Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study
Dimitri Titeca-Beauport; Delphine Daubin; Ly Van Vong; Guillaume Belliard; Cédric Bruel; Sami Alaya; Karim Chaoui; Maud Andrieu · 2020 · Critical Care
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Abstract
Abstract Background The urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyzed the utility of these biomarkers for distinguishing between transient and persistent AKI in the early phase of septic shock. Methods We performed a prospective, multicenter study in 11 French ICUs. Patients presenting septic shock, with the development of AKI within the first 6 h, were included. Urine [TIMP-2]*[IGFBP7] was determined at inclusion (0 h), 6 h, 12 h, an
Abstract by Dimitri Titeca-Beauport; Delphine Daubin; Ly Van Vong; Guillaume Belliard; Cédric Bruel; Sami Alaya; Karim Chaoui; Maud Andrieu, Critical Care (2020) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s13054-020-02984-6