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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 539 of 725

Negative / Null Result ReportMedicine

Presence and correlation of potentially toxic elements in honey, pollen, and soil samples in Kosovo.

Kastrati G, Sopaj F, Bytyqi V et al. · 2025 · Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

The study involved the determination of the concentrations of 11 potentially toxic elements (PTEs) in soil, honey, and pollen samples collected in the territory of Kosovo, followed by a statistical analysis. Inductively coupled…

View details →DOI: 10.1080/10934529.2025.2594372
Negative / Null Result Report

Personality disorder traits and impression formation: Individuals higher in detachment and antagonistic traits are perceived as less likable and trustworthy

Niedtfeld I, Störkel L, Didushok V et al. · 2025 · Preprint

The first impression a person makes can substantially influence whether and how they areapproached and treated by others. Prior research on this process suggests that individualsexhibiting higher levels of maladaptive personality traits…

View details →DOI: 10.31234/osf.io/k9sdg_v1
Failed Experiment ReportOpen accessMedicine

RETRACTION: Evaluating the Effectiveness of Echocardiographic Guidance in Diminishing Postoperative Wound Complications for Left Atrial Appendage Closure: A Clinical Retrospective Study.

· 2025 · International wound journal

Retraction C.-S. Li, X.-F. Li, X.-Y. Huang, and F.-F. Chen, "Evaluating the Effectiveness of Echocardiographic Guidance in Diminishing Postoperative Wound Complications for Left Atrial Appendage Closure: A Clinical Retrospective Study,"…

View details →DOI: 10.1111/iwj.70619
Negative / Null Result ReportMedicine

Peer victimization and emotion regulation strategies in adolescents: A cross-lagged panel model.

Alexander KN, Turner MS, Salazar JP et al. · 2025 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Many adolescents experience peer victimization during this critical period for development. Emotion regulation strategies, including cognitive reappraisal and emotional suppression, can help adolescents cope with such experiences. Although…

View details →DOI: 10.1111/jora.70119
Negative / Null Result Report

Acute and chronic dosing of the GABA A alpha 2,3 selective agonist BAER-101 do not alter behavior but may impact auditory-evoked EEG responses in adults with fragile X syndrome

DeStefano L, Kim H, Erickson C et al. · 2025 · Preprint

Abstract Background: Fragile X syndrome (FXS) is characterized by sensory hypersensitivity and neural hyperexcitability linked to GABAergic dysfunction. BAER-101, formerly known as AZD7325, is a positive allosteric modulator of GABA A…

View details →DOI: 10.21203/rs.3.rs-8123031/v1
Negative / Null Result Report

Daily and Weekly Fluctuations in the Microbiome of the Urinary Tract of Postmenopausal Women with No History of Urinary Tract Infections

Hogins J, Mekala S, Resendiz J et al. · 2025 · Preprint

At least half of all women will experience a urinary tract infection (UTI) in their lifetime. Age, sexual activity, hormonal status, and the urinary tract microbiome (urobiome) contribute to the probability of infection. While studies have…

View details →DOI: 10.1101/2025.11.04.686513
Negative / Null Result ReportMedicine

Lion-Tiger-Stripes: Delimiting the Semantic Association Effect on Working Memory With Mediated Association.

Ishiguro S, Guitard D, Saint-Aubin J · 2025 · Quarterly journal of experimental psychology (2006)

Semantic relatedness of items improves working memory performance. We targeted one type of semantic relatedness, semantic association. The beneficial effect of association is often explained by the spreading-activation process:…

View details →DOI: 10.1177/17470218251392562
Negative / Null Result ReportMedicine

Age, Intersectional Discrimination, and Health in Black Transgender Women.

Grant S, Goldberg E, Gadipudi A et al. · 2025 · Journal of racial and ethnic health disparities

Black transgender women report high levels of discrimination, which is associated with poor health outcomes. Some evidence suggests that intersectional discrimination-that is, interacting forms of marginalization related to one's real or…

View details →DOI: 10.1007/s40615-025-02710-4
Negative / Null Result ReportMedicine

Does the Perth Alexithymia Questionnaire Offer a Multidimensional Measurement of the Alexithymia Construct?

Bagby RM, Mortezaei A, McIntyre C et al. · 2026 · Journal of personality assessment

The Perth Alexithymia Questionnaire (PAQ) was developed to assess alexithymia as a multidimensional construct consistent with the attention-appraisal model. This study evaluated the hierarchical structure of the PAQ using Goldberg's…

View details →DOI: 10.1080/00223891.2025.2559701
Negative / Null Result ReportMedicine

The psychometric properties of the working memory questionnaire in a South African young adult sample.

Ferreira-Correia A, Mnisi N, Harwood K et al. · 2025 · Applied neuropsychology. Adult

The Working Memory Questionnaire (WMQ) was developed to assess everyday difficulties associated with working memory (WM) impairments. This study evaluated the psychometric properties of the WMQ within a South African context. A…

View details →DOI: 10.1080/23279095.2025.2556922
Negative / Null Result ReportOpen accessMedicine

Understanding how a tap on/tap off system supports clinical work in an emergency department: a qualitative study.

Baysari M, Stanceski K, Bamgboje-Ayodele A et al. · 2026 · BMC medical informatics and decision making

Background Single sign-on (SSO), tap-on-tap-off (TOTO) and virtual desktops (VD) are increasingly being used in hospitals to reduce the burden and risks of password management, but we know little about how these systems are used in…

View details →DOI: 10.1186/s12911-026-03424-1
Negative / Null Result ReportOpen accessMedicine

The causal association between systolic blood pressure and breast cancer: a two sample Mendelian randomization study.

Awada Z, Kazmi N, Jones HJ et al. · 2026 · BMC cancer

BACKGROUND: Breast cancer (BC) is the leading cause of cancer incidence worldwide. Observational studies have suggested that hypertension may be a risk factor for BC. We tested whether systolic blood pressure (SBP) may influence BC and BC…

View details →DOI: 10.1186/s12885-025-15513-x
Negative / Null Result ReportMedicine

AI and healthcare: surveying patient perspectives on artificial intelligence in neurosurgery.

Shah H, Ali M, Kilgallon JL et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Neurosurgery and neurosurgical care continues to evolve and to embrace technological advances. AI is used to interpret radiological studies and to distill medical information, with the potential to help guide physicians and patients in…

View details →DOI: 10.1016/j.jocn.2025.111731
Failed Experiment ReportMedicine

The Adherence Conundrum of Sleep Restriction Therapy for Insomnia.

Looman MI, Klau MM, Schoenmakers TM et al. · 2026 · Journal of sleep research

While time in bed restriction is a core treatment mechanism of Sleep Restriction Therapy (SRT), empirical research has not yielded a relationship between insomnia improvement and adherence to the prescribed time in bed. We coin this…

View details →DOI: 10.1111/jsr.70339
Negative / Null Result Report

Variation of The Dose of Norepinephrine in Septic Shock Patients Treated with an IgM and IgA-Enriched Immunoglobulin Preparation: Secondary Analysis of a Prospective Multicenter Observational Study

Bixio M, Scamperle A, Quarantotto G et al. · 2026 · Preprint

Background: /Objectives: The use of IgM- and IgA-enriched intravenous immunoglobulins (eIg) in septic shock remains controversial due to the lack of high-quality evidence, despite indications from observational studies and meta-analyses…

View details →DOI: 10.20944/preprints202604.2104.v1
Negative / Null Result ReportMedicine

How Orthographic Transparency Shapes Word Learning and Retention in Monolingual and Bilingual Adults.

Clark C, Lira Calabrich S, Lallier M et al. · 2026 · Quarterly journal of experimental psychology (2006)

This study examined how orthographic characteristics relate to the learning and retention of novel written words in monolingual English and bilingual Welsh-English adults. Participants learned pseudowords designed to follow either…

View details →DOI: 10.1177/17470218261441260
Negative / Null Result ReportMedicine

Development and psychometric validation of the Kanazawa University loneliness scale for children and adolescents.

Murayama Y, Soma D, Kameya M et al. · 2026 · Discover mental health

Loneliness is a key risk factor for youth mental health; however, existing scales often fail to capture its multidimensional and relational nature. This study developed the [blinded] University Loneliness Scale (KULoS) for students in…

View details →DOI: 10.1007/s44192-026-00462-z
Negative / Null Result ReportMedicine

Associations of physical activity and sedentary behaviors with mortality: An observational analysis and Mendelian randomization study.

Han M, Qu Y, Zeng M et al. · 2026 · Geriatric nursing (New York, N.Y.)

Background To investigate the associations of physical activity (PA) and sedentary behavior (SB) with the risk of mortality using observational and Mendelian randomization (MR) designs. Methods In a prospective cohort study based on UK…

View details →DOI: 10.1016/j.gerinurse.2026.103834
Negative / Null Result ReportMedicine

Changes in Peri-Implant Soft Tissue Dimensions Following Soft Tissue Contour Augmentation: A 3-Year Follow-Up of a Multi-Center RCT.

Jepsen K, Jepsen S, Hämmerle CHF et al. · 2026 · Clinical oral implants research

Aim To assess 3-year changes of peri-implant tissues following previous soft tissue (volume) augmentation (STA) with a volume-stable collagen matrix (VCMX) or connective tissue (SCTG) at single-implant restorations. Material and methods In…

View details →DOI: 10.1111/clr.70078
Negative / Null Result ReportMedicine

Parental care liberates juvenile growth: a common-garden test of the evolutionary benefits of care.

Eggert AK, Prang MA, Capodeanu-Nägler A et al. · 2026 · Evolution; international journal of organic evolution

Effects on juvenile growth have long been considered an important benefit of parental care, but they have rarely been tested empirically. Protection and feeding by parents might accelerate offspring growth by allowing offspring to allocate…

View details →DOI: 10.1093/evolut/qpaf223
Negative / Null Result ReportOpen accessMedicine

The association between weekend catch-up sleep and obesity in U.S. adults: A cross-sectional analysis of NHANES 2017-2020.

Zeng J, Huang D, Zhu M et al. · 2025 · Medicine

Weekend catch-up sleep (WCS) is a behavioral strategy employed to compensate for weekday sleep loss and has been reported to be associated with various metabolic outcomes. However, its association with obesity remains controversial. This…

View details →DOI: 10.1097/md.0000000000044670