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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 540 of 725

Negative / Null Result ReportMedicine

Comparison of susceptibility of Pseudomonas aeruginosa isolated from keratitis to antibiotics and multipurpose disinfecting solutions.

Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…

View details →DOI: 10.1016/j.clae.2024.102288
Negative / Null Result ReportOpen accessMedicine

Relationship between the anxiety of labor companion and labor satisfaction among laboring women.

Nasirzadeh A, Mohammadzadeh F, Kazeminia S et al. · 2025 · Scientific reports

The presence of a known labor companion was shown to improve childbirth satisfaction. However, a companion's anxiety might affect the satisfaction of laboring women. Therefore, this study aimed to evaluate the relationship between the…

View details →DOI: 10.1038/s41598-025-04754-2
Negative / Null Result ReportMedicine

Lack of Association Between Immunotherapy and Improvement of Survival for Non-small Cell Lung Cancer Patients With Hemodialysis: A Nationwide Retrospective Cohort Study.

Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer

Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…

View details →DOI: 10.1016/j.cllc.2023.11.003
Negative / Null Result ReportOpen accessMedicine

Peripheral immune system activity in young psychiatry patients.

Seizer L, Löchner J, Renner TJ · 2026 · Brain, behavior, & immunity - health

The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This…

View details →DOI: 10.1016/j.bbih.2025.101143
Negative / Null Result ReportOpen accessMedicine

Implicit Bias and Recognition of Biases Among Vascular Surgeons.

Howard KA, Witrick B, Clark A et al. · 2026 · The Journal of surgical research

Introduction Implicit bias can influence behavior and decision-making, such as treatment decisions in clinical settings. Given documented Black-White disparities in vascular care, the purpose of this study was to describe the prevalence…

View details →DOI: 10.1016/j.jss.2026.02.004
Negative / Null Result ReportOpen accessMedicine

Mechanosensitivity and Adipose Thickness as Determinants of Pressure to Reach Deep Fasciae in Cervical and Thoracolumbar Regions.

Pires S, Freitas M, Pinho F et al. · 2025 · Sensors (Basel, Switzerland)

Objective We aimed to quantify the mechanical pressure required to reach the deep cervical and thoracolumbar fasciae, to examine its association with pressure pain threshold (PPT) and adipose tissue thickness, and to determine whether PPT…

View details →DOI: 10.3390/s25165073
Negative / Null Result ReportOpen accessMedicine

Lack of association between breastfeeding duration and body mass index in children and adolescents - A Swedish cohort study.

Haahr Vad O, Önnestam L, Bengtsson Boström K et al. · 2025 · PloS one

Aims The aim of the study was to investigate the association between breastfeeding duration and body mass index (BMI), overweight and obesity in children during follow-up until 16 years of age. Methods Observational cohort study of mothers…

View details →DOI: 10.1371/journal.pone.0319502
Negative / Null Result ReportOpen accessMedicine

<i>IL4</i> Gene Variants rs2243250 and rs2243248 and Their Association with Clinical Phenotypes of Severe Asthma in the Mexican Population: In Silico Functional Analysis and Regulatory Implications.

Montoya-Delgado IB, Ochoa-García IV, Escobedo-Salcedo ZL et al. · 2026 · International journal of molecular sciences

Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and…

View details →DOI: 10.3390/ijms27114711
Negative / Null Result ReportOpen accessMedicine

Lack of association between food insecurity, eating disorders, and orthorexia nervosa: findings from a cross-sectional study in Lebanon.

Sacre H, Haddad C, Rizk R et al. · 2025 · Frontiers in public health

Objectives To investigate the association between food insecurity (FI), eating disorders (EDs), and orthorexia nervosa (ON) among Lebanese university students. Methods This cross-sectional study, conducted between 2021 and 2022, enrolled…

View details →DOI: 10.3389/fpubh.2025.1572654
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Sodium Intake and Cytokine Levels.

Wistrand H, Kaartinen NE, Jousilahti P et al. · 2024 · Integrated blood pressure control

Purpose The complex pathogenesis of hypertension, potentially involving inflammatory pathways, remains elusive. This study aimed to evaluate the relationship between 24-hour urinary sodium excretion and inflammatory cytokines alongside…

View details →DOI: 10.2147/ibpc.s483495
Negative / Null Result ReportOpen accessMedicine

Accounting for Time-Varying Confounding in a Self-Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen-Related Events.

Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives

We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…

View details →DOI: 10.1002/prp2.70124
Negative / Null Result ReportOpen accessMedicine

Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization.

Kayode GA, Zagkos L, Oboli G et al. · 2025 · PloS one

Background Subarachnoid haemorrhage (SAH) poses a life-threatening risk, contributing to half of all haemorrhagic strokes, with aneurysmal SAH (aSAH) affecting approximately 6 individuals per 100,000 annually. Following aSAH, the influx of…

View details →DOI: 10.1371/journal.pone.0329287
Negative / Null Result ReportMedicine

Y-Balance Test after ACL Reconstruction: The relationship with knee and hip muscle strength, ankle dorsiflexion range of motion and postural stability.

Rodrigues CAS, Albano TR, Pereira Melo AK et al. · 2024 · Journal of bodywork and movement therapies

Background Y-Balance Test (YBT) assesses postural stability. When is applied to patients after anterior cruciate ligament reconstruction (ACLR), it is not clear which variables influence its result. Objective To connect YBT and postural…

View details →DOI: 10.1016/j.jbmt.2024.10.016
Negative / Null Result ReportOpen accessMedicine

Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery.

Harik L, Gregg AC, Wu Y et al. · 2026 · Journal of the American Heart Association

Background Patient-surgeon sex concordance influences postoperative outcomes in general surgery, but its relevance in cardiac surgery is unknown. Methods This was a cohort study of 223 065 Medicare beneficiaries undergoing coronary artery…

View details →DOI: 10.1161/jaha.125.048015
Negative / Null Result ReportOpen accessMedicine

Associations between usual source of care characteristics and health outcomes in diabetes mellitus: a focus on medication adherence and healthy behaviors in Korea.

Lee SE, Kim CW, Bae JE et al. · 2025 · Epidemiology and health

Objectives This study investigated the associations between usual source of care (USC) characteristics, which incorporate primary care functions, and medication adherence and healthy behaviors in Korean adults with diabetes. Methods We…

View details →DOI: 10.4178/epih.e2025063
Negative / Null Result ReportOpen accessMedicine

Early recurrence of febrile seizures during acute illness: risk factors and lack of association with long-term epilepsy in a Pediatric cohort.

Jiang W, Cheng A, Wang J et al. · 2025 · Frontiers in neurology

Background Febrile seizures (FSs) are a common neurological manifestation in children, affecting 2%-5% of children worldwide. While acute-phase recurrences during the same febrile illness are frequent, their risk factors and implications…

View details →DOI: 10.3389/fneur.2025.1733941
Negative / Null Result ReportOpen accessMedicine

MRI-Based Evaluation of PRP Therapy in Knee Osteoarthritis: WORMS and Synovial Changes at 6 Months.

Wakayama T, Saita Y, Uchino S et al. · 2025 · Journal of clinical medicine

Objective: Platelet-rich plasma (PRP) therapy has become a popular treatment for knee osteoarthritis. We aimed to determine the outcomes of knee osteoarthritis patients following PRP therapy using magnetic resonance imaging (MRI) findings…

View details →DOI: 10.3390/jcm14186408
Negative / Null Result ReportMedicine

Lack of association between nonalcoholic fatty liver disease and intracerebral hemorrhage: A community-based cohort study.

Wu J, Guo J, Wang A et al. · 2023 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Background The association between nonalcoholic fatty liver disease (NAFLD) and intracerebral hemorrhage (ICH) remains unclear. This study aimed to investigate whether NAFLD and its severity predict incident ICH. Methods Participants free…

View details →DOI: 10.1016/j.jocn.2023.09.027
Negative / Null Result ReportMedicine

Insulin resistance and beta-cell dysfunction in adults with different patterns of diet: a cross-sectional study in north-western Tanzania.

Malindisa EK, Dika H, Rehman AM et al. · 2025 · European journal of clinical nutrition

Background The diabetes burden in sub-Saharan Africa is rising, but there is little African data on associations between diet, insulin resistance, and beta-cell dysfunction. Objective We investigated the association between dietary…

View details →DOI: 10.1038/s41430-024-01518-5
Negative / Null Result ReportOpen accessMedicine

Lack of association of ABO and RhD blood groups with COVID-19 mortality: A 2-center cross-sectional study in Saudi Arabia.

Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine

Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…

View details →DOI: 10.1097/md.0000000000039673
Negative / Null Result ReportOpen accessMedicine

Lack of association between prior or concurrent malignancies and overall survival in gastroesophageal cancer: evidence from a large European single-center cohort.

Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…

View details →DOI: 10.1007/s12094-025-04036-3
Negative / Null Result ReportOpen accessMedicine

Impact of Prediabetes on In-Hospital Mortality and Clinical Outcomes in Acute Pancreatitis: Insights from a Nationwide Inpatient Sample.

Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine

Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…

View details →DOI: 10.3390/jcm14124271
Negative / Null Result ReportOpen accessMedicine

Association of Gallstone and Polymorphisms of ABCB11 Gene among the Adult Patients in Iran: A Case Control Study : Gallstone and ABCB11 Gene.

Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal

Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…

View details →DOI: 10.31661/gmj.v14i.4066