Negative / Null Result ReportMedicine
Rincón-González AM, Galeano-Tamayo DC, Zuluaga LSD · 2025 · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
Objective To explore the factors associated with the use of the antibiotic implicated in an adverse reaction following a negative challenge test in pediatric patients in a clinical allergology service of a health institution in Medellin.…
View details →DOI: 10.29262/ram.v72i3.1465 Failed Experiment ReportMedicine
Mooghali M, Ramachandran R, Mohammad A et al. · 2026 · Journal of the National Cancer Institute
Industry payments to physician's influence prescribing, raising concern for drugs granted accelerated approval that failed confirmatory studies. We measured industry payments for oncology drugs granted accelerated approval before and after…
View details →DOI: 10.1093/jnci/djaf241 Negative / Null Result Report
Kilic A, Celiktas B · 2026 · Preprint
Abstract As Large Language Models (LLMs) are integrated into critical infrastructure, externally auditing their safety mechanism activation without internal access becomes essential. This paper investigates whether LLM safety refusals…
View details →DOI: 10.21203/rs.3.rs-9190463/v1 Negative / Null Result ReportMedicine
Warintaksa P, Youkhong C, Trikasemmart M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Introduction True labor is characterized by regular uterine contractions and cervical changes. However, the precise diagnosis of the "onset" of true labor is challenging, as the examination of cervical changes requires multiple timepoints,…
View details →DOI: 10.1080/14767058.2026.2670757 Negative / Null Result ReportMedicine
Dincer M, Aydin O, Karakus V et al. · 2026 · Laboratory medicine
Introduction Electrophoresis tests are reported as negative, positive, or-rarely-as suspicious for monoclonal band (SfMB). This study aimed to determine the fate of patients with SfMB findings in long-term follow-up. Methods Patients with…
View details →DOI: 10.1093/labmed/lmag013 Negative / Null Result Report
Slade T · 2026 · Preprint
Large language models (LLMs) are increasingly deployed in academic and professional contexts where epistemic restraint, boundary recognition, and instruction adherence are as important as raw capability. However, existing evaluations…
View details →DOI: 10.22541/au.177023469.90459572/v1 Negative / Null Result ReportMedicine
Hidalgo CM, Yin LX, Bogan AW et al. · 2026 · Head and neck pathology
Purpose The uses for circulating tumor high risk human papillomavirus DNA (ctHPVDNA) in the diagnostic work-up and treatment of HPV-associated oropharyngeal squamous cell carcinoma (HPV( +)OPSCC) patients are actively being investigated.…
View details →DOI: 10.1007/s12105-026-01911-5 Negative / Null Result ReportOpen accessMedicine
Omari Y, Nohomovich B, Sallam D et al. · 2026 · Cureus
Multitarget stool DNA-fecal immunochemical testing (mt-sDNA-FIT) is validated for colorectal cancer (CRC) screening in asymptomatic, average-risk adults. However, its application in symptomatic patients represents a misuse of a screening…
View details →DOI: 10.7759/cureus.110890 Negative / Null Result ReportOpen accessMedicine
Eldeeb MEA, Mostafa MA, Nagiub TA et al. · 2025 · BMC cardiovascular disorders
Purpose Prior studies have assessed in-stent diameter restenosis (ISDR) in coronary arteries using 64-slice multidetector computed tomography coronary angiography (MDCT-CA) compared to invasive coronary angiography (ICA), which is the gold…
View details →DOI: 10.1186/s12872-025-04836-z Negative / Null Result ReportMedicine
Follansbee CW, Landstrom AP, Aziz PF · 2025 · Cardiac electrophysiology clinics
Congenital long QT syndrome is the most common inherited arrhythmia syndrome and is characterized by prolongation of the QT interval in the absence of structural heart disease or external factors. Disease will often manifest during…
View details →DOI: 10.1016/j.ccep.2025.07.011 Abandoned HypothesisOpen accessMedicine
Trinh AT, McMurray JC, Pittman LM et al. · 2025 · JACC. Case reports
Background IgE-mediated anaphylaxis to iodinated contrast media (ICM) is rare but potentially life threatening. Unlike non-IgE-mediated reactions, cases are often resistant to corticosteroid and antihistamine premedication. Case summary A…
View details →DOI: 10.1016/j.jaccas.2025.104123 Negative / Null Result ReportOpen accessMedicine
Kim DH, Chun MK, Lim SY et al. · 2026 · Pediatric emergency care
Objectives This retrospective observational study evaluated the diagnostic efficiency of routine magnetic resonance imaging (MRI) in pediatric patients with facial palsy (FP) in the emergency department (ED). Methods Pediatric patients…
View details →DOI: 10.1097/pec.0000000000003506 Methods Dead-EndOpen accessMedicine
Sayeedi I, Goldin J, Widrich J · 2026
The methacholine challenge test is a bronchoprovocation test used to assess airway hyperresponsiveness and aid in the diagnosis of asthma. Methacholine, a derivative of acetylcholine, directly stimulates airway smooth muscle receptors,…
Negative / Null Result ReportOpen accessMedicine
Gürler M, Karaoğlu Ç, Yurtcu EE et al. · 2026 · The Indian journal of medical research
Background and objectives Multiplex molecular panels for meningitis and encephalitis (M&E) allow rapid detection of multiple pathogens directly from cerebrospinal fluid (CSF) samples. Although their use is expanding, real-world data on…
View details →DOI: 10.25259/ijmr_2107_2025 Negative / Null Result ReportOpen accessMedicine
Duan S, Lv T, Zheng L et al. · 2026 · BMC infectious diseases
BACKGROUND: Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, with increasing prevalence in China and the Asia-Pacific region. Despite its limited sensitivity, the enzyme immunoassay (EIA) is…
View details →DOI: 10.1186/s12879-026-13252-3 Negative / Null Result ReportOpen accessMedicine
Burdon D, Mullin S, Harris C · 2026 · The British and Irish orthoptic journal
Aim Progressive supranuclear palsy (PSP) is an atypical Parkinsonian disorder which, like other atypical Parkinsonian disorders, displays neurological motor and oculomotor signs at different stages along the disease course. The overlap in…
View details →DOI: 10.22599/bioj.505 Negative / Null Result ReportOpen accessMedicine
Deuitch N, Broadbridge E, Cunningham L et al. · 1993
Clinical characteristics RUNX1 familial platelet disorder with associated myeloid malignancies (RUNX1-FPDMM) is characterized by prolonged bleeding and/or easy bruising and an increased risk of developing a hematologic malignancy.…
Negative / Null Result ReportOpen accessMedicine
Tunçez HÇ · 2026 · Polish journal of radiology
Purpose To evaluate the Kaiser score (KS) on magnetic resonance imaging (MRI) in patients diagnosed with breast cancer and to identify clinical, pathological, and radiological factors associated with false-negative Kaiser score. Material…
View details →DOI: 10.5114/pjr/217365 Failed Experiment ReportOpen accessMedicine
Song M, Zhang Z, Huang H et al. · 2026 · The American journal of case reports
BACKGROUND Spinal tuberculosis is difficult to diagnose in patients undergoing maintenance hemodialysis (MHD) because of immunosuppression, atypical clinical manifestations, and the limited sensitivity of conventional microbiological…
View details →DOI: 10.12659/ajcr.951840 Negative / Null Result ReportMedicine
Sirchia F, Kalantari S, Carli D et al. · 2026 · Pediatric neurology
Background Many patients with rare genetic diseases remain undiagnosed or receive a molecular diagnosis only after years. In this study, we want to evaluate the usefulness of clinical genome sequencing (cGS) in a cohort of complex…
View details →DOI: 10.1016/j.pediatrneurol.2026.01.004 Negative / Null Result ReportMedicine
Jo HC, Park JE, Baek JC et al. · 2025 · Taiwanese journal of obstetrics & gynecology
Objective To report a case of mosaic trisomy 17 with inconsistent findings between noninvasive prenatal testing (NIPT) and genetic amniocentesis. Case report A 34-year-old primigravid woman presented for antenatal care at 9 weeks of…
View details →DOI: 10.1016/j.tjog.2024.10.024 Negative / Null Result ReportOpen accessMedicine
Kataria P, Upadhyay MK, Arya K et al. · 2025 · Journal of family medicine and primary care
Background Antenatal care (ANC) can be defined as the care provided by skilled health-care professionals to pregnant women in order to ensure the best health outcomes. Good quality routine antenatal care forms the foundation of positive…
View details →DOI: 10.4103/jfmpc.jfmpc_1940_24 Negative / Null Result ReportMedicine
O'Leary C, Yoong E, Matsika A et al. · 2025 · Asia-Pacific journal of clinical oncology
Aims Castrate-resistant prostate cancer (CRPC) is a common malignancy with poor prognostic outcomes. Breast cancer (BRCA) genes 1 and 2 mutations occur in prostate cancers and confer poorer prognoses. Somatic BRCA testing can lead to…
View details →DOI: 10.1111/ajco.70011 Negative / Null Result ReportMedicine
Makgoka TR, De Villiers M, Van Zyl DG · 2025 · South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Background Tuberculosis (TB) is a major contributor to mortality among patients affected by HIV. TB diagnosis can be challenging, especially in those who are severely ill and unable to produce sputum. Urine lipoarabinomannan (LAM) is a…
View details →DOI: 10.7196/samj.2025.v115i2.2143 Negative / Null Result ReportMedicine
Wang T, Park B, Anderson G et al. · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Early diagnosis of invasive fungal disease is essential for optimizing management. Although the clinical utility of fungal polymerase chain reaction (PCR) testing on plasma and bronchoalveolar lavage (BAL) has been established,…
View details →DOI: 10.1093/cid/ciae382 Negative / Null Result ReportOpen accessMedicine
May J, Waturangi DE, Tan WA et al. · 2026 · Scientific reports
Biofilm-forming bacteria, such as Bacillus cereus and Vibrio harveyi are major contributors to food contamination and problems in aquaculture. This study aimed to evaluate the antibiofilm compounds of the phyllosphere bacterial…
View details →DOI: 10.1038/s41598-026-34989-6 Negative / Null Result ReportMedicine
Zheng J, Guo Q, Yue G et al. · 2025 · World journal of urology
Objective There is ongoing debate regarding whether patients with a positive urine culture (UC) need to wait for the culture to turn negative following antimicrobial treatment before undergoing percutaneous nephrolithotomy (PCNL). This…
View details →DOI: 10.1007/s00345-025-05484-w Negative / Null Result ReportMedicine
Leech J, Sauer BM, Baduashvili A et al. · 2025 · Neurology. Clinical practice
Background and objectives The presence of oligoclonal bands (OCBs) indicates an augmented immune response within the CNS and is integral to the diagnosis of multiple sclerosis (MS). Expert consensus panels recommend OCB testing for…
View details →DOI: 10.1212/cpj.0000000000200510 Negative / Null Result ReportMedicine
Wezenberg BN, Koster M, van Wingen G et al. · 2025 · Schizophrenia research
Objective Sleep disturbances and brain alterations are common in psychotic disorders and individuals at clinical high risk for psychosis (CHR-P). It remains unclear whether gray matter volume changes are inherent to psychosis or partly…
View details →DOI: 10.1016/j.schres.2025.09.010 Negative / Null Result ReportOpen accessMedicine
Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Malaria journal
Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers' (HCWs) concerns…
View details →DOI: 10.1186/s12936-025-05674-2 