Negative / Null Result ReportOpen accessBiology (General)
Rosa Aghdam, Taban Baghfalaki, Pegah Khosravi et al. · 2017 · Genomics, Proteomics & Bioinformatics
Deciphering important genes and pathways from incomplete gene expression data could facilitate a better understanding of cancer. Different imputation methods can be applied to estimate the missing values. In our study, we evaluated various imputation methods for their performance in preserving significant genes and pathways. In the first step, 5% genes are considered in random for two types of ignorable and non-ignorable missingness mechanisms with various missing rates. Next, 10 well-known imputation methods were applied to the complete datasets. The significance analysis of microarrays (SAM)
View details →DOI: 10.1016/j.gpb.2017.08.003 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
L Elhampour, MA Azarbayjani, M Nasehi et al. · 2017 · Journal of Medicinal Plants
Introduction: There is need to more research because of extent drug trade in country and diversity of proposal cures such as non pharmacological ways including exercise and herbal medicine. The aim of the study: The aim of this study was study of synchronic effect of Curcumin and swimming training on depression in morphine addicted male mice. Methods: In an experimental research, 40 Albino NMRI male mice with 19- 21 gr were selected as subjects and they were divide randomly to care groups of control, morphine, swim training, Curcumin, swim training+ Curcumin. Subjects swam 60 min/day, 5 days/w
Negative / Null Result ReportOpen accessAnimal culture
RB Vieira, MCMM Ludke, JV Ludke et al. · 2023 · Brazilian Journal of Poultry Science
ABSTRACT The objective was to examine the effects of supplementing different levels of zeolite in the diet of laying hens during the laying phase, at 54 weeks of age, on production performance, egg quality, ammonia volatilization, excreta pH, blood parameters, weight, and organ morphometry. The treatments consisted of a control diet free of zeolite and five diets including increasing levels of zeolite (0.7, 1.4, 2.1, 2.8, and 3.5%). A completely randomized design was adopted with eight replicates of five birds per plot, totaling 240 laying hens, for four 28-day periods. Results were subjected
View details →DOI: 10.1590/1806-9061-2023-1797 Negative / Null Result ReportOpen accessAccounting. Bookkeeping
Dewi Kusuma Wardani, Moh. Rifqi Asis · 2017 · Akuntansi Dewantara
This study aimed to examine the effect of knowledge of the taxpayer, the taxpayer awareness, and Program SAMSAT Corner on tax compliance in the Motor Vehicle Galeria Mall. The data used in this study are primary data from the results of questionnaires. Respondents in this study Motor Vehicle Taxpayers who make tax payments in SAMSAT Corner Galeria Mall Yogyakarta. The questionnaire was distributed to 108 respondents and data that can be processed as many as 105 questionnaires. The sampling method using Accidental Sampling. Data analysis techniques in this study using multiple linear regression
View details →DOI: 10.29230/ad.v1i2.1488 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Yun-Feng Zhang, Yu-Ling Tang, Meng-Jun Jiang et al. · 2020 · International Journal of Food Properties
The objective of this study was to investigate the influence of granule-bound starch-binding domain fusion gene expression on the structure and properties of potato starch. The glgB/GASBD fusion gene and the glgB gene for control were transferred into the potato cultivar Desiree using Agrobacterium-mediated method, which were expressed in potato tubers driven by the potato granule-bound starch synthase gene promoter. The accumulation of glgB/GASBD fusion protein in starch granules was analyzed by Western blot hybridization. A large amount of glgB/GASBD fusion protein was found to accumulate in
View details →DOI: 10.1080/10942912.2020.1734614 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Nilsson KF, Goździk W, Frostell C et al. · 2018 · Drug Design, Development and Therapy
Kristofer F Nilsson,1,2 Waldemar Goździk,3 Claes Frostell,4 Stanisław Zieliński,3 Marzena Zielińska,3 Kornel Ratajczak,5 Piotr Skrzypczak,5 Sylwia Rodziewicz,5 Johanna Albert,6 Lars E Gustafsson1,† 1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; 2Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 3Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland; 4Department of Anesthesia and Intensive Care, Danderyd Hospital, Stockholm, Swede
Negative / Null Result ReportOpen accessDentistry
Sareh Habibzadeh, Solmauz Eskandarion, Seyed Mahmoud Amin Marashi et al. · 2021 · Frontiers in Dentistry
Objectives: This study aimed to evaluate the in vitro antifungal efficacy of addition of silver nanoparticles (SNPs) to Mucopren® silicone soft liner material. Materials and Methods: Twenty disc samples (8 × 2 mm) of Mucopren® silicone soft liner containing 0wt% (control), 0.5wt%, 1wt%, 2wt%, and 3wt% SNPs were fabricated. Samples were powdered and added to 150 mL of Sabouraud dextrose agar culture medium and placed on separate culture dish plates. Each plate was inoculated with 106 colony forming units per milliliter (CFUs/mL) of Candida albicans (PTCC 5027) according to the CLSI protocol, an
View details →DOI: 10.18502/fid.v18i8.6101 Negative / Null Result ReportOpen accessMaterials of engineering and construction. Mechanics of materials
Lihui ZHANG, Shuo XIE, Mingfa LUO et al. · 2024 · Jin'gangshi yu moliao moju gongcheng
Objectives: Bone tissue grinding is one of the common and basic applications in orthopedic surgery clinics. The grinding process is energy-intensive and generates a lot of grinding heat. The accumulation of this heat may cause thermal damage to biological tissues. This paper presents experimental research to investigate the bone-grinding heat and the cooling method. Methods: The combined influence of nozzle position and feed direction on the cooling effect of bone grinding under cryogenic spray cooling conditions is experimentally investigated. A bone grinding platform with three-dimensional m
View details →DOI: 10.13394/j.cnki.jgszz.2023.0238 Negative / Null Result ReportOpen accessMedicine
Darpan I. Patel, Kira Abuchowski, Bilal Sheikh et al. · 2019 · European Journal of Translational Myology
The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04).
View details →DOI: 10.4081/ejtm.2019.8520 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ju Chen, Faming Zhao, Faming Zhao et al. · 2023 · Frontiers in Pharmacology
Background and Purpose: The aim of this study was to explore the effect of half a year of evolocumab plus moderate-intensity statin treatment on carotid intraplaque neovascularization (IPN) and blood lipid levels.Methods: A total of 31 patients with 33 carotid plaques who received evolocumab plus statin treatment were included. Blood lipid levels, B-mode ultrasound and contrast-enhanced ultrasonography (CEUS) at baseline and after half a year of evolocumab plus statin therapy were collected. The area under the curve (AUC) reflected the total amount of acoustic developer entering the plaque or
View details →DOI: 10.3389/fphar.2022.999224 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Rafigheh Ghiasi, Mustafa Mohammadi, Javad Ashrafi Helan et al. · 2015 · Journal of Cardiovascular and Thoracic Research
Introduction: The previous studies have suggested that alteration in oxidative stress and antioxidant defense depends on various factors, such as mode, intensity, frequency and duration of exercise. In this study, we compared the effects of two various durations of resistance exercise (1 month and 4 month) on oxidative stress and antioxidant status in cardiac tissue. Methods: Thirty Wistar male rats divided into 3 groups: control (sedentary), exercise-1 (regular exercise for 1 month) and exercise-2 group (regular exercise for 4 months). After the final to the experiment, the rats were anesthet
View details →DOI: 10.15171/jcvtr.2015.32 Negative / Null Result ReportOpen accessDentistry
Mirian de Waele Souchois Marsillac, Alberto Carlos Botazzo Delbem, Ricardo de Sousa Vieira · 2016 · Brazilian Journal of Oral Sciences
A cross-sectional microhardness (CSMH) test was carried out in human dental enamel exposed to a demineralizing solution in order to evaluate two different times of indentation in sound tissue and artificially induced caries. Twenty caries-free extracted human molars had one of their smooth surfaces sectioned and the enamel surface was isolated with nail polish except for an area of 6 mm2 . These specimens were submitted to artificially induced enamel caries on a lactate buffer containing 0.1 ppm fluoride (F) during 28 days. All specimens were bisected to create groups A and B in which CSMH tes
View details →DOI: 10.20396/bjos.v7i24.8643022 Negative / Null Result ReportOpen accessMedicine
Jingjing Zhou, Shanshan Wu, Xiaojing Wu et al. · 2023 · PLoS ONE
The cultural landscape in traditional settlements is an important historical and cultural resource created by human beings in the process of historical evolution, and is an important resource for the development of traditional settlement tourism. This paper selected 21 representative traditional settlements for research using online comments from tourists as data and content analytical methods including high-frequency vocabulary, semantic networks and emotional attitudes to explore the public perspective on the connotations of cultural landscape features in traditional settlements. There are f
Negative / Null Result ReportOpen accessDentistry
M. A. Adedigba, O. O. Ojo, E. O. Ogunbodede et al. · 2008 · Nigerian Dental Journal
Objective: To determine the coping ability of people living with HIV/AIDS (PLWHA) across demographic variations of gender, duration of living with HIV infection, marital status and living arrangements either with the family or alone. Method: The research design adopted in this study was descriptive survey. The population consisted of all PLWHA in Nigeria. The sample comprised of 117 PLWHA attending clinic regularly at General Hospital Ilesa, Osun State, Nigeria. The subjects had all been exposed to voluntary counselling and testing (VCT). Only those who consented participated in the study. A s
View details →DOI: 10.61172/ndj.v16i1.179 Negative / Null Result ReportOpen accessSurgery
Eric R. Bain, Bistees George, Syed H. Jafri et al. · 2024 · Journal of Cardiothoracic Surgery
Abstract Background Patients with severe aortic stenosis (AS) and left ventricular (LV) dysfunction demonstrate improvement in left ventricular injection fraction (LVEF) after aortic valve replacement (AVR). The timing and magnitude of recovery in patients with very low LVEF (≤ 25%) in surgical or transcatheter AVR is not well studied. Objective Determine clinical outcomes following transcatheter aortic valve replacement (TAVR) and surgical aortic valve repair (SAVR) in the subset of patients with severely reduced EF ≤ 25%. Methods Single-center, retrospective study with primary endpoint of LV
View details →DOI: 10.1186/s13019-024-02724-9 Negative / Null Result ReportOpen accessPsychology
Sime Nkemeni Darrin, Hong Hao, Cheng Long et al. · 2026 · Frontiers in Psychology
IntroductionThis study investigates the cognitive effects of long term (years of practice) Tai Chi practice, revealing mixed outcomes for executive functions. This study equally addresses the gap in research regarding the long term effects of Tai Chi, emphasizing its influence on the executive functions of young adults.MethodsUsing the BRIEFA scale and tasks like the Flanker task, More Odd Shift Task, and Nback tasks, significant differences emerged between Tai Chi students and nonstudents.ResultsIn the results, Tai Chi students demonstrated superior inhibitory control and working memory compa
View details →DOI: 10.3389/fpsyg.2025.1702253 Negative / Null Result ReportOpen accessAnesthesiology
Volkan Hancı, Şule Özbilgin, Seda Özbal et al. · Revista Brasileira de Anestesiologia
Abstract Background: Intra-arterial injection of medications may cause acute and severe ischemia and result in morbidity and mortality. There is no information in the literature evaluating the arterial endothelial effects of sugammadex and dexmedetomidine. The hypothesis of our study is that sugammadex and dexmedetomidine will cause histological changes in arterial endothelial structure when administered intra-arterially. Methods: Rabbits were randomly divided into 4 groups. Group Control (n = 7); no intervention performed. Group Catheter (n = 7); a cannula inserted in the central artery of th
View details →DOI: 10.1016/j.bjane.2015.01.003 Negative / Null Result ReportOpen accessDentistry
Priscilla Coutinho ROMUALDO, Thaís Rodrigues GUERRA, Fábio Lourenço ROMANO et al. · Journal of Applied Oral Science
Abstract Bacterial endotoxin (LPS) adhesion to orthodontic brackets is a known contributing factor to inflammation of the adjacent gingival tissues. Objective The aim of this study was to assess whether LPS adheres to orthodontic adhesive systems, comparing two commercial brands. Material and Methods Forty specimens were fabricated from Transbond XT and Light Bond composite and bonding agent components (n=10/component), then contaminated by immersion in a bacterial endotoxin solution. Contaminated and non-contaminated acrylic resin samples were used as positive and negative control groups, res
View details →DOI: 10.1590/1678-7757-2016-0434 Negative / Null Result ReportOpen accessMedicine (General)
Olivia Anna Mair, Maren Himmler, Suna Brunnemer et al. · 2022 · Medicina
Background and Objectives : Although urogenital injuries are common in severely injured patients, their diagnosis is often delayed. Predicting genitourinary injuries (GUI), especially in the immediate stages post injury, remains a challenge. This study aims to evaluate and determine positive predictive factors for the presence of GUI in polytrauma patients. Subsequently, these factors shall be used to develop an easy-to-use scoring system, deployable directly in the emergency setting. Materials and Methods : This study evaluates all severely injured patients with an Injury Severity Score (ISS)
View details →DOI: 10.3390/medicina58111583 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology
ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv
View details →DOI: 10.3389/fneur.2024.1406293 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ghasem Rahmatpour Rokni, Massoud Golpour, Alimorad Heidari Gorji et al. · 2017 · Journal of Advanced Pharmaceutical Technology & Research
Vitiligo is one of the most primitive well-known dermatoid disorders with different suggested therapies. Therefore, this study investigated the efficiency and safety of topical tacrolimus in treatment of patients with vitiligo. This study was a clinical randomized designed study pre- post-test method, has been conducted on thirty cases with vitiligo who have referred to polyclinic and dermatology clinic. Participant′s evaluated and demographic information recorded in designed checklist. In the next stage, the disease activity scored by vitiligo index disease activity system. Photography and de
View details →DOI: 10.4103/2231-4040.197388 Negative / Null Result ReportOpen accessAgriculture
Kristýna Balážová, Jitka Kumhálová, Jan Chyba · 2024 · Agronomy
With the changing climate, there is an increasing emphasis on drought-resistant varieties, including the ability to maintain quality production. As there is also interest in ancient wheat varieties, the aim of this study was to evaluate the growth parameters of the ancient Khorasan (Kamut ® ) and modern Kabot spring wheat varieties using remote sensing data. Images from unmanned aerial vehicles during four growing seasons were processed. Based on vegetation indices, the growth of these varieties and their response to meteorological conditions were evaluated, as well as the ability to resist dr
View details →DOI: 10.3390/agronomy14010147 Negative / Null Result ReportOpen accessFood processing and manufacture
Ardiyanti Rahma Setiawati, Dedes Amertaningtyas, Ahmad Khoirul Umam · 2025 · Jurnal Ilmu dan Teknologi Hasil Ternak
Salted egg is a well-known traditional product, particularly in many Asian countries, where it is valued for its unique savory taste, extended shelf life, and convenience. Consumer demand for healthier, more appealing food has sparked interest in enriching salted eggs with natural ingredients. The purpose of this study was to analyze the effect of adding kaffir lime leaf powder (Citrus hystrix) and citronella leaf powder (Cymbopogon nardus) to salted eggs on pH, antioxidants, moisture and organoleptics. The research method used was experimental using a completely randomized design (CRD) with 6
View details →DOI: 10.21776/ub.jitek.2025.020.01.5 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Kenji Morimoto, Junji Uchino, Takashi Yokoi et al. · 2021 · OncoImmunology
Although previous studies suggest that cancer cachexia is a poor prognostic factor for immune checkpoint inhibitor monotherapy, the impact of cancer cachexia on chemoimmunotherapy is unclear. We investigated the impact of cancer cachexia on the therapeutic outcomes of chemoimmunotherapy for non-small cell lung cancer (NSCLC). We retrospectively analyzed patients’ medical records with NSCLC who received chemoimmunotherapy in 12 institutions in Japan between January and November 2019. We defined cancer cachexia as weight loss exceeding 5% of the total body weight or a body mass index of < 20 kg/
View details →DOI: 10.1080/2162402x.2021.1950411 Negative / Null Result ReportOpen accessMedicine
Hassan Talakesh, Alizamen Salehifard Jouneghani, Karamali Kasiri et al. · 2024 · Journal of Shahrekord University of Medical Sciences
Background and aims: Constipation in children is a serious problem that affects both children and their families. We aimed to compare the clinical efficacy of lactulose and polyethylene glycol in the treatment of constipation in children. Methods: This randomized clinical trial was performed on 92 patients referred to a private gastroenterology clinic in Shahrekord, Iran. The patients were randomly assigned into two groups receiving polyethylene glycol or lactulose. Defecation patterns and complications were assessed 0, 3, 7, and 21 days after the intervention. Data were analyzed using the chi
View details →DOI: 10.34172/jsums.892 Negative / Null Result ReportOpen accessMedicine (General)
Krdžić Igor, Kenić Marko, Šćepanović Milena et al. · 2020 · Vojnosanitetski Pregled
Background/Aim. In colon and rectal cancer surgery, resection is considered radical when circumferential, proximal and distal resection margins are without the presence of tumor cells. Concept of total mesorectal excision in rectal surgery involves complete removal of the tumor with mesorectal fascia which surrounds lymph nodes, lymphatics and blood vessels. The aim of this study was to determine whether laparoscopic approach provides all parameters of oncological radicality as open surgery of colorectal cancer. Methods. The study included 122 patients with carcinoma of colon and rectum, divid
View details →DOI: 10.2298/vsp180607127k Negative / Null Result ReportOpen accessMedicine
Fuengfa Khobkhun, Jenjira Thanakamchokchai · 2023 · Scientific Reports
Abstract Biological sexes (male and female) have been reported to influence postural control and balance due to differences in musculoskeletal structures, hormonal factors, and neuromuscular control. These factors can contribute to the turning performance, potentially leading to an increased incidence of falls, particularly during turning. Therefore, this study aimed to explore the whole-body coordination and stepping characteristics and during standing turns in healthy adults to determine the effects of biological sex and turn speed. Fifty participants (25 males and 25 females) completed 180°
View details →DOI: 10.1038/s41598-023-49201-2 Negative / Null Result ReportOpen accessMedicine
Sung Hee Lim, Jong-Mu Sun, Joohyun Hong et al. · 2021 · The Korean Journal of Internal Medicine
Background/Aims Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Methods Treatment-naïve patients with stage III/IV (M0) hypopharynx or BOT cancer were randomly assigned to receive CRT alone (CRT arm: cisplatin 100 mg/m2 on D1 3-weekly, two times plus radiotherapy 68.4 Gy/30 fractions on we
View details →DOI: 10.3904/kjim.2019.161 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Runsheng Zhao, Kaiyu Fan, Weiqing Wan · 2023 · BMC Endocrine Disorders
Abstract Background To prevent thyroid storm and ensure surgical safety, it is imperative to regulate excessive thyroid hormone levels in patients with thyrotropin-secreting pituitary adenomas (TSHoma) prior to surgery. Somatostatin analogues (SSAs), such as octreotide, have showed efficacy in shrinking tumors, which may facilitate surgical resection. This retrospective study aimed to investigate the effect of shortterm preoperative octreotide treatment on the surgical outcome of TSHoma. Methods A total of 65 TSHoma patients from January 2010 to July 2019 were included in the study. Of these,4
View details →DOI: 10.1186/s12902-023-01398-z Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Andrea Buonsenso, Domenico Di Fonza, Gloria Di Claudio et al. · 2025 · Journal of Functional Morphology and Kinesiology
Objectives : The lat pulldown machine is one of the most versatile pieces of equipment for back strengthening, allowing variations in grip and load. However, there are significant gaps in the literature regarding the relationship between exercise modality and specific muscle activation. Methods : This study examined the electromyographic (EMG) activity of major back muscles during seven lat pulldown exercise variants that differed in grip type, width, and trunk inclination. Forty male subjects, with at least 5 years of resistance training experience, performed five repetitions of lat pulldown
View details →DOI: 10.3390/jfmk10030345 