin, Alan G. McElligott et al. · 2020 · Frontiers in Psychology
Dogs (Canis lupus familiaris) are extremely adept in interpreting human-given cues, such as the pointing gesture. However, the underlying mechanisms on how domestic non-companion species use these cues are not well understood. We investigated the use of human-given pointing gestures by goats (Capra hircus) in an object choice task, where an experimenter surreptitiously hid food in one of two buckets. Subjects first had to pass a pre-test where the experimenter indicated the location of the food to the subject by a proximal pointing gesture. Subjects that succeeded in the use of this gesture we
View details →DOI: 10.3389/fpsyg.2020.00915 Negative / Null Result ReportOpen access
Ananda Krisma Delya, Tri Naimah, U. Wibowo et al. · 2023 · AL-TANZIM : JURNAL MANAJEMEN PENDIDIKAN ISLAM
This study aims to determine the organizational climate's effect on work happiness with Islamic religiosity as a moderator variable for Islamic-based school teachers in the Banyumas Regency. A correlational quantitative approach was used…
View details →DOI: 10.33650/al-tanzim.v7i3.3999 Failed Experiment ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Diana Jansen, Annemijn H. Jonkman, Lisanne Roesthuis et al. · 2018 · Critical Care
Abstract Background Diaphragm dysfunction develops frequently in ventilated intensive care unit (ICU) patients. Both disuse atrophy (ventilator over-assist) and high respiratory muscle effort (ventilator under-assist) seem to be involved. A strong rationale exists to monitor diaphragm effort and titrate support to maintain respiratory muscle activity within physiological limits. Diaphragm electromyography is used to quantify breathing effort and has been correlated with transdiaphragmatic pressure and esophageal pressure. The neuromuscular efficiency index (NME) can be used to estimate inspira
View details →DOI: 10.1186/s13054-018-2172-0 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Christopher J. Kirwan, Barbara J. Philips, Iain A. M. MacPhee · 2013 · Critical Care Research and Practice
Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is needed, and some published data suggest that equations based on serum creatinine that estimate glomerular filtration rate (eGFR) can provide this. In addition, incorporating serum cystatin C concentration into estimates of GFR may improve their accuracy, but no eGFR equations are validated in critically ill patients with AKI. Aim. This study t
View details →DOI: 10.1155/2013/406075 Negative / Null Result ReportOpen accessPsychology
Phietica R. R. Silva, Phietica R. R. Silva, Regina H. Silva et al. · 2020 · Frontiers in Psychology
Empathy is the ability to (a) be affected by and share the emotional state of another; (b) assess the reasons for the other’s state; and (c) identify with the other, adopting their perspective. This phenomenon has been shown to exist in several species and is proposed as a motivator for prosocial behavior. The experimental study of this feature in laboratory rodents is a more viable alternative in comparison to wild animals. A recent report showed that rats opened a door to free their cage mate from a restraint box. Although this behavior has been suggested to be motivated by empathy, this fac
View details →DOI: 10.3389/fpsyg.2020.01795 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Jing Long, Yan Huang, Gang Wang et al. · 2023 · Antioxidants
Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and elevated circulatory levels of sFlt1, sEng IL-1β, and TNFα. Abnormal mitochondrial morphology and mitochondrial dysfunction in placentas occurred in DEX rats. Omics showed that a large spectrum of placental signaling pathways, including oxidative phosphorylation (OXPHOS), energy metabolism, inflammation, and insulin-like growth factor (IGF) system
View details →DOI: 10.3390/antiox12050987 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
M. Sadaka, M. Loutfy, M. Sobhy · 2013 · The Egyptian Heart Journal
Aim: The purpose of this study was to compare the impact of incomplete revascularization (IR) plus optimal medical therapy (OMT) to OMT alone on 1 year clinical outcomes in patients with multivessel coronary artery disease (MVD) who were not eligible for coronary bypass graft surgery (CABG). Methods: This is a prospective randomized study conducted on 50 selected patients with chronic stable angina with documented MVD and CABG was refused by the surgeon due to poor distal vessel quality. Patients were randomized 1:1 into two groups, group (I): 25 patients were subjected to OMT alone and group
View details →DOI: 10.1016/j.ehj.2012.10.002 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Tobias Wollersheim, Julius J. Grunow, Niklas M. Carbon et al. · 2019 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Early mobilization improves physical independency of critically ill patients at hospital discharge in a general intensive care unit (ICU)‐cohort. We aimed to investigate clinical and molecular benefits or detriments of early mobilization and muscle activating measures in a high‐risk ICU‐acquired weakness cohort. Methods Fifty patients with a SOFA score ≥9 within 72 h after ICU admission were randomized to muscle activating measures such as neuromuscular electrical stimulation or whole‐body vibration in addition to early protocol‐based physiotherapy (intervention) or early p
View details →DOI: 10.1002/jcsm.12428 Replication FailureOpen accessMedicine
A. Bühler, Johannes Thrul, Evelin Strüber et al. · 2015 · Health Promotion International
Because of scarce research, the effectiveness of substance abuse prevention in leisure settings remains unclear. In this study, we evaluated the effectiveness of a peer-led educational prevention measure with adolescent groups in…
View details →DOI: 10.1093/heapro/dav007 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Solberg Peter, Were Willy, Downing Robert S et al. · 2007 · AIDS Research and Therapy
Abstract Background CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs) have not proven sufficiently accurate in identifying subjects with low CD4 counts. We developed clinical algorithms using TLCs, hemoglobin (Hb), and body mass index (BMI) to identify patients who require ART. Methods We conducted a cross-sectional study of HIV-infected adults in Uganda, who presented for assessment for ART-eligibility with WHO clinical stages I, II or
View details →DOI: 10.1186/1742-6405-4-1 Negative / Null Result ReportOpen accessSpecialties of internal medicine
Colleen M. Badke, Matthew L. Friedman, Z. Leah Harris et al. · 2020 · Resuscitation Plus
Aim: To determine if an untrained cardiopulmonary resuscitation (CPR) Coach, with no access to real-time CPR feedback technology, improves CPR quality. Methods: This was a prospective randomized pilot study at a tertiary care children's hospital that aimed to integrate an untrained CPR Coach into resuscitation teams during simulated pediatric cardiac arrest. Simulation events were randomized to two arms: control (no CPR Coach) or intervention (CPR Coach). Simulations were run by pediatric intensive care unit (PICU) providers and video recorded. Scenarios focused on full cardiopulmonary arrest;
View details →DOI: 10.1016/j.resplu.2020.100035 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Cassandra A. A. Locatelli, My-Anh Nguyen, Nadya M. Morrow et al. · 2026 · Cardiovascular Diabetology
Abstract Background The ketogenic diet (KD) is widely recognized for its potential benefits in individuals with type 2 diabetes, but findings from both human and animal studies remain inconsistent. Type 2 diabetes is often comorbid with liver steatosis and atherosclerosis which are characterized by inflammation and dysregulated lipid metabolism. Moreover, whereas KD has shown mixed, sometimes detrimental, effects on circulating cholesterol levels in humans, it is currently unclear the whole-body balance of risk and benefit across hepatic, atherosclerotic, and pancreatic effects. Methods We use
View details →DOI: 10.1186/s12933-025-03046-3 Negative / Null Result ReportOpen accessPublic aspects of medicine
Abolghasem Pourreza, Ali Mohammad Mosadeghrad, Parsa Zoleikani · 2017 · پژوهشهای سلامتمحور
Background & Objectives: Accreditation, as a formal external evaluation system, has a critical role in improving quality, safety and effectiveness of hospital services. The aim of this study was to evaluate the effects of accreditation standards on the performance of Accident and Emergency (A&E) departments of hospitals in Sari, Iran. Methods: This cross-sectional descriptive - analytic study was carried out in eight hospitals in Sari, Iran. Information related to the accreditation scores and five performance indicators of A&E departments (i.e., average triage time, percentage of cardiopulmona
Negative / Null Result ReportOpen accessPsychiatry
Fatemeh Asgharian Asl, Sajjad Abbaszade, Sajjad Abbaszade et al. · 2024 · Frontiers in Psychiatry
BackgroundExciting left DLPFC activity with high frequency and inhibiting right DLPFC with low frequency repetitive transcranial magnetic stimulation (rTMS) has shown antidepressant effects in major depressive disorder (MDD) and executive functions. However, few studies have directly compared unilateral and bilateral protocols.MethodsForty-seven individuals with treatment-resistant MDD underwent 10 sessions of rTMS over left DLPFC (20 Hz), bilateral DLPFC (left 20 Hz, right 1 Hz), or sham stimulation. Outcomes were depression (Beck Depression Inventory-II), visual-spatial memory (Corsi Block T
View details →DOI: 10.3389/fpsyt.2024.1400414 Negative / Null Result ReportOpen accessRenewable energy sources
Elias Stathatos, Panagiotis Lianos · 2002 · International Journal of Photoenergy
Dye-sensitized photoelectrochemical cells based on TiO2 mesoporous films, a ruthenium bipyridyl derivative as photosensitizer and a SiO2/poly(ethylene glycol)-200 nanocomposite thin film as electrolyte support, have been constructed. TiO2 films have been deposited on conductive transparent Indium-Tin Oxide glass slides by means of a sol-gel procedure carried out in reverse-micellar solutions. The photosensitizer has been adsorbed on titania films from ethanolic solutions while the electrolyte layer has been synthesized by a sol-gel procedure. The presence of silica in the nanocomposite electro
View details →DOI: 10.1155/s1110662x02000028 Negative / Null Result Report
Didin Muwahhidin, Henokh Ziw Apritoba · 2026 · Klabat Accounting Review
understanding that accounting functions as an economic language that reflects the influence of macroeconomic factors on company performance and value in the capital market. Fluctuations in stock returns in the property sector in Indonesia…
View details →DOI: 10.60090/kar.v7i1.1455.21-31 Negative / Null Result ReportOpen accessDentistry
Duaa Subhi Rasan, Firas Abdulameer Farhan · 2023 · Dental Hypotheses
Introduction: This study was designed to examine the effects of addition of the combination of polymerized polymethyl methacrylate (PMMA) and zirconia (ZrO2) particles to heat cure PMMA resin on impact strength, surface hardness, and roughness. Methods: The 70% (w/w) of polymerized PMMA powder (particle size: 0.70 µm) was mixed with 30% (w/w) of zirconia powder (ZrO2) (1 µm) to produce PMMA-ZrO2 filler. Ninety acrylic specimens created were divided into three groups containing 0% wt (Control group), 2% wt, and 4% wt, PMMA-ZrO2 filler. Ten specimens were used for impact strength, surface hardne
View details →DOI: 10.4103/denthyp.denthyp_151_22 Negative / Null Result ReportOpen accessMedicine
David J. Harris, Shawn D. Taylor, Ethan P. White · 2018 · PeerJ
Biodiversity forecasts are important for conservation, management, and evaluating how well current models characterize natural systems. While the number of forecasts for biodiversity is increasing, there is little information available on how well these forecasts work. Most biodiversity forecasts are not evaluated to determine how well they predict future diversity, fail to account for uncertainty, and do not use time-series data that captures the actual dynamics being studied. We addressed these limitations by using best practices to explore our ability to forecast the species richness of bre
View details →DOI: 10.7717/peerj.4278 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Megan Kristy Herbert, Marjolein B Aerts, Marijke eBeenes et al. · 2015 · Frontiers in Neurology
The differentiation between multiple system atrophy (MSA) and Parkinson’s disease (PD) is difficult, particularly in early disease stages. Therefore, we aimed to evaluate the diagnostic value of neurofilament light chain (NFL), fms-like tyrosine kinase ligand (FLT3L) and total tau protein (t-tau) in cerebrospinal fluid (CSF) as biomarkers to discriminate MSA from PD. Using commercially available enzyme-linked immunoassays (ELISAs), we measured CSF levels of NFL, FLT3L and t-tau in a discovery cohort of 36 PD patients, 27 MSA patients and 57 non-neurological controls and in a validation cohort
View details →DOI: 10.3389/fneur.2015.00091 Negative / Null Result ReportOpen accessMedicine (General)
O.E. Soares, A.A.V. Cruz · 2004 · Brazilian Journal of Medical and Biological Research
The objective of the present study was to describe, for the first time in Brazil, the use by a non-ophthalmologist of a community-based marginal rotation procedure by a posterior approach in the indigenous population from the Upper Rio Negro basin. Seventy-three upper eyelids of 46 Indians (11 males and 35 females) with cicatricial upper eyelid entropion and trichiasis were operated in the Indian communities using a marginal rotational procedure by a posterior approach by a non-ophthalmologist physician who had general surgery experience but only an extremely short period (one week) of ophthal
View details →DOI: 10.1590/s0100-879x2004000500007 Negative / Null Result ReportOpen accessMedicine
Cláudia Saraiva, Daniela Talhada, Akhilesh Rai et al. · 2018 · PLoS ONE
There is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential in an in vitro and in vivo model of stroke. For that, neuroprotective and neurogenic responses were assessed in an in vitro model of stroke. Here, we found that miR-124 NPs decreased cell death and imp
View details →DOI: 10.1371/journal.pone.0193609 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Maria Comas, Alejandra Solis Flores, Nicole Lovato et al. · 2023 · Brain Sciences
Insomnia is a highly prevalent sleep disorder with strong bidirectional associations with depressive symptoms. The circadian preference for eveningness has been shown to be associated with depressive symptoms in insomnia and other mental health conditions. However, there is a lack of studies in insomnia investigating whether objective measures, such as dim light melatonin onset (DLMO) or polysomnographic (PSG) sleep, are associated with depressive symptoms. Therefore, we investigated the associations between subjective measures (questionnaires assessing anxiety, sleep quality and circadian pre
View details →DOI: 10.3390/brainsci13040613 Negative / Null Result ReportOpen accessVeterinary medicine
William Taylor Fair, Jeffrey Bryan Breeden, Thomas Wayne Atchley et al. · 2022 · Animals
Mesquite ( Prosopis L.) is considered an invasive browse species in most of the American Southwest. Mechanical intervention removes yields an excess of organic debris. Anecdotal evidence in the past has supported using such browse as feed for livestock. Thus, our objectives were to (1) determine the nutritive value and fermentation characteristics of silage produced with mesquite biomass, and (2) evaluate solvent treatment of mesquite biomass prior to ensiling. In Experiment 1, we evaluated mesquite inclusion rate (0, 250, 500, 750, or 1000 g kg −1 DM), length of fermentation (28, 56, or 84 d)
View details →DOI: 10.3390/ani12202795 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Michał Sobstyl, Nina Kożuch, Magdalena Iwaniuk-Gugała et al. · 2023 · Epilepsy & Behavior Reports
Progressive myoclonic epilepsy (PME) is characterized by prominent myoclonus, generalized tonic-clonic seizures, and less often focal, tonic, or absence seizures. The KCNC1 mutation is responsible for specific clinical phenotype of PME which has been defined as myoclonic epilepsy and ataxia due to potassium channel mutation (MEAK). We present a case of a 44 years-old male patient with genetically proven MEAK who underwent subthalamic nucleus/substantia nigra (STN/SNr) deep brain stimulation (DBS) for his pharmacological-refractory myoclonus and drug-resistant epilepsy (DRE). Since the age of 4
View details →DOI: 10.1016/j.ebr.2023.100627 Negative / Null Result ReportOpen accessPsychiatry
Jiaojiao Zhou, Xu Chen, Le Xiao et al. · 2021 · Frontiers in Psychiatry
Background: Insomnia is a common clinical manifestation in patients with depression. Insomnia is not only a depression symptom but also an independent risk factor for recurrence. Cordyceps militaris (C. militaris) is thought to have the potential to treat insomnia. This study aimed to examine the efficacy and safety of duloxetine with C. militaris in improving sleep symptoms in patients with depression.Methods: This study was a single-center, randomized, double-blind, placebo-controlled study that recruited outpatients admitted to Beijing Anding hospital from January 2018 to January 2019. Majo
View details →DOI: 10.3389/fpsyt.2021.754921 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Sylvain Rheims, Vania Herbillon, Ségolène Gaillard et al. · 2024 · Epilepsia Open
Abstract Background Attention‐deficit hyperactivity disorder (ADHD) is a frequent comorbidity in children with epilepsy, which management mostly relies on the usual treatments of ADHD, especially methylphenidate. Supplementation with polyunsaturated n‐3 Fatty Acid (PUFA) has been proposed as an alternative therapeutic approach in ADHD without epilepsy but has never been evaluated in epilepsy‐associated ADHD. Methods A multicenter double blind randomized placebo‐controlled trial evaluating supplementation with PUFA, in eicosapentaenoic‐ and docosahexaenoic‐acid form, conjugated to a phospholipi
View details →DOI: 10.1002/epi4.12892 