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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 538 of 725

Negative / Null Result ReportMedicine

Calm in the Chaos: A Mixed-Methods Pilot Study Using a Mobile Mindfulness App to Manage Stress and Burnout Among Emergency Department Nurses.

Kober M, Livingston JA, Barrick C et al. · 2026 · Journal of holistic nursing : official journal of the American Holistic Nurses' Association

Background: Emergency department (ED) nurses are routinely exposed to high-stress clinical environments, increasing their risk for burnout and emotional exhaustion. In holistic nursing, self-care is viewed as a professional and ethical…

View details →DOI: 10.1177/08980101261424557
Negative / Null Result ReportMedicine

The effect of discharge education provided with two different teaching techniques on nursing students' knowledge, self-efficacy and satisfaction: A randomized controlled trial.

Kayin Y, Oztas B · 2026 · Nurse education in practice

Aim This study examined the effects of PechaKucha and Teach-Back teaching techniques on nursing students' knowledge, self-efficacy and satisfaction regarding discharge education. Background Effective discharge education requires strategies…

View details →DOI: 10.1016/j.nepr.2026.104807
Negative / Null Result Report

Current Evidence on the Effects of Non-Nutritive Sweeteners on the Gut Microbiota-Incretin Axis and Metabolic Outcomes in Adult Human Populations: A Scoping Review

Sharma V, Verma Y · 2026 · Preprint

Abstract Non‑nutritive sweeteners (NNS) are widely consumed under the assumption of metabolic inertness, but emerging evidence suggests they may affect the gut microbiome, incretin hormones, and glucose homeostasis. This scoping review…

View details →DOI: 10.21203/rs.3.rs-10106611/v1
Negative / Null Result ReportMedicine

Sinonasal microbiome remains stable during dupilumab therapy in chronic rhinosinusitis: a pilot study.

Hirsch T, Moser U, Wolf A et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose This prospective pilot study aimed to evaluate whether dupilumab therapy induces measurable changes in the sinonasal microbiome of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Methods Eight CRSwNP patients…

View details →DOI: 10.1007/s00405-026-10378-7
Negative / Null Result ReportMedicine

Anterior maxillary distraction for maxillary advancement in growing patients with cleft lip and palate : Soft and hard tissue changes.

Parakkal T, Kuriakose MJ, Natarajan PV et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie

Surgically facilitated anterior maxillary distraction (AMD) is used for the treatment of maxillary hypoplasia secondary to cleft lip and palate (CLP). In this study, the soft and hard tissue changes following AMD in growing patients with…

View details →DOI: 10.1007/s00056-026-00676-4
Negative / Null Result ReportMedicine

Incline and decline treadmill trotting produce electromyographic changes in specific canine shoulder muscle activity: implications for therapeutic exercise.

Stanford K, Cain RM, Millis D et al. · 2026 · American journal of veterinary research

Objective To identify the effects of incline and decline treadmill trotting on forelimb muscle activity in dogs using electromyography (EMG). Methods Data were collected for a prospective within-subject, repeated-measures study in January…

View details →DOI: 10.2460/ajvr.26.04.0180
Negative / Null Result ReportMedicine

Ultrasound processing induces mild protein oxidation and significant changes in physicochemical properties of milk proteins.

Bhavya ML, Bayati M, Poojary MM et al. · 2026 · Food chemistry

Ultrasound (US) processing is a promising food technology to improve protein solubility, reduce particle size, and modify functional properties. However, concerns exist regarding US-induced protein oxidation due to reactive oxygen species…

View details →DOI: 10.1016/j.foodchem.2026.149898
Negative / Null Result ReportMedicine

Safety of Co-Administered Cannabidiol (CBD) and alcohol: a Phase I study.

Wolinsky D, Blaine S, Strickland JC et al. · 2026 · Journal of cannabis research

Background This Phase I randomized controlled trial aimed to assess the safety and tolerability of cannabidiol (CBD) and alcohol co-administration among moderate alcohol consumers in acute laboratory and chronic outpatient settings.…

View details →DOI: 10.1186/s42238-026-00457-1
Negative / Null Result ReportMedicine

Corneal epithelial morphological changes in orthokeratology lens wearers.

Qasim MSA, Kang P, Evans B et al. · 2026 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose To investigate the utility of in vivo confocal microscopy (IVCM) combined with standardized image grading for identifying early morphological changes in the central corneal and superior limbal basal epithelial cells during…

View details →DOI: 10.1016/j.clae.2026.102667
Negative / Null Result Report

Antidepressant Effects of Lauric Acid in a Corticosterone-Induced Murine Model of Depression: Behavioral and Neurochemical Insights

de Paulo MC, Aguiar LM, Ferreira NMC et al. · 2026 · Preprint

Background Lauric acid (LA) is a medium-chain saturated fatty acid found in several foods, including vegetable oils and seeds. Previous studies have demonstrated that LA exhibits neuroprotective, antioxidant, and anti-inflammatory…

View details →DOI: 10.64898/2026.05.15.725442
Negative / Null Result ReportOpen accessMedicine

Role of Ethnicity and Age in Corneal Curvature and Thickness Changes Following Corneal Cross-Linking for Keratoconus.

Alenezi BM, Khoyratty F, Biswas S et al. · 2026 · Translational vision science & technology

Purpose To investigate the effect of corneal cross-linking (CXL) on corneal curvature and thickness in two different keratoconic populations, one based in the Middle East (Saudi Arabia) and one in Europe (UK), and to explore whether age…

View details →DOI: 10.1167/tvst.15.3.12
Negative / Null Result ReportMedicine

Evaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.

Zhuang SR, Leong PY, Chiang HP et al. · 2026 · Nutrients

Objective This study aimed to evaluate the effects of 12 weeks of Astragalus membranaceus saponins (AMS) supplementation on functional performance, knee joint mobility, self-reported outcomes, and biomarkers of inflammation and cartilage…

View details →DOI: 10.3390/nu18121842
Negative / Null Result ReportOpen accessMedicine

Microbial evaluation of zirconia and titanium implants in the anterior mandibula: a randomized controlled clinical trial.

Kniha K, Scholz K, Kohnert E et al. · 2026 · Scientific reports

To evaluate the effect of the implant material-either titanium or zirconia-on the development of bacterial deposits. In this one-year prospective split-mouth study, 20 patients with an edentulous lower jaw were treated with two zirconia…

View details →DOI: 10.1038/s41598-026-54915-0
Negative / Null Result ReportOpen accessMedicine

Effects of repeated freeze and thaw cycles on the stability of faecal microbiome composition.

Sangermani M, Desiati I, Quattrini N et al. · 2026 · Scientific reports

Reanalysing previously collected samples to address new research questions offers a time-efficient alternative to initiating new cohort studies. However, concerns remain regarding the stability of the faecal microbiome following repeated…

View details →DOI: 10.1038/s41598-026-39939-w
Negative / Null Result ReportMedicine

Erythropoietin and Hematological Responses in Recreational Scuba Divers: Insight into the Hyperoxic-Hypoxic Paradox.

Perović A, Juričić G, Bratičević MN et al. · 2026 · Medicine and science in sports and exercise

Purpose During scuba diving, breathing under elevated pressure leads to hyperoxia, which may induce oxidative stress and erythrocyte damage. Hyperoxia may also influence erythropoietin (EPO) production, a phenomenon referred to as the…

View details →DOI: 10.1249/mss.0000000000004007
Negative / Null Result ReportMedicine

Compatibility and physicochemical stability of ceftriaxone for injection admixed with pantoprazole sodium and ondansetron hydrochloride in different infusion solutions.

Dobariya A, Patel R, Patel M · 2026 · European journal of hospital pharmacy : science and practice

Objective The study aimed to analyse the physicochemical stability and compatibility of ceftriaxone sodium (CEF) (2mg/mL) with pantoprazole sodium (PAN) (0.08mg/mL) and ondansetron hydrochloride (OND) (0.008mg/mL) in different infusion…

View details →DOI: 10.1136/ejhpharm-2025-004511
Negative / Null Result ReportMedicine

Intraocular Pressure During Short-Term Topical or Systemic Corticosteroid Treatment: Analysis of 3 Randomized Clinical Trials.

Amiri D, Hellmann PH, Thyssen JP et al. · 2026 · JAMA dermatology

Importance Increased intraocular pressure (IOP) is a known adverse effect of corticosteroid use and may lead to corticosteroid-induced glaucoma. However, clinical evidence on the impact of topical corticosteroids (TCS) on IOP is limited.…

View details →DOI: 10.1001/jamadermatol.2026.1183
Negative / Null Result ReportMedicine

Three-Dimensional Speckle-Tracking Echocardiography-Derived Aortic Valve Annular Plane Systolic Excursion and Left Ventricular Volumes Are Not Associated in Healthy Adults (Insights from MAGYAR-Healthy Study).

Nemes A, Ambrus N, Szili-Török T et al. · 2026 · Journal of clinical medicine

Introduction : The left ventricular (LV) function can be characterized by the spatial displacement of the aortic valve annulus (AVA), represented by the AVA plane systolic excursion (AAPSE). AAPSE, measured using 3DSTE, has been shown to…

View details →DOI: 10.3390/jcm15041507